List of works - Hiroaki Sakurai

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

scientific article

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

scientific article

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells

scientific article published on April 2006

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

scientific article published on 20 August 2013

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

scientific article

A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity

scientific article

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

scientific article published on January 2010

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.

scientific article published on November 2006

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

scientific article

Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib

scientific article published in February 2006

Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.

scientific article published in March 2011

Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats

scientific article

Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.

scientific article published on December 2000

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.

scientific article published on 20 February 2009

Analysis of chemical properties of edible and medicinal ginger by metabolomics approach

scientific article

Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

scientific article published on 25 September 2017

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

scientific article

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b

scientific article

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice

scientific article published in December 2004

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

scientific article

Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo

scientific article

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

scientific article

Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

scientific article published on 14 February 2017

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

scientific article published in December 2006

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells

scientific article

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

scientific article

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

scientific article

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

scientific article

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

scientific article published on 01 June 2012

Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

scientific article published on 18 January 2012

Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation

scientific article published on 01 March 2000

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model

scientific article published on 13 December 2012

Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis

scientific article published on March 2007

Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.

scientific article

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

scientific article

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

scientific article published on 7 December 2004

Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

scientific article published on 21 April 2009

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

scientific journal article

Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells

scientific article published on 2 January 2007

Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas

scientific article published on 5 December 2012

Developmentally and regionally regulated alterations of octamer- and GC-box-binding activities during the postnatal development of mouse cerebellum

scientific article published in August 1991

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

scientific article published on 3 December 2001

Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.

scientific article published on 15 April 2011

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

scientific article published on 27 July 2010

Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

scientific article published on 24 February 2011

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells

scientific article published on 22 July 2016

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells

scientific article published on 22 January 2017

Enzymatic and biochemical properties of a novel human serine dehydratase isoform

scientific article published on 20 March 2006

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

scientific article published on 7 July 2008

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways

scientific article published on 17 February 2017

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

scientific article

Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

scientific article published on 17 August 2016

Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization

scientific article published on 14 March 2007

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

scientific article (publication date: 9 April 1999)

Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.

scientific article

Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways

scholarly article by Pornthip Waiwut et al published 28 December 2010 in Molecular and Cellular Biochemistry

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

scientific article

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

scientific article

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

scientific article

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer

scientific article published on May 2007

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

scientific article published on 02 December 2009

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

scientific article

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

scientific article

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

scientific article

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

scientific article published on 6 May 2006

Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients

scientific article published on 3 July 2007

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

scientific article

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

scientific article published on 15 October 2015

Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.

scientific article

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy

scientific article published on 15 July 2015

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.

scientific article published on 17 December 2014

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells

scientific article published on 10 June 2004

Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

scientific article published on August 2013

Iodine-catalyzed etherification of morroniside

scientific article

Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages

scientific article

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

scientific article

MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells

scientific article published in February 2006

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

scientific article published on 30 December 2008

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.

scientific article published on 29 January 2014

Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.

scientific article

Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation

scientific article published on 01 May 2019

Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression

scientific article published on January 2017

Novel inhibitor for fibroblast growth factor receptor tyrosine kinase

scientific article published on 26 June 2007

P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer

scientific article published on 12 July 2016

PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

scientific article

Pharmaceutical evaluation of liquorice before and after roasting in mice

scientific article

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

scientific article

Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses

scientific article

Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model

scientific article

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

scientific article published on 16 October 2013

Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats

scientific article

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

scientific article

RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.

scientific article published on 5 July 2006

RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells

scientific article published on 22 October 2007

Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

scientific article published on 30 June 2010

Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death

scientific article published on 01 December 1996

Rational Combination Therapy for Melanoma with Dinaciclib by Targeting BAK-Dependent Cell Death

scientific article published on 19 November 2019

Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption

scientific article

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

scientific article published on 28 April 2015

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer

scientific article published on February 2006

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells

scientific article

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice

scientific article

Severe pulmonary metastasis in obese and diabetic mice

scientific article published on December 2006

Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.

scientific article published in December 2005

Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action

scientific article published on 01 December 1997

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

scientific article

Synthesis and evaluation of myxochelin analogues as antimetastatic agents

scientific article published on 25 February 2009

TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

scientific article published in August 2003

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

scientific article published on 31 October 2005

TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress.

scientific article

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways

scientific article (publication date: 11 October 2002)

TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling

scientific article published on 17 August 2009

TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.

scientific article

TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells

scientific article

TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism

scientific article

TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.

scientific article published on 10 April 2012

Targeting of TAK1 in inflammatory disorders and cancer

scientific article published on 12 July 2012

Telomerase upregulates expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor in normal human fibroblasts

scientific article published on May 2003

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

scientific article

The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination

scientific article

The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment

scientific article published on 01 October 2019

Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway

scientific article published on 27 February 2007

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

scientific article

Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells

scientific article published on 13 June 2007

Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.

scientific article published on 08 July 2013

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

scientific article published on 20 October 2009

Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells.

scientific article

eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells

scientific article published on 01 March 2011

p38-Mediated phosphorylation of Eps15 endocytic adaptor protein

scientific article published on 21 November 2013

List of works by Hiroaki Sakurai

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib

Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.

Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats

Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.

Analysis of chemical properties of edible and medicinal ginger by metabolomics approach

Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model

Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis

Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells

Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas

Developmentally and regionally regulated alterations of octamer- and GC-box-binding activities during the postnatal development of mouse cerebellum

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells

Enzymatic and biochemical properties of a novel human serine dehydratase isoform

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.

Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells

Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

Iodine-catalyzed etherification of morroniside

Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.