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List of works by Christian Obinger

(-)-Epicatechin enhances the chlorinating activity of human myeloperoxidase

scientific article published on 16 December 2009

A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients.

scientific article published on 28 March 2018

A protein fold with multiple functions: Chlorite dismutase, HemQ and DyP-type peroxidase

scientific article published on 02 April 2015

A stable bacterial peroxidase with novel halogenating activity and an autocatalytically linked heme prosthetic group

scientific article

A transient kinetic study on the reactivity of recombinant unprocessed monomeric myeloperoxidase

scientific article

Active site structure and catalytic mechanisms of human peroxidases

scientific article

Activity, Peroxide Compound Formation, and Heme d Synthesis in Escherichia coli HPII Catalase

scientific article published on 01 June 1997

Agaricus meleagris pyranose dehydrogenase: influence of covalent FAD linkage on catalysis and stability.

scientific article published on 17 July 2014

Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis

scientific article published on 15 February 2021

Biochemical Characterization of a Membrane-bound Manganese-containing Superoxide Dismutase from the CyanobacteriumAnabaenaPCC 7120

scientific article published in Journal of Biological Chemistry

Biochemical characterization of the major N-acetylmuramidase from Lactobacillus buchneri

scientific article published on 24 May 2014

Bovine lactoperoxidase - a versatile one- and two-electron catalyst of high structural and thermal stability

scientific article published on 29 December 2010

Catalase-peroxidase from synechocystis is capable of chlorination and bromination reactions

scientific article published in September 2001

Catalase-peroxidase from the cyanobacterium Synechocystis PCC 6803: cloning, overexpression in Escherichia coli, and kinetic characterization.

scientific article

Catalases and hydrogen peroxide metabolism ⬇️

scientific article published on September 15, 2012

Characterization of chemical features of potent myeloperoxidase inhibitors.

scientific article published on 12 July 2016

Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ.

scientific article

Chemistry and biology of human peroxidases

scientific article published on 14 November 2005

Chlorite dismutases - a heme enzyme family for use in bioremediation and generation of molecular oxygen.

scientific article published on 12 February 2014

Comparison between catalase-peroxidase and cytochrome c peroxidase. The role of the hydrogen-bond networks for protein stability and catalysis

scientific article

Conformational and thermal stability of mature dimeric human myeloperoxidase and a recombinant monomeric form from CHO cells

scientific article published on 13 October 2010

Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing

scientific article

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution

scientific article

Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

scientific article

Cyanobacterial cytochrome c(M): probing its role as electron donor for Cu(A) of cytochrome c oxidase

scientific article published on 24 December 2008

Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors

scientific article published on 6 May 2013

Dimeric chlorite dismutase from the nitrogen-fixing cyanobacterium Cyanothece sp. PCC7425

scientific article

Direct conversion of ferrous myeloperoxidase to compound II by hydrogen peroxide: an anaerobic stopped-flow study

scientific article published on 01 December 2003

Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display ⬇️

scientific article published on December 23, 2012

Directed evolution of proteins for increased stability and expression using yeast display ⬇️

scientific article published on May 3, 2012

Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast

scientific article

Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.

scientific article

Disruption of the H-bond network in the main access channel of catalase-peroxidase modulates enthalpy and entropy of Fe(III) reduction

scientific article published on 3 March 2010

Disruption of the aspartate to heme ester linkage in human myeloperoxidase: impact on ligand binding, redox chemistry, and interconversion of redox intermediates

scientific article

Distal side tryptophan, tyrosine and methionine in catalase-peroxidases are covalently linked in solution

scientific article published in September 2003

Distal site aspartate is essential in the catalase activity of catalase-peroxidases

scientific article published in May 2003

Distinct Fcα receptor N-glycans modulate the binding affinity to immunoglobulin A (IgA) antibodies

scientific article published on 30 July 2019

Editorial: biomolecular technology of proteins - BioToP.

scientific article published in April 2014

Effect of Distal Cavity Mutations on the Formation of Compound I in Catalase-Peroxidases

scientific article published in Journal of Biological Chemistry

Engineered IgG1-Fc--one fragment to bind them all

scientific article

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

scientific article published on 20 August 2020

Engineering the proximal heme cavity of catalase-peroxidase

scientific article

Enhancing hypothiocyanite production by lactoperoxidase - mechanism and chemical properties of promotors

scientific article published on 9 October 2015

Essential Role of Proximal Histidine-Asparagine Interaction in Mammalian Peroxidases

scientific article

Eukaryotic Catalase-Peroxidase: The Role of the Trp-Tyr-Met Adduct in Protein Stability, Substrate Accessibility, and Catalysis of Hydrogen Peroxide Dismutation

scientific article

Eukaryotic extracellular catalase-peroxidase from Magnaporthe grisea - Biophysical/chemical characterization of the first representative from a novel phytopathogenic KatG group.

scientific article published on 29 September 2011

Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.

scientific article published on 7 August 2012

Evolution of catalases from bacteria to humans.

scientific article published on September 2008

Evolution of structure and function of Class I peroxidases

scientific article published on 04 April 2010

Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design

scientific article published in April 2005

Exploring Site-Specific N-Glycosylation of HEK293 and Plant-Produced Human IgA Isotypes

scientific article

Fast quantification of recombinant protein inclusion bodies within intact cells by FT-IR spectroscopy.

scientific article published on 11 May 2007

Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies

scientific article published on 18 May 2017

Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase

scientific article published on 24 June 2016

From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors

scientific article

From chlorite dismutase towards HemQ - the role of the proximal H-bonding network in haeme binding

scientific article published on 8 February 2016

Fungal Hybrid B heme peroxidases - unique fusions of a heme peroxidase domain with a carbohydrate-binding domain

scientific article

Genome sequence of the filamentous soil fungus Chaetomium cochliodes reveals abundance of genes for heme enzymes from all peroxidase and catalase superfamilies

scientific article

Heme peroxidase biochemistry – Facts and perspectives

scientific article published on 26 June 2010

Heme to protein linkages in mammalian peroxidases: impact on spectroscopic, redox and catalytic properties

scientific article

Heme-copper oxidases and their electron donors in cyanobacterial respiratory electron transport.

scientific article published on October 2008

Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria.

scientific article published in August 2009

High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases: ANSWERS FROM FIRST CRYSTAL STRUCTURE AND UNFOLDING STUDIES

scientific article

How covalent heme to protein bonds influence the formation and reactivity of redox intermediates of a bacterial peroxidase

scientific article published on 22 September 2014

Human peroxidasin 1 promotes angiogenesis through ERK1/2, Akt, and FAK pathways

scientific article published on 01 February 2019

Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.

scientific article published on 27 March 2014

Hydrogen peroxide oxidation by catalase-peroxidase follows a non-scrambling mechanism

scientific article published on 10 January 2007

Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies.

scientific article

Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro

scientific article

Identification of Trp106 as the tryptophanyl radical intermediate in Synechocystis PCC6803 catalase-peroxidase by multifrequency Electron Paramagnetic Resonance spectroscopy

scientific article published on 06 March 2006

Identification of a periplasmic c-type cytochrome as electron donor to the plasma membrane-bound cytochrome oxidase of the cyanobacterium Nostoc Mac

scientific article published on 01 June 1990

Immunocytochemical localization of the cytochrome-c oxidase in a cyanobacterium, Synechococcus PCC7942 (Anacystis nidulans)

Impact of different cultivation and induction regimes on the structure of cytosolic inclusion bodies of TEM1-beta-lactamase

scientific article published in October 2008

Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100.

scientific article published on 17 February 2014

Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutases

scientific article published on 6 June 2012

Inactivation of human myeloperoxidase by hydrogen peroxide

scientific article

Independent evolution of four heme peroxidase superfamilies

scientific article

Influence of the covalent heme-protein bonds on the redox thermodynamics of human myeloperoxidase

scientific article published on 24 August 2011

Influence of the unusual covalent adduct on the kinetics and formation of radical intermediates in synechocystis catalase peroxidase: a stopped-flow and EPR characterization of the MET275, TYR249, and ARG439 variants

scientific article

Insights into the Active Site of Coproheme Decarboxylase from Listeria monocytogenes

scientific article

Integrin binding human antibody constant domains--probing the C-terminal structural loops for grafting the RGD motif.

scientific article

Interaction with the Redox Cofactor MYW and Functional Role of a Mobile Arginine in Eukaryotic Catalase-Peroxidase

scientific article published on 13 June 2016

Interactions of hydrogen sulfide with myeloperoxidase

scientific article

Intracellular catalase/peroxidase from the phytopathogenic rice blast fungus Magnaporthe grisea: expression analysis and biochemical characterization of the recombinant protein

scientific article

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

scientific article published on 5 March 2015

Investigation of ion binding in chlorite dismutases by means of molecular dynamics simulations

scientific article published on 14 July 2014

Isoniazid as a substrate and inhibitor of myeloperoxidase: Identification of amine adducts and the influence of superoxide dismutase on their formation

scientific article published on 27 July 2012

Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase

scientific article published on 6 May 2008

Kinetics of Interconversion of Ferrous Enzymes, Compound II and Compound III, of Wild-type Synechocystis Catalase-peroxidase and Y249F: PROPOSAL FOR THE CATALATIC MECHANISM

scientific article published in Journal of Biological Chemistry

Kinetics of electron transfer between plastocyanin and the soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published in October 2004

Kinetics of interprotein electron transfer between cytochrome c6 and the soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published in October 2004

Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II

scientific article published on 01 January 1999

Kinetics of oxygen binding to ferrous myeloperoxidase

scientific article published on 01 June 2004

Long-Term Effects of (-)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats

scientific article (publication date: 2016)

Mammalian heme peroxidases: From innate immunity to pathology and extracellular matrix biosynthesis

scientific article published on 11 August 2018

Manipulating Conserved Heme Cavity Residues of Chlorite Dismutase: Effect on Structure, Redox Chemistry, and Reactivity

scientific article

Manipulating the covalent link between distal side tryptophan, tyrosine, and methionine in catalase-peroxidases: an electronic absorption and resonance Raman study

scientific article

Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase

scientific article published on 22 September 2011

Mechanism of chlorite degradation to chloride and dioxygen by the enzyme chlorite dismutase.

scientific article

Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid

scientific article published in July 2005

Mechanism of reaction of chlorite with mammalian heme peroxidases

scientific article published on 28 February 2014

Mechanism of reaction of horseradish peroxidase with chlorite and chlorine dioxide

scientific article published on 26 September 2007

Mechanism of reaction of melatonin with human myeloperoxidase

scientific article published in March 2001

Mechanism of reaction of myeloperoxidase with hydrogen peroxide and chloride ion

scientific article published on 01 October 2000

Mechanism of reaction of myeloperoxidase with nitrite

scientific journal article

Mechanisms of catalase activity of heme peroxidases

scientific article

Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species.

scientific article

Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies.

scientific article published on 13 October 2017

Molecular diversity of katG genes in the soil bacteria Comamonas

scientific article published in March 2010

Molecular dynamics simulation of the crystallizable fragment of IgG1-insights for the design of Fcabs

scientific article published on 2 January 2014

Molecular evolution of hydrogen peroxide degrading enzymes

scientific article published on 07 February 2012

Molecular evolution, structure, and function of peroxidasins

scientific article (publication date: September 2012)

Monomeric and homotrimeric solution structures of truncated human peroxidasin 1 variants

scientific article published on 08 July 2019

Multidomain human peroxidasin 1 is a highly glycosylated and stable homotrimeric high spin ferric peroxidase.

scientific article

Myeloperoxidase-catalyzed chlorination: the quest for the active species.

scientific article

Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques?

scientific article published on 01 March 2018

Myeloperoxidase-catalyzed taurine chlorination: initial versus equilibrium rate

scientific article published on 17 August 2007

Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions

scientific article published on 27 March 2019

New insights into the heme cavity structure of catalase-peroxidase: a spectroscopic approach to the recombinant synechocystis enzyme and selected distal cavity mutants

scientific article

New insights into thiocyanate oxidation by human myeloperoxidase

scientific article published on 15 June 2016

Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.

scientific article published on 25 July 2016

Nucleotide sequence analysis, overexpression in Escherichia coli and kinetic characterization of Anacystis nidulans catalase-peroxidase.

scientific article published on March 2000

Occurrence, phylogeny, structure, and function of catalases and peroxidases in cyanobacteria

scientific article published on 06 January 2009

Peroxynitrite efficiently mediates the interconversion of redox intermediates of myeloperoxidase

scientific article published on 30 September 2005

Phylogenetic distribution of catalase-peroxidases: Are there patches of order in chaos?

article

Posttranslational Modification of Heme b in a Bacterial Peroxidase: The Role of Heme to Protein Ester Bonds in Ligand Binding and Catalysis.

scientific article

Posttranslational modification of heme in peroxidases - Impact on structure and catalysis.

scientific article published on 17 February 2018

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1

scientific article

Probing hydrogen peroxide oxidation kinetics of wild-type Synechocystis catalase-peroxidase (KatG) and selected variants

scientific article published on 21 December 2009

Probing the structure and bifunctionality of catalase-peroxidase (KatG).

scientific article

Probing the two-domain structure of homodimeric prokaryotic and eukaryotic catalase-peroxidases

scientific article published on 21 July 2010

Protein-based radicals in the catalase-peroxidase of synechocystis PCC6803: a multifrequency EPR investigation of wild-type and variants on the environment of the heme active site

scientific article published in November 2003

Purification and Characterization of a Homodimeric Catalase-Peroxidase from the Cyanobacterium Anacystis nidulans

scientific article published on 01 June 1997

Purification and Physical-Chemical Characterization of the Three Hydroperoxidases from the Symbiotic BacteriumSinorhizobium meliloti†

article by Silvia Ardissone et al published October 2004 in Biochemistry

Reaction of E. coli catalase HPII with cyanide as ligand and as inhibitor

scientific article published on 01 December 1996

Reaction of Lactoperoxidase Compound I with Halides and Thiocyanate†

scientific article published on 01 October 2002

Reaction of ferrous lactoperoxidase with hydrogen peroxide and dioxygen: an anaerobic stopped-flow study

scientific article published on 01 February 2005

Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.

scientific article

Reaction of pyranose dehydrogenase from Agaricus meleagris with its carbohydrate substrates

scientific article published on 18 August 2015

Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b

scientific article published on 18 June 2019

Redox Intermediates in the Catalase Cycle of Catalase-Peroxidases fromSynechocystisPCC 6803, Burkholderia pseudomallei, andMycobacterium tuberculosis†

scientific article published on 01 February 2007

Redox Thermodynamics of the Fe(III)/Fe(II) Couple of Human Myeloperoxidase in Its High-Spin and Low-Spin Forms†

scientific article published on 01 October 2006

Redox Thermodynamics of the Ferric−Ferrous Couple of Wild-TypeSynechocystisKatG and KatG(Y249F)†

scientific article published on 01 April 2006

Redox intermediates of plant and mammalian peroxidases: a comparative transient-kinetic study of their reactivity toward indole derivatives

scientific article published in February 2002

Redox properties of myeloperoxidase ⬇️

scientific article published on January 1, 2003

Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase

scientific article published on 01 October 2001

Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase

scientific article published in February 2003

Redox thermodynamics of B-class dye-decolorizing peroxidases

scientific article published on 11 July 2019

Redox thermodynamics of high-spin and low-spin forms of chlorite dismutases with diverse subunit and oligomeric structures

scientific article

Redox thermodynamics of lactoperoxidase and eosinophil peroxidase.

scientific article

Refolding of hexameric porcine leucine aminopeptidase using a cationic detergent and dextrin-10 as artificial chaperones.

scientific article published on 7 February 2009

Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intermediates of human myeloperoxidase

scientific article published in May 2005

Role of the main access channel of catalase-peroxidase in catalysis

scientific article

Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage

scientific article published in Journal of Biological Chemistry

Secreted heme peroxidase from Dictyostelium discoideum: Insights into catalysis, structure, and biological role.

scientific article published on 14 December 2017

Soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published on 12 December 2003

Spectral and Kinetic Studies on the Formation of Eosinophil Peroxidase Compound I and Its Reaction with Halides and Thiocyanate†

scientific article published on 01 December 2000

Spectral and kinetic studies of the oxidation of monosubstituted phenols and anilines by recombinant Synechocystis catalase-peroxidase compound I.

scientific article published in August 1999

Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc

scientific article

Standard reduction potentials of all couples of the peroxidase cycle of lactoperoxidase

scientific article published on 01 May 2005

Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": identification of a catalytically important amino acid residue

scientific article

Structure and heme-binding properties of HemQ (chlorite dismutase-like protein) from Listeria monocytogenes

scientific article published on 17 January 2015

Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

scientific article

Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors

scientific article published on 22 November 2010

The bioenergetic role of dioxygen and the terminal oxidase(s) in cyanobacteria

scientific article

The catalytic role of the distal site asparagine-histidine couple in catalase-peroxidases

scientific article

The hydrogen bonding network of coproheme in coproheme decarboxylase from Listeria monocytogenes: Effect on structure and catalysis

scientific article published on 21 March 2019

The iron superoxide dismutase from the filamentous cyanobacterium Nostoc PCC 7120. Localization, overexpression, and biochemical characterization

scientific article published on 9 August 2004

The molecular peculiarities of catalase-peroxidases.

scientific article

The peroxidase-cyclooxygenase superfamily: Reconstructed evolution of critical enzymes of the innate immune system

scientific article

The respiratory chain of blue-green algae (cyanobacteria).

scientific article published in March 2004

The role of distal tryptophan in the bifunctional activity of catalase-peroxidases

scientific article

The role of the sulfonium linkage in the stabilization of the ferrous form of myeloperoxidase: a comparison with lactoperoxidase

scientific article

The soluble curcumin derivative NDS27 inhibits superoxide anion production by neutrophils and acts as substrate and reversible inhibitor of myeloperoxidase

scientific article published on 18 October 2018

The vinyl-sulfonium bond in human myeloperoxidase: impact on compound I formation and reduction by halides and thiocyanate

scientific article published on 8 March 2007

Total conversion of bifunctional catalase-peroxidase (KatG) to monofunctional peroxidase by exchange of a conserved distal side tyrosine

scientific article published on 20 March 2003

Transient and Steady-state Kinetics of the Oxidation of Substituted Benzoic Acid Hydrazides by Myeloperoxidase

scientific article published in Journal of Biological Chemistry

Transient-state and steady-state kinetics of the oxidation of aliphatic and aromatic thiols by horseradish peroxidase

scientific article published on 01 July 1997

Transiently produced hypochlorite is responsible for the irreversible inhibition of chlorite dismutase

scientific article

Turning points in the evolution of peroxidase-catalase superfamily: molecular phylogeny of hybrid heme peroxidases

scientific article published on 21 May 2014

Two distinct groups of fungal catalase/peroxidases

scientific article published on August 2009

Two-electron reduction and one-electron oxidation of organic hydroperoxides by human myeloperoxidase

scientific article published on 01 November 2000

Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex.

scientific article

UDP-sulfoquinovose formation by Sulfolobus acidocaldarius.

scientific article published on 21 January 2015

Unexpected Diversity of Chlorite Dismutases: a Catalytically Efficient Dimeric Enzyme from Nitrobacter winogradskyi

scientific article

Versatile Oxidase and Dehydrogenase Activities of Bacterial Pyranose 2-Oxidase Facilitate Redox Cycling with Manganese Peroxidase In Vitro

scientific article published on 17 June 2019

X-ray induced photoreduction of heme metal centers rapidly induces active site perturbations in a protein-independent manner

scientific article published on 28 July 2020

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