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List of works by Gerard Clarke

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

scientific article

A Microbial Drugstore for Motility

scientific article published on 01 June 2018

A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X.

scientific article published on 24 July 2014

A psychology of the human brain-gut-microbiome axis

scientific article published on 18 April 2017

A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action

scientific article

A sensitive period of mice inhibitory system to neonatal GABA enhancement by vigabatrin is brain region dependent

scientific article

A serologic test for irritable bowel syndrome: real meat or bare bones?

scientific article published on 27 October 2009

A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome

scientific article published on 17 March 2014

A systematic review of the psychobiological burden of informal caregiving for patients with dementia: Focus on cognitive and biological markers of chronic stress.

scientific article

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome

scientific article published on 23 October 2014

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

scientific article published on 9 January 2015

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus.

scientific article published on 03 June 2016

Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain

scientific article

An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour.

scientific article

An isocratic high performance liquid chromatography method for the determination of GABA and glutamate in discrete regions of the rodent brain

scientific article published on 24 October 2006

Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder.

scientific article published on 12 February 2009

Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.

scientific article published on 11 October 2016

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

scientific article

Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior

scientific article published in 2021

Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test

scientific article

Birth by Caesarean Section and the Risk of Adult Psychosis: A Population-Based Cohort Study.

scientific article published on 27 November 2015

Brain-gut-microbe communication in health and disease

scientific article published on 7 December 2011

Brain-gut-microbiota axis: challenges for translation in psychiatry.

scientific article published on 08 March 2016

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

scientific article

Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.

scientific article published on 16 July 2009

Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs

scientific article published on 13 November 2018

Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent

scientific article

Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory.

scientific article published on 29 August 2013

Cross Talk: The Microbiota and Neurodevelopmental Disorders

scientific article published on 15 September 2017

Diet and depression: exploring the biological mechanisms of action

scientific article published on 03 November 2020

Differential effect of lithium on cell number in the hippocampus and prefrontal cortex in adult mice: a stereological study

scientific article published on 4 February 2016

Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function

article

Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains ⬇️

scientific article published on December 3, 2010

Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain

scientific article published on 19 July 2013

Dimensional thinking in psychiatry in the era of the Research Domain Criteria (RDoC)

scientific article published on 01 June 2018

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy

scientific article

Drug-gut microbiota interactions: implications for neuropharmacology

Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity ⬇️

scientific article published on March 20, 2012

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

scientific article

Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction

scientific article

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

scientific article published on 6 August 2010

Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors

scientific article

Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.

scientific article published on 9 September 2016

Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model

scientific article

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

scientific article published on 14 October 2019

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

scientific article published on 11 November 2011

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

scientific article

Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions

scientific article published on 01 April 2019

Gut memories: towards a cognitive neurobiology of irritable bowel syndrome

scientific article published on 13 July 2011

Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers

scientific article published on 18 May 2019

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

scientific article published on 10 April 2015

Gut-brain axis serotonergic responses to acute stress exposure are microbiome-dependent

scientific article published on 11 May 2020

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling.

scientific article

Host Microbiota Regulates Central Nervous System Serotonin Receptor 2C Editing in Rodents

scientific article published on 19 August 2019

Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability

scientific article published on 9 August 2013

Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology

scientific article

Impact of short-term cycle ergometer training on quality of life, cognition and depressive symptomatology in multiple sclerosis patients: a pilot study.

scientific article published on 26 December 2017

Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease

scientific article published on 26 June 2019

Informal caregiving for dementia patients: the contribution of patient characteristics and behaviours to caregiver burden

scientific article published on 01 December 2019

Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats

scientific article

Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?

scientific article

Irritable bowel syndrome: a microbiome-gut-brain axis disorder?

scientific article

Irritable bowel syndrome: towards biomarker identification

scientific article published on 05 October 2009

Kynurenine pathway in psychosis: evidence of increased tryptophan degradation.

scientific article published on 18 June 2008

Kynurenine pathway metabolism and the neurobiology of treatment-resistant depression: Comparison of multiple ketamine infusions and electroconvulsive therapy

scientific article published on 10 February 2018

Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice.

scientific article

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

scientific article published on 16 November 2016

Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats

scientific article published on 18 March 2019

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

scientific article

Menstrual Cycle Influences Toll-Like Receptor Responses

article

Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction

scientific article published on 01 October 2019

MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c

scientific article published on 2 August 2016

Microbes & neurodevelopment--Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala.

scientific article published on 13 July 2015

Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes

scientific article published on 20 July 2017

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex.

scientific article published on 25 August 2017

Microbial regulation of microRNA expression in the brain-gut axis

scientific article published on 04 October 2019

Microbiota and neurodevelopmental windows: implications for brain disorders

scientific article

Microbiota is essential for social development in the mouse

scientific article published on 21 May 2013

Microbiota regulates visceral pain in the mouse

scientific article

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

scientific article published on 10 September 2019

Microbiota-gut brain axis involvement in neuropsychiatric disorders

scientific article published on 11 July 2019

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

scientific article

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

scientific article published on 16 May 2019

Milk protein-derived peptides induce 5-HT2C-mediated satiety in vivo

article

Minireview: Gut microbiota: the neglected endocrine organ

scientific article (publication date: August 2014)

Molecular biomarkers of depression.

scientific article published on 21 February 2016

Mood and Microbes: Gut to Brain Communication in Depression

scientific article published on 12 June 2019

Natural compulsive-like behaviour in the deer mouse (Peromyscus maniculatus bairdii) is associated with altered gut microbiota composition

scientific article published on 21 November 2019

No effect of a musical intervention on stress response to venepuncture in a neonatal population

scientific article published on 18 October 2019

Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer's patches of mice

scientific article published in Scientific Reports

P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents

scientific article

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction

scientific article

Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants

scientific article published in Scientific Reports

Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour.

scientific article

Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease

scientific article published on 27 June 2018

Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts

scientific article published on 21 May 2018

Psychotropics and the Microbiome: a Chamber of Secrets…

scientific article published on 26 February 2019

Re: Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

scientific article

Regulation of prefrontal cortex myelination by the microbiota.

scientific article

Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria.

scientific article published on 08 January 2012

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.

scientific article

Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT.

scientific article

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

article published in 2018

Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice.

scientific article

Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression

scientific article published on 24 November 2010

Targeting the Infant Gut Microbiota Through a Perinatal Educational Dietary Intervention: Protocol for a Randomized Controlled Trial

scientific article published on 21 October 2019

Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice.

scientific article

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

scientific article

The Microbiota-Gut-Brain Axis

scientific article published on 01 October 2019

The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram

scientific article published on 23 November 2013

The Trier Social Stress Test: Principles and practice.

scientific article

The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome

scientific article published in 2021

The brain-gut axis: a target for treating stress-related disorders.

scientific article

The gut microbiome and diet in psychiatry: focus on depression

scientific article

The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis

scientific article published on 10 May 2019

The gut microbiome as a virtual endocrine organ with implications for farm and domestic animal endocrinology.

scientific article published on July 2016

The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

scientific article published on 3 February 2018

The impact of microbiota on brain and behavior: mechanisms & therapeutic potential

scientific article

The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

scientific article published on 23 November 2020

The kynurenine pathway: Towards metabolic equilibrium

scientific article published on 24 August 2016

The microbiome regulates amygdala-dependent fear recall.

scientific article published on 16 May 2017

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

scientific article

The microbiome: stress, health and disease

scientific article

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

scientific article published on 23 June 2016

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.

scientific article published on 5 May 2008

The role of the microbiota in acute stress-induced myeloid immune cell trafficking

scientific article published on 05 December 2019

Thinking small: towards microRNA-based therapeutics for anxiety disorders

scientific article published on 08 January 2015

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.

scientific article published on 25 July 2016

Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity

scientific article published on 24 September 2008

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort

scientific article

Tryptophan metabolic profile in term and preterm breast milk: implications for health.

scientific article published on 4 April 2018

Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic Encephalopathy

scientific article published on 01 March 2019

Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?

scientific article published in April 2009

n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress

scientific article published on 28 April 2015

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