Search filters

List of works by Jochen Guck

3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK

scientific article published on 24 July 2019

3D correlative single-cell imaging utilizing fluorescence and refractive index tomography.

scientific article published on 11 August 2017

3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments

scientific article published on 10 March 2016

3D inverted colloidal crystals in realistic cell migration assays for drug screening applications

scientific article published on 31 October 2011

A Nanoprinted Model of Interstitial Cancer Migration Reveals a Link between Cell Deformability and Proliferation.

scientific article published on 7 June 2016

A comparison of methods to assess cell mechanical properties

scientific article published on 18 June 2018

A comparison of microfluidic methods for high-throughput cell deformability measurements

scientific article published on 27 April 2020

A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

scientific article published on March 2015

A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy.

scientific article published on 22 March 2016

Accurate evaluation of size and refractive index for spherical objects in quantitative phase imaging

scientific article published on 01 April 2018

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

scientific article

Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens

scientific article published on 01 January 2022

Alterations in Cell Mechanics by Actin Cytoskeletal Changes Correlate with Strain-Specific Rubella Virus Phenotypes for Cell Migration and Induction of Apoptosis

Analysis of Biomechanical Properties of Hematopoietic Stem and Progenitor Cells Using Real-Time Fluorescence and Deformability Cytometry

scientific article published on 01 January 2019

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia

scientific article published on 07 October 2015

Axonal Transport, Phase-Separated Compartments, and Neuron Mechanics - A New Approach to Investigate Neurodegenerative Diseases

Bacterial infection of macrophages induces decrease in refractive index

scientific article published on 6 August 2012

Biophotonic techniques for the study of malaria-infected red blood cells

scientific article published on 27 July 2010

Bone marrow niche-mimetics modulate HSPC function via integrin signaling

scientific article

Brain tissue stiffness is a sensitive marker for acidosis

scientific article

Buckling of epithelium growing under spherical confinement: Supplementary Information

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability

scientific article published on 26 June 2019

Cell Mechanics Based Computational Classification of Red Blood Cells Via Machine Intelligence Applied to Morpho-Rheological Markers

scientific article published on 28 October 2019

Cell nuclei have lower refractive index and mass density than cytoplasm.

scientific article published on 24 March 2016

Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression

scientific article

Characterizing single suspended cells by optorheology

scientific article published on May 2005

Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis

scientific article published on 26 September 2016

Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells

scientific article

Colloidal crystals of compliant microgel beads to study cell migration and mechanosensitivity in 3D

scientific article published on 01 December 2019

Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory.

scientific article

Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response

scientific article published on 29 March 2021

Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery

scientific article published on 30 May 2019

Coupling of active motion and advection shapes intracellular cargo transport

scientific article published on 12 July 2012

Critical review: cellular mechanobiology and amoeboid migration

scientific article published on 27 September 2010

Deformability-based flow cytometry

scientific article

Deformation of phospholipid vesicles in an optical stretcher

scientific article published on 2 July 2015

Detection of Plasmodium falciparum-infected red blood cells by optical stretching

scientific article published in May 2010

Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.

scientific article published on 13 January 2018

Direct observation of light focusing by single photoreceptor cell nuclei

scientific article published on 01 May 2014

Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions

scientific article published on 21 September 2018

DryMass: handling and analyzing quantitative phase microscopy images of spherical, cell-sized objects

scientific article published on 03 June 2020

Dual-beam laser traps in biology and medicine: when one beam is not enough

Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

scientific article

Effects of rigosertib on the osteo-hematopoietic niche in myelodysplastic syndromes

scientific article published on 16 July 2019

Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies.

scientific article published on 13 March 2017

Erratum: Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation

article

Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin

scientific article published on 15 October 2020

Exact analytical expansion of an off-axis Gaussian laser beam using the translation theorems for the vector spherical harmonics.

scientific article

Excitation beyond the monochromatic laser limit: simultaneous 3-D confocal and multiphoton microscopy with a tapered fiber as white-light laser source

scientific article published in September 2005

Extracting Cell Stiffness from Real-Time Deformability Cytometry: Theory and Experiment

scientific article published on November 2015

Feeling for cells with light

Fluorescence ratio thermometry in a microfluidic dual-beam laser trap

scientific article

Grouped retinae and tapetal cups in some Teleostian fish: occurrence, structure, and function

scientific article

High-Throughput Microfluidic Characterization of Erythrocyte Shapes and Mechanical Variability

scientific article published on 29 May 2019

High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications

scientific article

High-throughput microfluidic characterization of erythrocyte shape and mechanical variability

High-throughput rheological measurements with an optical stretcher

scientific article

High-throughput single-cell mechanical phenotyping with real-time deformability cytometry

scientific article published on 29 July 2018

Impact of heating on passive and active biomechanics of suspended cells

scientific article

Initiation of acute graft-versus-host disease by angiogenesis.

scientific article

Intelligent image-based deformation-assisted cell sorting with molecular specificity

scientific article published on 25 May 2020

Interaction of Gaussian beam with near-spherical particle: an analytic-numerical approach for assessing scattering and stresses

scientific article published in August 2009

Materials and technologies for soft implantable neuroprostheses

Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells

publication published on 21 September 2021

Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging.

scientific article published on 4 August 2018

Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression

scientific article

Mechanical changes of peripheral nerve tissue microenvironment and their structural basis during development

scientific article published on 17 September 2019

Mechanical deformation induces depolarization of neutrophils

scientific article

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.

scientific article

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

scientific article published on 3 July 2012

Mechanical mapping of spinal cord development and repair in living zebrafish larvae using Brillouin microscopy

Mechanical mismatch between Ras transformed and untransformed epithelial cells

scientific article published on 01 November 2017

Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry

scientific article published on 16 March 2016

Mechanics in neuronal development and repair

scientific article published on 03 May 2013

Mechanics meets medicine

scientific article published in November 2013

Mechanosensing is critical for axon growth in the developing brain

scientific article published on 19 September 2016

Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

Mechanotransduction in neutrophil activation and deactivation

scientific article published on 23 July 2015

Mesenchymal stem cell mechanics from the attached to the suspended state

scientific article

Metabolic Profiling of Human Eosinophils

scientific article published on 21 June 2018

Micro and nanotechnology for biological and biomedical applications

scientific article published on 16 September 2010

Monitoring of laser micromanipulated optically trapped cells by digital holographic microscopy

scientific article

Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry

scientific article published on 20 May 2019

Muller cells are living optical fibers in the vertebrate retina

scientific article

Myosin II Activity Softens Cells in Suspension.

scientific article

Near- and far-field scattering from arbitrary three-dimensional aggregates of coated spheres using parallel computing.

scientific article

Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells

scientific article published on 20 December 2016

Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution.

scientific article

ODTbrain: a Python library for full-view, dense diffraction tomography

scientific article

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

scientific article published on 06 February 2020

Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence

scientific article

Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement

scientific article published on 24 November 2020

Optical rheology of biological cells

scientific article published on 11 March 2005

Oral cancer diagnosis by mechanical phenotyping

scientific article

Photonic Crystal Light Collectors in Fish Retina Improve Vision in Turbid Water

scientific article published in Science

Physical insight into light scattering by photoreceptor cell nuclei

scientific article published on August 2010

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion ⬇️

scientific article (publication date: 18 April 2017)

Quantifying cellular differentiation by physical phenotype using digital holographic microscopy

scientific article

Quantifying the contribution of actin networks to the elastic strength of fibroblasts

scientific article published on 23 May 2006

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

scientific article published on 01 April 2020

Real-Time Deformability Cytometry: Label-Free Functional Characterization of Cells

scientific article

Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming

article

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

scientific article published on 2 February 2015

Real-time fluorescence and deformability cytometry.

scientific article

Recent progress and current opinions in Brillouin microscopy for life science applications

scientific article published on 26 May 2020

Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications

scientific article

Refractive index measurements of single, spherical cells using digital holographic microscopy.

scientific article published on 8 January 2015

Response to Comment on "Cell nuclei have lower refractive index and mass density than cytoplasm": A Comment on "How a phase image of a cell with nucleus refractive index smaller than that of the cytoplasm should look like?", e201800033

scientific article published on 02 May 2018

SAMHD1 prevents autoimmunity by maintaining genome stability

scientific article

Separation of blood cells with differing deformability using deterministic lateral displacement(†).

scientific article

Single-cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage.

scientific article published in December 2017

Some thoughts on the future of cell mechanics

scientific article published on 16 September 2019

Spatial mapping of the mechanical properties of the living retina using scanning force microscopy

Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation

article

Stretching biological cells with light

article by Jochen Guck et al published 2 May 2002 in Journal of Physics: Condensed Matter

Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14

scientific article published on 29 July 2019

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

scientific article

The biophysics of neuronal growth

The cavity-to-cavity migration of leukaemic cells through 3D honey-combed hydrogels with adjustable internal dimension and stiffness

scientific article published on 16 December 2009

The mechanics of myeloid cells

scientific article published on 20 January 2020

The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology

The optical cell rotator

scientific article

The regulatory role of cell mechanics for migration of differentiating myeloid cells

scientific article

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

scientific article published on 11 February 2014

The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells

scientific article published on 20 February 2019

Toll-Like Receptor-Mediated Upregulation of CXCL16 in Psoriasis Orchestrates Neutrophil Activation

scientific article published on 20 September 2017

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

scientific article published on 28 December 2016

Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher ⬇️

scientific article published on September 24, 2012

Viscoelastic properties of differentiating blood cells are fate- and function-dependent

scientific article published in 2012

Viscoelastic properties of individual glial cells and neurons in the CNS.

scholarly article

Volume Transitions of Isolated Cell Nuclei Induced by Rapid Temperature Increase

scientific article published in March 2017

Zebrafish Spinal Cord Repair Is Accompanied by Transient Tissue Stiffening

scientific article published on 07 December 2019

nanite: using machine learning to assess the quality of atomic force microscopy-enabled nano-indentation data

scientific article published on 10 September 2019

Paulina is supported by:

About Paulina

Help