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List of works by Reginald F. Frye

A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration

scientific article published on 5 July 2016

A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.

scientific article

A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study

scientific article published on 21 August 2014

Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats

scientific article published on 20 May 2011

Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping

scientific article

Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients

scientific article published on 9 February 2015

Atenolol Exposure and Risk for Development of Adverse Metabolic Effects: A Pilot Study ⬇️

scientific article published on September 1, 2010

Bioequivalence revisited: influence of age and sex on CYP enzymes

scientific article published in December 2004

Cefazolin as empiric therapy in hemodialysis-related infections: Efficacy and blood concentrations ⬇️

scientific article published on September 1, 1998

Cefazolin dialytic clearance by high-efficiency and high-flux hemodialyzers.

scientific article

Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine.

scientific article

Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail

scientific article published on September 1998

Comparison of iothalamate clearance methods for measuring GFR.

scientific article published in August 1999

Concentration-dependent response to pioglitazone in nonalcoholic steatohepatitis.

scientific article published on 3 May 2017

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation

scientific article published in May 2003

Current clinical evidence on pioglitazone pharmacogenomics.

scientific article

Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis ⬇️

scientific article published on September 1, 2012

Cytochrome P-450 activity is differentially altered in severely injured patients

scientific article

Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction

scientific article published on 22 July 2005

Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure

scientific article published on 16 April 2003

DHEA and DHEA-S: a review

scientific article

Debilitating reaction following the initial dose of tramadol

scientific article published on 01 October 1997

Determinants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.

scientific article

Determinants of ceftriaxone clearance by continuous venovenous hemofiltration and hemodialysis

scientific article published on 01 June 2000

Determinants of vancomycin clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.

scientific article published in June 1998

Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS).

scientific article published in September 2003

Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies

scientific article published on 18 January 2008

Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography

scientific article published on 01 November 1996

Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry

scientific article published on 20 June 2008

Determination of trimethoprim in low-volume human plasma by liquid chromatography

scientific article published in August 2004

Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies

scientific article published on 21 January 2009

Drug administration in patients with renal insufficiency. Minimising renal and extrarenal toxicity

scientific article

ESRD impairs nonrenal clearance of fexofenadine but not midazolam

scientific article published on 20 August 2009

Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats

scientific article published on 28 May 2009

Early thrombin formation capacity in trauma patients and association with venous thromboembolism

scientific article published on 20 September 2016

Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle-aged and Elderly Postmenopausal Women

scientific article published in November 2006

Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics

scientific article

Effect of St John's wort on imatinib mesylate pharmacokinetics

scientific article published on October 2004

Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.

scientific article published in June 2005

Effect of ceftazidime on systemic cytokine concentrations in rats

scientific article published on November 2000

Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects

scientific article published on February 2002

Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.

scientific article published on October 2011

Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites

scientific article published in March 2003

Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients

scientific article published in October 2002

Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.

scientific article

Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro

scientific article published in February 2007

Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies

scientific article

Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects ⬇️

scientific article published on December 5, 2011

Effects of liver disease on the disposition of the opioid antagonist nalmefene

scientific article

Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.

scientific article published on 10 June 2015

Estimation of the hepatic extraction ratio of indocyanine green in swine

scientific article published on 01 June 1993

Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.

scientific article

Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity

scientific article published on 01 February 2000

Examination of Metoprolol Pharmacokinetics and Pharmacodynamics across CYP2D6 Genotype-Derived Activity Scores

scientific article published on 17 October 2020

Hepatic drug metabolism and transport in patients with kidney disease.

scientific article published on November 2003

Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection

scientific article

Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies

scientific article

Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection

scientific article published on 01 February 1996

In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.

scientific article published on 06 September 2013

In vivo modulation of CYP enzymes by quinidine and rifampin

scientific article published on 01 October 2000

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

scientific article

Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation

scientific article

Influence of DHEA administration on 24-hour cortisol concentrations

scientific article published in February 2003

Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids

scientific article published on 4 November 2009

Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes

scientific article published on 28 November 2014

Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.

scientific article

Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity

scientific article published on October 2010

Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study

scientific article published on 25 February 2011

Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms.

scientific article

Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?

scientific article

Liver disease selectively modulates cytochrome P450--mediated metabolism

scientific article published on 01 September 2006

Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism

scientific article published on 8 March 2018

Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone

scientific article published in August 2001

Nicotine as a factor in stress responsiveness among detoxified alcoholics.

scientific article

Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach

scientific article published on 13 July 2016

Pharmacokinetic Properties of Pure Xanthones in Comparison to a Mangosteen Fruit Extract in Rats

Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.

scientific article published on 27 April 2009

Pharmacokinetics of abecarnil in patients with renal insufficiency.

scientific article

Pharmacokinetics of intermittent intraperitoneal ceftazidime

scientific article published on 01 January 1999

Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations

scientific article published on 12 March 2012

Pharmacokinetics of α-mangostin in rats after intravenous and oral application.

scientific article published on 20 January 2011

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

scientific article

Pharmacometabolomics reveals racial differences in response to atenolol treatment

scientific article

Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin

scientific article published on August 2008

Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure

scientific article published in October 2002

Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol

scientific article published on 15 September 2016

Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes

scientific article published on 01 December 2004

Rapid microtiter plate assay for determination of inulin in human plasma and dialysate

scientific article

Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.

scientific article

Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics

scientific article published in July 2002

Simplified method for determination of rosiglitazone in human plasma

scientific article published in April 2004

Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry

scientific article published on 25 November 2008

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.

scientific article published on 29 December 2017

Stability of atropine sulfate prepared for mass chemical terrorism

scientific article published in January 2003

Stability of cefepime in icodextrin peritoneal dialysis solution

scientific article published on 19 October 2004

Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry.

scientific article published in January 2003

The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney

scientific article

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes

scientific article published on 27 April 2017

The effect of renal insufficiency and hemodialysis on the pharmacokinetics of nalmefene

scientific article published on 01 February 1996

The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.

scientific article published in January 2005

The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity

scientific article

The role of pharmacogenetics in the treatment of chronic hepatitis C infection

scientific article published on 30 September 2013

Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans

scientific article

Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days

scientific article

Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure

scientific article published on 01 January 1998

Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.

scientific article

Validation of incorporating flurbiprofen into the Pittsburgh cocktail

scientific article published on 01 September 2006

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

scientific article published on 01 October 1997

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