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List of works by Michael Gough

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

scientific article

A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

scientific article published on 16 August 2016

A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity

scientific article published in PLoS ONE

A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell-tumor cell hybrid vaccines

scientific article published on 17 August 2003

A simple method to cure established tumors by inflammatory killing of normal cells

scientific article

A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component

scientific article

Abstract A60: Expression of NFκB p50 in pancreatic tumor stroma drives M2 differentiation and limits the control of tumors by radiation therapy

Abstract IA10: Effective immunotherapy regimens incorporating highly active human STING-activating cyclic dinucleotide derivatives

Activating the Nucleic Acid-Sensing Machinery for Anticancer Immunity

scientific article published on 02 October 2018

Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice

scientific article published on October 2010

Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity

scientific article published on 17 November 2017

Association of Immunologic Markers With Survival in Upfront Resectable Pancreatic Cancer

scientific article published on 01 November 2018

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

scientific article published on 06 February 2019

Cell death associated with genetic prodrug activation therapy of colorectal cancer

scientific article

Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?

scientific article

Circulating and intratumoral macrophages in patients with hepatocellular carcinoma: correlation with therapeutic approach

scientific article published in May 2013

Circulating immune cells in patients with surgically resected nonfunctional pancreatic neuroendocrine tumors

scientific article published on 4 November 2015

Combination approaches to immunotherapy: the radiotherapy example

scientific article

Comparing equals when evaluating immunotherapy with different doses and fractions of radiation therapy

Correction: STING expression and response to treatment with STING ligands in premalignant and malignant disease

scientific article published on 15 February 2018

Corrigendum: Tumor antigen—specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor—modified T cells

scholarly article published in Nature Biotechnology

Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy

scientific article published on 7 September 2016

Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist

scientific article published on December 2007

Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy

scientific article published on 27 April 2020

Dendritic cells for the immunotherapy of cancer

scientific article

Developing an Immunotherapy Strategy for the Effective Treatment of Oral, Head and Neck Squamous Cell Carcinoma.

scientific article

Effects of Combined Immune and Radiation Cancer Therapy on Inflammatory Environment in the Brain of a Mouse Model

Erratum to 'Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy' [Oral Oncol. 61 (2016) 166-176].

scientific article

Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma

article

Expression of NF-κB p50 in tumor stroma limits the control of tumors by radiation therapy

scientific article

Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice

scientific article

Facets of heat shock protein 70 show immunotherapeutic potential.

scientific article

Fusogenic membrane glycoprotein-mediated tumour cell fusion activates human dendritic cells for enhanced IL-12 production and T-cell priming

scientific article published on January 2006

Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy.

scientific article

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

scientific article published on 17 March 2021

Immune consequences of CT-guided radiation therapy of mouse mammary tumors

scientific article published on 7 November 2013

Immune system plays an important role in the success and failure of conventional cancer therapy

Implantable biomaterials to provide local immunotherapy following surgical resection

scientific article published on 28 December 2018

Improved Efficacy of Radiation in Combination With Systemic Immunomodulatory Therapy in a Syngeneic Mouse Model of Colorectal Cancer

Improved efficacy of radiation in combination with TGFβ inhibition in a colorectal cancer mouse model

scientific article published on 7 November 2013

Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer

publication published on 01 February 2021

Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity

scientific article published on July 2004

Intratumoral immunotherapy: using the tumour against itself

scientific article

Intratumoral injection of STING ligand promotes abscopal effect.

scientific article

Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo

scientific article

MIP-3alpha transfection into a rodent tumor cell line increases intratumoral dendritic cell infiltration but enhances (facilitates) tumor growth and decreases immunogenicity

scientific article

Macrophages orchestrate the immune response to tumor cell death

scientific article published in October 2001

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

scientific article published on 2 September 2016

Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model

scientific article

OX40 (CD134) and OX40L.

scientific article published on January 2009

OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor

scientific article published in July 2008

OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment

scientific article

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy

scientific article

PKC-δ is an apoptotic lamin kinase

article by Timothy Cross et al published May 2000 in Oncogene

Preparative immunotherapy with anti-OX40 and anti-CTLA4 improves the response to chemotherapy

scientific article published on 6 November 2014

Programmed cell death-1 blockade enhances response to stereotactic radiation in an orthotopic murine model of hepatocellular carcinoma.

scientific article published on 8 August 2016

Programmed cell death-1 blockade in combination with stereotactic radiation in an orthotopic mouse model of hepatocellular carcinoma

scientific article published on 4 November 2015

Radiation therapy and vaccination against tumor-specific EGFRvIII effectively clears tumors in a murine model of head and neck squamous cell carcinoma

scientific article published on 4 November 2015

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

scientific article

Renal carcinoma cell lines inhibit natural killer activity via the CD94 receptor molecule

scientific article published in July 2001

Role of the immunosuppressive microenvironment in immunotherapy

STING expression and response to treatment with STING ligands in premalignant and malignant disease

scientific article published on 14 November 2017

Secondary Prevention in Patients with Peripheral Arterial Disease: Are We Letting Our Patients Down?

scientific article published on 11 December 2006

Signaling through OX40 enhances antitumor immunity

scientific article published on October 2010

Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control

scientific article

Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation.

scientific article published on 05 April 2016

Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells

scientific article published on 19 April 2007

TGFβ inhibition prior to hypofractionated radiation enhances efficacy in preclinical models

scientific article

Targeting Cancer-Associated Fibroblasts in Combination With Radiation

Targeting macrophages in the tumour environment to enhance the efficacy of αOX40 therapy.

scientific article published in August 2012

The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells

scientific article published on 4 March 2013

The impact of the myeloid response to radiation therapy

scientific article

The peripheral myeloid expansion driven by murine cancer progression is reversed by radiation therapy of the tumor

scientific article

The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis--preliminary findings

scientific article published in April 1999

The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis— Preliminary findings

Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.

scientific article published on 28 August 2017

Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity

scientific article published on 30 April 2020

Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer

scientific article published on 31 August 2020

Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells.

scientific article published in March 2002

Tumor control by intravenous administration of STING ligand requires combination with precisely timed radiation therapy.

scientific article published on 4 November 2015

Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.

scientific article published on 3 May 2018

Tumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy

scientific article

Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy

scientific article published on 01 April 2020

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