Search filters

List of works by Des R. Richardson

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

scientific article

24p3 and its receptor: dawn of a new iron age?

scientific article

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

scientific article published on 19 November 2016

A low-spin iron complex in human melanoma and rat hepatoma cells and a high-spin iron(II) complex in rat hepatoma cells

scientific article published in June 1992

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.

scientific article published on December 2016

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

scientific article published on 9 August 2017

A relationship between glucose metabolism and NO-mediated iron mobilization from cells

scientific article published on 01 December 2000

A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?

scientific article published in February 2002

ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells.

scientific article published on January 2009

Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease

scientific article published in February 1999

Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation

scientific article

Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation

scientific article

Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents

scientific article published on October 2010

Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes

scientific article

Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway

scientific article published in April 2003

Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool

scientific article published on 26 August 2013

Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells

scientific article published in March 2009

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

scientific article published on 12 July 2011

Beta-thalassaemia: emergence of new and improved iron chelators for treatment.

scientific article

Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.

scientific article published on 22 July 2008

Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia.

scientific article published on August 2013

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells.

scientific article published on 24 May 2016

Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly.

scientific article published on 16 May 2016

Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti‐tumour efficacy ⬇️

scientific article published on January 1, 2012

Can we target the α2-macroglobulin-hepcidin interaction to treat pathologic hypoferremia?

scientific article published on January 2014

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

scientific article published on 27 April 2008

Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes

scientific article

Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.

scientific article

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

scientific article

Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.

scientific article published on October 2013

Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

scientific article published on 01 August 2014

Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

scientific article published on December 2006

Chelators to the Rescue: Different Horses for Different Courses!

scientific article published on 07 January 2011

Cloning of the ferrireductase that may be involved in iron transport in the small intestine: revisiting Crane's controversial oxidoreductase

scientific article published on 01 January 2001

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

scientific article

Competing pathways of iron chelation: angiogenesis or anti-tumor activity: targeting different molecules to induce specific effects

scientific article published in June 2004

Complexes of cytotoxic chelators from the dipyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues

scientific article published on January 2006

Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload

scientific article published in February 2010

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

scientific article published on 23 June 2016

Copper that cancer with lysosomal love!

scientific article published on 25 February 2016

Correction: N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion

scientific article published on 25 February 2016

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes

scientific article published on 16 May 2018

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

scientific article published on 01 June 1999

Cytosolic phospholipase A2α sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells

scientific article published on 14 March 2013

Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues

scientific article published on 15 October 2003

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo ⬇️

scientific article published on March 1, 2013

Deferiprone: greater efficacy at depleting myocardial than hepatic iron?

scientific article published in August 2002

Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.

scientific article published on 27 October 2007

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

scientific article

Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity

scientific article published on 12 December 2006

Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers ⬇️

scientific article published on August 15, 2012

Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.

scientific article published on 2 February 2010

Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism

scientific article published on 01 August 1998

Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs

scientific article

Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron

scientific article published in May 2001

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

scientific article

Differential effects on cellular iron metabolism of the physiologically relevant diatomic effector molecules, NO and CO, that bind iron

scientific article published on May 2004

Differential regulation of the Menkes and Wilson disease copper transporters by hormones: an integrated model of metal transport in the placenta

scientific article published on March 2007

Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types

scientific article published on 22 August 2015

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

scientific article published on 01 November 2006

Does free extracellular iron exist in haemochromatosis and other pathologies, and is it redox active?

scientific article published on 01 March 2001

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.

scientific article published on 3 January 2013

Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

scientific article published on 31 March 2015

ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK

scientific article

Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes

scientific article published on October 1988

Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.

scientific article

Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron

scientific article

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

scientific article published on 04 September 2009

Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancer ⬇️

scientific article published on November 3, 2010

Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells

scientific article published on 30 April 2012

Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization

scientific article

Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human.

scientific article published on 4 January 2005

Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin

scientific article published on August 2000

Examination of the mechanism(s) involved in doxorubicin-mediated iron accumulation in ferritin: studies using metabolic inhibitors, protein synthesis inhibitors, and lysosomotropic agents

scientific article published on January 2004

Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.

scientific article published on 25 January 2014

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

scientific article

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships

scientific article

Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxia

scientific article published on April 2014

Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde ⬇️

scientific article published on October 22, 2003

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

scientific article published on June 2016

Frataxin, a molecule of mystery: trading stability for function in its iron-binding site

scientific article published on 09 February 2010

Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia.

scientific article

Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy

scientific article published on 3 April 2007

Gene of the month. AMP kinase (PRKAA1).

scientific article published on September 2014

Gene of the month: BECN1.

scientific article published on 07 May 2014

Gene of the month: Interleukin 6 (IL-6).

scientific article published on 16 July 2014

Generation and characterization of transgenic mice hyper-expressing melanoma tumour antigen p97 (Melanotransferrin): no overt alteration in phenotype

scientific article published on 24 February 2009

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.

scientific article published on 24 November 2015

Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics.

scientific article published on 17 March 2015

Growth arrest and DNA damage-45 alpha (GADD45alpha).

scientific article published on 05 August 2008

Growth of human tumor cell lines in transferrin-free, low-iron medium

scientific article published on 01 September 1995

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents

scientific article

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity

scientific article

Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels ⬇️

scientific article published on July 11, 2013

Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression.

scientific article published in June 2013

Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.

scientific article

Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity.

scientific article

Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity

scientific article published on 08 June 2007

Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.

scientific article published on 13 August 2008

Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction

scientific article published on 01 November 1995

Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization

scientific article published on 17 August 2015

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

scientific article published on 18 April 2018

Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo

scientific article published on 21 April 2007

Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry

scientific article published on 22 November 2012

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

scientific article

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

scientific article

Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages

scientific article

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.

scientific article published on 14 June 2017

Investigating biological activity spectrum for novel quinoline analogues

scientific article published on 14 November 2006

Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers

scientific article published on 15 October 2010

Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

scientific article published on 19 February 2010

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.

scientific article

Investigating the spectrum of biological activity of ring-substituted salicylanilides and carbamoylphenylcarbamates.

scientific article published on 10 November 2010

Investigation of substituted 6-aminohexanoates as skin penetration enhancers

scientific article

Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity

scientific article published on 27 May 2010

Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2.

scientific article published on 14 June 2016

Iron and gallium increase iron uptake from transferrin by human melanoma cells: further examination of the ferric ammonium citrate-activated iron uptake process

scientific article

Iron and neoplasia: serum transferrin receptor and ferritin in prostate cancer

scientific article published on 01 October 2004

Iron catalysed assembly of an asymmetric mixed-ligand triple helicate

scientific article published on 7 September 2004

Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

scientific article published on 11 April 2007

Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking.

scientific article published on 20 November 2007

Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression

scientific article published on 29 December 2006

Iron chelation: deciphering novel molecular targets for cancer therapy. The tip of the iceberg of a web of iron-regulated molecules

scientific article published on December 2011

Iron chelation: inhibition of key signaling pathways in the induction of the epithelial mesenchymal transition in pancreatic cancer and other tumors

scientific article published on January 2013

Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.

scientific article published on 18 December 2009

Iron chelators as therapeutic agents for the treatment of cancer.

scientific article

Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity.

scientific article

Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

scientific article

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

scientific article

Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

scientific article published on 13 July 2004

Iron trafficking in the mitochondrion: novel pathways revealed by disease.

scientific article

Iron uptake and metabolism in the new millennium.

scientific article

Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity

scientific article published on 20 March 2018

Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia.

scientific article published on 8 December 2013

Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes

scientific article published on 9 December 2015

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.

scientific article published on 17 February 2012

Laying Down a Solid "Iron Foundation": Professor Erica Baker

scientific article published on 15 August 2018

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.

scientific article

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

scientific article published on 18 April 2016

Making a case for albumin – a highly promising drug-delivery system.

scientific article published in January 2015

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

scientific article published on 05 April 2016

Melanotransferrin: search for a function.

scientific article published on 10 September 2011

Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer.

scientific article published on 6 July 2010

Metal chelation

scientific article published on 01 January 2011

Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents.

scientific article published on 7 December 2016

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

scientific article published on 13 May 2013

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect

scientific article published on 16 April 2012

Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia.

scientific article published on 4 August 2017

Mitochondrial iron metabolism and sideroblastic anemia

scientific article published on 10 November 2009

Mitochondrial mayhem: the mitochondrion as a modulator of iron metabolism and its role in disease

scientific article published on 05 May 2011

Mobilization of iron from neoplastic cells by some iron chelators is an energy-dependent process

scientific article published on May 1997

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

scientific article

Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.

scientific article published on 22 July 2013

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

scientific article

Molecular pharmacology of ABCG2 and its role in chemoresistance

scientific article published on 10 September 2013

Multiple effects of iron chelators on molecules controlling cell cycle progression

scientific article published on 01 December 2000

Mysteries of the transferrin-transferrin receptor 1 interaction uncovered

scientific article published in February 2004

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.

scientific article

NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis

scientific article

Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes ⬇️

scientific article published on November 14, 2011

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.

scholarly article

Nitrogen monoxide (no) and glucose: unexpected links between energy metabolism and no-mediated iron mobilization from cells

scientific article published on 14 November 2000

Nitrogen monoxide activates iron regulatory protein 1 RNA-binding activity by two possible mechanisms: effect on the [4Fe-4S] cluster and iron mobilization from cells

scientific article

Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells

scientific article published on May 1995

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.

scientific article

Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells

scientific article published in July 2002

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

scientific article published on 8 December 2015

Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1)

scientific article published on 8 March 2017

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.

scientific article published on 25 November 2015

Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-resistant and -sensitive parasites

scientific article published on March 2004

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease

scientific article published on 01 May 2018

Novel chelators for cancer treatment: where are we now?

scientific article published on 11 May 2012

Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions.

scientific article published on March 2004

Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

scientific article published on 18 May 2004

Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity.

scientific article published on 8 November 2005

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

scientific article

Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer

scientific article published on 30 June 2011

Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.

scientific article published on August 2010

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion

scientific article

P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.

scientific article published on 23 September 2013

PCTH: a novel orally active chelator of the aroylhydrazone class that induces iron excretion from mice.

scientific article published in December 2004

PGRMC1 regulation by phosphorylation: potential new insights in controlling biological activity!

scientific article

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies

scientific article published on 16 November 2018

Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer.

scientific article published on 03 December 2008

Potent antimycobacterial activity of the pyridoxal isonicotinoyl hydrazone analog 2-pyridylcarboxaldehyde isonicotinoyl hydrazone: a lipophilic transport vehicle for isonicotinic acid hydrazide.

scientific article

Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation

scientific article

Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation

scientific article

Potential of iron chelators as effective antiproliferative agents

scientific article published on October 1, 1997

Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class.

scientific article published on 18 April 2008

Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells.

scientific article published on 11 June 2013

Proteomic analysis of hearts from frataxin knockout mice: marked rearrangement of energy metabolism, a response to cellular stress and altered expression of proteins involved in cell structure, motility and metabolism

scientific article

Proton transfer and ferredoxin I: the secrets of redox-driven proton transfer between solvent and a buried iron-sulphur cluster.

scientific article

Pyridoxal isonicotinoyl hydrazone and analogues. Study of their stability in acidic, neutral and basic aqueous solutions by ultraviolet-visible spectrophotometry

scientific article

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

scientific article published on 17 February 2017

Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates

scientific article published on 22 December 2005

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

scientific article published on February 2016

Role of ceruloplasmin and ascorbate in cellular iron release

scientific article

Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.

scientific article

Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines

scientific article published in 2012

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

scientific article published on 20 November 2013

Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.

scientific article published on 13 August 2016

Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.

scientific article published on 27 December 2007

Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity.

scientific article published on October 2013

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.

scientific article published on 18 April 2012

Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.

scientific article published on 7 August 2014

Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure–activity relationships underpinning their anti-proliferative and chelation efficacy ⬇️

scientific article published on December 21, 2012

Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy

scientific article

Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes

scientific article published on 24 July 2019

Synthetic and natural products as iron chelators

scientific article published on January 2011

Targeting Oncogenic NF-κB Signaling with Redox-Active Agents for Cancer Treatment

scientific article

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

scientific article published on 5 May 2016

Targeting cancer by binding iron: Dissecting cellular signaling pathways

scientific article

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

scientific article published on 19 February 2016

Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway

scientific article published on 27 November 2012

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells

scientific article published on 15 September 2016

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1) ⬇️

scientific article published on March 27, 2012

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

scientific article

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

scientific article published on 07 April 2019

The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer

scientific article published on January 2009

The active role of vitamin C in mammalian iron metabolism: much more than just enhanced iron absorption!

scientific article

The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.

scientific article

The biogenesis of [Fe-S] clusters: the role of the unorthodox ABC ATPase, SufC, and the wider implications for understanding iron metabolism

scientific article published on 01 January 2003

The cardioprotective effect of the iron chelator dexrazoxane (ICRF-187) on anthracycline-mediated cardiotoxicity.

scientific article

The controversial role of deferiprone in the treatment of thalassemia.

scientific article

The double-edged nature of using genetic databases: melanotransferrin genes and transcripts

scientific article published on 01 July 2003

The effect of desferrioxamine and ferric ammonium citrate on the uptake of iron by the membrane iron-binding component of human melanoma cells

scientific article published on January 31, 1992

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake

scientific article

The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.

scientific article published on 17 July 2003

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology.

scientific article published on 22 July 2016

The evolution of iron chelators for the treatment of iron overload disease and cancer.

scientific article

The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis

scientific article

The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia.

scientific article published on 09 December 2009

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

scientific article

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action

scientific article

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

scientific article published on 23 July 2010

The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways

scientific article

The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets

scientific article

The lure of a LYR: The logistics of iron sulfur cluster delivery

scientific article published on 01 March 2014

The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells. NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner

scientific article

The mechanistic role of chemically diverse metal ions in the induction of autophagy

scientific article published on 10 January 2017

The medicinal chemistry of novel iron chelators for the treatment of cancer.

scientific article published on January 2011

The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.

scientific article

The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.

scientific article published on 14 May 2014

The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms

scientific article published on 11 March 2011

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

scientific article published on 15 February 2014

The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.

scientific article published on 18 September 2015

The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer

scientific article

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

scientific article published on March 1997

The nitric oxide-iron interplay in mammalian cells: transport and storage of dinitrosyl iron complexes.

scientific article published on 16 January 2008

The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity

scientific article

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.

scientific article published on 27 September 2016

The old and new biochemistry of polyamines

scientific article published on 08 June 2018

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

scientific article published on 9 March 2011

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression

scientific article published in August 2001

The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism.

scientific article published on 19 February 2013

The release of iron and transferrin from the human melanoma cell

scientific article published on February 1991

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

scientific article published on 26 August 2015

The role of NDRG1 in the pathology and potential treatment of human cancers

scientific article published on 08 June 2013

The role of hypoxia and nitrogen monoxide in the regulation of cellular iron metabolism

scientific article published in May 2003

The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain

scientific article published on 01 October 2004

The translational regulator eIF3a: the tricky eIF3 subunit!

scientific article published on 17 July 2010

The uptake of inorganic iron complexes by human melanoma cells

scientific article published on June 1991

The uptake of iron and transferrin by the human malignant melanoma cell

scientific article published on June 1990

The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

scientific article published on 03 December 2014

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

scientific article published on September 2009

Thiosemicarbazones: The New Wave in Cancer Treatment ⬇️

scientific article published on September 1, 2009

Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by the chelator, Dp44mT.

scientific article published on 12 October 2017

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

scientific article published on 5 January 2018

Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands

scientific article

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance.

scientific article published on 3 May 2016

Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: the effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake

scientific article published on October 1994

Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity

scientific article published on 01 October 2002

Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy

scientific article published in October 2001

Unraveling the mysteries of serum albumin-more than just a serum protein.

scientific article

Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.

scientific article published on 26 April 2016

Paulina is supported by:

About Paulina

Help