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List of works by Shigeo Ohno

A Ca2+-Independent Protein Kinase C, nPKC.ETA.. Its Structure, Distribution and Possible Function ⬇️

scientific article published on October 1, 1992

A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

scientific article published on 01 February 1993

A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells

scientific article published on October 1996

A cell polarity protein aPKClambda is required for eye lens formation and growth

scientific article published on 14 October 2009

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells

scientific article

A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.

scientific article published on March 1997

A fourth type of rabbit protein kinase C.

scientific article

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

scientific article

A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines

scientific article

A novel yeast gene coding for a putative protein kinase

scientific article

A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts

scientific article published on January 1995

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

scientific article

ASPP2 regulates epithelial cell polarity through the PAR complex.

scientific article published on 8 July 2010

Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis

scientific article published on 3 November 2015

Aberrant activation of atypical protein kinase C in carbon tetrachloride-induced oxidative stress provokes a disturbance of cell polarity and sealing of bile canalicular lumen.

scientific article published on 14 February 2015

Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction

scientific article

An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

scientific article

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

scientific journal article

An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms

scientific article

Analysis of interferon-beta mRNA stability control after poly(I:C) stimulation using RNA metabolic labeling by ethynyluridine

scientific article published on 9 October 2012

Analysis of nonsense-mediated mRNA decay by monitoring mRNA half-lives in mammalian cells

scientific article published in February 2010

Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells

scientific journal article

Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

scientific journal article

Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence.

scientific article published on 15 June 2015

Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway

scientific article published in April 2011

Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization

scientific article published on October 2005

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

scientific article

Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide

scientific article published in December 1997

Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.

scientific article published on November 1989

Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis

scientific article published in December 2001

Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element

scientific article

Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.

scientific article

Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component

scientific article published on 20 June 2014

Concentration-dependent phorbol stimulation of PKCalpha localization at the nucleus or subplasmalemma in A7r5 cells

scientific article

Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells ⬇️

scientific article published on July 3, 2013

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.

scientific article published in March 1997

Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

scientific article published on May 1995

Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum

scientific article published on 7 March 2006

Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2 ⬇️

scientific article published on March 27, 1998

Differential Induction of Protein Kinase C Isoforms at the Cardiac Hypertrophy Stage and Congestive Heart Failure Stage in Dahl Salt-Sensitive Rats

scientific article published on 01 May 2003

Differential effects of overexpression of PKC alpha and PKC delta/epsilon on cellular E2F activity in late G1 phase

scientific article

Differential targeting of protein kinase C and CaM kinase II signalings to vimentin

scientific article published on November 1995

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

scientific article published on 01 September 1999

Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay

scientific article

Dynamic changes in protein components of the tight junction during liver regeneration

scientific article published on 01 September 2001

Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?

scientific article

Expression and localisation of apical junctional complex proteins in lens epithelial cells

scientific article

Expression in lung tumors and genetic mapping of the novel murine protein kinase Cη

scientific article published on 01 March 1994

Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo

scientific article

Extrinsic Wnt signalling controls the polarity component aPKC

scientific article published on 01 July 2007

Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina

scientific journal article

GP130 Is Involved in Stretch-Induced MAP Kinase Activation in Cardiac Myocytes

scientific article published on 01 April 1998

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

scientific article published on 24 October 2011

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

scientific article published on May 2007

High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis

scientific article published on 27 December 2012

High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence

scientific article published on 23 September 2009

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

scientific article

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

scientific article

Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex

scientific article published on 29 March 2006

Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

scientific article published on February 1982

Inhibition of insulin-induced glucose uptake by atypical protein kinase C isotype-specific interacting protein in 3T3-L1 adipocytes

scientific article published on August 2000

Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease

scientific article

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

scientific article published on January 2012

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells

scientific article published on 28 April 2009

Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

scientific article

Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex

scientific article published on 22 June 2009

Involvement of PKC ??? in anti-proliferating action of a new antitumor compound gnidimacrin ⬇️

scientific article published on 01 July 2003

Involvement of protein kinase C epsilon in thyrotropin-releasing hormone-stimulated phosphorylation of the myristoylated alanine-rich C kinase substrate in rat pituitary clonal cells

scientific article published on January 2000

Involvement of protein kinase C in the activation of extracellular signal-regulated kinase 1/2 by UVC irradiation

scientific article published on November 1997

Junctional adhesion molecules (JAMs): more molecules with dual functions?

scientific article published on January 2004

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

scientific article published on 14 April 2011

Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.

scientific article published on 25 April 2006

Localization and developmental expression of a novel protein kinase C delta gene

scientific article published in December 1992

Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains

scientific article (publication date: 2013)

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice

scientific journal article

Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

scientific article published in May 2003

MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

scientific article published on May 1996

MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase

scientific article

Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth

scientific article

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity ⬇️

scientific article published on April 29, 2003

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

scientific article

Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation

scientific article (publication date: 14 January 2000)

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD ⬇️

scientific article published on 29 September 2011

Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages

scientific article published on 10 November 2006

Nucleotide exchange factor ECT2 regulates epithelial cell polarity

scientific article published on 21 February 2006

Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG.

scientific article published on May 1994

Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells.

scientific article

PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules

scientific article published on 03 December 2011

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

scientific article

PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.

scientific article published on 20 February 2005

PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.

scientific article

PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice

scientific article published in January 1993

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

scientific journal article

Phosphatidylinositol 3-kinase is involved in TRE-dependent gene expression in response to arginine vasopressin.

scientific article

Phosphoinositide binding by par-3 involved in par-3 localization.

scientific article published on 2 April 2011

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR3

scientific article published on 22 October 2020

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

scientific article

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase

scientific article

Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons

scientific article published in November 2007

Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.

scientific article

Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc

scientific article published in Journal of Biological Chemistry

Protein Kinase C δ Inhibits the Proliferation of Vascular Smooth Muscle Cells by Suppressing G1Cyclin Expression

scientific article published in Journal of Biological Chemistry

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

scientific article published on September 1996

Protein kinase C epsilon phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone.

scientific article

Protein kinase C is involved in 24-hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells

scientific article published on June 1994

Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

scientific article (publication date: 2003)

Purification and characterization of protein kinase C .epsilon. from rabbit brain ⬇️

scientific article published on January 21, 1992

Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells

scientific article published in November 2002

Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates

scientific article

Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.

scientific article

Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells

scientific article

Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.

scientific article

Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts

scientific article

Regulation of δ protein kinase C during rat ovarian differentiation

scientific article published on 01 November 1993

Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity

scientific journal article

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

scientific article

Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

scientific article published in Journal of Biological Chemistry

Spatial regulation of VEGF receptor endocytosis in angiogenesis

scientific journal article

Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of ullrich disease fibroblasts

scientific article published on 27 June 2006

Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC

scientific article published on 01 September 1993

Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.

scientific article

Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo

scientific article published on 16 April 2008

The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus

scientific article published in August 1997

The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription

scientific article

The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b

scientific article

The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity

scientific article published on March 2012

The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.

scientific article published in November 2006

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

scientific article

The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.

scientific article published in November 1996

The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain ⬇️

scientific article published on March 4, 2013

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

scientific article

The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells

scientific article

The nucleotide sequence of human fibroblast interferon cDNA

scientific article

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

scientific article published on 01 June 2008

The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions

scientific article published on 22 January 2014

The role of SMG-1 in nonsense-mediated mRNA decay.

scientific article

The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression

scientific article published in April 2003

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

scientific article

Tissue-specific expression of three distinct types of rabbit protein kinase C.

scientific article

Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o -tetradecanoyl-phorbol-13-acetate

article

Transient Up-regulation of Myotonic Dystrophy Protein Kinase-binding Protein, MKBP, and HSP27 in the Neonatal Myocardium

scientific article published on 01 February 1999

Translocation of HSP27 and MKBP in Ischemic Heart

scientific article published on 01 August 1999

Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

scientific article

Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex

scientific article

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

scientific article published in September 2012

Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms.

scientific article published in July 1993

Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation

scientific article published on 01 December 1995

[30] Cloning and evolution of calcium-dependent protease, cDNA cloning of a novel family of calcium-binding proteins

scientific article published on 01 January 1987

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

scientific article published in Nature Communications

aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables

scientific article

aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization

scientific article published on 01 September 2002

aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region.

scientific article published on 28 January 2008

aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

scientific article published on 02 September 2009

aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.

scientific article published on 3 April 2014

sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.

scientific article published on 9 September 2004

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