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List of works by Hector R. Wong

A Cohort Study of Pediatric Shock: Frequency of Corticosteriod Use and Association with Clinical Outcomes

scientific article published on 13 February 2015

A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.

scientific article

A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury

scientific article

A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.

scientific article published on 12 April 2017

A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement

scientific article published on 15 October 2021

A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

scientific article (publication date: 13 May 2015)

A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium

scientific article published in October 2002

A multibiomarker-based outcome risk stratification model for adult septic shock*.

scientific article

A novel role for matrix metalloproteinase-8 in sepsis

scientific article

A survey of stated physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion-dependent shock

scientific article

ARDS. The future.

scientific article

Ablation of the heat shock factor-1 increases susceptibility to hyperoxia-mediated cellular injury

scientific article

Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine

scientific article

Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage

scientific article published in March 2002

Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway

scientific article (publication date: 2006)

Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock

scientific article

Age-dependent responses to hepatic ischemia/reperfusion injury.

scientific article

Age-related decrease in proteasome expression contributes to defective nuclear factor-kappaB activation during hepatic ischemia/reperfusion

scientific article published on May 2009

An Enrichment Strategy For Sepsis Clinical Trials

scientific article published on 21 July 2016

Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a two-hit mouse model

scientific article published on 15 June 2011

Biological activity of truncated C-terminus human heat shock protein 72.

scientific article

Biomarker discovery and development in pediatric critical care medicine

scientific article

Biomarkers for pediatric sepsis and septic shock

scientific article published on January 2011

Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment

scientific article

Cardiac Troponin Measurement in the Critically Ill: Potential for Guiding Clinical Management

scientific article

Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans

article

Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock

scientific article

Clinical Utility of Computed Tomography and Magnetic Resonance Imaging for Diagnosis of Posterior Reversible Encephalopathy Syndrome after Stem Cell Transplantation in Children and Adolescents.

scientific article

Clinical review: sepsis and septic shock--the potential of gene arrays

scientific article

Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis

scientific article published on April 2014

Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids.

scientific article published on 31 May 2016

Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery.

scientific article

Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock

scientific article published on 12 January 2015

Contribution of MKP-1 regulation of p38 to endotoxin tolerance.

scientific article

Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis

scientific article

Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock

scientific article

Corticosteroids in Pediatric Shock: A Call to Arms

scientific article published on 29 July 2015

Critically associating

scientific article published in April 2009

Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children.

scientific article

Developing a clinically feasible personalized medicine approach to pediatric septic shock

scientific article

Differential expression of the Nrf2-linked genes in pediatric septic shock.

scientific article

Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

scientific article

Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.

scientific article published on 11 December 2003

Divergence of canonical danger signals: the genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide

scientific article

Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt

scientific article published on 01 November 2007

Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.

scientific article

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

scientific article published on 17 June 2017

Emerging infection and sepsis biomarkers: will they change current therapies?

scientific article

Estimating Mortality Risk of Pediatric Critical Illness: A Worthy Obsession

scientific article published on September 2016

Estimating the probability of bacterial infection using a novel biomarker among pediatric patients in the emergency department

scientific article published on 16 May 2016

Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia.

scientific article published on 19 July 2016

Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock

scientific article published on 01 May 2007

Extracellular hsp70 levels in children with septic shock

scientific article published on 01 May 2005

Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers.

scientific article

Gene expression profiling in sepsis: timing, tissue, and translational considerations

scientific article published on 15 February 2014

Genetic approach to pediatric septic shock

scientific article published on 01 May 2008

Genetic association research: understanding its challenges and limitations.

scientific article

Genetics and genomics in pediatric septic shock ⬇️

scientific article published on May 1, 2012

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome

scientific article

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock

scientific article

Genome-wide expression profiling in pediatric septic shock ⬇️

scientific article published on January 17, 2013

Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.

scientific article

German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells

scientific article published on August 2006

Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children.

scientific article published on June 2015

Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock

scientific article published on 7 February 2017

Glutamine's protection against cellular injury is dependent on heat shock factor-1.

scientific article published on 25 January 2006

HDL Cholesterol: A "Pathogen Lipid Sink" for Sepsis?

scientific article published on 01 April 2019

HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest

scientific article

Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation.

scientific article

Heat shock inhibits activation of NF-kappaB in the absence of heat shock factor-1

scientific article published on 01 March 2002

Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes

scientific article published on November 1996

Heat shock-mediated regulation of MKP-1.

scientific article published on 15 June 2005

Hepatocyte NF-kappaB activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia

scientific article published on 31 August 2006

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

scientific article published on 15 June 2016

Hypothermia decreases excitatory neurotransmitter release in bacterial meningitis in rabbits

scientific article published on 01 November 1999

Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.

scientific article

Identifying critically ill patients who may benefit from adjunctive corticosteroids: not as easy as we thought

scientific article

Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP.

scientific article published on 21 March 2017

Improved outcome for young children with AIDS, Pneumocystis carinii pneumonia, and acute respiratory failure

scientific article published on 01 August 1994

Incorporation of biomarkers with the renal angina index for prediction of severe AKI in critically ill children.

scientific article

Induction of HSP70 is dispensable for anti-inflammatory action of heat shock or NSAIDs in mast cells

scientific article (publication date: April 2006)

Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis

scientific article published on September 2008

Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice

scientific article published on 01 December 2000

Innovation in Pediatric Cardiac Intensive Care: An Exponential Convergence Toward Transformation of Care

scientific article published on October 2015

Intensive care medicine in 2050: precision medicine

scientific article published on 24 February 2017

Intensivist-led team approach to critical care of children with heart disease

scientific article published in May 2006

Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children

scientific article published on 29 October 2012

Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill.

scientific article

Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis

scientific article published on 22 October 2015

Intracatheter nitroglycerin infusion fails to prevent catheter-related venous thrombosis: a randomized, controlled trial

scientific article

Intracellular delivery of HSP70 using HIV-1 Tat protein transduction domain

scientific article published on January 2003

Leukocyte subset-derived genomewide expression profiles in pediatric septic shock

scientific article

Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity

scientific article published in August 2017

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

scientific article published on 12 January 2015

Mast cell activation is differentially affected by heat shock

scientific article published in August 2005

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.

scientific article published on 08 August 2016

Mechanism and function of heat shock-dependent IkappaBalpha expression

scientific article published on June 2006

Mechanisms and regulation of the gene-expression response to sepsis.

scientific article published on 17 May 2010

Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality.

scientific article published on May 2013

Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

scientific article

Nitric oxide decreases surfactant protein A gene expression in H441 cells

scientific article published on July 1998

Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response

scientific article published on June 2009

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

scientific article

Nuclear factor-kappa B and nitric oxide regulating life and death: nonsense or harsh reality?

scientific article published on 01 September 1998

Olfactomedin 4 Positive Neutrophils are Upregulated Following Hemorrhagic Shock

scientific article published on 30 November 2020

Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock

scientific article

PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock

scientific article published on 01 April 2020

PP2A regulates upstream members of the c-jun N-terminal kinase mitogen-activated protein kinase signaling pathway

scientific article published on February 2008

Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis

scientific article published in September 2003

Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents

scientific article published in May 2002

Pathophysiology and treatment of septic shock in neonates.

scientific article

Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype

scientific article

Pediatric sepsis: challenges and adjunctive therapies.

scientific article published on 3 January 2013

Pediatric septic shock treatment: new clues from genomic profiling

scientific article published on 01 October 2007

Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.

scientific article

Personalized medicine, endotypes, and intensive care medicine

scientific article published on 24 April 2015

Phosphatase inhibition leads to activation of IkappaB kinase in murine macrophages

scientific article published on 01 October 2002

Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass.

scientific article published on 31 May 2008

Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis

scientific article published on 26 December 2011

Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis.

scientific article published on February 2014

Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis

scientific article

Pre-exposure to heat shock inhibits peroxynitrite-induced activation of poly(ADP) ribosyltransferase and protects against peroxynitrite cytotoxicity in J774 macrophages

scientific article published on 01 November 1996

Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review.

scientific article published on 17 January 2017

Prognostic and predictive enrichment in sepsis

scientific article published on 11 September 2019

Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis ⬇️

scientific article published on September 1, 2012

Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock: Implications for Septic Shock Biology.

scientific article

Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model

scientific article published on 01 November 2019

Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells

scientific article published on February 2004

Protective effects of isohelenin, an inhibitor of nuclear factor kappaB, in endotoxic shock in rats

scientific article published in January 2002

Reduced Peroxisome Proliferator-Activated Receptor α Expression Is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis ⬇️

scientific article published on February 1, 2012

Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays?

scientific article published on 10 March 2016

Robust classification of bacterial and viral infections via integrated host gene expression diagnostics

scientific article published on July 2016

Role of biomarkers in sepsis care.

scientific article

Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice

scientific article published on 21 December 2006

Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion

scientific article published on 19 July 2016

SOCS1 is a negative regulator of metabolic reprogramming during sepsis

scientific article

Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.

scientific article published on 19 February 2015

Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity.

scientific article published in July 2005

Sepsis in Pediatric Cardiac Intensive Care

scientific article published on August 2016

Sepsis in the pediatric cardiac intensive care unit.

scientific article published on July 2011

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock

scientific article

Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium

scientific article published on 01 March 2000

Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells

scientific article published on 01 August 1999

Simplification of a Septic Shock Endotyping Strategy for Clinical Application

scientific article published in January 2017

Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial

scientific article published on 6 May 2016

Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid

scientific article (publication date: 30 April 2007)

Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells

scientific article published on September 1999

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

scientific article published on 25 April 2016

Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IkappaBalpha in macrophages.

scientific article published on June 2002

Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model.

scientific article published on 29 January 2014

The PICU perspective on monitoring hemodynamics and oxygen transport

scientific article

The United States critical illness and injury trials group: an introduction

scientific article

The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis

scientific article published in September 2007

The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I kappa-B degradation and NF-kappa B nuclear translocation

scientific article published on February 1997

The host response to sepsis and developmental impact

scientific article

The immunomodulatory effects of albumin in vitro and in vivo.

scientific article

The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock

scientific article

The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology.

scientific article

The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming

scientific article published on September 2008

The stress response decreases NF-kappaB activation in liver of endotoxemic mice

scientific article published in July 2002

The temporal version of the pediatric sepsis biomarker risk model

scientific article

Theaflavin, a black tea extract, is a novel anti-inflammatory compound

scientific article published in October 2004

Therapeutic application of intrapericardial tissue plasminogen activator in a 4-month-old child with complex fibropurulent pericarditis

scientific article published in January 2008

Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis

scientific article published on 30 October 2007

Time for a neonatal-specific consensus definition for sepsis.

scientific article

Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept

scientific article

Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease

scientific article published in September 2001

Validating the genomic signature of pediatric septic shock.

scientific article

Validation of a gene expression-based subclassification strategy for pediatric septic shock.

scientific article

Zinc detection in serum by anodic stripping voltammetry on microfabricated bismuth electrodes

journal article published in 2013

Zinc homeostasis in pediatric critical illness

scientific article published in January 2009

Zinc supplementation in critically ill patients: a key pharmaconutrient?

scientific article published on 31 July 2008

Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis.

scientific article published on 7 November 2016

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