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List of works by Eckhard Wolf

3D structured illumination microscopy of mammalian embryos and spermatozoa

scientific article

A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization.

scientific article

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

scientific article

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A decade of experience with genetically tailored pig models for diabetes and metabolic research

scientific article published on 26 August 2020

A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse

scientific article published on 18 December 2006

A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum.

scientific article published in February 2008

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

scientific article (publication date: 29 May 2009)

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation

scientific article

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?

scientific article published on 30 April 2009

A new mouse model for studying EGFR-dependent gastric polyps

scientific article published on 8 May 2012

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.

scientific article

A porcine model of familial adenomatous polyposis

scientific article published in August 2012

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

scientific article

A reliable procedure for differential staining of in vitro produced bovine blastocysts: comparison of tissue culture medium 199 and Ménézo's B2 medium ⬇️

scientific article published on February 27, 1998

A transgenic mouse line expressing cre recombinase in pancreatic β-cells

scientific article

AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms

scientific article published on 2 June 2010

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments

scientific article

Accelerated growth and visceral lesions in transgenic mice expressing foreign genes of the growth hormone family: an overview

scientific article published on July 1991

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice

scientific article published in May 1997

Actions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium

scientific article

Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases

scientific article published in April 2000

Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

scientific article

Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin

scientific article published on 15 September 2004

Adult cloning in cattle: potential of nuclei from a permanent cell line and from primary cultures

scientific article published on November 1999

Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse

scientific journal article

Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system

scientific article published in April 1998

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Behavior of M-phase synchronized blastomeres after nuclear transfer in cattle

scientific article published in September 2000

Betacellulin overexpression in the mouse ovary leads to MAPK3/MAPK1 hyperactivation and reduces litter size by impairing fertilization

scientific article published on 3 October 2007

Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology

scientific article published on 22 September 2005

Betacellulin overexpression in transgenic mice improves glucose tolerance and enhances insulin secretion by isolated islets in vitro

scientific article

Betacellulin protects from pancreatitis by activating stress-activated protein kinase

scientific article published on 29 December 2009

Betacellulin regulates hair follicle development and hair cycle induction and enhances angiogenesis in wounded skin

scientific article published on 25 October 2007

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice

scientific journal article

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology

scientific article published on 13 June 2008

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

scientific article published on 9 June 2016

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

scientific article published on 06 January 2017

Blood Collection from Mice and Hematological Analyses on Mouse Blood

scientific article

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender

scientific article published in April 2002

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

scientific article

Bovine somatic cell nuclear transfer using recipient oocytes recovered by ovum pick-up: effect of maternal lineage of oocyte donors

scientific article

CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue

scientific article published in January 2005

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

scientific journal article

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

scientific article

Canine Embryo-Derived Stem Cells-Toward Clinically Relevant Animal Models for Evaluating Efficacy and Safety of Cell Therapies

scientific article published in July 2007

Canine embryo-derived stem cells and models for human diseases

scientific article published on April 2008

Canine embryonic stem cells: state of the art.

scientific article published on 05 December 2009

Cell arrest and cell death in mammalian preimplantation development: lessons from the bovine model

scientific article published on 21 July 2011

Cell-Mediated Transgenesis in Rabbits: Chimeric and Nuclear Transfer Animals

article by Valeri Zakhartchenko et al published 13 October 2010 in Biology of Reproduction

Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos

scientific article

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass

scientific article

Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract

scientific article published in December 2001

Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene

scientific journal article

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

scientific article published on 5 April 2016

Chimeric pigs following blastocyst injection of transgenic porcine primordial germ cells

scientific article published on November 1999

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.

scientific article published on 3 April 2017

Chronic growth hormone excess is associated with increased aldosterone: a study in patients with acromegaly and in growth hormone transgenic mice.

scientific article published on 2 June 2009

Clinical Chemistry and Other Laboratory Tests on Mouse Plasma or Serum

scientific article

Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

scientific article published on 13 July 2009

Clinical chemistry of human FcRn transgenic mice

Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing

scientific article

Cloning of animals--perspectives for biomedical research

scientific article published on 01 August 2002

Coenzyme Q(10) in submicron-sized dispersion improves development, hatching, cell proliferation, and adenosine triphosphate content of in vitro-produced bovine embryos.

scientific article published in August 1999

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation

scientific article published on 25 August 2020

Commentary on “Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood” (by Harris et al.): tailoring donor pigs for xenotransplantation

scientific article published on 25 February 2015

Comparative aspects of early lineage specification events in mammalian embryos - insights from reverse genetics studies

scientific article published on 21 August 2018

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

scientific article published on 21 April 2016

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium1

article

Comparison of ultrasound-guided vs laparoscopic transvaginal ovum pick-up (OPU) in simmental heifers

scientific article published in July 1998

Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

scientific article published on 17 March 2014

Completion of the swine genome will simplify the production of swine as a large animal biomedical model

scientific article published on 15 November 2012

Composition of parental mitochondrial DNA in cloned bovine embryos.

scientific article

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures

scientific article

Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets

scientific article published on 23 November 2015

Concise classification of the genomic porcine endogenous retroviral gamma1 load to defined lineages

scientific article published on 26 October 2007

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

scientific article published in November 1994

Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos

scientific article

Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice.

scientific article published on March 2000

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers.

scientific article published on 17 May 2013

Correlation of in vivo and in vitro release data for rh-INFalpha lipid implants

scientific article published on 5 June 2008

Correlations between chemical parameters, mitogenic activity and embryotrophic activity of bovine oviduct-conditioned medium.

scientific article published on September 1997

Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling

scientific article published in May 2008

Creating new knowledge for ruminant reproduction from rapidly expanding and evolving scientific databases.

scientific article published on January 2010

Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF

article

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo

scientific article

Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice

scientific article

DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice

scientific article published on 22 July 2014

Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis

scientific article published on 16 February 2011

Decreased p44/42 mitogen-activated protein kinase phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice

scientific article published on 23 October 2008

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

scientific article published on 13 April 2018

Development of frozen-thawed porcine blastocysts in vitro and in vivo

scientific article published on August 1996

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation

scientific article published on 17 December 2015

Developmental regulation of hyaluronan-binding protein (RHAMM/IHABP) expression in early bovine embryos

scientific article published in January 2003

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium

scientific article published on January 2017

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects

scientific article published on 04 December 2007

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis

scientific article published on 11 February 2009

Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice

scientific article

Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn).

scientific article published on 23 October 2007

Differential autocrine regulation of intestine epithelial cell proliferation and differentiation by insulin-like growth factor (IGF) system components

article

Differential endometrial gene expression in pregnant and nonpregnant sows

scientific article published on 14 April 2010

Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs

scientific article

Disruption of the CNTF gene results in motor neuron degeneration

scientific article published in September 1993

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice

scientific article

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation

scientific article published in March 2009

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

scientific journal article

Does the overexpression of pro-insulin-like growth factor-II in transfected human embryonic kidney fibroblasts increase the secretion of lysosomal enzymes?

scientific article published on August 1995

Domestic animal models for biomedical research

scientific article published on August 2012

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

article by Nadja Herbach et al published 15 February 2007 in Diabetes

Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus

scientific article

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle

scientific article published on February 2008

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy

scientific article

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle

scientific article

EGFR ligands exert diverging effects on male reproductive organs

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta

scientific article

Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2 C95S)

article

Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells

scientific article

Effect of chronic GH overproduction on cardiac ANP expression and circulating ANP levels

scientific article published on 01 September 1998

Effect of donor embryo cell number and cell size on the efficiency of bovine embryo cloning

scientific article published in September 1995

Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice

scientific article published on 24 July 2007

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

scientific article published on 20 August 2008

Effects of IGFBP-2 overexpression in vitro and in vivo

scientific article (publication date: July 2000)

Effects of a novel co-culture system on development, metabolism and gene expression of bovine embryos produced in vitro

scientific article published in October 2002

Effects of bovine serum albumin and estrous cow serum on development and ultrastructure of in vitro-produced porcine embryos

scientific article published in June 2002

Effects of growth hormone on the ultrastructure of bovine preimplantation embryos

scientific article published on 29 May 2004

Effects of growth hormone overproduction on grip strength of transgenic mice

scientific article published in December 1995

Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro.

scientific article published in July 2002

Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models

article

Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts.

scientific article published in March 1999

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition

scientific article

Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor

scientific article published in May 1994

Efficient in vitro production of cat embryos in modified synthetic oviduct fluid medium: effects of season and ovarian status

scientific article published in July 2001

Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing

scientific article published on 29 June 2016

Efficient transgenesis in farm animals by lentiviral vectors

scientific article published on 17 October 2003

Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity

scientific article published in August 2006

Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk.

scientific article

Embryonic Stem Cells and Nuclear Transfer Strategies

scientific article published in 2000

Energy status of nonmatured and in vitro-matured domestic cat oocytes and of different stages of in vitro-produced embryos: enzymatic removal of the zona pellucida increases adenosine triphosphate content and total cell number of blastocysts

scientific article published in September 2001

Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters

scientific article published on 21 October 2015

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants

scientific journal article

Enhanced proapoptotic gene expression of XAF1, CASP8 and TNFSF10 in the bovine endometrium during early pregnancy is not correlated with augmented apoptosis.

scientific article published on 25 January 2010

Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels

scientific article published in January 2001

Epigen Transgenic Mice Develop Enlarged Sebaceous Glands

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

scientific article published on 21 February 2018

Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.

scientific article published on July 2003

Epigenetic regulation of lentiviral transgene vectors in a large animal model

scientific article

Epigenetic reprogramming in mammalian nuclear transfer

scientific article

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland

scientific article published on 25 February 2010

Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts.

scientific article

Evaluation of laser-assisted lentiviral transgenesis in bovine

scientific article published in August 2006

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes

scientific article

Evidence for estrogen-dependent uterine serpin (SERPINA14) expression during estrus in the bovine endometrial glandular epithelium and lumen

scientific article

Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.

scientific article published on 23 January 2016

Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling

scientific article published on 30 December 2010

Expression of biologically active human TRAIL in transgenic pigs

scientific article

Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice

scientific article published on July 2003

Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits

scientific article published in November 1994

Expression of the vascular endothelial growth factor and its receptors and effects of VEGF during in vitro maturation of bovine cumulus-oocyte complexes (COC).

scientific article

Expression pattern of STAT5A gene during early bovine embryogenesis

scientific article

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

scientific article

FISH on 3D preserved bovine and murine preimplantation embryos

scientific article published in January 2010

Factors affecting proliferation and dedifferentiation of primary bovine oviduct epithelial cells in vitro

scientific article published on 21 April 1999

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.

scientific article

Fine mapping of genome activation in bovine embryos by RNA sequencing

scientific article published on 03 March 2014

First inducible transgene expression in porcine large animal models

scientific article published on December 2011

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 2b: genetically modified source pigs

scientific article published on March 2016

Formation of nucleoli in interspecies nuclear transfer embryos derived from bovine, porcine, and rabbit oocytes and nuclear donor cells of various species

scientific article published on 14 January 2011

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers

scientific article published on 8 July 2015

Functional consequences of IGFBP excess-lessons from transgenic mice

scientific article

Functional genomics: tools for improving farm animal health and welfare.

scientific article published in April 2005

Functional organization of secondary lymphoid organs by homeostatic chemokines.

scientific article published in September 2000

Functional organization of secondary lymphoid organs by the chemokine system

scientific article published in January 2000

Gene expression of galectin-9/ecalectin, a potent eosinophil chemoattractant, and/or the insertional isoform in human colorectal carcinoma cell lines and detection of frame-shift mutations for protein sequence truncations in the second functional lec

article

Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes.

scientific article published in June 2005

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes

scientific article published on 26 October 2011

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

scientific article

Generation and characterization of dickkopf3 mutant mice

scientific article

Generation of ENU-Induced Mouse Mutants with Hypocholesterolemia: Novel Tools for Dissecting Plasma Lipoprotein Homeostasis

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters

scientific article published on 8 May 2011

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models

scientific article published on 16 January 2009

Generation of transgenic cattle by lentiviral gene transfer into oocytes

scientific article published on 24 March 2004

Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

scientific article published on February 2008

Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis

scientific article

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice

scientific article published on 10 July 2014

Genetic modification of pigs as organ donors for xenotransplantation

scientific article published in March 2010

Genetically engineered pig models for diabetes research

scientific article

Genetically engineered pigs as investigative and translational models in dermatology

scientific article published on 17 November 2015

Genome activation in bovine embryos: review of the literature and new insights from RNA sequencing experiments

scientific article published on 06 June 2014

Genome-wide search for loci controlling serum IGF binding protein levels of mice

scientific article published on 01 April 2001

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

scientific article

Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes

scientific article published on 13 May 2010

Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice

scientific article published on 7 February 2006

Genotyping of transgenic mice: old principles and recent developments

scientific article published on 9 April 2005

Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology

scientific article published on 28 October 2009

Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice

Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function

scientific article published on 25 February 2010

Growth Hormone (GH)/GH Receptor Expression and GH-Mediated Effects During Early Bovine Embryogenesis1

scientific article published in June 2001

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment

scientific article

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. I. Body weight gain and external body dimensions

scientific article

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. II. Skeleton.

scientific article

Growth factors and components for extracellular proteolysis are differentially expressed during in vitro maturation of bovine cumulus-oocyte complexes

scientific article published in October 1998

Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth

scientific article published on March 2016

Growth hormone inhibits apoptosis in in vitro produced bovine embryos

scientific article published in February 2002

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies

scientific article published on 25 November 2020

Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes

scientific article published on 27 November 2002

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

scientific article published in May 2001

Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system

scientific article published in April 2004

HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity

scientific article

Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood

scientific article published in January 2003

High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent

scientific article published in March 2009

High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice

scientific article

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

scientific article

Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro

scientific article

Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period

scientific article published in July 2005

Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA.

scientific article published on 5 March 2014

Hosting the preimplantation embryo: potentials and limitations of different approaches for analysing embryo-endometrium interactions in cattle

scientific article published on January 2012

Human Insulin-Like Growth Factor I (IGF-I) Produced in the Mammary Glands of Transgenic Rabbits: Yield, Receptor Binding, Mitogenic Activity, and Effects on IGF-Binding Proteins

scientific article published in January 1997

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses

article

Hypercholesterolemia in ENU-induced mouse mutants

scientific article published in September 2004

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect

scientific article published on 3 December 2002

IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

scientific article

IGF-binding protein-4: biochemical characteristics and functional consequences

scientific journal article

IGF-binding protein-5: flexible player in the IGF system and effector on its own

scientific article (publication date: March 2002)

IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis

scientific article published in May 2009

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters

scientific article published on 18 March 2017

Identification of immunological relevant phenotypes in ENU mutagenized mice

scholarly article by Heinrich Flaswinkel et al published July 2000 in Mammalian Genome

Identification of transgenic mice by direct PCR analysis of lysates of epithelial cells obtained from the inner surface of the rectum

scientific article published on 01 March 1998

Immune aspects of embryo-maternal cross-talk in the bovine uterus

scientific article published on March 2013

Immunological mechanisms to establish embryo tolerance in early bovine pregnancy.

scientific article published in January 2011

Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor

scientific article

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

scientific article published in October 2001

In vitro systems for intercepting early embryo-maternal cross-talk in the bovine oviduct.

scientific article published on 05 December 2009

In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland

scientific article published on 13 September 2011

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

scientific article published on 23 November 2019

In-vivo biodegradation of extruded lipid implants in rabbits

scientific article published in October 2012

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs

scientific article

Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice

scientific article

Increase of essential amino acids in the bovine uterine lumen during preimplantation development

scientific article

Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy

scientific article published on 27 July 2013

Increased activity of catalase in tumor cells overexpressing IGFBP-2.

scientific article published on November 2003

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models

scientific article published on 12 October 2015

Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos

scientific article published on 19 March 2003

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cells

scientific article published on 19 July 2012

Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation

scientific article published on 16 January 2016

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways

scientific article published on 21 April 2005

Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms

scientific article published on March 2004

Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cells in vivo

scientific article

Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells

scientific article

Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? ⬇️

scientific article published on December 15, 2001

Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice

scientific article published on 20 November 2002

Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines

scientific article published on September 1998

Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice.

scientific article published on April 2004

Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells

scientific article published in October 2001

Insulin-like growth factors and IGF-binding proteins in bovine seminal plasma

scientific article published in July 1999

Integration of nano- and biotechnology for beta-cell and islet transplantation in type-1 diabetes treatment

scientific article published on 27 April 2020

Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice

scientific article published in December 1997

Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells

scientific article published in April 2000

Intestinal dimensions of mice divergently selected for body weight

scientific article

Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pretreatment and injection technique

scientific article published in October 2000

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

scientific article

Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor

scientific article

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

scientific article published on 15 January 2020

Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos: effect on developmental potential

scientific article published in November 1997

Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA.

scientific article published on February 2004

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data

scientific article

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly

scientific article published on 18 October 2011

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants

scientific article published on 20 April 2005

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Leptin promotes meiotic progression and developmental capacity of bovine oocytes via cumulus cell-independent and -dependent mechanisms.

scientific article published on 8 November 2006

Lessons from gene knockouts

scientific article published on April 1998

Ligand-independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

scientific article published in October 2013

Longitudinal in vivo effects of growth hormone overexpression on bone in transgenic mice

scientific article

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

scientific article (publication date: 2 March 2010)

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation

scientific article published on 12 November 2015

Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer

scientific article published on October 1, 2001

Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice

scientific article

Maternal-Fetal Transplacental Leakage of Mitochondrial DNA in Bovine Nuclear Transfer Pregnancies: Potential Implications for Offspring and Recipients

Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts

scientific article published on 15 June 2005

Meis1: effects on motor phenotypes and the sensorimotor system in mice

scientific article published on 23 June 2017

Metamizol Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice

scientific article published on 24 September 2015

Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice

scientific article published on 28 July 2014

Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos

scientific article published on 17 March 2004

Microarray analysis of equine endometrium at days 8 and 12 of pregnancy

scientific article published on 14 July 2010

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

scientific article published on 12 May 2022

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring

scientific article published on 12 August 2019

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

scientific article published in February 2016

Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle

scientific article published on 15 July 2016

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

scientific journal article

Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear-mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombination

scientific article

Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning

Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD)

scientific article published on 21 February 2017

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Miz1 is a critical repressor of cdkn1a during skin tumorigenesis

scientific article

Miz1 is required to maintain autophagic flux.

scientific article published in January 2013

Modeling hepatic osteodystrophy in Abcb4 deficient mice

scientific article

Modeling lethal X-linked genetic disorders in pigs with ensured fertility.

scientific article published on 8 January 2018

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice

scientific article

Molecular biological fingerprinting of human lectin expression by RT-PCR.

scientific article

Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34-->q36 by fluorescence in situ hybridization and radiation hybrid mapping

scientific article published in January 2005

Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period

scientific article published on 5 October 2005

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus

scientific article

Mouse phenotyping

scientific article

Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype

scientific journal article

Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse

scientific article (publication date: 15 November 1999)

Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia

scientific article published on 10 March 2010

Mutation of the RGD sequence does not affect plasma membrane association and growth inhibitory effects of elevated IGFBP-2 in vivo

scientific article published in July 2002

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels

scientific article published on 08 June 2009

NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

scientific article published on 7 January 2013

Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis

scientific article published in February 2012

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

scientific article

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis

scientific article

No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.

scientific article

Non-balanced mix of mitochondrial DNA in cloned cattle produced by cytoplast-blastomere fusion.

scientific article published in April 1998

Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone

scientific article published on 26 October 2011

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism

scientific article published on 19 August 2009

Nuclear transfer and transgenesis in the pig.

scientific article published in January 2015

Nuclear transfer in cattle using in vivo-derived vs. in vitro-produced donor embryos: effect of developmental stage

scientific article published in August 1996

Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts

scientific article published in 2001

Nuclear transfer in mammals: recent developments and future perspectives.

scientific article

Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetuses

scientific article published on 17 December 2003

Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells

scientific article

Nucleolar proteins and ultrastructure in bovine in vivo developed, in vitro produced, and parthenogenetic cleavage-stage embryos

scientific article

OCT4/POU5F1 is required for NANOG expression in bovine blastocysts

scientific article published on 26 February 2018

Objectively measured sperm motility and sperm head morphometry in boars (Sus scrofa): relation to fertility and seminal plasma growth factors

article

One-year heterotopic cardiac xenograft survival in a pig to baboon model

scientific article published on 11 December 2013

Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development

scientific article published in February 2005

Overexpression of insulin-like growth factor-II in mouse embryonic stem cells promotes myogenic differentiation

scientific article

Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain

scientific article published in December 1999

Overexpression of insulin-like growth factor-binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells

scientific article published on 01 February 2000

Overgrowth of Skin in Growth Hormone Transgenic Mice Depends on the Presence of Male Gonads

article published in 1999

Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice

scientific article

Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rγ(null) mice engrafted with human peripheral blood mononuclear cells.

scientific article published on May 2013

PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

scientific article published on 30 October 2020

Partial leptin receptor gene deletion in transgenic mice prevents expression of the membrane-bound isoforms except for Ob-Rc

scientific article published on March 2000

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

scientific article

Peri/nuclear localization of intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment in vivo

scientific article published in November 2004

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

scientific article published on 28 December 2012

Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis

scientific article

Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake

scientific article published on 4 April 2006

Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).

scientific article published in December 2009

Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis

scientific article published on 03 August 2013

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

scientific article published on 30 January 2007

Phytohemagglutinin facilitates the aggregation of blastomere pairs from Day 5 donor embryos with Day 4 host embryos for chimeric bovine embryo multiplication

scientific article published on 29 August 2015

Pig instead of human--how safe?. Interview by Dr. Beate Schumacher

scientific article published in September 1999

Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

scientific article

Pigs pave a way to de novo formation of functional human kidneys

scientific article

Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23-33.

scientific article published in January 2016

Pleiotropic effects in Eya3 knockout mice

scientific article

Pleiotropic functions for transcription factor zscan10.

scientific article

Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy

scientific article published in June 2002

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells.

scientific article published on 11 March 2003

Positional changes of a pluripotency marker gene during structural reorganization of fibroblast nuclei in cloned early bovine embryos

scientific article published on January 2014

Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice

scientific article

Postnatal overexpression of insulin-like growth factor II in transgenic mice is associated with adrenocortical hyperplasia and enhanced steroidogenesis

scientific article published on April 1999

Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight

scientific article published on 28 September 2006

Potential of fetal germ cells for nuclear transfer in cattle

scientific article published in April 1999

Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig.

scientific article

Pre-clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique.

scientific article published on 25 November 2015

Precision of high-resolution dual energy X-ray absorptiometry of bone mineral status and body composition in small animal models.

scientific article

Pregnancy rate after ultrasound-guided follicle aspiration in nonlactating cows from different breeds

scientific article published in February 1999

Primary culture of porcine PGCs requires LIF and porcine membrane-bound stem cell factor

article

Progress in Clinical Encapsulated Islet Xenotransplantation

scientific article published in August 2016

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy

scientific article published on 16 September 2016

Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts

scientific article published on February 1999

Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion

scientific article published on 02 December 2013

Proteome analysis of early lineage specification in bovine embryos

scientific article published on 9 October 2014

Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle

scientific article published in April 2010

Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle

scientific article published on 21 February 2007

Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation

scientific article published in January 2007

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Reduced amino acids in the bovine uterine lumen of cloned versus in vitro fertilized pregnancies prior to implantation

scientific article

Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro

scientific article published in February 2006

Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach

scientific article published on 30 October 2002

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs

scientific article published on January 2014

Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol.

scientific article published in August 2001

Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications

scientific article (publication date: 2015)

Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud

scientific article published on 01 December 2003

Reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts.

scientific article

Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

Retinopathy with central oedema in an INS C94Y transgenic pig model of long-term diabetes

scientific article published on 8 May 2017

Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.

scientific article published in June 2004

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

scientific article published on 18 March 2013

Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres

scientific article published on 24 March 2009

Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels

scientific article published in 2015

Screening for dysmorphological abnormalities—a powerful tool to isolate new mouse mutants

article published in 2000

Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models

scientific journal article

Secretion of Biologically Active InterferoNτ by in Vitro-Derived Bovine Trophoblastic Tissue1

scientific article published in December 1995

Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi-embryos

scientific article published in April 1999

Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis

scientific article published on 15 December 2011

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

scientific article published on 2 December 2016

Skeletal growth of transgenic mice with elevated levels of circulating insulin-like growth factor-II.

scientific article published in December 1995

Species-Specific Alternative Splicing of Transgenic RNA in the Mammary Glands of Pigs, Rabbits, and Mice

scientific article published in April 1999

Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation

scientific article published on 01 February 1996

Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter

scientific article published on 12 August 2009

Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations

scientific article published in 1998

Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development

scientific article published on 4 December 2015

Stage-specific proteome signatures in early bovine embryo development

scientific article published on 10 September 2014

Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

scientific article

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

scientific article

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

scientific article published on 17 August 2017

Support for the development of bovine embryos in vitro by secretions of bovine trophoblastic vesicles derived in vitro

article

Systemic first-line phenotyping

scientific article published on January 2009

Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathology

article

Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies

scientific article

Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality

scientific journal article

The ABC of BTC: structural properties and biological roles of betacellulin

scientific article published on 15 January 2014

The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice

scientific article published on 27 March 2009

The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes

scientific article published on 19 July 2001

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies.

scientific article

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

scientific article

The Use of Transgenic Animals in the European Union: The Report and Recommendations of ECVAM Workshop 28

scientific article published on January 1, 1998

The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells

scientific article published on 28 July 2006

The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes

article by Birgit Rathkolb et al published July 2000 in Mammalian Genome

The effect of activation of Mammalian oocytes on remodeling of donor nuclei after nuclear transfer

scientific article published in January 2002

The endocytic adaptor Eps15 controls marginal zone B cell numbers

scientific article

The endometrium responds differently to cloned versus fertilized embryos

scholarly article

The epidermal growth factor receptor and its ligands in female reproduction: insights from rodent models

scientific article published on 4 March 2008

The epidermal growth factor receptor ligands at a glance

scientific article published on March 2009

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis

scientific article

The large-scale Munich ENU-mouse-mutagenesis screen

The mitochondrial genome in embryo technologies

scientific article (publication date: August 2003)

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

scientific article published on 21 December 2015

The variability of ovum pick-up response and in vitro embryo production from monozygotic twin cows

scientific article published on 19 July 2005

Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters

scientific article published on December 2005

Tissue Sampling Guides for Porcine Biomedical Models

scientific article published on 16 February 2016

Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight

scientific article

Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses

scientific article published on 22 March 2006

Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques

scientific article published on 17 March 2004

Topography of growth hormone receptor expression in the bovine embryo

scientific article published on 17 March 1998

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

scientific article

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase

scientific article published on 11 August 2012

Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression

scientific article published in February 2005

Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy.

scientific article published on 17 June 2008

Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions

scientific article published on 8 May 2015

Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation

scientific article published on 13 April 2016

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation

scientific article published on 7 April 2004

Transgenic pigs as models for translational biomedical research

scientific article published on 26 March 2010

Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression

scientific article published on April 2010

Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons

scientific article published on 16 July 2019

Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.

scientific article published in June 2012

Tumor galectinology: insights into the complex network of a family of endogenous lectins

scientific article published on January 2004

Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice

scientific article published on 6 June 2013

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

scientific article (publication date: 2016)

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

scientific article

Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements

scientific article published on 3 July 2014

Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease

scientific article

Uterine responses to the preattachment embryo in domestic ungulates: recognition of pregnancy and preparation for implantation

scientific article

Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism

scientific article

V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice

scientific article published on 01 August 2002

Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation

scientific article

Viability and Functionality of Neonatal Porcine Islet-like Cell Clusters Bioprinted in Alginate-Based Bioinks

scientific article published in 2022

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation

scientific article

Viable pigs with a conditionally-activated oncogenic KRAS mutation

scientific article published on 26 February 2015

Virus safety of islet cell transplantation from transgenic pigs to marmosets

scientific article

What is the function of IGF-II in postnatal life? Answers from transgenic mouse models.

scientific article

Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice

scientific article published on 20 April 2012

Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127.

scientific article published on January 2015

Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future

scientific article

[Application of stem cell technology and nuclear transfer in animal models]

scientific article published on 01 July 2002

[Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle]

scientific article published on 01 January 2006

[Role of podocyte damage in the pathogenesis of glomerulosclerosis and tubulointerstitial lesions: findings in the growth hormone transgenic mouse model of progressive nephropathy]

article

[Xenotransplantation. Possibilities of animal breeding]

scientific article published on 01 January 1999

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

scientific journal article

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells.

scientific article published on 18 April 2013

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