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List of works by Graham Pawelec

2nd Symposium on Advances in Cancer Immunology and Immunotherapy, December 15-17, 2016, Athens, Greece

scientific article published in December 2017

A clinical and biological perspective of human myeloid-derived suppressor cells in cancer

scientific article published on 28 May 2016

A lack of telomeric non-reciprocal recombination (TENOR) may account for the premature proliferation blockade of Werner's syndrome fibroblasts

scientific article published on January 2003

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people

scientific article

A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies.

scientific article published on 5 November 2012

A satellite symposium of the 1st European Congress of Immunology Paris, France, September 2006, Aging research in immunology: The genomic facet in Paris

article

Accumulations of KIR+ T cells in the elderly

Accurate quantification of T-cells expressing PD-1 in patients on anti-PD-1 immunotherapy

scientific article published on 14 September 2018

Activation marker expression and apoptotic susceptibility of T-cell clones derived from CD34(+), young and SENIEUR donors

scientific article published in April 2004

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

scientific article published on 16 June 2020

Age and immunity

scientific article

Age and immunity: What is "immunosenescence"?

scientific article published on 27 October 2017

Age related microsatellite instability in T cells from healthy individuals

Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing

scientific article published on 11 September 2015

Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)

scientific article (publication date: August 2003)

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus

scientific article published on 03 July 2013

Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system

scientific article

Aging affects the proportions of T and B cells in a group of elderly men in a developing country--a pilot study from Pakistan

scientific article published on 19 July 2012

Aging and Innate Immunity

Aging and immunity - impact of behavioral intervention

scientific article published on 04 December 2013

Aging as an inflammatory disease and possible reversal strategies

scientific article published on 04 March 2020

Aging in COVID-19: Vulnerability, immunity and intervention

scientific article published on 30 October 2020

Aging of the immune system as a prognostic factor for human longevity

scientific article published on April 2008

Aging, immunity, and cancer

scientific article published on 01 June 2011

Aging, immunosenescence and membrane rafts: the lipid connection

scientific article published on 04 October 2012

Alteration of high-density lipoprotein functionality in Alzheimer's disease patients

scientific article

Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus

scientific article published on 14 November 2015

Altered expression of mismatch repair proteins associated with acquisition of microsatellite instability in a clonal model of human T lymphocyte aging.

scientific article

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

scientific article published on 01 May 2005

An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness

scientific article published in April 2003

An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human CD4+T cell clones from donors of different ages

scientific article

An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells

scientific article published on 21 February 2013

Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing

scientific article published on 8 February 2008

Are lower antibody responses to influenza vaccination in cytomegalovirus-seropositive older adults the result of beta adrenergic blockade?

scientific article published on 16 November 2016

Are skin senescence and immunosenescence linked within individuals?

scientific article published on 06 May 2019

As we age: Does slippage of quality control in the immune system lead to collateral damage?

scientific article

Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines

scientific article

Association of cytokine gene polymorphisms with malignant melanoma in Caucasian population

scientific article published on 12 July 2006

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

scientific article published on 10 September 2020

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

scientific article published on 19 January 2016

Basic biology and clinical impact of immunosenescence

scientific article published in January 2002

Basic biology and clinical impact of immunosenescence

article

Better immunity in later life: a position paper.

scientific article

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

scientific article published on 15 June 2009

CASIN the joint: immune aging at the stem cell level

scientific article published on 01 August 2018

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

scientific article published on 7 April 2015

CD14+ HLA-DR-/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation

scientific article published on 11 December 2017

CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study.

scientific article published on 7 December 2016

CD4:8 ratio >5 is associated with a dominant naive T-cell phenotype and impaired physical functioning in CMV-seropositive very elderly people: results from the BELFRAIL study.

scientific article published on 25 February 2014

CMV and Immunosenescence: from basics to clinics

scientific article published on 31 October 2012

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer's Disease?

Can an effective SARS-CoV-2 vaccine be developed for the older population?

scientific article published on 11 April 2020

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Cancer vaccination progress

scientific article published on 01 December 2002

Cellular Senescence, Immunosenescence and HIV.

scientific article published on 22 November 2016

Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines

scientific article

Characterization of γδ T-cells via flow cytometry

scientific article published on 04 December 2015

Chronic phase CML patients possess T cells capable of recognising autologous tumour cells

scientific article

Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma

scientific article published on 17 June 2014

Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells

Cohort profile: The Berlin Aging Study II (BASE-II).

scientific article published on 14 March 2013

Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?

scientific article

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

scientific article published on February 2017

Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells

scientific article

Cytokines and antitumor immunity

scientific article

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults

scientific article published on 29 January 2016

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.

scientific article

Cytomegalovirus and human immunosenescence

scientific article published on January 2009

Cytomegalovirus infection: a driving force in human T cell immunosenescence

scientific article published on October 2007

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

scientific article

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

scientific article

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size

scientific article

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometry

scientific article

Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients

scientific article

Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer

scientific article

Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients.

scientific article published in June 2009

Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma

scientific article

Does cytomegalovirus infection contribute to socioeconomic disparities in all-cause mortality?

scientific article

Does patient age influence anti-cancer immunity?

scholarly article by Graham Pawelec published 13 July 2018 in Seminars in Immunopathology

Does the human immune system ever really become "senescent"?

scientific article

Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease

scientific article

Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly

scientific article published in April 2004

Dysregulation of T-cell function in the elderly : scientific basis and clinical implications

scientific article

ESTDAB: a collection of immunologically characterised melanoma cell lines and searchable databank

scientific article published on 19 January 2006

Editorial

scientific article published on 29 January 2016

Editorial

Editorial statement from Graham Pawelec

Editorial: Immunology of Aging

scientific article published on 10 July 2019

Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines

scientific article

Effects of a reduced oxygen tension culture system on human T cell clones as a function of in vitro age.

scientific article published in April 2004

Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background.

scientific article published on January 2013

Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm.

scientific article published on January 2013

Engineering anticancer T cells for extended functional longevity

scientific article published in June 2004

Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease

scientific article

Epigenetic and immune function profiles associated with posttraumatic stress disorder

scientific article

Erratum to: Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer.

scientific article published on 30 May 2017

Escape Mechanisms in Tumour Immunity

Escape mechanisms in tumor immunity: an update.

scientific article

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients

scientific article published on 16 December 2016

Evaluating the physiological reserves of older patients with cancer: the value of potential biomarkers of aging?

scientific article published on 29 September 2013

Evidence for less marked potential signs of T-cell immunosenescence in centenarian offspring than in the general age-matched population

scientific article published on 24 August 2013

Expansion and Determination of Antigen-Reactive T Cells by Flow Cytometry

scientific article published on 01 January 2019

Expansion of peripheral CD8+ CD28- T cells in response to Epstein-Barr virus in patients with rheumatoid arthritis.

scientific article published on February 2005

Exploratory study on immune phenotypes in Alzheimer's Disease and vascular dementia

scientific article published on 22 May 2020

Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines

scientific article published on 04 March 2009

Faculty of 1000 evaluation for Acyclovir Therapy Reduces the CD4+ T Cell Response against the Immunodominant pp65 Protein from Cytomegalovirus in Immune Competent Individuals

Faculty of 1000 evaluation for Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

Faculty of 1000 evaluation for Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

Faculty of 1000 evaluation for Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

Faculty of 1000 evaluation for Cytomegalovirus infection is associated with increased mortality in the older population

Faculty of 1000 evaluation for Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy

Faculty of 1000 evaluation for In vivo electroporation restores the low effectiveness of DNA vaccination against HER-2/neu in aging

Faculty of 1000 evaluation for Interleukin-22 drives endogenous thymic regeneration in mice

Faculty of 1000 evaluation for Nivolumab plus ipilimumab in advanced melanoma

Faculty of 1000 evaluation for Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

Faculty of 1000 evaluation for Spleen cells from young but not old immunized mice eradicate large established cancers

Faculty of 1000 evaluation for The NLRP3 inflammasome promotes age-related thymic demise and immunosenescence

Faculty of 1000 evaluation for Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Faculty of 1000 evaluation for Tumor-Derived γδ Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

Flow cytometric lymphocyte subset analysis using material from frozen whole blood

scientific article published in January 2012

Frailty, Inflammation and Immunosenescence

scientific article published on 17 July 2015

Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine

scientific article published on 6 July 2017

Frequency of Immune Cell Subtypes in Peripheral Blood Correlates With Outcome for Patients With Metastatic Breast Cancer Treated With High-Dose Chemotherapy

scientific article published on 27 May 2019

From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly

scientific article published on 19 June 2008

Functional T Cells Targeting NY-ESO-1 or Melan-A Are Predictive for Survival of Patients With Distant Melanoma Metastasis

scientific article published on 23 April 2012

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence

scientific article

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection

scientific article

HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides

scientific article

HER-2/neu-derived peptide 884-899 is expressed by human breast, colorectal and pancreatic adenocarcinomas and is recognized by in-vitro-induced specific CD4(+) T cell clones

scientific article published on 23 November 2001

Hallmark features of immunosenescence are absent in familial longevity

scientific article published on 20 September 2010

Hallmarks of human “immunosenescence”: adaptation or dysregulation? ⬇️

scientific article published on July 25, 2012

High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors.

scientific article published in October 2005

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity

scholarly article by Teresa Rodriguez et al published 1 October 2004 in Cancer Immunology, Immunotherapy

High response rate after intratumoral treatment with interleukin-2

article

Higher Lipoprotein (a) Levels Are Associated with Better Pulmonary Function in Community-Dwelling Older People - Data from the Berlin Aging Study II.

scientific article

Higher estimates of daily dietary net endogenous acid production (NEAP) in the elderly as compared to the young in a healthy, free-living elderly population of Pakistan

scientific article

Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters

scientific article published on 8 August 2012

Human CD4+ T cell clone longevity in tissue culture: lack of influence of donor age or cell origin

article

Human T Cell Clones in Long-Term Culture as Models for the Impact of Chronic Antigenic Stress in Aging

article

Human T-Cell Clones

scientific article published on 01 January 2000

Human cytomegalovirus infection and T cell immunosenescence: a mini review

scientific article

Human immunosenescence: is it infectious?

scientific article

IL7R gene expression network associates with human healthy ageing

scientific article

Immune Compromise in the Elderly

Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer

scientific article published on 09 June 2020

Immune checkpoint targeting as anti-cancer immunotherapy: promises, questions, challenges and the need for predictive biomarkers at ASCO 2015.

scientific article published on 13 August 2015

Immune correlates of clinical outcome in melanoma

scientific article

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

scientific article published on 25 March 2015

Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium

scientific article published on 28 November 2017

Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty

scientific article published on 28 February 2017

Immune profiling of Alzheimer patients

scientific article

Immune profiling of breast cancer patients: relationship between tumour antigen T cell responses with suppressor and effector leukocyte populations.

scientific article published on 4 November 2015

Immune receptor signaling, aging and autoimmunity

scientific article published on January 2008

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe

scientific article published on 11 April 2018

Immune signatures predicting responses to immunomodulatory antibody therapy

scientific article published on 15 March 2018

Immune system changes and immunosenescence

Immune therapy for age-related diseases

scientific article published on 21 June 2009

Immunity and ageing in man.

scientific article published on 21 November 2006

Immunity and ageing in man: Annual Review 2006/2007.

scientific article published on October 2007

Immunity, ageing and cancer

scientific article published on 24 September 2008

Immunogenicity of WT-1 peptides

article published in 2002

Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

scientific article published on October 2006

Immunology and ageing in Europe: ImAginE-ation in the EU

scientific article published on 01 April 2003

Immunology of aging and cancer development

scientific article published on 17 January 2013

Immunorejuvenation in the elderly

scientific article

Immunosenenescence: role of cytomegalovirus

scientific article published on 28 November 2013

Immunosenescence

Immunosenescence and Cytomegalovirus: where do we stand after a decade?

scientific article published on 7 September 2010

Immunosenescence and cancer

scientific article

Immunosenescence and cancer

scientific article published on January 2013

Immunosenescence and cancer

scientific article published on 20 February 2017

Immunosenescence and human longevity

scientific article

Immunosenescence and vaccination

scientific article

Immunosenescence and vaccination in nursing home residents

scientific article published on February 2009

Immunosenescence and vaccine failure in the elderly

scientific article published on June 2009

Immunosenescence comes of age. Symposium on Aging Research in Immunology: The Impact of Genomics

scientific article published on 16 February 2007

Immunosenescence in Montecatini

scientific article published on 01 January 2003

Immunosenescence in vertebrates and invertebrates

scientific article published on 2 April 2013

Immunosenescence: what is it and what can be done about it? Session 20 of the BSI Annual Congress, Harrogate, December, 2003.

scientific article published in January 2004

Immunosupportive therapies in aging

scientific article published on January 2007

Immunotherapy and immunoselection -- tumour escape as the final hurdle

scientific article published on June 2004

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

scientific article

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily.

scientific article published on 23 May 2007

Impact of age on T cell signaling: a general defect or specific alterations?

scientific article published on 08 October 2010

Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study

scientific article published on 3 March 2015

Impact of aging on cancer immunity and immunotherapy

scientific article published on 01 December 2009

Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease

scientific article

Income and Markers of Immunological Cellular Aging

scientific article published on 16 May 2016

Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab

scientific article

Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells

scientific article published on 5 November 2009

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

scientific article published on 3 August 2011

Inflammation, ageing and chronic disease

scientific article published on 22 April 2014

Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications

article

Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults

scientific article published on 09 April 2020

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells

scientific article published on 21 February 2018

Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population

scientific article published on 10 January 2020

International conference: progress in vaccination against cancer (PIVAC) 2002, Nottingham, UK.

scientific article published on 9 April 2003

International conference: progress in vaccination against cancer-2006 (PIVAC 6), Granada, Spain.

scientific article published on 21 March 2007

Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses.

scientific article published on 4 April 2014

Introduction to Ageing of the Adaptive Immune System

article

Invited Editorial: Despite COVID-19, Influenza Must Not Be Relegated to "Only the Sniffles"

scientific article published on 07 August 2020

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.

scientific article published on 18 June 2018

Is There a Positive Side to T Cell Exhaustion?

Is human aging still mysterious enough to be left only to scientists?

article

Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’

scientific article published on 01 July 2002

Is immunosenescence infectious?

scientific article published in August 2004

KEYNOTE-006: a success in melanoma, but a long way to go

scientific article published on 16 August 2017

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

scientific article published on 18 July 2020

Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old

scientific article published on 01 July 2003

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly

scientific article published on 3 September 2014

Linking tumor with systemic environment in the search for novel biomarkers in breast cancer.

scientific article published on 4 November 2015

List of Contributors

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

scientific article

Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival.

scientific article published on 20 April 2018

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

scientific article published on 04 June 2012

Lymphocyte activation in response to melanoma: interaction of NK-associated receptors and their ligands

scientific article

Mechanisms of immunosenescence

scientific article

Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?

Microsatellite Instability and Compromized Mismatch Repair Gene Expression During In Vitro Passaging of Monoclonal Human T Lymphocytes

article

Microsatellite instability in in vitro ageing of T lymphocyte clones

scientific article published in April 2004

Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?

scientific article

Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?

scientific article published on January 2014

Multi-parametric phospho-flow cytometry: a crucial tool for T lymphocyte signaling studies

scientific article published on 28 January 2013

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

scientific article

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

article

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARβ signaling

scientific article published on 12 July 2013

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity.

scientific article published on 15 May 2019

Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells

scientific article published on 9 December 2013

NK Cells are Activated in Amnestic Mild Cognitive Impairment but not in Mild Alzheimer's Disease Patients

scientific article published on 26 February 2015

NKp80 defines and stimulates a reactive subset of CD8 T cells

scientific article published on 15 October 2008

Natural killer cells, ageing and cancer

scientific article published on 11 March 2016

Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women

scientific article published on 04 December 2019

New advances in CMV and immunosenescence

scientific article

Ninth international conference on progress in vaccination against cancer (PIVAC 9), 8-10 October 2009, Sofia, Bulgaria

scientific article published on 10 March 2010

No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study

scientific article published on 21 May 2007

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

scientific article

Nutritional Zinc, Oxidative Stress and Immunosenescence: Biochemical, Genetic, and Lifestyle Implications for Healthy Ageing

scientific article published on 01 January 2004

Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan

scientific article

OMIP-020: phenotypic characterization of human γδ T-cells by multicolor flow cytometry

scientific article published on 22 April 2014

On the immunological theory of aging

scientific article published on 13 May 2014

Oxidative stress modulation and T cell activation

scientific article published on 18 May 2007

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit

scientific article

Pathways to a robust immune response in the elderly

scientific article

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

scientific article published on 3 February 2017

Peripheral Immune Signatures in Alzheimer Disease

scientific article published on 21 February 2016

Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade

scientific article published on 16 August 2019

Peripheral T cell responses to tumour antigens are associated with molecular, immunogenetic and cellular features of breast cancer patients.

scientific article published on 27 October 2016

Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II

scientific article

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, December 5th 2015.

scientific article published on 18 October 2016

Phenotypic characterization and prognostic impact of circulating γδ and αβ T-cells in metastatic malignant melanoma

scientific article published on 27 August 2015

Pitfalls in the characterization of circulating and tissue-resident human γδ T cells

scientific article published on 22 January 2020

Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients

scientific article published on 29 July 2017

Potential role of immunosenescence in cancer development

scientific article published on June 2010

Prediction of an HLA-DR-binding peptide derived from Wilms' tumour 1 protein and demonstration of in vitro immunogenicity of WT1(124-138)-pulsed dendritic cells generated according to an optimised protocol

scientific article published on 26 April 2002

Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes

scientific article

Presence of circulating Her-2 reactive CD8 T cells is associated with a lower frequency of MDSCs and better survival in elderly breast cancer patients

Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients

scientific article

Pretreatment frequency of circulating IL-17+CD4+T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients

article

Professor Enrico Mihich, 1928-2016.

scientific article published on 29 May 2017

Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients

scientific article

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer

scientific article published on 28 May 2016

Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab ⬇️

scientific article published on 8 July 2016

Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner

scientific article published on 30 October 2008

Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes

scientific article

Recent advances in influenza vaccines

scientific article published on 28 April 2020

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers

scientific article

Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation.

scientific article published on 28 September 2009

Relationship between anthropometric variables and nutrient intake in apparently healthy male elderly individuals: a study from Pakistan

scientific article published on 12 October 2011

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer

scientific article published on 06 March 2020

Relationships between cancer and aging: a multilevel approach

scientific article

Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan.

scientific article published on 15 June 2018

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Research on immunity and ageing comes of age

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young

scientific article published on 27 November 2015

Role of CMV in immune senescence

scientific article published on October 2010

Role of persistent CMV infection in configuring T cell immunity in the elderly

scientific article published on 21 March 2007

Role of the peripheral innate immune system in the development of Alzheimer's disease

scientific article published on 21 December 2017

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

scientific article published on 12 July 2013

SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence

scientific article

SENIEUR status of the originating cell donor negates certain 'anti-immunosenescence' effects of ebselen and N-acetyl cysteine in human T cell clone cultures

scientific article

Senescence: the cost of being young and healthy?

scientific article published on 01 October 2002

Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States

scientific article

Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas

scientific article published on 20 October 2009

Synthetic peptides derived from the Wilms' tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells

T Cell Immunity and Aging

scientific article published on 30 November 2005

T Cell Immunosenescence

T cells and aging, January 2002 update.

scientific article

T-CIA: investigating T cells in aging

scientific article published on 6 July 2005

T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?

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T-cell immunity in the aging human

scientific article published on May 2014

Telomere-dependent senescence

The Aging Immune System

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The European searchable tumour line database.

scientific article published on 27 January 2009

The Immune System and Its Dysregulation with Aging

scientific article published on 01 January 2019

The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4+ and CD8+ T lymphocytes

scientific article published on 21 January 2003

The concept of telomeric non-reciprocal recombination (TENOR) applied to human fibroblasts grown in serial cultures: concordance with genealogical data

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The conundrum of human immune system "senescence"

scientific article published on 16 September 2020

The fifteenth International Conference on Progress in Vaccination against Cancer (PIVAC-15), 6-8 October 2015, Tübingen, Germany: looking back on 15 years of progress.

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The genetics of human longevity

scientific article published on May 2006

The heat shock proteins in cellular aging: is zinc the missing link?

scientific article published on October 2006

The human immunosenescence phenotype: does it exist?

scientific article published on 05 August 2020

The immune response to influenza in older humans: beyond immune senescence

scientific article published on 07 May 2020

The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

The impact of CMV infection on survival in older humans

scientific article published on 27 April 2012

The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters

scientific article published on 18 April 2016

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function--data from the Berlin Aging Study II.

scientific article published on 7 November 2015

The nascent field of AllergoOncology ⬇️

scientific article published on August 22, 2012

The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma.

scientific article published on 30 January 2015

The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

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Translating immunity into cancer therapy: new findings from the first conference of the European Society for Cancer Immunology and Immunotherapy, an ESMO-EIS held in Athens, 15–17 November 2007

Tumour escape: antitumour effectors too much of a good thing?

scientific article published on 18 December 2003

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

scientific article published on 15 June 2018

Vaccination in the elderly

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Vaccines for Improved Cellular Immunity to Influenza.

scientific article published on 5 March 2018

Vδ2+ and α/ß T cells show divergent trajectories during human aging

scientific article published on 15 June 2016

When T cells get old.

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Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing

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Zoster Vaccination in Older Adults: Efficacy and Public Health Implications

scientific article published on 01 July 2019

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