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List of works by Karen T Liby

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent.

scientific article

A BET bromodomain inhibitor suppresses adiposity-associated malignant transformation

scientific article

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

scientific article published on 17 January 2008

A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice

scientific article published on 14 August 2019

A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland

scientific article

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

scientific article published on August 2008

A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer

scientific article

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

scientific article

Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.

scientific article

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer

scientific article published on 27 February 2017

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer

scientific article published on 16 April 2020

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

scientific article

CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells

scientific article

CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.

scientific article published on 20 September 2011

Chemoprevention of preclinical breast and lung cancer with the bromodomain inhibitor I-BET 762.

scientific article

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

scientific article published in Scientific Reports

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

scientific article

Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids

scientific article published on 01 July 2017

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets

scientific article published in September 2004

Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation

scientific article published on 15 November 2017

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

scientific article

Endostatin expression by MDA-MB-435 breast cancer cells effectively inhibits tumor growth.

scientific article

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

scientific article

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

scientific article published on 15 April 2008

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

scientific article published on 21 April 2009

Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO.

scientific article published on 07 May 2008

Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice.

scientific article published on 13 March 2018

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

scientific article published on 16 July 2019

Is lycopene an effective agent for preventing prostate cancer?

scientific article published on 12 March 2013

JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells

scientific article published on 3 January 2007

Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer

article

NRF2 and cancer: the good, the bad and the importance of context.

scientific article

NRF2 as an Emerging Therapeutic Target.

scientific article published on 31 January 2017

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

scientific article

Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

scientific article

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

scientific article

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

scientific article

Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention

scientific article published on 31 July 2015

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents

scientific article published on 17 March 2007

Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing

scientific article published on 9 March 2017

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

scientific article

Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression

scientific article published on 15 July 2013

PARP Inhibitors for Chemoprevention--Reply

scientific article published on 01 November 2014

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

scientific article

Platforms and networks in triterpenoid pharmacology

scholarly article by Michael B. Sporn et al published 2007 in Drug Development Research

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

scientific article published in February 2006

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

scientific article

Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

scientific article published on July 2008

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

scientific article published on 01 July 2019

Prolactin as an autocrine/paracrine growth factor in human cancer.

scientific article

Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth

scientific article

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

scientific article published on 3 November 2005

Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin

scientific article published on September 1999

Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR

scientific article

Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.

scientific article

Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models

scientific article published on 01 November 2019

Rexinoids for prevention and treatment of cancer: opportunities and challenges

scientific article published on 16 June 2016

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

scientific article published on 19 August 2009

Sustained Release Talazoparib Implants for Localized Treatment of BRCA1-deficient Breast Cancer

scientific article published on 26 September 2017

Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).

scientific article published on 15 December 2013

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

scientific article

Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

scientific article

Synthetic triterpenoids can protect against toxicity without reducing the efficacy of treatment with Carboplatin and Paclitaxel in experimental lung cancer

scientific article published on August 2013

Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.

scientific article

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

scholarly article

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease

scientific article published on 13 August 2012

Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention

scientific article published on 13 February 2019

The Bromodomain Inhibitor, INCB057643, Targets Both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer

scientific article published on 30 December 2020

The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice

scientific article

The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice

scientific article published on 10 November 2015

The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in Kras; Pdx1-Cre (KC) mice

scientific article published on 08 May 2019

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

scientific article

The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer

scientific article published on October 2006

The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer

scientific article published on 17 December 2020

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

scientific article

The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer

scientific article

The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.

scientific article

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta

scientific article published on 5 December 2006

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells

scientific article published on July 2006

The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.

scientific article published on 15 January 2011

The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells

scientific article published on 01 June 2006

The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.

scientific article published on 8 March 2012

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

scientific article published on March 2007

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

scientific article published on June 2005

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice

scientific article published on 13 August 2009

The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer

scientific article published on 22 September 2016

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

scientific article

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

scientific article

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

scientific article

Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.

scientific article

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

scientific article published on 19 April 2007

ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

scientific article published on 14 December 2012

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