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List of works by Helena E. Richardson

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues.

scientific article published on 13 June 2017

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis ⬇️

scientific article published on April 5, 1991

A family of cyclin homologs that control the G1 phase in yeast

scientific article

A fission yeast B-type cyclin functioning early in the cell cycle ⬇️

scientific article published on July 12, 1991

A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

scientific article

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

article

APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle

scientific article

Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

scientific article

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila

scientific article published in December 2000

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

scientific article published on 20 September 2012

Analysis of Drosophila cyclin EI and II function during development: identification of an inhibitory zone within the morphogenetic furrow of the eye imaginal disc that blocks the function of cyclin EI but not cyclin EII.

scientific article published in January 2002

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

scientific article

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

scientific article published on 5 June 2017

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.

scientific article published on 24 July 2015

Basic and Translational Models of Cooperative Oncogenesis

scientific article published on 18 August 2020

Bcl-2 in cell cycle regulation.

scientific article published on January 2004

Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions

scientific article

Characterization of the Drosophila caspase, DAMM.

scientific article published on 3 May 2001

Control of gene expression in the P2-related temperate coliphage 186

article

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

scientific article

Cooperates with Oncogenic in Tumourigenesis via the JNK and PI3K Pathways in epithelial Tissue

scientific article published on 27 May 2018

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

scientific article

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

scientific article published in April 1994

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2

scientific article published on November 1, 1992

DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7.

scientific article published in October 1999

DNA replication studies with coliphage 186

scientific article published on 01 March 1989

DRONC, an ecdysone-inducible Drosophila caspase

scientific article

Death takes a holiday--non-apoptotic role for caspases in cell migration and invasion.

scientific article published on 15 January 2013

Death to flies: Drosophila as a model system to study programmed cell death

scientific article

Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery.

scientific article

Differential regulation of protein tyrosine kinase signaling by Dock and the PTP61F variants

scientific article

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis

scientific article published in June 1995

Dominant negative protein kinase mutations that confer a G1 arrest phenotype

scientific article

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation

scientific article published in March 2004

Drosophila cyclin E interacts with components of the Brahma complex

scientific article

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

scientific article

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.

scientific article published on 21 April 2010

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

scientific article

Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis

scientific article

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

scientific article published on 05 June 2018

Lgl regulates Notch signaling via endocytosis, independently of the apical aPKC-Par6-Baz polarity complex.

scientific article published on 11 September 2014

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

scientific article published in April 2010

Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

scientific article published on 10 August 2010

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

scientific article published on 21 October 2010

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

scientific article

Making brundlefly, one gene at a time

scientific article published in January 2009

Modelling Cooperative Tumorigenesis in Drosophila.

scientific article published on 6 March 2018

POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

scientific article published on 12 February 2018

Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation

scientific article published on 14 July 2018

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor.

scientific article

Robo-Enabled Tumor Cell Extrusion

scientific article published in December 2016

STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.

scientific article

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

scientific article published on 24 September 2009

The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state

scientific article (publication date: 2013)

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

scientific article published on 11 March 2014

The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis

scientific article

The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila

scientific article published on 9 July 2008

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

scientific article

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumourigenesis.

scientific article published on 30 January 2018

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

scientific article published on January 2012

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

scientific article

Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway.

scientific article published on 28 March 2017

Upstream regulation of the hippo size control pathway

scientific article published on July 2010

Using Drosophila melanogaster to map human cancer pathways

scientific article

Vinegar flies turn to porto for cell division cycle meeting.

scientific article published in August 2006

When cell cycle meets development

scientific article

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

scientific article (publication date: 18 December 2003)

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK.

scientific article

miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila.

scientific article

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

scientific article

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