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List of works by Hans-Uwe Simon

10 years of Cell Death & Disease

scientific article published on 12 December 2020

2B4 (CD244) is expressed and functional on human eosinophils

scientific article published in January 2005

A differential concentration-dependent effect of IVIg on neutrophil functions: relevance for anti-microbial and anti-inflammatory mechanisms

scientific article

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.

scientific article

A novel link between p53 and ROS.

scientific article published on 15 January 2012

A novel signaling pathway in TNFα-induced neutrophil apoptosis.

scientific article

ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression

scientific article published on 30 October 2020

ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics

scientific article published on 16 December 2019

ATG5 can regulate p53 expression and activation

scientific article published on 17 July 2014

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

scientific article

ATG5: a distinct role in the nucleus

scientific article

Abnormal Clones of T Cells Producing Interleukin-5 in Idiopathic Eosinophilia

scientific article published on 7 October 1999

Acute hepatitis associated with montelukast

scientific article published in May 2003

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

scientific article

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema

scientific article published in August 2008

Alginate-coated chitosan nanogel capacity to modulate the effect of TLR ligands on blood dendritic cells

scientific article published on 22 January 2013

Allergen-specific immunotherapy: current concepts and future directions

scientific article published in June 2011

Allergic inflammation: focus on eosinophils ⬇️

scientific article published on July 1, 2013

Allergic responses in the lung and skin: new players in the game

scientific article published in December 2012

Allergy - Committed to Progress in Allergy and Immunology

scientific article published on 13 January 2018

Anti-CD20 (rituximab) treatment improves atopic eczema

scientific article published in January 2008

Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells

scientific article

Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils

scientific article published in December 1997

Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis

scientific article published on 5 February 2013

Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis

scientific article published in June 2002

Anti-inflammatory and immunosuppressive effects of the enaminone E121.

scientific article published on 16 December 2009

Anti-interleukin-5 antibody therapy in eosinophilic diseases

scientific article

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

scientific article published on 13 October 2009

Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells

scientific article published on 09 July 2019

Anti–IL-5 (mepolizumab) therapy does not alter IL-5 receptor α levels in patients with eosinophilic esophagitis

scientific article published in January 2009

Anti–TNF-α (infliximab) therapy for severe adult eosinophilic esophagitis

scientific article published in August 2008

Apoptosis - Regulation and clinical implications

scientific article published in May 2001

Apoptosis in Inflammatory Diseases

scientific article published in 1999

Apoptosis regulation by autophagy gene 5.

scientific article published on 20 July 2007

Apoptotic Neutrophils Release Macrophage Migration Inhibitory Factor upon Stimulation with Tumor Necrosis Factor-α

scientific article published in Journal of Biological Chemistry

Apoptotic pathways are inhibited by leptin receptor activation in neutrophils

scientific article published in June 2005

Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report

scientific article

Autophagic-like cell death in neutrophils induced by autoantibodies

scientific article published on 27 January 2007

Autophagy in Myocardial Differentiation and Cardiac Development ⬇️

scientific article published on February 17, 2012

Autophagy in cancer and chemotherapy

scientific article published on January 2009

Autophagy in cells of the blood

scientific article published in September 2009

Autophagy in malignant transformation and cancer progression

scientific article

Autophagy is required for self-renewal and differentiation of adult human stem cells

scientific article published on 20 December 2011

Autophagy protects from liver injury

scientific article published in July 2013

Autophagy regulation in macrophages and neutrophils

scientific article published on 04 January 2012

Autophagy researchers

scientific article published in September 2014

Autophagy suppresses melanoma tumorigenesis by inducing senescence

scientific article published on 26 November 2013

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth

scientific article published on 03 June 2020

Bcl-2 expression by eosinophils in a patient with hypereosinophilia

scientific article published on 01 December 1998

Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential

scientific article published on 28 August 2018

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

scientific article

Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis

scientific article published on August 2010

CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death

scientific article published on 16 March 2006

CD8+ T cells producing IL-3 and IL-5 in non-IgE-mediated eosinophilic diseases

scientific article published on 11 November 2013

Calpain-1 Regulates Bax and Subsequent Smac-dependent Caspase-3 Activation in Neutrophil Apoptosis

scientific article published in Journal of Biological Chemistry

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

scientific article

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

scientific article published on 25 February 2008

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

scientific article published on 10 August 2008

Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis

scientific article

Cathepsins and their involvement in immune responses

scientific article published on 20 July 2010

Cathepsins: key modulators of cell death and inflammatory responses

scientific article published on 12 August 2008

Cell death in allergic diseases

scientific article published on April 2009

Cell death in immune thrombocytopenia: novel insights and perspectives.

scientific article

Cell death modulation by intravenous immunoglobulin

scientific article published on May 2010

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

scientific article

Chemokine-triggered microtubule polymerization promotes neutrophil chemotaxis and invasion but not transendothelial migration

scientific article published on 25 February 2019

Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation

scientific article published in December 2005

Clinical and Immunological Features of Patients with Interleukin-5-Producing T Cell Clones and Eosinophilia

scientific article published in 2001

Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma

scientific article published in December 2003

Comparison of different biopsy forceps models for tissue sampling in eosinophilic esophagitis

scientific article published on 4 November 2016

Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations

scientific article

Consensus statements, evidence-based medicine and guidelines in allergic diseases

scientific article published on 5 December 2007

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

scientific article

Correlation of Vascular Endothelial Growth Factor subtypes and their receptors with melanoma progression: A next-generation Tissue Microarray (ngTMA) automated analysis

scientific article published in PLoS ONE

Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosis

scientific article published in October 2001

Cross-talk between death and survival pathways

scientific article

Cytokine Expression in Healthy and Inflamed Mucosa: Probing the Role of Eosinophils in the Digestive Tract

scientific article published in August 2005

Cytokine and anti-cytokine therapy for asthma

scientific article

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation

scientific article published on November 1999

DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants

scientific article

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

scientific article published in January 2002

Delay in Diagnosis of Eosinophilic Esophagitis Increases Risk for Stricture Formation in a Time-Dependent Manner

scientific article published in December 2013

Different patterns of Siglec-9-mediated neutrophil death responses in septic shock

scientific article published in October 2009

Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils

scientific article

Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes

scientific article published on 9 March 2011

Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis

scientific article published on 05 June 2017

Disruption of fas receptor signaling by nitric oxide in eosinophils.

scientific article

Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.

scientific article published on 12 September 2008

Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma

scientific article published on September 2013

Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy

scientific article published on 07 September 2018

EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders

scientific article published on 24 April 2015

Early-Onset and Adult Periodontitis Associated With Abnormal Cytokine Production by Activated T Lymphocytes

scientific article published in October 1998

Efalizumab-Associated Papular Psoriasis

scientific article published in July 2007

Effect of 3 weeks' rehabilitation on neutrophil surface antigens and lung function in cystic fibrosis

scientific article published in May 2000

Effects of obesity on asthma: immunometabolic links

scientific article published on 27 July 2018

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

scientific article

Eosinophil apoptosis in allergic diseases - an emerging new issue

scientific article published in November 1998

Eosinophil apoptosis--pathophysiologic and therapeutic implications.

scientific article

Eosinophil extracellular DNA traps in skin diseases

scientific article

Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease

scientific article published on 13 September 2012

Eosinophile Zellulitis (Wells-Syndrom)

scientific article published on 7 March 2000

Eosinophilia in Dermatologic Disorders

scientific article published on 19 June 2015

Eosinophilic bioactivities in severe asthma

scientific article

Eosinophilic disorders

scientific article

Eosinophilic esophagitis and allergy

scientific article published on 28 February 2014

Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases

scientific article

Eosinophilic esophagitis: Escalating epidemiology?

scientific article published in February 2005

Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients

scientific article published on 14 April 2008

Eosinophilic esophagitis: red on microscopy, white on endoscopy

scientific article published on 20 September 2004

Eosinophils

scientific article published in 2014

Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory Diseases

scientific article published on 15 July 2002

Eosinophils Maintain Their Capacity to Signal and Release Eosinophil Cationic Protein Upon Repetitive Stimulation with the Same Agonist

scientific article published in October 2000

Eosinophils as putative therapeutic targets in bullous pemphigoid

scientific article published on 20 August 2017

Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation

scientific article published on 6 August 2018

Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesions

scientific article

Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2.

scientific article published on 20 January 2010

Escalating incidence of eosinophilic esophagitis: A 20-year prospective, population-based study in Olten County, Switzerland

article

Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation

scientific article published on 24 November 2009

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome ⬇️

scientific article published on October 1, 1992

Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.

scientific article

Expression of CD95 on mature leukocytes of MRL/lpr mice after transplantation of genetically modified bone marrow stem cells

scientific article published on 26 December 2007

Extensive accumulation of eosinophil extracellular traps in bullous delayed-pressure urticaria: a pathophysiological link?

scientific article published on 23 April 2012

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

scientific article published on 16 February 2017

Fas Ligand Reduces Viability in Primary Melanoma Short-Term Cell Cultures More than in Metastatic Melanoma Short-Term Cell Cultures

scientific article published in 2005

Food allergy in EAACI journals (2016).

scientific article published on 25 October 2017

Food-induced Immediate Response of the Esophagus - a newly identified Syndrome in Patients with Eosinophilic Esophagitis

scientific article published on 14 July 2020

Fragility of the esophageal mucosa: A pathognomonic endoscopic sign of primary eosinophilic esophagitis?

scientific article published in March 2003

Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders

scientific article published in July 2001

Functional antagonism by a monoclonal antibody to digoxin in a test system of cultured rat heart myocytes

scientific article published in 1996

Functional expression of CD134 by neutrophils.

scientific article published in August 2004

General laboratory diagnostics of eosinophilic GI diseases

scientific article published on January 2008

Glucocorticoids in Autoimmune Bullous Diseases: Are Neutrophils the Key Cellular Target?

scientific article published in October 2013

Granulocyte Death Regulation by Naturally Occurring Autoantibodies ⬇️

scientific article published on January 1, 2012

Granulocyte apoptosis: death by a secreted lipocalin?

scientific article published on 01 June 2002

Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG)

scientific article published on 06 February 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death

scientific article

High altitude climate therapy reduces peripheral blood T lymphocyte activation, eosinophilia, and bronchial obstruction in children with house-dust mite allergic asthma

scientific article published in May 1994

High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome

scientific article published in September 2002

Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment

scientific journal article

Human mast cells express intracellular TRAIL

scientific article published in 2010

Human mast cells undergo TRAIL-induced apoptosis

scientific article published on February 2006

Hyper-IgE syndrome associated with an IL-4–producing γ/δ+ T-cell clone

scientific article published in January 2007

Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung

scientific article published in June 2012

Hypereosinophilia in patients with multiple sclerosis treated with natalizumab

scientific article published on 5 October 2011

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy

scientific article

IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist

scientific article published on 01 May 2014

IVIG regulates the survival of human but not mouse neutrophils

scientific article

IVIG--mechanisms of action.

scientific article

Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation

scientific article published on 19 October 2015

Idiopathic eosinophilic esophagitis is associated with a TH2-type allergic inflammatory response

scientific article published in December 2001

Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations

scientific article published on 15 December 2006

Immunological Effects of Competitive Versus Recreational Sports in Cross-Country Skiing

scientific article published in January 2001

Immunologische Grundlagen des Asthma bronchiale

scientific article published on 2 August 1999

Immunopathogenesis of eosinophilic esophagitis

scientific article published on 28 February 2014

Important questions in allergy: novel research areas

scientific article published on 4 January 2008

In Allergy, ‘A new day has begun’

scientific article published in June 2008

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

scientific article published in January 2013

In vivo evidence for extracellular DNA trap formation

scientific article published on 30 April 2020

Increased autophagy contributes to impaired smooth muscle function in neurogenic lower urinary tract dysfunction

scientific article published on 24 May 2018

Increased expression and a potential anti-inflammatory role of TRAIL in atopic dermatitis

scientific article published in October 2005

Induction of Bim limits cytokine-mediated prolonged survival of neutrophils

scientific article published in May 2009

Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation

scientific article published on 9 August 2004

Inflammation-Associated Autophagy-Related Programmed Necrotic Death of Human Neutrophils Characterized by Organelle Fusion Events

scientific article published on 22 April 2011

Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils

scientific article

Inhibition of autophagy significantly increases the antitumor effect of Abiraterone in prostate cancer

scientific article published on 27 June 2018

Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia?

scientific article published on February 1995

Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis

scientific article published in October 2002

Integrin expression by eosinophils

scientific article published in September 2000

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance

scientific article published on 24 February 2014

Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome

scientific article published in April 2003

International Archives of Allergy and Immunology: A Commitment to Serving the Community Worldwide

scientific article published on 10 January 2018

Intravenous immunoglobulin preparations contain anti–Siglec-8 autoantibodies

scientific article published in April 2007

Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosis

scientific article published on 12 October 2006

LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis.

scientific article

Leptin is an eosinophil survival factor

scientific article

Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma

scientific article published in The Lancet

Levels of soluble interleukin-2 receptor-α are elevated in serum and ascitic fluid from epithelial ovarian cancer patients

scientific article published in March 1994

Life and death partners: apoptosis, autophagy and the cross-talk between them

scientific article

Linking glucocorticoid-induced osteoporosis to osteoimmunology

scientific article published on 14 December 2020

Living and dying for inflammation: neutrophils, eosinophils, basophils

scientific article published on 09 May 2013

Long-Term Budesonide Maintenance Treatment Is Partially Effective for Patients With Eosinophilic Esophagitis

scientific article published in May 2011

Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy.

scientific article published on 18 March 2018

Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells

scientific article

Machine learning with autophagy-related proteins for discriminating renal cell carcinoma subtypes

scientific article published on 20 January 2020

Mathematical modeling of the regulation of caspase-3 activation and degradation

scientific article published in May 2005

Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis

scientific article published in July 2010

Metastatic Carcinoma Presenting with Concomitant Eosinophilia and Thromboembolism

scientific article published in August 2003

Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation

scientific article

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

scientific article (publication date: 2012)

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monocytes enhance neutrophil-induced blister formation in an ex vivo model of bullous pemphigoid.

scientific article

NADPH oxidase-independent formation of extracellular DNA traps by basophils

scientific article

NET formation can occur independently of RIPK3 and MLKL signaling

scientific article

NETosis - Does It Really Represent Nature's "Suicide Bomber"?

scientific article published on 26 August 2016

Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils

scientific article published in 2022

Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg).

scientific article published on 18 April 2008

Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years

scientific article published in December 2003

Necroptosis and neutrophil-associated disorders

scientific article published on 25 January 2018

Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.

scientific article published on 7 March 2017

Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation

scientific article published on 13 July 2017

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming.

scientific article published on 7 October 2016

Neutrophil apoptosis pathways and their modifications in inflammation

scientific article

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

scientific article published in Nature Communications

New Drug Targets in Atopic Dermatitis ⬇️

scientific article published on March 13, 2012

Notch-1 decreased expression contributes to leptin receptor downregulation in nasal epithelium from allergic turbinates

scientific article published on 02 April 2019

Novel approaches to therapy of hypereosinophilic syndromes

scientific article published on August 2007

Novel targeted therapies for eosinophil-associated diseases and allergy

scientific article

Novel targeted therapies for eosinophilic disorders

scientific article published on September 2012

Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation

scientific article published on 7 May 2018

Partially Hydrolyzed Whey Infant Formula: Literature Review on Effects on Growth and the Risk of Developing Atopic Dermatitis in Infants from the General Population

article

Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

scientific article

Pathophysiologic and pharmacotherapeutic aspects of IgE-mediated allergic reactions

scientific article published in May 2001

Peculiarities of cell death mechanisms in neutrophils.

scientific article

Physiologie der eosinophilen Granulozyten

scientific article published in November 2017

Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor

scientific article published on July 1996

Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

scientific article

Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology

scientific article published on 25 January 2017

Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

scientific article

Prediction and prevention of allergy and asthma in EAACI journals (2016).

scientific article published on 2 December 2017

Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia

scientific article published on 30 January 2008

Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis

scientific article published on 23 December 2014

Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransduction

scientific article

Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

scientific article published in November 1994

Proteomic analysis of human eosinophil activation mediated by mast cells, granulocyte macrophage colony stimulating factor and tumor necrosis factor alpha

scientific article published on November 2002

Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils

scientific article published on 18 January 2009

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α

scientific article published on 12 August 2020

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation.

scientific article

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

scientific article

Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment

scientific article published in October 2004

Refining the definition of hypereosinophilic syndrome

scientific article

Regulation of Allergic Inflammation by T Cells and Cytokines in Atopic Dermatitis

scientific article published in 2001

Regulation of Eosinophil Apoptosis: Transduction of Survival and Death Signals

scientific article published in 1999

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

scientific article published on 08 February 2019

Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells

scientific article published on 08 February 2019

Relative lack of T regulatory cells in adult eosinophilic esophagitis - no normalization after corticosteroid therapy

scientific article published on 8 December 2010

Reply

scientific article published on 03 August 2017

Reply

scientific article published in June 2008

Reply

scientific article published in December 2007

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

scientific article published on April 1996

Retrograde signaling from autophagy modulates stress responses.

scientific article published on 28 February 2017

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)

scientific article published in July 2018

RhoH is a negative regulator of eosinophilopoiesis.

scientific article published on 14 October 2016

RhoH/TTF negatively regulates leukotriene production in neutrophils

scientific article

Role of granule proteases in the life and death of neutrophils

scientific article published on January 2017

SHP-1: a regulator of neutrophil apoptosis ⬇️

scientific article published on June 1, 2003

Schwieriges Asthma: Klinische Phänotypen und Prinzipien der Therapie

scientific article published on 13 February 2002

Shaping the future of Allergy

scientific article published in January 2010

Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes

scientific article published in April 2006

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

scientific article published on 15 April 2019

Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment

scientific article

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth

scientific article published on 08 March 2016

Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma

scientific article published in February 1997

Systems medicine and integrated care to combat chronic noncommunicable diseases

scientific article

T Cells and T Cell-Derived Cytokines as Pathogenic Factors in the Nonallergic Form of Atopic Dermatitis

scientific article published in October 1999

TRAIL mediated signaling in human mast cells: the influence of IgE-dependent activation

scientific article published in March 2008

TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8.

scientific article published on 21 February 2008

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy ⬇️

scientific article published on May 31, 2011

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

scientific article published on 9 January 2018

Targeting autophagy as a potential therapeutic approach for melanoma therapy

scientific article published on 02 July 2013

Targeting disease by immunomodulation

scientific article published on February 2015

Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils.

scientific article

The CONSORT statement checklist in allergen-specific immunotherapy: a GA2LEN paper

article

The Differential Fate of Cadherins during T-Cell-Induced Keratinocyte Apoptosis Leads to Spongiosis in Eczematous Dermatitis

scientific article published in October 2001

The Lymphoid Variant of HES (L-HES) as Differential Diagnose of Severe Asthma in Childhood

scientific article published on 15 November 2016

The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndrome

scientific article published in September 2005

The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells

scientific article

The expanding role of immunopharmacology: IUPHAR Review 16

scientific article (publication date: September 2015)

The generation of neutrophils in the bone marrow is controlled by autophagy

scientific article

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

scientific article published on January 2015

The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract.

scientific article published on January 2004

The role of autophagy in anticancer therapy: promises and uncertainties

scientific article published on 22 October 2010

The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

scientific article published on 13 September 2013

Themes in Allergy

scientific article published in January 2006

Therapeutic Approaches to Patients With Hypereosinophilic Syndromes ⬇️

scientific article published on April 1, 2012

Therapeutic interleukin (IL) 1 blockade normalises increased IL1 beta and decreased tumour necrosis factor alpha and IL10 production in blood mononuclear cells of a patient with CINCA syndrome

scientific article published in December 2005

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

scientific article published on 08 January 2019

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation

scientific article published on 26 February 2015

Treatment of patients with the hypereosinophilic syndrome with mepolizumab

scientific article

Treatment with IFN-alpha in corticosteroid-unresponsive asthma

scientific article published on 01 May 2000

Untangling "NETosis" from NETs.

scientific article

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

scientific article published on 17 July 2009

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

scientific article

[Benralizumab: Targeting the IL-5 Receptor in Severe Eosinophilic Asthma]

[Eosinophilic granulocytes-Physiology and pathophysiology]

scientific article published on 01 May 2019

[The Hypereosinophilic Syndromes in Childhood].

scientific article

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.

scientific article published on 02 August 2013

p73 regulates basal and starvation-induced liver metabolism in vivo

scientific article published on 7 September 2015

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