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List of works by Hiroyuki Kobori

AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension ⬇️

scientific article published on September 7, 2011

Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats.

scientific article published on 15 January 2013

Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats

scientific article published on 9 January 2013

Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan

scientific article published on 22 May 2012

Addition of Angiotensin II Type 1 Receptor Blocker to CCR2 Antagonist Markedly Attenuates Crescentic Glomerulonephritis ⬇️

scientific article published on January 31, 2011

Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity

scientific article

Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy

scientific article

Aldosterone aggravates glucose intolerance induced by high fructose

scientific article published on 4 November 2013

Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice

scientific article published on 24 November 2011

Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells ⬇️

scientific article published on October 1, 2012

Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases

scientific article published on 30 January 2018

Angiotensin II blockade and renal protection

scientific article published on January 2013

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy ⬇️

scientific article published on September 2, 2010

Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells

scientific article published on 30 June 2011

Angiotensin II-induced reduction in body mass is Ang II receptor mediated in association with elevated corticosterone

scientific article published on 18 May 2010

Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats

scientific article

Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease.

scientific article published on September 2011

Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus

scientific article

Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease ⬇️

scientific article published on August 24, 2012

Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats

scientific article published on 16 December 2010

Brain-Targeted (Pro)renin Receptor Knockdown Attenuates Angiotensin II–Dependent Hypertension ⬇️

scientific article published on April 23, 2012

Calcium channel blocker enhances beneficial effects of an angiotensin II AT1 receptor blocker against cerebrovascular-renal injury in type 2 diabetic mice

scientific article

Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte.

scientific article

Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats.

scientific article published on 21 April 2008

Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is corre

scientific article published on December 2010

Contribution of a Nuclear Factor-κB Binding Site to Human Angiotensinogen Promoter Activity in Renal Proximal Tubular Cells ⬇️

scientific article published on January 31, 2011

Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters

scientific article published on 29 August 2009

Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats

scientific article

Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells.

scientific article published on 7 May 2008

Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA

scientific article published on 19 March 2008

Direct Evidence for Intrarenal Chymase-Dependent Angiotensin II Formation on the Diabetic Renal Microvasculature ⬇️

scientific article published on December 3, 2012

Divergent localization of angiotensinogen mRNA and protein in proximal tubule segments of normal rat kidney

scientific article

Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts

scientific article published on 7 September 2011

Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.

scientific article

Effects of Angiotensin II AT1^|^ndash;Receptor Blockade on High Fat Diet^|^ndash;Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats ⬇️

scientific article published on January 22, 2013

Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats

scientific article published on February 2011

Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats

scientific article published on March 2004

Enhanced Urinary Angiotensinogen Excretion in Cyp1a1-Ren2 Transgenic Rats With Inducible ANG II-Dependent Malignant Hypertension ⬇️

scientific article published on November 1, 2010

Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients.

scientific article

Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet.

scientific article published on 10 February 2003

Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways ⬇️

scientific article published on August 5, 2010

IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells.

scientific article published on 05 July 2009

Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats

scientific article published on 24 August 2011

Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes

scientific article published on December 2009

Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease ⬇️

scientific article published on March 6, 2012

Interactions between Host PPARs and Gut Microbiota in Health and Disease

article

Interferon‐γ biphasically regulates angiotensinogen expressionviaa JAK‐STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells ⬇️

scientific article published on February 1, 2012

Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension.

scientific article

Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition

scientific article

Intratubular Renin-Angiotensin System in Hypertension ⬇️

scientific article published on January 31, 2011

Intratubular Renin-Angiotensin System in Hypertension.

scientific article published in January 2006

Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II ⬇️

scientific article published on April 19, 2012

Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy.

scientific article published on January 1999

Major role for ACE-independent intrarenal ANG II formation in type II diabetes

scientific article

Mechanism of hyperthyroidism-induced renal hypertrophy in rats

scientific article published in October 1998

Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats.

scientific article

Multiphoton Imaging of the Glomerular Permeability of Angiotensinogen ⬇️

scientific article published on September 20, 2012

N-type Calcium Channel Inhibition With Cilnidipine Elicits Glomerular Podocyte Protection Independent of Sympathetic Nerve Inhibition ⬇️

scientific article published on July 21, 2012

New Generation Calcium Channel Blockers in Hypertensive Treatment

scientific article published on May 2006

Oxidative Stress-Induced Glomerular Mineralocorticoid Receptor Activation Limits the Benefit of Salt Reduction in Dahl Salt-Sensitive Rats ⬇️

scientific article published on July 24, 2012

Oxidative stress/angiotensinogen/renin-angiotensin system axis in patients with diabetic nephropathy

scientific article

Proximal tubular angiotensinogen in renal biopsy suggests nondipper BP rhythm accompanied by enhanced tubular sodium reabsorption ⬇️

scientific article published on July 1, 2012

Quantification of human angiotensinogen by a novel sandwich ELISA.

scientific article

Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1–7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats ⬇️

scientific article published on January 5, 2011

Regulation of a novel angiotensin II precursor, proangiotensin-12, in the tissues by blockade of the renin-angiotensin system

scientific article

Relationship Between Urinary Angiotensinogen and Salt Sensitivity of Blood Pressure in Patients With IgA Nephropathy ⬇️

scientific article published on June 13, 2011

Renal Sympathetic Denervation Suppresses De Novo Podocyte Injury and Albuminuria in Rats With Aortic Regurgitation ⬇️

scientific article published on February 10, 2012

Renoprotective effects of direct renin inhibition in glomerulonephritis

scientific article published on October 2014

Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury ⬇️

scientific article published on June 2, 2011

Roles of Na⁺/H⁺ exchanger type 1 and intracellular pH in angiotensin II-induced reactive oxygen species generation and podocyte apoptosis

scientific article

Salt-induced renal injury in SHRs is mediated by AT1 receptor activation ⬇️

scientific article published on April 1, 2011

Sexual dimorphism in urinary angiotensinogen excretion during chronic angiotensin II-salt hypertension.

scientific article

Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats.

scientific article published on 16 November 2011

Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system

scientific article published on 27 November 2009

Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats

scientific article published on 12 January 2005

The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease

scientific article published on 15 November 2012

The establishment of a primary culture system of proximal tubule segments using specific markers from normal mouse kidneys.

scientific article

The growth factor midkine regulates the renin-angiotensin system in mice

scientific article published on 18 May 2009

The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome

scientific article published in April 2012

Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells

scientific article

Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes.

scientific article

Urinary Angiotensinogen as a Novel Early Biomarker of Intrarenal Renin^|^ndash;Angiotensin System Activation in Experimental Type 1 Diabetes ⬇️

scientific article published on July 31, 2012

Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients

scientific article published on 15 December 2008

Variants and Haplotypes in Angiotensinogen Gene Are Associated With Plasmatic Angiotensinogen Level in Mexican Population ⬇️

scientific article published on September 1, 2011

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