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List of works by Paul Furtmüller

(-)-Epicatechin enhances the chlorinating activity of human myeloperoxidase

scientific article published on 16 December 2009

A stable bacterial peroxidase with novel halogenating activity and an autocatalytically linked heme prosthetic group

scientific article

A transient kinetic study on the reactivity of recombinant unprocessed monomeric myeloperoxidase

scientific article

Active site structure and catalytic mechanisms of human peroxidases

scientific article

Agaricus meleagris pyranose dehydrogenase: influence of covalent FAD linkage on catalysis and stability.

scientific article published on 17 July 2014

Analysis of Binding Interactions of Ramipril and Quercetin on Human Serum Albumin: A Novel Method in Affinity Evaluation

scientific article published on 27 January 2020

Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis

scientific article published on 15 February 2021

Biochemical Characterization of a Membrane-bound Manganese-containing Superoxide Dismutase from the CyanobacteriumAnabaenaPCC 7120

scientific article published in Journal of Biological Chemistry

Bovine lactoperoxidase - a versatile one- and two-electron catalyst of high structural and thermal stability

scientific article published on 29 December 2010

Catalase-peroxidase from synechocystis is capable of chlorination and bromination reactions

scientific article published in September 2001

Characterization of chemical features of potent myeloperoxidase inhibitors.

scientific article published on 12 July 2016

Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells.

scientific article published on 7 April 2016

Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ.

scientific article

Chlorite dismutases - a heme enzyme family for use in bioremediation and generation of molecular oxygen.

scientific article published on 12 February 2014

Conformational and thermal stability of mature dimeric human myeloperoxidase and a recombinant monomeric form from CHO cells.

scientific article published on 13 October 2010

Corrigendum to "Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells" [J. Biotechnol. 227 (2016) 120-130].

scientific article published on 4 June 2016

Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase

scientific article published on 03 December 2019

Cyanobacterial cytochrome c(M): probing its role as electron donor for Cu(A) of cytochrome c oxidase

scientific article published on 24 December 2008

Degradation of the Cellulosic Key Chromophore 5,8-Dihydroxy-[1,4]-naphthoquinone by Hydrogen Peroxide under Alkaline Conditions.

scientific article

Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors

scientific article published on 6 May 2013

Dimeric chlorite dismutase from the nitrogen-fixing cyanobacterium Cyanothece sp. PCC7425

scientific article

Disruption of the H-bond network in the main access channel of catalase-peroxidase modulates enthalpy and entropy of Fe(III) reduction

scientific article published on 3 March 2010

Disruption of the aspartate to heme ester linkage in human myeloperoxidase: impact on ligand binding, redox chemistry, and interconversion of redox intermediates

scientific article

Distal side tryptophan, tyrosine and methionine in catalase-peroxidases are covalently linked in solution

scientific article published in September 2003

Distal site aspartate is essential in the catalase activity of catalase-peroxidases

scientific article published in May 2003

Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer.

scientific article published on June 2000

Engineering the proximal heme cavity of catalase-peroxidase

scientific article

Enhancing hypothiocyanite production by lactoperoxidase - mechanism and chemical properties of promotors

scientific article published on 9 October 2015

Essential Role of Proximal Histidine-Asparagine Interaction in Mammalian Peroxidases

scientific article

Eukaryotic Catalase-Peroxidase: The Role of the Trp-Tyr-Met Adduct in Protein Stability, Substrate Accessibility, and Catalysis of Hydrogen Peroxide Dismutation

scientific article

Eukaryotic extracellular catalase-peroxidase from Magnaporthe grisea - Biophysical/chemical characterization of the first representative from a novel phytopathogenic KatG group.

scientific article published on 29 September 2011

Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.

scientific article published on 7 August 2012

Evolution of catalases from bacteria to humans.

scientific article published on September 2008

Evolution of structure and function of Class I peroxidases

scientific article published on 04 April 2010

Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design

scientific article published in April 2005

Expression and glycoengineering of functionally active heteromultimeric IgM in plants

scientific article

Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase.

scientific article published on 24 June 2016

From chlorite dismutase towards HemQ - the role of the proximal H-bonding network in haeme binding

scientific article published on 8 February 2016

Heme to protein linkages in mammalian peroxidases: impact on spectroscopic, redox and catalytic properties

scientific article

Heme-copper oxidases and their electron donors in cyanobacterial respiratory electron transport.

scientific article published on October 2008

Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria.

scientific article published in August 2009

High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases: ANSWERS FROM FIRST CRYSTAL STRUCTURE AND UNFOLDING STUDIES

scientific article

How covalent heme to protein bonds influence the formation and reactivity of redox intermediates of a bacterial peroxidase

scientific article published on 22 September 2014

Hybrid Heme Peroxidases from Rice Blast Fungus Magnaporthe oryzae Involved in Defence against Oxidative Stress

scientific article published on 23 July 2020

Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.

scientific article published on 27 March 2014

Hydrogen peroxide-mediated conversion of coproheme to heme b by HemQ-lessons from the first crystal structure and kinetic studies.

scientific article

Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro

scientific article

Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100.

scientific article published on 17 February 2014

Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutases

scientific article published on 6 June 2012

Inactivation of human myeloperoxidase by hydrogen peroxide

scientific article

Independent evolution of four heme peroxidase superfamilies

scientific article

Influence of the covalent heme-protein bonds on the redox thermodynamics of human myeloperoxidase.

scientific article published on 24 August 2011

Influence of the unusual covalent adduct on the kinetics and formation of radical intermediates in synechocystis catalase peroxidase: a stopped-flow and EPR characterization of the MET275, TYR249, and ARG439 variants

scientific article

Insights into the Active Site of Coproheme Decarboxylase from Listeria monocytogenes.

scientific article

Interaction with the Redox Cofactor MYW and Functional Role of a Mobile Arginine in Eukaryotic Catalase-Peroxidase

scientific article published on 13 June 2016

Interactions of hydrogen sulfide with myeloperoxidase

scientific article

Intracellular catalase/peroxidase from the phytopathogenic rice blast fungus Magnaporthe grisea: expression analysis and biochemical characterization of the recombinant protein

scientific article

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

scientific article published on 5 March 2015

Isoniazid as a substrate and inhibitor of myeloperoxidase: Identification of amine adducts and the influence of superoxide dismutase on their formation

scientific article published on 27 July 2012

Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase

scientific article published on 6 May 2008

Kinetics of Interconversion of Ferrous Enzymes, Compound II and Compound III, of Wild-type Synechocystis Catalase-peroxidase and Y249F: PROPOSAL FOR THE CATALATIC MECHANISM

scientific article published in Journal of Biological Chemistry

Kinetics of electron transfer between plastocyanin and the soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published in October 2004

Kinetics of interprotein electron transfer between cytochrome c6 and the soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published in October 2004

Kinetics of oxygen binding to ferrous myeloperoxidase

scientific article published on 01 June 2004

Long-Term Effects of (-)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats

scientific article (publication date: 2016)

Manipulating Conserved Heme Cavity Residues of Chlorite Dismutase: Effect on Structure, Redox Chemistry, and Reactivity

scientific article

Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase

scientific article published on 22 September 2011

Mechanism of chlorite degradation to chloride and dioxygen by the enzyme chlorite dismutase.

scientific article

Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid

scientific article published in July 2005

Mechanism of reaction of chlorite with mammalian heme peroxidases

scientific article published on 28 February 2014

Mechanism of reaction of horseradish peroxidase with chlorite and chlorine dioxide

scientific article published on 26 September 2007

Mechanism of reaction of melatonin with human myeloperoxidase

scientific article published in March 2001

Mechanism of reaction of myeloperoxidase with hydrogen peroxide and chloride ion

scientific article published on 01 October 2000

Mechanism of reaction of myeloperoxidase with nitrite

scientific journal article

Mechanisms of catalase activity of heme peroxidases

scientific article

Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies.

scientific article published on 13 October 2017

Molecular evolution of hydrogen peroxide degrading enzymes

scientific article published on 07 February 2012

Molecular evolution, structure, and function of peroxidasins

scientific article (publication date: September 2012)

Multidomain human peroxidasin 1 is a highly glycosylated and stable homotrimeric high spin ferric peroxidase.

scientific article

Myeloperoxidase attracts neutrophils by physical forces

scientific article published on 27 October 2010

Myeloperoxidase-catalyzed chlorination: the quest for the active species.

scientific article

Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques?

scientific article published on 01 March 2018

Myeloperoxidase-catalyzed taurine chlorination: initial versus equilibrium rate

scientific article published on 17 August 2007

New insights into thiocyanate oxidation by human myeloperoxidase.

scientific article published on 15 June 2016

Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.

scientific article published on 25 July 2016

Nucleotide sequence analysis, overexpression in Escherichia coli and kinetic characterization of Anacystis nidulans catalase-peroxidase.

scientific article published on March 2000

Occurrence, phylogeny, structure, and function of catalases and peroxidases in cyanobacteria

scientific article published on 06 January 2009

Peroxynitrite efficiently mediates the interconversion of redox intermediates of myeloperoxidase.

scientific article published on 30 September 2005

Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

scientific article published on 01 December 2018

Posttranslational modification of heme in peroxidases - Impact on structure and catalysis.

scientific article published on 17 February 2018

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1

scientific article

Probing hydrogen peroxide oxidation kinetics of wild-type Synechocystis catalase-peroxidase (KatG) and selected variants

scientific article published on 21 December 2009

Probing the two-domain structure of homodimeric prokaryotic and eukaryotic catalase-peroxidases

scientific article published on 21 July 2010

Proline is not uniquely capable of providing the pivot point for domain swapping in 2G12, a broadly neutralizing antibody against HIV-1.

scientific article

Reaction of Lactoperoxidase Compound I with Halides and Thiocyanate†

scientific article published on 01 October 2002

Reaction of ferrous lactoperoxidase with hydrogen peroxide and dioxygen: an anaerobic stopped-flow study

scientific article published on 01 February 2005

Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.

scientific article

Reaction of pyranose dehydrogenase from Agaricus meleagris with its carbohydrate substrates

scientific article published on 18 August 2015

Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b

scientific article published on 18 June 2019

Redox Thermodynamics of the Fe(III)/Fe(II) Couple of Human Myeloperoxidase in Its High-Spin and Low-Spin Forms†

scientific article published on 01 October 2006

Redox intermediates of plant and mammalian peroxidases: a comparative transient-kinetic study of their reactivity toward indole derivatives

scientific article published in February 2002

Redox properties of myeloperoxidase ⬇️

scientific article published on January 1, 2003

Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase

scientific article published on 01 October 2001

Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase

scientific article published in February 2003

Redox thermodynamics of high-spin and low-spin forms of chlorite dismutases with diverse subunit and oligomeric structures

scientific article

Redox thermodynamics of lactoperoxidase and eosinophil peroxidase.

scientific article

Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intermediates of human myeloperoxidase

scientific article published in May 2005

Role of the main access channel of catalase-peroxidase in catalysis

scientific article

Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage

scientific article published in Journal of Biological Chemistry

Soluble CuA domain of cyanobacterial cytochrome c oxidase

scientific article published on 12 December 2003

Spectral and Kinetic Studies on the Formation of Eosinophil Peroxidase Compound I and Its Reaction with Halides and Thiocyanate†

scientific article published on 01 December 2000

Standard reduction potentials of all couples of the peroxidase cycle of lactoperoxidase

scientific article published on 01 May 2005

Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": identification of a catalytically important amino acid residue

scientific article

Structure and heme-binding properties of HemQ (chlorite dismutase-like protein) from Listeria monocytogenes

scientific article published on 17 January 2015

Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

scientific article

Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors

scientific article published on 22 November 2010

Study of Interactions between Amlodipine and Quercetin on Human Serum Albumin: Spectroscopic and Modeling Approaches

scientific article published on 30 January 2019

The catalytic role of the distal site asparagine-histidine couple in catalase-peroxidases

scientific article

The iron superoxide dismutase from the filamentous cyanobacterium Nostoc PCC 7120. Localization, overexpression, and biochemical characterization

scientific article published on 9 August 2004

The peroxidase-cyclooxygenase superfamily: Reconstructed evolution of critical enzymes of the innate immune system

scientific article

The role of distal tryptophan in the bifunctional activity of catalase-peroxidases

scientific article

The role of the sulfonium linkage in the stabilization of the ferrous form of myeloperoxidase: a comparison with lactoperoxidase

scientific article

The soluble curcumin derivative NDS27 inhibits superoxide anion production by neutrophils and acts as substrate and reversible inhibitor of myeloperoxidase

scientific article published on 18 October 2018

The vinyl-sulfonium bond in human myeloperoxidase: impact on compound I formation and reduction by halides and thiocyanate

scientific article published on 8 March 2007

Total conversion of bifunctional catalase-peroxidase (KatG) to monofunctional peroxidase by exchange of a conserved distal side tyrosine

scientific article published on 20 March 2003

Transient and Steady-state Kinetics of the Oxidation of Substituted Benzoic Acid Hydrazides by Myeloperoxidase

scientific article published in Journal of Biological Chemistry

Transiently produced hypochlorite is responsible for the irreversible inhibition of chlorite dismutase

scientific article

Turning points in the evolution of peroxidase-catalase superfamily: molecular phylogeny of hybrid heme peroxidases

scientific article published on 21 May 2014

Two distinct groups of fungal catalase/peroxidases

scientific article published on August 2009

Two-electron reduction and one-electron oxidation of organic hydroperoxides by human myeloperoxidase

scientific article published on 01 November 2000

Unexpected Diversity of Chlorite Dismutases: a Catalytically Efficient Dimeric Enzyme from Nitrobacter winogradskyi

scientific article

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