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List of works by Juan Antonio Marchal

5-Fluorouracil derivatives: a patent review (2012 - 2014).

scientific article published on 13 July 2015

5-Fluorouracil derivatives: a patent review.

scientific article

5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation

scientific article published on May 2007

A formulation of pancreatic pro-enzymes provides potent anti-tumour efficacy: a pilot study focused on pancreatic and ovarian cancer.

scientific article published on 25 October 2017

A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.

scientific article published on 24 November 2006

Actinomycin D treatment leads to differentiation and inhibits proliferation in rhabdomyosarcoma cells

scientific article published on July 1997

Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

scientific article published on 16 July 2018

Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation ⬇️

scientific article published on February 12, 2013

Actual targets in cytodifferentiation cancer therapy.

scientific article published on January 2004

Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: antiproliferative activities, cellular differentiation and apoptosis

scientific article published on January 2009

Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.

scientific article published on 10 February 2014

Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine.

scientific article published on 27 May 2011

Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies.

scientific article published on January 2008

Antiproliferative activity, cell-cycle dysregulation, and cellular differentiation: salicyl- and catechol-derived acyclic 5-fluorouracil O,N-acetals against breast cancer cells

scientific article published on December 2007

Antitumoural properties of benzannelated seven-membered 5-fluorouracil derivatives and related open analogues. Molecular markers for apoptosis and cell cycle dysregulation.

scientific article published on February 2005

Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population

scientific article published on 15 January 2011

Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs

scientific article published on 03 February 2020

Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

scientific article published on 29 October 2013

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

scientific article published on 09 July 2020

Cadmium Modifies the Cell Cycle and Apoptotic Profiles of Human Breast Cancer Cells Treated with 5-Fluorouracil ⬇️

scientific article published on August 12, 2013

Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells

scientific article

Cancer gene therapy: strategies and clinical trials.

scientific article

Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment

scientific article published on 15 October 2020

Cardiomyogenic differentiation potential of human endothelial progenitor cells isolated from patients with myocardial infarction

scientific article published on 23 June 2014

Cell surface immobilization of GABAA Rs in cerebellar granule cells depends on the M3/M4 cytoplasmatic loop of the alpha 1 subunit

scientific article published on 30 September 2008

Cellular extracts from post-mortem human cardiac tissue direct cardiomyogenic differentiation of human adipose tissue-derived stem cells.

scientific article

Characterization of different functionalized lipidic nanocapsules as potential drug carriers

scientific article

Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells

scientific article

Clinical Trials of Thermosensitive Nanomaterials: An Overview

scientific article published on 02 February 2019

Clinical failure of nanoparticles in cancer: mimicking nature's solutions

scientific article published on 24 September 2020

Clinical significance of antiheart antibodies after myocardial infarction

scientific article published on 01 November 1997

Contractile regulatory proteins tropomyosin and troponin-T as indicators of the modulatory role of retinoic acid.

scientific article published in January 2003

Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation

scientific article published on 2 October 2011

Deciphering the Mechanism of Action Involved in Enhanced Suicide Gene Colon Cancer Cell Killer Effect Mediated by Gef and Apoptin

article

Development of chick cardiomyocytes: modulation of intermediate filaments by basic fibroblast and platelet-derived growth factors

scientific article published on 01 January 2000

Differentiation in the RD rhabdomyosarcoma cell line after electroporation

scientific article published on 01 May 1995

Differentiation of intestinal epithelial cells mediated by cell confluence and/or exogenous nucleoside supplementation.

scientific article

Diheterocyclanes as synthons for the preparation of novel series of nucleoside and acyclonucleoside analogues

scientific article published on 01 May 1997

EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer

scientific article

Effect of levobupivacaine on articular chondrocytes: an in-vitro investigation

scientific article

Enantiospecific synthesis of heterocycles linked to purines: different apoptosis modulation of enantiomers in breast cancer cells

scientific article published on January 2013

Epigenetic control of retrotransposon expression in human embryonic stem cells.

scientific article

Evaluation of Glycerylphytate Crosslinked Semi- and Interpenetrated Polymer Membranes of Hyaluronic Acid and Chitosan for Tissue Engineering

scientific article published on 11 November 2020

Exosome: A New Player in Translational Nanomedicine

scientific article published on 26 July 2020

Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases

scientific article published on 30 December 2020

Factors influencing mobilisation of endothelial progenitor cells and angiogenic cytokines after an extensive acute myocardial infarction

scientific article published on 23 December 2011

Functionalized nanostructures with application in regenerative medicine

scientific article published on 22 March 2012

Fundamentals of light-cell-polymer interactions in photo-cross-linking based bioprinting

scientific article published on 12 October 2020

GENYOi005-A: An induced pluripotent stem cells (iPSCs) line generated from a patient with Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM) carrying a p.Thr196Ala variant

scientific article published on 15 October 2019

GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells

scientific article published on February 1999

Growth inhibition, G(1)-arrest, and apoptosis in MCF-7 human breast cancer cells by novel highly lipophilic 5-fluorouracil derivatives

scientific article published on November 2004

HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound.

scientific article

Heavy Metals and Multiple Sclerosis in Sardinian Population (Italy)

article

How Can Nanotechnology Help to Repair the Body? Advances in Cardiac, Skin, Bone, Cartilage and Nerve Tissue Regeneration

scientific article published on 28 March 2013

How is gene transfection able to improve current chemotherapy? The role of combined therapy in cancer treatment.

scientific article published on January 2012

Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes

scientific article published in May 2010

In vitro nanoparticle-mediated intracellular delivery into human adipose-derived stem cells

scientific article published on 01 January 2013

In vitro treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the EMT programme and promotes cell differentiation

scientific article published on 16 May 2013

Indirect immunofluorescence study on the cytoskeleton of normal (FG) and neoplastic (SGS/3A) cadmium treated fibroblasts

scientific article published on 01 October 2005

Induction of drug resistance in embryonal rhabdomyosarcoma treated with conventional chemotherapy is associated with HLA class I increase

scientific article published in 2006

Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction.

scientific article published on 25 April 2011

Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene.

scientific article published on July 2003

Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid.

scientific article published on 17 March 2017

Large-Scale Production of Lentiviral Vectors: Current Perspectives and Challenges

scientific article published on 03 November 2020

LdrB Toxin with In Vitro and In Vivo Antitumor Activity as a Potential Tool for Cancer Gene Therapy

scientific article published on 20 July 2019

Low concentrations of actinomycin D potentially cause therapeutic differentiation in human rhabdomyosarcoma cell line RD.

scientific article published on February 1996

Low sample volume causes differentiation in human rhabdomyosarcoma cell line RD subjected to electroporation

scientific article published on December 1996

Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study

scientific article published on 30 September 2019

Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats.

scientific article

Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma

scientific article published on 14 October 2020

Modulation of HLA class I expression in multidrug-resistant human rhabdomyosarcoma cells.

scientific article published on January 2003

Modulation of Ki-67 expression and morphological changes induced by gef gene in MCF-7 human breast cancer cells.

scientific article published on 2 September 2005

Modulation of alpha-actin and alpha-actinin proteins in cardiomyocytes by retinoic acid during development

scientific article published in January 1999

Modulation of myogenic differentiation in a human rhabdomyosarcoma cell line by a new derivative of 5-fluorouracil (QF-3602).

scientific article

Multidrug resistance phenotype in the RMS-GR human rhabdomyosarcoma cell line obtained after polychemotherapy

scientific article published on July 1999

Nanomedicine: application areas and development prospects.

scientific article published on 19 May 2011

New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.

scientific article published on 3 December 2010

Obtaining Human Breast Adipose Cells for Breast Cancer Cell Co-culture Studies

scientific article published on 11 December 2020

Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction

scientific article published on December 1998

Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting

scientific article published on 06 August 2019

Phenformin as an Anticancer Agent: Challenges and Prospects

scientific article published on 05 July 2019

Polymers, scaffolds and bioactive molecules with therapeutic properties in osteochondral pathologies: what's new?

scientific article published on 24 June 2016

Production and characterization of a new monoclonal antibody, GR-ICOR-2, recognizing sarcomeric actin: analysis of the expression in the developing chick heart

scientific article published on 01 October 1994

Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients

scientific article published on January 2006

Promotion of human adipose-derived stem cell proliferation mediated by exogenous nucleosides.

scientific article published in September 2010

Purification and long-term expansion of multipotent endothelial-like cells with potential cardiovascular regeneration

scientific article published on 17 June 2011

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

scientific article published on 12 November 2019

Recent Progress in Gene Therapy for Ovarian Cancer

scientific article published on 30 June 2018

Reference intervals for blood Cd and Pb in the general population of Sardinia (Italy)

scientific article published on 20 October 2010

Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines

scientific article published on 25 October 2007

Resident and non-resident stem cells in acute myocardial infarction.

scientific article published on September 2010

Reverse transcriptase-polymerase chain reaction detection of circulating tumor cells in patients with melanoma: correlation with clinical stage, tumor thickness and histological type

scientific article published on 01 April 2002

Revisiting the dynamic cancer stem cell model: Importance of tumour edges

scientific article published on 28 August 2018

Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use

scientific article published on 06 February 2020

Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem stability

scientific article published on 15 August 2013

Synthesis and anticancer activity of (R,S)-9-(2,3-dihydro-1,4-benzoxathiin-3-ylmethyl)-9H-purines

scientific article published on January 2008

Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.

scientific article published on 26 May 2011

Synthesis and anticancer activity of the (R,S)-benzofused 1,5-oxathiepine moiety tethered to purines through alkylidenoxy linkers.

scientific article

Synthesis and characterization of lipid immuno-nanocapsules for directed drug delivery: selective antitumor activity against HER2 positive breast-cancer cells

scientific article

Synthesis and evaluation of new 5-fluorouracil antitumor cell differentiating derivatives

scientific article

The Inhibitory Role of miR-486-5p on CSC Phenotype Has Diagnostic and Prognostic Potential in Colorectal Cancer

scientific article published on 19 November 2020

The M3/M4 cytoplasmic loop of the alpha1 subunit restricts GABAARs lateral mobility: a study using fluorescence recovery after photobleaching

scientific article published on 01 December 2006

The biomimetic extracellular matrix: a therapeutic tool for breast cancer research

scientific article published in 2022

The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells

scientific article

The impact of PKR activation: from neurodegeneration to cancer.

scientific article published on 12 February 2014

The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis

scientific article

Therapeutic differentiation in a human rhabdomyosarcoma cell line selected for resistance to actinomycin D.

scientific article

Therapeutic strategies for skin regeneration based on biomedical substitutes

scientific article published on 22 February 2019

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

scientific article published on 13 November 2018

Transdifferentiation: why and how?

scientific article published on April 2011

Transfection of MS-36 melanoma cells with gef gene inhibits proliferation and induces modulation of the cell cycle

scientific article published in June 2003

Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells.

scientific article

Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells

scientific article published on 22 July 2010

Uncovering Tumour Heterogeneity through PKR and nc886 Analysis in Metastatic Colon Cancer Patients Treated with 5-FU-Based Chemotherapy

scientific article published on 07 February 2020

Unifying Different Cancer Theories in a Unique Tumour Model: Chronic Inflammation and Deaminases as Meeting Points

scientific article published in 2022

Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration

scientific article published on 10 January 2019

What's new in the diagnosis of pancreatic cancer: a patent review (2011-present).

scientific article published on 20 September 2017

gef Gene Expression in MCF-7 Breast Cancer Cells is Associated with a Better Prognosis and Induction of Apoptosis by p53-Mediated Signaling Pathway ⬇️

scientific article published on October 31, 2011

miRNAs as radio-response biomarkers for breast cancer stem cells

scientific article published on 06 February 2020

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