List of works - Sang-Jun Ha

4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection

scientific article published on 8 July 2011

A neuron-specific gene transfer by a recombinant defective Sindbis virus

scientific article published in December 1998

A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC).

scientific article published on 20 December 2012

A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens.

scientific article published on 3 December 2015

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.

scientific article

Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation

scientific article published on 13 August 2012

Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments

scientific article published on 28 July 2015

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

scientific article published on 12 December 2011

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

scientific article published on 19 July 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury

scientific article published on 22 July 2019

Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells

scientific article

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

scientific article

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity.

scientific article published on 09 May 2016

Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis

scientific article published on November 2011

Combination of TLR1/2 and TLR3 ligands enhances CD4(+) T cell longevity and antibody responses by modulating type I IFN production.

scientific article published on September 2016

Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization.

scientific article

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

scientific article

Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

scientific article published on 25 August 2017

Diagnostic performance of a cytokine and IFN-γ-induced chemokine mRNA assay after Mycobacterium tuberculosis-specific antigen stimulation in whole blood from infected individuals.

scientific article published on January 2015

Differentiation of Antigen-Specific T Cells with Limited Functional Capacity during Mycobacterium tuberculosis Infection.

scientific article published in August 2014

Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection

scientific article published on 14 October 2013

Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production

scientific article

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.

scientific article

Dysregulation of T<sub>FH</sub>-B-T<sub>RM</sub> lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer

scientific article published on 18 October 2021

Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues.

scientific article published on 28 April 2016

Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity

scientific article published in July 2013

Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization.

scientific article

Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

scientific article

Enhancement of VP1-specific immune responses and protection against EMCV-K challenge by co-delivery of IL-12 DNA with VP1 DNA vaccine

scientific article published in February 2001

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor

scientific article

Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection.

scientific article

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

scientific article

Extrinsic Acquisition of CD80 by Antigen-Specific CD8+ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection

scientific article published on 16 August 2019

Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer.

scientific article

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications

scientific article

Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer

scientific article published on 02 September 2020

Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages

scientific article

High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma.

scientific article

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

scientific article

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

scholarly article

IL-15 Generates IFN-γ-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell Differentiation

scientific article published on 01 January 2019

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.

scientific article published on 9 October 2015

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation

scientific article published on 04 August 2020

Identification of a subnuclear body involved in sequence-specific cytokine RNA processing.

scientific article published on 5 January 2015

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

scientific article published on 11 February 2009

Inhibition of IL-17A suppresses enhanced-tumor growth in low dose pre-irradiated tumor beds

scientific article

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.

scientific article published on May 2013

Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model

scientific article published on 29 October 2019

Lung cancer in never smokers: change of a mindset in the molecular era.

scientific article published on 26 January 2011

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

scientific article published on June 2008

Mechanism of T cell exhaustion in a chronic environment

scientific article published on April 2011

Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection

scientific article published on 05 March 2019

MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation.

scientific article published on 7 August 2017

MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20.

scientific article

Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation

scientific article published on 27 April 2012

Molecular signature of CD8+ T cell exhaustion during chronic viral infection

scientific article published on 18 October 2007

Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection

scientific article published on 16 August 2019

Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.

scientific article

PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.

scientific article published on May 2015

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

scientific article published on 15 May 2013

PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients.

scientific article published on 14 November 2016

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

scientific article

Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory setting

scientific article published on 24 November 2014

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice.

scientific article published on 22 June 2016

Rapid recruitment of macrophages in interleukin-12-mediated tumour regression

scientific article published on 01 September 1998

Re-defining T-Cell Exhaustion: Subset, Function, and Regulation

scientific article published on 20 February 2020

Recruitment of monocytes/macrophages in different tumor microenvironments

scientific article published on 31 December 2012

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.

scientific article

Regulatory T cells—an important target for cancer immunotherapy

scientific article published on 29 April 2014

Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration.

scientific article published on 24 October 2017

Structural Study of Monomethyl Fumarate-Bound Human GAPDH

scientific article published on 01 August 2019

Sustained Type I Interferon Reinforces NK Cell-Mediated Cancer Immunosurveillance during Chronic Virus Infection

scientific article published on 26 February 2019

TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection

scientific article published on 25 February 2017

The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice

scientific article published on 14 March 2019

The Ratio of Peripheral Regulatory T Cells to Lox-1 PMN-MDSC Predicts the Early Response to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer Patients

scientific article published on 01 January 2019

The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma

scientific article published on July 2013

Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosis

scientific article published in September 2003

Tumor-Infiltrating Regulatory T Cell Accumulation in the Tumor Microenvironment is Mediated by IL33/ST2 Signaling

scientific article published on 02 September 2020

Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors.

scientific article

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection

scientific article

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation.

scientific article published on September 2017

List of works by Sang-Jun Ha

4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection

A neuron-specific gene transfer by a recombinant defective Sindbis virus

A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC).

A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens.

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.

Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation

Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

CD160 serves as a negative regulator of NKT cells in acute hepatic injury

Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity.

Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis

Combination of TLR1/2 and TLR3 ligands enhances CD4(+) T cell longevity and antibody responses by modulating type I IFN production.

Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization.

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

Diagnostic performance of a cytokine and IFN-γ-induced chemokine mRNA assay after Mycobacterium tuberculosis-specific antigen stimulation in whole blood from infected individuals.

Differentiation of Antigen-Specific T Cells with Limited Functional Capacity during Mycobacterium tuberculosis Infection.

Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection

Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.

Dysregulation of T<sub>FH</sub>-B-T<sub>RM</sub> lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer

Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues.

Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity

Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization.

Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Enhancement of VP1-specific immune responses and protection against EMCV-K challenge by co-delivery of IL-12 DNA with VP1 DNA vaccine

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor

Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection.

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

Extrinsic Acquisition of CD80 by Antigen-Specific CD8+ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection

Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer.

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications

Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer

Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages

High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma.

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

IL-15 Generates IFN-γ-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell Differentiation

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation

Identification of a subnuclear body involved in sequence-specific cytokine RNA processing.

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

Inhibition of IL-17A suppresses enhanced-tumor growth in low dose pre-irradiated tumor beds

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.

Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model

Lung cancer in never smokers: change of a mindset in the molecular era.

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

Mechanism of T cell exhaustion in a chronic environment

Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8 T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection

MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation.

MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20.

Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation

Molecular signature of CD8+ T cell exhaustion during chronic viral infection

Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection

Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.

PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients.

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory setting

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice.

Rapid recruitment of macrophages in interleukin-12-mediated tumour regression

Re-defining T-Cell Exhaustion: Subset, Function, and Regulation

Recruitment of monocytes/macrophages in different tumor microenvironments

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.

Regulatory T cells—an important target for cancer immunotherapy

Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration.

Structural Study of Monomethyl Fumarate-Bound Human GAPDH

Sustained Type I Interferon Reinforces NK Cell-Mediated Cancer Immunosurveillance during Chronic Virus Infection

TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection

The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice

The Ratio of Peripheral Regulatory T Cells to Lox-1 PMN-MDSC Predicts the Early Response to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer Patients

The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma

Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosis

Tumor-Infiltrating Regulatory T Cell Accumulation in the Tumor Microenvironment is Mediated by IL33/ST2 Signaling

Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors.