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List of works by John A Widness

A 'bottom-up' approach for endo-PK/PD analysis

scientific article

A System Approach to Pharmacodynamics. Plasma Iron Mobilization by Endogenous Erythropoietin in the Sheep Fetus; Evidence of Threshold Response in Spontaneous Hypoxemia

scientific article published on 01 August 1993

A comparison of nonlinear pharmacokinetics of erythropoietin in sheep and humans

scientific article published in May 1999

A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity

scientific article published on 01 November 1995

A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep

scientific article published on 15 May 2003

A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia

scientific article published on 4 October 2012

A sensitive and specific erythropoietin immunoprecipitation assay: application to pharmacokinetic studies

scientific article published on March 1, 1992

A tracer interaction method for nonlinear pharmacokinetics analysis: application to evaluation of nonlinear elimination

scientific article published in October 1997

Abnormal iron distribution in infants of diabetic mothers: Spectrum and maternal antecedents

scientific article published on 01 September 1990

Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label.

scientific article published on 24 October 2011

Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia ⬇️

scientific article published on November 20, 2010

Adaptive responses during anemia and its correction in lambs

article

Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension

scientific article published in January 2004

Amniotic fluid erythropoietin concentrations differentiate between acute and chronic causes of fetal death

scientific article published on 01 March 2002

Amniotic fluid erythropoietin predicts fetal distress in Rh-immunized pregnancies

scientific article published on 01 February 1989

An integrated pharmacodynamic analysis of erythropoietin, reticulocyte, and hemoglobin responses in acute anemia

scientific article published in November 2002

Antepartum fetal and maternal carboxyhemoglobin and cotinine levels among cigarette smokers

scientific article published on 01 March 1999

Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose

scientific article published on 5 March 2017

Association of fetal and maternal carboxyhemoglobin levels in normal and Rh-alloimmune pregnancies

scientific article published on 01 June 2000

Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count

scientific article published in September 2004

Case study: conjoined twins and anencephaly

scientific article published on January 1990

Change in erythropoietin pharmacokinetics following hematopoietic transplantation.

scientific article

Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pathway

scientific article published in August 2001

Changing patterns of red blood cell transfusion in very low birth weight infants.

scientific article published on November 1996

Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes

scientific article published on 01 October 1984

Chronic hyperinsulinemia in the fetal rhesus monkey: effects on fetal growth and composition

scientific article

Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism

scientific article published on December 1979

Circulatory and metabolic effects of hypoxia in the hyperinsulinemic ovine fetus

scientific article published on July 1995

Clinical performance of an in-line point-of-care monitor in neonates

scientific article published in September 2000

Clinical performance of an in-line, ex vivo point-of-care monitor: a multicenter study

scientific article published on 01 November 2002

Comment: Epoetin alfa loss with NaCl 0.9% dilution

scientific article published on 01 December 1996

Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease.

scientific article published on 9 January 2012

Comparison of the Bactec 9240 and BacT/Alert blood culture systems for evaluation of placental cord blood for transfusion in neonates.

scientific article published on 15 April 2009

Correction for non-ideal tracer pharmacokinetic disposition by disposition decomposition analysis (DDA)

scientific article published on 01 September 1998

Correction of hemorrhage-induced anemia with intra-amniotic iron in the ovine fetus

scientific article published in January 1999

Correlation of plasma erythropoiesis stimulating factor(s) and immunoreactive erythropoietin levels during rapid growth in the mouse

scientific article published on 01 August 1989

Cost Analysis of a Neonatal Point-of-Care Monitor

scientific article published on 01 May 2002

Cost-effectiveness of a limited-donorblood program for neonatal red cell transfusions

scientific article published on 01 September 1999

Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia

scientific article

Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations

scientific article published on 16 May 2018

Developmental differences in erythropoietin pharmacokinetics: increased clearance and distribution in fetal and neonatal sheep

scientific article published in June 1992

Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep

scientific article published on 15 June 2011

Direct Relationship of Fetal Carboxyhemoglobin with Hemolysis in Alloimmunized Pregnancies

scientific article published on 01 June 1994

Direct relationship of antepartum glucose control and fetal erythropoietin in human type 1 (insulin-dependent) diabetic pregnancy

scientific article

Effect of chronic erythropoietin administration on plasma iron in newborn lambs

scientific article published on 01 January 1996

Effect of intravenous beta-sympathomimetic tocolysis on human fetal serum erythropoietin levels

scientific article published on 01 April 1993

Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.

scientific article

Effect of maternal exercise and fetoplacental growth rate on serum erythropoietin concentrations

scientific article published on 01 April 2003

Effect of recombinant human erythropoietin on the switchover from fetal to adult hemoglobin synthesis in preterm infants

scientific article published on 01 September 1995

Effects of chronic fetal hyperinsulinemia on plasma arachidonic acid and prostaglandin concentrations

scientific article published on 01 October 1989

Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat

scientific article published on May 1978

Effects of prolonged hyperinsulinemia on erythropoiesis in fetal sheep

scientific article published on November 1989

Elevated erythropoietin levels in cord blood of newborns with Down's syndrome

scientific article published on 01 January 1994

Endogenous and recombinant erythropoietin levels decline in human amniotic fluid and fetal plasma in vitro at 37 degrees C.

scientific article published in April 2004

Erythrocyte Incorporation and Absorption of 58Fe in Premature Infants Treated with Erythropoietin

scientific article published on 01 March 1997

Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia

scientific article published in August 2005

Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants

scientific article

Erythropoietin elevation in the chronically hyperglycemic fetal lamb

scientific article published on 01 May 1982

Erythropoietin levels and erythropoiesis at birth in infants with Potter syndrome

scientific article published on 01 July 1990

Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia.

scientific article published in February 2009

Erythropoietin pharmacokinetics in premature infants: developmental, nonlinearity, and treatment effects

scientific article published in January 1996

Erythropoietin production rate in phlebotomy-induced acute anemia

scientific article published in December 2004

Erythropoietin responses to progressive blood loss over 10 days in the ovine fetus

scientific article published in October 2001

Erythropoietin transplacental passage--review of animal studies.

scientific article

Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor

scientific article published on 01 January 2001

Evidence of receptor-mediated elimination of erythropoietin by analysis of erythropoietin receptor mRNA expression in bone marrow and erythropoietin clearance during anemia.

scientific article

Expanded Möbius syndrome

scientific article

Experimental-induced hyperinsulinemia in a fetus and newborn rhesus monkey (Macaca mulatta)

scientific article published on 01 June 1981

Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration

scientific article published in March 1992

Fetal plasma iron and restoration of red blood cell mass after hemorrhage of the ovine fetus

scientific article published in November 1997

Glycohemoglobin (HbAIc): a predictor of birth weight in infants of diabetic mothers

scientific article published in January 1978

Glycohemoglobin in diabetic pregnancy: a sequential study

scientific article published on 01 April 1980

Glycohemoglobin in postpartum women.

scientific article published in April 1981

Glycosylation of Hemoglobin in Normal and Diabetic Mothers and their Fetuses

scientific article published on 01 March 1983

Haemoglobin Aic (glycohaemoglobin) in diabetic pregnancy: an indicator of glucose control and fetal size

scientific article published in November 1978

Hematocrit correlates well with circulating red blood cell volume in very low birth weight infants

scientific article published in October 2001

Hemoglobin AIc in the glucose-intolerant, streptozotocin-treated or pancreatectomized macaque monkey

scientific article published on December 1978

How fast is too fast? a practice change in umbilical arterial catheter blood sampling using the Iowa Model for Evidence-Based Practice.

scientific article published on August 2008

Hydroxyl Radical Generation in Oxygen-treated Infants ⬇️

scientific article published on October 1, 1997

Immunoreactive erythropoietin and erythropoiesis stimulating factor(s) in plasma from hypertransfused neonatal and adult mice. Studies with a radioimmunoassay and a cell culture assay for erythropoietin

scientific article

Impermeability of the Ovine Placenta to 35S-Recombinant Erythropoietin

scientific article published on 01 June 1989

Impermeability of the rat placenta to insulin during organogenesis

article

In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage

scientific article published on 29 November 2017

In vivo 125I-erythropoietin pharmacokinetics are unchanged after anesthesia, nephrectomy and hepatectomy in sheep

scientific article

Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses.

scientific article published on March 1981

Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia

scientific article

Increased plasma erythropoietin levels in lambs treated with parenteral iron

scientific article published on 01 June 1997

Increased wave latency in auditory brainstem response to anemia in newborn and adult sheep

scientific article published in January 2003

International survey of transfusion practices for extremely premature infants.

scientific article

Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs.

scientific article published in December 1997

Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity?

scientific article

Kinetic evaluation of nonlinear drug elimination by a disposition decomposition analysis. Application to the analysis of the nonlinear elimination kinetics of erythropoietin in adult humans

scientific article published in June 1995

Lack of maternal to fetal transfer of 125I-labelled erythropoietin in sheep

scientific article published on March 1, 1991

Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products

scientific article published in December 2002

Long-term neurodevelopmental outcome and brain volume after treatment for hydrops fetalis by in utero intravascular transfusion

scientific article published on 21 April 2006

Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions

scientific article published on 3 January 2011

Management of fetal hemolytic disease by cordocentesis. I. Prediction of fetal anemia

scientific article published on 01 September 1991

Management of fetal hemolytic disease by cordocentesis. II. Outcome of treatment

scientific article published on 01 November 1991

Maternal age and screening for gestational diabetes: a population-based study

scientific article published in April 1989

Maternal alcohol abuse is associated with elevated fetal erythropoietin levels

scientific article published on 01 August 1990

Maternal smoking and fetal carboxyhaemoglobin and blood gas levels

scientific article published on 01 November 1996

Measurement of circulating red cell volume using biotin-labeled red cells: validation against 51Cr-labeled red cells

scientific article published on 01 February 1999

Measurement of red cell survival using biotin-labeled red cells: validation against 51Cr-labeled red cells

scientific article published on 01 February 1999

Microanalysis of non-heme iron in animal tissues

scientific article published in March 2004

Modeling time variant distributions of cellular lifespans: increases in circulating reticulocyte lifespans following double phlebotomies in sheep

scientific article published on 14 June 2008

Multidose optimization simulation of erythropoietin treatment in preterm infants ⬇️

scientific article published on February 15, 2012

Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia

scientific article published on 01 April 1998

Myocardial, erythropoitic, and metabolic adaptations to anemia of prematurity

scientific article published on 01 August 1994

Neonatal laboratory blood sampling: comparison of results from arterial catheters with those from an automated capillary device

scientific article published on 01 February 2000

Neonatal morbidities in infants of mothers with glucose intolerance in pregnancy

scientific article published on 01 June 1985

Nonenzymatic glycosylation of erythrocytic proteins in normal and diabetic subjects. Enzymes of nucleoside and nucleotide metabolism

scientific article published in March 1985

Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.

scientific article published on August 2012

Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity

scientific article

Permanent neonatal diabetes in an infant of an insulin-dependent mother

scientific article published on 01 June 1982

Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis

scientific article published on August 2005

Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep

scientific article published on 10 January 2011

Pharmacodynamic modeling of the effect of changes in the environment on cellular lifespan and cellular response.

scientific article published on 21 October 2008

Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a tracer interaction methodology.

scientific article

Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin

scientific article

Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phlebotomy-induced anemia and bone marrow ablation

scientific article published in May 2004

Pharmacokinetic/pharmacodynamic analysis of paradoxal regulation of erythropoietin production in acute anemia

scientific article published on 26 February 2004

Pharmacokinetics and pharmacodynamics of erythropoietin during therapy in an infant with renal failure

scientific article published in November 1992

Pilot evaluation of instructing parents of newborns about poison prevention strategies

scientific article published on June 1988

Placental morphometric studies in diabetic pregnancies

scientific article published on 01 January 1981

Placentas in pregnancies complicated by maternal diabetes

scientific article published on January 1984

Plasma immunoreactive erythropoietin in normal women studied sequentially during and after pregnancy

scientific article published on 01 July 1984

Plasma transferrin receptor levels and indices of erythropoiesis and iron status in healthy term infants

scientific article published in July 1998

Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin ⬇️

scientific article published on March 13, 2013

Postnatal changes in serum immunoreactive erythropoietin in relation to hypoxia before and after birth

scientific article published on 01 June 1990

Postpartum testing for antecedent gestational diabetes

scientific article published in November 1988

Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants

scientific article

Posttransfusion recovery of stored red blood cells in very low birth weight infants using a hemoglobin balance model

scientific article published in July 2004

Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with (51) Cr.

scientific article published in July 2012

Pseudomembranous colitis in a preterm neonate.

scientific article

RBCs labeled at two biotin densities permit simultaneous and repeated measurements of circulating RBC volume

scientific article published in March 2004

Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants.

scientific article

Rapid fluctuations in glycohemoglobin (hemoglobin Alc) related to acute changes in glucose

scientific article published on 01 March 1980

Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy.

scientific article

Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics

scientific article published on 01 April 2001

Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants.

scientific article published in January 1995

Recombinant human erythropoietin vs transfusions in the treatment of anemia of prematurity. A cost-benefit analysis

scientific article published on 01 June 1994

Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities

scientific article

Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin.

scientific article

Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin.

scientific article

Red blood cell volume can be independently determined in vitro using sheep and human red blood cells labeled at different densities of biotin

scientific article published on 10 February 2009

Red cell mass responses to daily erythropoietin and iron injections in the ovine fetus

scientific article

Red cell volume can be accurately determined in sheep using a nonradioactive biotin label

scientific article

Renal and placental secretion of erythropoietin during anemia or hypoxia in the ovine fetus

scientific article published on 01 December 2003

Restoration of fetal red blood cells and plasma proteins after a moderately severe hemorrhage in the ovine fetus

scientific article published in December 1993

Rhesus Isoimmunization: Increased Hemolysis during Early Infancy

scientific article published on 01 May 1997

Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level.

scientific article

Serum erythropoietin levels during infancy: Associations with erythropoiesis

scientific article published on 01 June 1996

Should the fifty-gram, one-hour plasma glucose screening test for gestational diabetes be administered in the fasting or fed state?

scientific article published in May 1986

Somatomedins and insulin in diabetic pregnancies: effects on fetal macrosomia in the human and rhesus monkey

scientific article published on 01 June 1984

Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep

scientific article published on 21 April 2006

Temporal Response of Immunoreactive Erythropoietin to Acute Hypoxemia in Fetal Sheep

scientific article published on 01 January 1986

Temporal response of plasma erythropoietin to hemorrhage in the ovine fetus

scientific article

The "breakfast tolerance test": screening for gestational diabetes with a standardized mixed nutrient meal

scientific article published on 01 November 1987

The Life Span of Erythrocytes Transfused to Preterm Infants1

scientific article published on 01 July 1997

The Reactivation of Fetal Hemoglobin Synthesis during Anemia of Prematurity

scientific article published on 01 August 1994

The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time.

scientific article

The effect of prolonged intrauterine hyperinsulinemia on iron utilization in fetal sheep

scientific article

The effect of regular maternal exercise on erythropoietin in cord blood and amniotic fluid

scientific article published on 01 May 1995

The effects of acute uterine ischemia on fetal circulation

scientific article published on June 1990

The hematologic and plasma iron responses to severe fetal hemorrhage in the ovine fetus

scientific article published in January 1996

The proportions of G gamma- and A gamma-globins in the fetal hemoglobin synthesized in preterm and term infants

scientific article published on 01 March 1995

The relationship between fetal arterial oxygen saturation and heart and skeletal muscle myoglobin concentrations in the ovine fetus

scientific article published on 01 March 1993

Total glycosylated hemoglobin in mothers of large-for-gestational-age infants: a postpartum test for undetected maternal diabetes?

scientific article published in January 1981

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