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List of works by Katherine L Nathanson

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

scientific article (publication date: 14 December 2010)
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

scientific article
The tuberous sclerosis complex

scientific article (publication date: 28 September 2006)
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

scientific article (publication date: May 2002)
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

scientific article published on August 2006
Network modeling links breast cancer susceptibility and centrosome dysfunction

scientific article
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013
Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program

article
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

scientific article published on December 2008
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

scientific article
Gene-panel sequencing and the prediction of breast-cancer risk

scientific article
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

scientific article published on 7 June 2017
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

scientific article
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer

scientific article
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer

scientific article
The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

scientific article published in January 2008
Two decades after BRCA: setting paradigms in personalized cancer care and prevention

scientific article
ENIGMA--evidence-based network for the interpretation of germline mutant alleles: an international initiative to evaluate risk and clinical significance associated with sequence variation in BRCA1 and BRCA2 genes

scientific article published on 3 November 2011
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

scientific article published on September 2008
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

scientific article published on 16 October 2007
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

scientific article (publication date: 2013)
Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns

scientific article
Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

scientific article
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

scientific article
Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

scientific article
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

scientific article
Identification of six new susceptibility loci for invasive epithelial ovarian cancer

scientific article published on 12 January 2015
Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma

scientific article published on 15 February 2011
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

scientific article
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma

scientific article published on 19 September 2013
Meta-analysis identifies four new loci associated with testicular germ cell tumor

scientific article published on 12 May 2013
The Y deletion gr/gr and susceptibility to testicular germ cell tumor

scientific article
Postoperative ERCP versus laparoscopic choledochotomy for clearance of selected bile duct calculi: a randomized trial.

scientific article published in August 2005
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma

scientific article
Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: Mapping of the effects to different regions of the viral genome

scientific article published on 01 December 1986
A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

scientific journal article
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

scientific article
Biallelic TSC gene inactivation in tuberous sclerosis complex

scientific article
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk

scientific article published on 27 March 2013
Genome-wide linkage screen for testicular germ cell tumour susceptibility loci

scientific article published on 11 January 2006
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression

scientific article published on July 2008
Counselling framework for moderate-penetrance cancer-susceptibility mutations

scientific article
Factors determining dissemination of results and uptake of genetic testing in families with known BRCA1/2 mutations

scientific article
Pheochromocytoma: the expanding genetic differential diagnosis

scientific article
Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436).

scientific article published on 05 July 2013
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

scientific article published on 23 October 2017
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers

scientific article published on 05 August 2009
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

scientific article

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