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List of works by Eyal Gottlieb

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

scientific article published on 26 November 2018

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

scientific article published on 19 May 2013

A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis

scientific article

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

scientific article published on 11 May 2016

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

scientific article published on January 2017

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Alcohol-derived acetate modulates brain function

scientific article published on 01 November 2019

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

scientific article published on 20 October 2017

Analysis of Cell Metabolism Using LC-MS and Isotope Tracers

scientific article published on 17 August 2015

Anti-cancer effects of vitamin C revisited.

scientific article published on 15 January 2016

Auto-Commentary on: "Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells".

scientific article published on 18 December 2017

BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

scientific article published on 12 November 2010

Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation

scientific article published on 20 March 2013

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

scientific article

Cancer and metabolism: Why should we care?

scientific article published on 01 July 2015

Cancer metabolism at a glance

scientific article published in September 2016

Cancer metabolism: Friendly neighbours feed tumour cells

scientific article

Cancer: The fat and the furious

scientific article published in September 2009

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.

scientific article published on 18 May 2009

Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

scientific article

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

scientific article

Defining functional classes of Barth syndrome mutation in humans

scientific article

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

scientific article

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

scientific article published on 31 August 2016

Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect

scientific article

Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification

scientific article published on 19 June 2014

Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective

scientific article published on 21 October 2009

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

scientific article

Glutaminolysis activates Rag-mTORC1 signaling.

scientific article published on 29 June 2012

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

scientific article published on 01 December 2020

Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis

scientific article

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

scientific article published on 11 April 2010

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

scientific article published on 22 October 2012

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

scientific article

Harnessing synthetic lethality to predict the response to cancer treatment.

scientific article

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

scientific article published on 26 July 2021

IDH1 mutations in gliomas: when an enzyme loses its grip

scientific article published in January 2010

IN SITU METABOLIC PROFILING SHEDS LIGHT ON OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT OLIGODENDROGLIOMA.

scientific article published in July 2014

In memory of Marcos Vidal (1974-2016).

scientific article published on 12 January 2016

Inborn and acquired metabolic defects in cancer ⬇️

scientific article published on 08 February 2011

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

scientific article

KRAS4A directly regulates hexokinase 1

scientific article published on 11 December 2019

MAPPING THE GLIOBLASTOMA METABOLOME AFTER BEVACIZUMAB THERAPY BY 13C6-GLUCOSE METABOLOMIC FLUX ANALYSIS.

scientific article published in July 2014

METB-09IDENTIFYING NOVEL VULNERABILITIES IN OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT GLIOMA.

scientific article

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

scientific article

Metabolic transformation in cancer.

scientific article published on 25 March 2009

Mind your media

scientific article published on 12 October 2020

Mitochondria in cancer: not just innocent bystanders

scientific article published on 03 December 2008

Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

scientific article published on June 2003

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

scientific article (publication date: 2012)

Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis.

scientific article published on 26 June 2015

OPA1 and PARL keep a lid on apoptosis

scientific article published on July 2006

Oncometabolites: tailoring our genes

scientific article

One carbon, many roads

scientific article published on 6 January 2017

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

scientific article

PGAMgnam Style: A Glycolytic Switch Controls Biosynthesis

scientific article published on 01 November 2012

Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection

scientific article

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality

scientific article

Predicting selective drug targets in cancer through metabolic networks.

scientific article

Prolyl hydroxylases as regulators of cell metabolism.

scientific article published on February 2009

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress.

scientific article published on 20 April 2018

Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability

scientific article

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

scientific article

RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells

scientific article

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

scientific article published on 31 August 2009

Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells.

scientific article published on 17 May 2006

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

scientific article published on August 1994

Research into cancer metabolomics: Towards a clinical metamorphosis

scientific article

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

scientific article

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

scientific article published on 28 May 2021

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

scientific article

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

scientific article published on 23 May 2012

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

scientific article

Serine one-carbon catabolism with formate overflow

scientific article published on 28 October 2016

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

scientific article published on 16 December 2012

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

scientific article published on 21 September 2016

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

scientific article

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

scientific article

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

scientific journal article

Targeting metabolic transformation for cancer therapy.

scientific article published on 19 March 2010

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

scientific article published on 18 September 2017

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

scientific article published on 05 September 2018

The Nurture of Tumors Can Drive Their Metabolic Phenotype

scientific article published on 01 March 2016

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

scientific article published on 07 January 2021

The metabolic fate of acetate in cancer

scientific article

The music of lipids: how lipid composition orchestrates cellular behaviour

scientific article

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.

scientific article published on 19 May 2016

Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965

scientific article published on 26 June 2020

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

scientific article

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

scientific article

p53 guards the metabolic pathway less travelled

scientific article published on 20 February 2011

p53 regulation of metabolic pathways

scientific article published on 02 December 2009

p53 status determines the role of autophagy in pancreatic tumour development

scientific article published on 4 December 2013

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