List of works - Pei Zhou

(4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K).

scientific article published in June 2005

A 'just-in-time' HN(CA)CO experiment for the backbone assignment of large proteins with high sensitivity

scientific article published on 27 April 2006

A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data

scientific article

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.

scientific article published on 29 April 2016

A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs

scientific article published on 28 October 2011

A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers

scientific article published on 27 April 2011

A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.

scientific article

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.

scientific article published on 13 December 2017

A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins

scientific article published in May 2001

Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240

scientific article published on 26 November 2009

Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514

scientific article published on 01 February 2004

Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates

scientific article

Chasing acyl carrier protein through a catalytic cycle of lipid A production

scientific article

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

scientific article

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.

scientific article

Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.

scientific article published on 22 March 2016

Drug design from the cryptic inhibitor envelope

scientific article published on 25 February 2016

Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins.

scientific article published on 9 March 2012

Fast acquisition of high resolution 4-D amide-amide NOESY with diagonal suppression, sparse sampling and FFT-CLEAN.

scientific article

Filtered backprojection for the reconstruction of a high-resolution (4,2)D CH3-NH NOESY spectrum on a 29 kDa protein

scientific article published in August 2005

Generalized reconstruction of n-D NMR spectra from multiple projections: application to the 5-D HACACONH spectrum of protein G B1 domain.

scientific article published in February 2004

HASH: a program to accurately predict protein Hα shifts from neighboring backbone shifts

scientific article published on 16 December 2012

HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.

scientific article

High resolution 4-D spectroscopy with sparse concentric shell sampling and FFT-CLEAN.

scientific article published on 14 October 2008

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

scientific article published on 20 June 2016

High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations

scientific article

Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli

scientific article published on 3 March 2007

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.

scientific article

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

scientific article

Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4′-Kinase LpxK Involved in Lipid A Biosynthesis

scientific article

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.

scientific article published on 11 January 2013

NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.

scientific article published on 14 June 2019

NMR assignment of the SRI domain of human Set2/HYPB

scientific article published on 01 January 2006

Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies

scientific article published on January 2010

PACES: Protein sequential assignment by computer-assisted exhaustive search.

scientific article published in June 2003

Polar Fourier transforms of radially sampled NMR data

scientific article

Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).

scientific article published on 14 July 2017

Protein loop closure using orientational restraints from NMR data

scientific article

Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data

scientific article

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

scientific article published on 09 November 2020

Radial sampling for fast NMR: Concepts and practices over three decades ⬇️

scientific article published on July 30, 2010

Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments

scientific article published in July 2005

Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY.

scientific article published on 21 September 2012

Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

scientific article

Sampling of the NMR time domain along concentric rings.

scientific article published on 27 October 2006

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

scientific article

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin

scientific article

Solution structure of the core NFATC1/DNA complex

scientific article

Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins ⬇️

scientific article published on January 4, 2011

Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes

scientific article

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design ⬇️

scientific article published on December 16, 2010

Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging

scientific article published on 24 June 2013

Structural Basis of Lipid Binding for the Membrane-embedded Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK

scientific article

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ ⬇️

scientific article published on August 2, 2012

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

scientific article

Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics

scientific article published on 10 February 2020

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

scientific article

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

scientific article

Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis

scientific article published on 15 August 2016

Structure, inhibition, and regulation of essential lipid A enzymes

scientific article published on 8 December 2016

Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay

scientific article published on 05 February 2019

Suppression of conformational heterogeneity at a protein-protein interface.

scientific article published on 8 July 2015

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

scientific article

Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors

scientific article

Systematic solution to homo-oligomeric structures determined by NMR.

scientific article

The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.

scientific article

The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis

scientific article published on 18 June 2019

The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.

scientific article published on 29 July 2013

The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

scientific article published on 27 March 2007

The unusual UBZ domain of Saccharomyces cerevisiae polymerase η

scientific article

Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.

scientific article

Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra

scientific article published on 27 July 2016

Unconventional Ubiquitin Recognition by the Ubiquitin-Binding Motif within the Y Family DNA Polymerases ι and Rev1

scientific article

Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

scientific article

Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.

scientific article published in April 2009

cis-Proline-mediated Ser(P)5 Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72 ⬇️

scientific article published on December 15, 2010

¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72.

scientific article published on 6 July 2011

List of works by Pei Zhou

(4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K).

A 'just-in-time' HN(CA)CO experiment for the backbone assignment of large proteins with high sensitivity

A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.

A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs

A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers

A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.

A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins

Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240

Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514

Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates

Chasing acyl carrier protein through a catalytic cycle of lipid A production

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.

Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.

Drug design from the cryptic inhibitor envelope

Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins.

Fast acquisition of high resolution 4-D amide-amide NOESY with diagonal suppression, sparse sampling and FFT-CLEAN.

Filtered backprojection for the reconstruction of a high-resolution (4,2)D CH3-NH NOESY spectrum on a 29 kDa protein

Generalized reconstruction of n-D NMR spectra from multiple projections: application to the 5-D HACACONH spectrum of protein G B1 domain.

HASH: a program to accurately predict protein Hα shifts from neighboring backbone shifts

HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.

High resolution 4-D spectroscopy with sparse concentric shell sampling and FFT-CLEAN.

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations

Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli

Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4′-Kinase LpxK Involved in Lipid A Biosynthesis

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.

NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.

NMR assignment of the SRI domain of human Set2/HYPB

Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies

PACES: Protein sequential assignment by computer-assisted exhaustive search.

Polar Fourier transforms of radially sampled NMR data

Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).

Protein loop closure using orientational restraints from NMR data

Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Radial sampling for fast NMR: Concepts and practices over three decades ⬇️

Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments

Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY.

Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

Sampling of the NMR time domain along concentric rings.

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin

Solution structure of the core NFATC1/DNA complex

Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins ⬇️

Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design ⬇️

Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging

Structural Basis of Lipid Binding for the Membrane-embedded Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ ⬇️

Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC

Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis

Structure, inhibition, and regulation of essential lipid A enzymes

Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay

Suppression of conformational heterogeneity at a protein-protein interface.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors

Systematic solution to homo-oligomeric structures determined by NMR.

The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.

The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis

The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.

The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

The unusual UBZ domain of Saccharomyces cerevisiae polymerase η

Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.

Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra

Unconventional Ubiquitin Recognition by the Ubiquitin-Binding Motif within the Y Family DNA Polymerases ι and Rev1

Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.

cis-Proline-mediated Ser(P)5 Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72 ⬇️

¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72.