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List of works by Manlio Vinciguerra

A Lipidomic Signature Complements Stemness Features Acquisition in Liver Cancer Cells

scientific article published on 10 November 2020

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

scientific article published on 18 June 2015

A Timeless Link Between Circadian Patterns and Disease.

scientific article published on 12 December 2015

A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice

scientific article

A ticking clock links metabolic pathways and organ systems function in health and disease.

scientific article published on 04 April 2013

ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer.

scientific article

Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells

scientific article published on 13 August 2015

Adipokines as Biomarkers in Health and Disease

article

Advance in molecular diagnostic tools for hepatitis B virus detection ⬇️

scientific article published on September 1, 2013

Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a.

scientific article published on 3 June 2013

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans

scientific article published on 18 August 2015

Aging signaling pathways and circadian clock-dependent metabolic derangements

scientific article

Aldosterone activates NF-kappaB in the collecting duct.

scientific article

Aldosterone, but not increased Na+ influx or NF-kappaB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells

scientific article published on 27 October 2008

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

scientific article published on 6 March 2015

An association study between epicardial fat thickness and cognitive impairment in the elderly

scientific article published in November 2014

Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease

scientific article

Aryl hydrocarbon receptor-fibroblast growth factor 21 dissociation of fatty liver from insulin resistance: A timely matter?

scientific article

Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib.

scientific article

Caloric restriction and aging stem cells: the stick and the carrot?

scientific article

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

scientific article published on 06 October 2020

Cardio-hepatic metabolic derangements and valproic acid

scientific article published on May 2014

Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice

scientific article published on June 2012

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

scientific article

Circadian clock circuitry in colorectal cancer

scientific article published on April 2014

Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

scientific article

Circulating histone signature of human lean metabolic-associated fatty liver disease (MAFLD)

scientific article published on 20 August 2020

Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation

scientific article published in January 2016

Clock gene expression in mouse kidney and testis: analysis of periodical and dynamical patterns.

scientific article published in April 2012

Clock genes and clock-controlled genes in the regulation of metabolic rhythms

scientific article published on April 2012

Commentary: Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

scientific article published on 2 June 2017

Correction: Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma.

scientific article published on 22 March 2013

Correlations among PPARγ, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer

scientific article published on 8 August 2012

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy

Cytokines and sodium induce protein kinase A-dependent cell-surface Na,K-ATPase recruitment via dissociation of NF-kappaB/IkappaB/protein kinase A catalytic subunit complex in collecting duct principal cells.

scientific article published on 6 July 2005

DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis

scientific article (publication date: 2015)

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

scientific article published on 15 January 2016

DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes

scientific article published on 24 April 2012

Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

scientific article published on 22 August 2019

Deregulated expression of cryptochrome genes in human colorectal cancer

scientific article

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

scientific article published on 16 April 2008

Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach

scientific article published on 06 November 2012

Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart

scientific article published on 01 October 2012

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.

scientific article published on July 2011

Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells

scientific article

Editorial: Exploring Lipid-related Treatment Options for the Treatment of NASH

scientific article published on 01 January 2014

Effects of hypercapnia on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

scientific article

Effects of the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals

scientific article published on 23 April 2010

Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma.

scientific article published on 11 August 2016

Exploitation of host clock gene machinery by hepatitis viruses B and C.

scientific article published on December 2013

Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models.

scientific article

Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells.

scientific article

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

scientific article

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.

scientific article published in January 2013

Functional Impact of Autophagy-Related Genes on the Homeostasis and Dynamics of Pancreatic Cancer Cell Lines

scientific article published on May 2015

Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet

scientific article

Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation.

scientific article published on 22 June 2017

Hedgehog signaling keeps liver clock in check

scientific article published on 28 February 2019

Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity

scientific article

Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells

scientific article published on 31 March 2010

Hepatitis delta virus induces specific DNA methylation processes in Huh-7 liver cancer cells

scientific article published on 21 March 2013

Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis.

scientific article published on 25 October 2016

Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells

scientific article published on 29 September 2018

Histone variants and lipid metabolism

scientific article

Hormone and cytokine circadian alteration in non-small cell lung cancer patients

scientific article published on 01 July 2012

Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein

scientific article published on 27 May 2011

Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma

scientific article published in 2013

Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease

scientific article

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma.

scientific article

Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer.

scientific article published on 11 April 2013

Interplay between transglutaminases and heparan sulphate in progressive renal scarring

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Is Drinking Alcohol Really Linked to Cardiovascular Health? Evidence from the Kardiovize 2030 Project

scientific article published on 17 September 2020

Isolation of senescent cells by iodixanol (OptiPrep) density gradient-based separation

scientific article published on 13 September 2019

LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis

scientific article

Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes

scientific article

Liver diseases and aging: friends or foes?

scientific article published on 30 July 2013

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity.

scientific article published on 10 December 2009

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population

scientific article published on 17 July 2015

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

scientific article

Management strategies for hepatocellular carcinoma: old certainties and new realities.

scientific article

Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas

scientific article published on 15 March 2016

Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice

scientific article published on 14 May 2015

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

scientific article published on 08 September 2011

MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2.

scientific article

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes

scientific article published on 11 June 2007

Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients.

scientific article

Molecular bases of circadian rhythmicity in renal physiology and pathology.

scientific article published on 30 July 2013

Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes

scientific article

Nitric oxide as a protector from nonalcoholic fatty liver disease

scientific article published on 18 April 2015

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects

scientific article published on 24 November 2021

Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity.

scientific article published on 09 April 2014

Non-alcoholic fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms

scientific article

Normalization of a NAFLD gene expression signature

scientific article published on 21 August 2014

Obesity-induced nucleosome release predicts poor cardio-metabolic health

scientific article published on 31 December 2019

Old Age and Steatohepatitis: A Dangerous Liaison? ⬇️

scientific article published on June 12, 2013

PPARs Signaling and Cancer in the Gastrointestinal System

scientific article published on 17 September 2012

PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling.

scientific article published on April 2006

PTEN at the crossroad of metabolic diseases and cancer in the liver.

scientific article published on July 2008

PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism

scientific article published on 10 October 2007

Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer

scientific article published on 11 March 2014

Protein intake, chronic liver diseases, and hepatocellular carcinoma

scientific article published on 19 September 2014

REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge.

scientific article published in April 2012

Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NAFLD).

scientific article published on January 2013

Regulation of muscle atrophy in aging and disease.

scientific article published on January 2010

SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.

scientific article

SIRT1 and the clock gene machinery in colorectal cancer.

scientific article

SIRT1 signaling as potential modulator of skeletal muscle diseases.

scientific article published on 07 March 2012

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

scientific article published on January 2014

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

scientific article published on 21 September 2016

SirT1 in muscle physiology and disease: lessons from mouse models.

scientific article

Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells

scientific article

Targeting chromatin remodelers to treat hepatocellular carcinoma ⬇️

scientific article published on February 4, 2013

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction

scientific article published on 27 January 2020

The Effects of Meal Timing and Frequency, Caloric Restriction, and Fasting on Cardiovascular Health: an Overview

scientific article published on 15 January 2020

The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue

scientific article published on 10 February 2009

The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling

scientific article published on 8 August 2014

The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population

scientific article

The biological clock and the molecular basis of lysosomal storage diseases.

scientific article published on 13 January 2015

The circadian clock and the hypoxic response pathway in kidney cancer.

scientific article published on 14 August 2013

The circadian clock circuitry and the AHR signaling pathway in physiology and pathology.

scientific article published on 21 February 2013

The transcriptional regulators, the immune system and the the circadian clock

scientific article published on 01 January 2013

Time-related dynamics of variation in core clock gene expression levels in tissues relevant to the immune system.

scientific article published in October 2011

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

scientific article

Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

scientific article published in April 2009

Zeolite Nanoparticles for Selective Sorption of Plasma Proteins.

scientific article published on 30 November 2015

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.

scientific article

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