List of works - Arian Laurence

4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism

scientific article published in December 2007

A degrading view of regulatory T cells

scientific article

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

scientific article

ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages

scientific article published on 01 August 2019

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

scientific article

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

scientific article published on 19 July 2020

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

scientific article

An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure

scientific article published in October 2004

Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number.

scientific article

Approaches to define antigen receptor-induced serine kinase signal transduction pathways

scientific article

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

scientific article

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

scientific article published on 22 May 2017

Back to the future: oral targeted therapy for RA and other autoimmune diseases

scientific article

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation ⬇️

scientific article published on 8 November 2017

Biochemical basis for the impaired immune response in chronic renal failure?

scientific article published on 01 January 1998

Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo

scientific article

Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

scientific article published on 7 February 2015

Cerebral and pulmonary nocardia in a bone marrow transplant patient

scientific article published in June 2005

Distinct requirements for T-bet in gut innate lymphoid cells

scientific article

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

scientific article

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

scientific article published on 19 June 2015

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

scientific article published on 25 May 2018

Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia

scientific article published in October 2004

Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF)

scientific article published on 01 January 1998

Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique

scientific article published on 01 January 1998

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

scientific article

Genomic views of STAT function in CD4+ T helper cell differentiation

scientific article

Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.

scientific article

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

scientific article

Helper T-cell differentiation and plasticity: insights from epigenetics.

scientific article

Helper T-cell identity and evolution of differential transcriptomes and epigenomes.

scientific article published on March 2013

IL-1 watches the watchmen

scientific article published in March 2015

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo ⬇️

scientific article published on April 27, 2011

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

scientific article

Identification of pro-interleukin 16 as a novel target of MAP kinases in activated T lymphocytes

scientific article published in February 2004

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

scientific article published on 13 August 2006

Interleukin-22: a sheep in wolf's clothing

scientific article published on 01 March 2008

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

article

JAK Kinases in Health and Disease: An Update

scientific article

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease ⬇️

scientific article published on July 19, 2012

Janus kinase inhibitors in autoimmune diseases

scientific article

Kinase inhibitors in the treatment of immune-mediated disease

scientific article published on March 2012

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression

scientific article published on 07 January 2019

Location, movement and survival: the role of chemokines in haematopoiesis and malignancy.

scientific article

Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma

scientific article published on 18 December 2015

Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis

scientific article

Nonredundant roles for Stat5a/b in directly regulating Foxp3

scientific article published on 16 January 2007

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

scientific article

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

scientific article published in September 2003

Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

scientific article published on 11 June 2019

Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders

scholarly article published 2008

Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

scientific article

Regulation of microRNA expression and abundance during lymphopoiesis

scientific article

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology

scientific article published on 01 January 2019

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

scientific article

STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

scientific article

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

scientific article

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

scientific article

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

scientific article published on 21 March 2016

Signal transduction and Th17 cell differentiation

scientific article published on 18 April 2009

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

scientific article

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

scientific article published on 31 December 2007

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

scientific article

T(H)-17 differentiation: of mice and men

scientific article published on 01 September 2007

TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

scientific article published on 23 July 2018

Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors

scientific article

Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease

scientific article published on 4 May 2017

Th17 cells are long lived and retain a stem cell-like molecular signature

scientific article

The Current STATus of lymphocyte signaling: new roles for old players.

scientific article published on 09 April 2009

The JAK-STAT pathway: impact on human disease and therapeutic intervention

scientific article

The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1

scientific article published on 01 December 2000

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

scientific article

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

scientific article published on 29 January 2019

The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma.

scientific article

Therapeutic targeting of Janus kinases

scientific article

Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene

scientific article

Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17

scientific article published on May 2008

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

scientific article published on 12 July 2018

Viral integration drives multifocal HCC during the occult HBV infection.

scientific article published on 14 June 2019

When half a glass of STAT3 is just not enough

scientific article

List of works by Arian Laurence

4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism

A degrading view of regulatory T cells

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure

Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number.

Approaches to define antigen receptor-induced serine kinase signal transduction pathways

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Back to the future: oral targeted therapy for RA and other autoimmune diseases

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation ⬇️

Biochemical basis for the impaired immune response in chronic renal failure?

Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo

Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

Cerebral and pulmonary nocardia in a bone marrow transplant patient

Distinct requirements for T-bet in gut innate lymphoid cells

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia

Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF)

Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

Genomic views of STAT function in CD4+ T helper cell differentiation

Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

Helper T-cell differentiation and plasticity: insights from epigenetics.

Helper T-cell identity and evolution of differential transcriptomes and epigenomes.

IL-1 watches the watchmen

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo ⬇️

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

Identification of pro-interleukin 16 as a novel target of MAP kinases in activated T lymphocytes

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

Interleukin-22: a sheep in wolf's clothing

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

JAK Kinases in Health and Disease: An Update

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease ⬇️

Janus kinase inhibitors in autoimmune diseases

Kinase inhibitors in the treatment of immune-mediated disease

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression

Location, movement and survival: the role of chemokines in haematopoiesis and malignancy.

Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma

Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders

Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

Regulation of microRNA expression and abundance during lymphopoiesis

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Signal transduction and Th17 cell differentiation

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

T(H)-17 differentiation: of mice and men

TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors

Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease

Th17 cells are long lived and retain a stem cell-like molecular signature

The Current STATus of lymphocyte signaling: new roles for old players.

The JAK-STAT pathway: impact on human disease and therapeutic intervention

The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma.

Therapeutic targeting of Janus kinases

Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene

Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

Viral integration drives multifocal HCC during the occult HBV infection.