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List of works by Irene Orlow

A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data

scientific article

A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival

scientific article published on 4 June 2012

APOE polymorphisms and cognitive functions in patients with brain tumors

scientific article

Accuracy of Self-reported Smoking Exposure Among Bladder Cancer Patients Undergoing Surveillance at a Tertiary Referral Center

scientific article

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

scientific article published on 12 December 2018

Alcohol and Lung Cancer Risk Among Never Smokers: A Pooled Analysis from the International Lung Cancer Consortium and the SYNERGY Study

scientific article (publication date: 27 February 2017)

Allergies, variants in IL-4 and IL-4Rα genes, and risk of pancreatic cancer

article

Alterations in the retinoblastoma pathway of cell cycle control in parathyroid tumors

scientific article published on 01 March 2000

Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival

scientific article published in January 1999

Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastoma

scientific article

Altered patterns of MDM2 and TP53 expression in human bladder cancer

scientific article published on 01 September 1994

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study

scientific article published on 23 April 2019

Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report

scientific article

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

scientific article published on 19 March 2013

Analysis of p21WAF1/CIP1 in primary bladder tumors

scientific article published on 01 January 1996

Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO).

scientific article published on 11 October 2011

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

scientific article published on 21 June 2016

Association Between Aryl Hydrocarbon Receptor Genotype and Survival in Soft Tissue Sarcoma

scientific article published on 01 October 2004

Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma

scientific article published on June 2015

Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma

scientific article

Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways

scientific article published on 08 February 2016

Association of known melanoma risk factors with primary melanoma of the scalp and neck

scientific article published on 20 August 2020

Associations of MC1R genotype and patient phenotypes with BRAF and NRAS mutations in melanoma

scientific article

Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis

scientific article

Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium

scientific article

CDKN2A Germline Mutations in Individuals with Cutaneous Malignant Melanoma

scientific article published on 11 January 2007

CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study

Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium

scientific article published on 30 June 2014

Characterization of large structural genetic mosaicism in human autosome

journal article published in 2015

Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors

scientific article published on 01 June 1994

Cigarette smoking and chromosome 9 alterations in bladder cancer

scientific article published in May 1997

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

scientific article published on 22 September 2015

Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas

scientific article published on 13 September 2011

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

scientific article published on 19 June 2015

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

scientific article

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

scientific article published on 22 June 2015

Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study.

scientific article

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk

scientific article

Contralateral breast cancers: Independent cancers or metastases?

scientific article

Correction: vitamin d metabolic pathway genes and pancreatic cancer risk

scientific article published on 3 June 2015

DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors

scientific article published on July 2008

Deletion of the p16 and p15 Genes in Human Bladder Tumors

article

Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence

scientific article published on July 1999

Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas

scientific article published on December 1999

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

scientific article published in 2013

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

scientific article

Erratum to: Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas

scholarly article published in Annals of Surgical Oncology

Estimating the relative risk of developing melanoma in INK4A carriers.

scientific article published in February 2004

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study

scientific article published on 17 December 2014

Evaluation of Alterations in the Tumor Suppressor Genes INK4A and INK4B in Human Bladder Tumors

article

Evaluation of the clonal origin of multiple primary melanomas using molecular profiling

scientific article published on 12 March 2009

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk

scientific article published on 4 July 2016

Exome-wide association study of endometrial cancer in a multiethnic population

scientific article

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

journal article published in 2016

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

scientific article published on 7 September 2016

Functional melanoma-risk variant IRF4 rs12203592 associated with Breslow thickness: a pooled international study of primary melanomas

scientific article

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers

scientific article

Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression

scientific article

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

scientific article published on April 2013

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

scientific article published on 23 March 2016

Gastrointestinal stromal tumors, somatic mutations and candidate genetic risk variants

scientific article

Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression

scientific article published on May 1995

Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC)

scientific article

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

scientific article

Genome-wide analysis of the role of copy-number variation in pancreatic cancer risk

scientific article published on 13 February 2014

Genome-wide association study for ovarian cancer susceptibility using pooled DNA.

scientific article published on 13 July 2012

Genome-wide association study of endometrial cancer in E2C2

scientific article (publication date: February 2014)

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

scientific article published on 5 November 2013

Genome-wide gene-diabetes and gene-obesity interaction scan in 8,255 cases and 11,900 controls from the PanScan and PanC4 Consortia

scientific article published on 16 June 2020

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

scientific article published on 8 February 2018

Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers

scientific article

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

scientific article published on January 2013

Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics

article

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

scientific article

Identification of nine new susceptibility loci for endometrial cancer

scientific article published in Nature Communications

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

scientific article published on 12 January 2015

Identifying Etiologically Distinct Sub-Types of Cancer: A Demonstration Project Involving Breast Cancer

scientific article

Including additional controls from public databases improves the power of a genome-wide association study

scientific article published on 17 August 2011

Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium

scientific article

Inherited genetic variants associated with occurrence of multiple primary melanoma

scientific article published on 2 April 2015

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

scientific article published on July 2016

Inherited variation at MC1R and ASIP and association with melanoma-specific survival

scientific article

Inherited variation at MC1R and histological characteristics of primary melanoma

scientific article published on 19 March 2015

Interaction of CDKN2A and sun exposure in the etiology of melanoma in the general population

scientific article published on 11 August 2011

Interpretation of melanoma risk feedback in first-degree relatives of melanoma patients

scientific article

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

scientific article

Investigation of the Effect of MDM2 SNP309 and TP53 Arg72Pro Polymorphisms on the Age of Onset of Cutaneous Melanoma

scientific article published on 16 February 2012

Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome

scientific article published on 27 January 2014

Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample

scientific article

Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma

scientific article published on 8 March 2007

Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium

scientific article published on 25 April 2017

Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer

scientific article

Mitochondrial DNA deletions in skin from melanoma patients

scientific article published on 01 January 2008

Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer

scientific article

Molecular analysis of the INK4A and INK4B gene loci in human breast cancer cell lines and primary carcinomas

article

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

Mutagen sensitivity as an indicator of soft tissue sarcoma risk

scientific article published in January 2001

NC-03POLYMORPHISMS IN THE COMT, BDNF AND DTNBP1 GENES AND COGNITIVE FUNCTIONS IN PATIENTS WITH BRAIN TUMORS.

scientific article published in November 2014

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

scientific article

Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma

scientific article

No association between prediagnosis exercise and survival in patients with high-risk primary melanoma: A population-based study

scientific article

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival

scientific article

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

scientific article published in December 2016

Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patients

scientific article published on January 2009

Phase II study of extended-dose temozolomide in patients with melanoma

scientific article published in May 2008

Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development

scientific article

Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium

scientific article

Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers

scientific article

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10

scientific article published on 22 November 2013

Sun exposure and melanoma survival: a GEM study

scientific article

Sun exposure, vitamin D receptor genetic variants, and risk of breast cancer in the Agricultural Health Study

scientific article

Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma

scientific article published on 25 May 2011

Sunburn, sun exposure, and sun sensitivity in the Study of Nevi in Children

scientific article

The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival

scientific article published on 9 October 2017

The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women

scientific article (publication date: 8 February 2011)

The p.Ser64Leu and p,Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response

scientific article published on 10 November 2020

The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study

scientific article published in August 2006

The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma

scientific article published on May 2008

Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study

scientific article published on 14 October 2013

Validation of denaturing high performance liquid chromatography as a rapid detection method for the identification of human INK4A gene mutations

scientific article published on November 2001

Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based study

scientific article published on 17 October 2016

Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review

scientific article published on 16 November 2006

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

scientific article published in PLoS ONE

Variants in hormone biosynthesis genes and risk of endometrial cancer

scientific article published on 25 April 2008

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer

scientific article published on 16 April 2014

Vitamin D metabolic pathway genes and pancreatic cancer risk

scientific article

Vitamin D receptor gene haplotypes and polymorphisms and risk of breast cancer: a nested case-control study

scientific article

Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study

scientific article

Vitamin D receptor polymorphisms in patients with cutaneous melanoma

scientific article

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

scientific article published on 21 August 2018

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