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List of works by Anjaneyulu Kowluru

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats

scientific article published on 01 September 1999

A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetes

scientific article

A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells

scientific article published on August 2009

Activation of pancreatic islet myosin ATPase by ATP and actin

scientific article published on June 1985

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.

scientific article

Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells

scientific article published on 11 October 2006

Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.

scientific article published on 28 June 2007

COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis

scientific article published on 17 June 2015

Calcium-activated factors in pancreatic islets that inhibit actin polymerization

scientific article published on 01 December 1982

Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion

scientific article published on 01 June 1996

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell

scientific article published on August 2005

Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells

scientific article

Characterization of nucleoside diphosphokinase activity in human and rodent pancreatic beta cells: evidence for its role in the formation of guanosine triphosphate, a permissive factor for nutrient-induced insulin secretion

scientific article published on 01 October 1994

Deoxysphingolipids: β-cell, beware of these new kids on the block

scientific article published on April 2014

Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells

scientific article published in June 2007

Differential regulation by fatty acids of protein histidine phosphorylation in rat pancreatic islets

scientific article published in November 2004

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells

scientific journal article

Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity

scientific journal article

EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.

scientific article

Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.

scientific article published on 8 April 2008

Enzymes of phospholipid metabolism in rat pancreatic islets: subcellular distribution and the effect of glucose and calcium

scientific article published on 01 January 1986

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

scientific article published on September 2005

Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells

scientific article published on 01 November 1997

Evidence for phosphorylation of pancreatic islet pyruvate kinase

scientific article published on 01 July 1985

Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells.

scientific article published on 21 February 2017

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches

scientific article

Functional inactivation by interleukin-1beta of glyceraldehyde-3-phosphate dehydrogenase in insulin-secreting cells

scientific article

GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells

scientific article published in March 2004

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell

scientific article

Glucose activates prenyltransferases in pancreatic islet beta-cells.

scientific article

Glucose-induced, calcium-mediated protein phosphorylation in intact pancreatic islets

scientific article published on 01 June 1984

Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells

scientific article

High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit

scientific journal article

Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: potential mechanisms and functional consequences

scientific article published on 11 May 2012

Inappropriate movement of Rac1 contributes to glucotoxicity of the islet β-cell

scientific article

Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation

scientific article published on October 2002

Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions.

scientific article

L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells

scientific article

Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase

scientific journal article

Localization of a nuclear serine/threonine protein phosphatase in insulin-secreting INS-1 cells: potential regulation by IL-1beta

scientific journal article

Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins

scientific article published on 19 June 2003

Metastasis suppressor NME1 regulates melanoma cell morphology, self-adhesion and motility via induction of fibronectin expression

scientific article published on 27 April 2015

NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.

scientific article published on 29 July 2016

Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells

scientific article published on January 2013

Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis

scientific article published on 30 August 2013

Non-specific stimulatory effects of mastoparan on pancreatic islet nucleoside diphosphokinase activity: dissociation from insulin secretion

scientific article published on 01 January 1995

Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells

scientific article published on 21 January 2004

Novel regulatory roles for protein phosphatase-2A in the islet beta cell.

scientific article

Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells

scientific article published in November 2003

Novel roles for the rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from betaTC3 cells: further evidence in support of the succinate mechanism of insulin release

scientific article published on August 2003

On a sugary-relationship between caspases and lamins

scientific article published in January 2014

PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine

scientific article published on 29 September 2010

Paradoxical regulation of glucose-induced Rac1 activation and insulin secretion by RhoGDIβ in pancreatic β-cells

scientific article published on 03 July 2019

Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).

scientific article

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.

scientific article

Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell

scientific article

Phospholipid methyltransferase activity in pancreatic islets: activation by calcium

scientific article

Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells

scientific article published on December 2001

Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis

scientific article published on 01 September 1998

Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells.

scientific article

Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

scientific article

Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion.

scientific article

Protein phosphorylation in pancreatic islets: evidence for separate Ca2+ and cAMP-enhanced phosphorylation of two 57,000 Mr proteins

scientific article published on February 1984

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective

scientific article

Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together.

scientific article

Purine nucleotide- and sugar phosphate-induced inhibition of the carboxyl methylation and catalysis of protein phosphatase-2A in insulin-secreting cells: protection by divalent cations

scientific article published on 01 August 1998

Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells

scientific article published on 9 January 2016

Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells

scientific article published on 17 February 2004

Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells

scientific article

Regulation of guanine-nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion

scientific article published on July 1994

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

scientific article published on September 2011

Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells

scientific journal article

Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells.

scientific article published on 05 December 2007

Regulatory roles for nm23/nucleoside diphosphate kinase-like enzymes in insulin secretion from the pancreatic islet beta cell

scientific article published on August 2006

Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion

scientific article published on December 2005

Role of G-proteins in islet function in health and diabetes

scientific article

Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction

scientific article published on 31 August 2020

Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets

scientific article published on March 1986

Stimulation of phospholipid methylation by glucose in pancreatic islets

scientific article published on 01 July 1984

Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells

scientific article published on July 1994

The Regulatory Roles of Mitogen-activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-cell.

scientific article

The two faces of protein palmitoylation in islet β-cell function: potential implications in the pathophysiology of islet metabolic dysregulation and diabetes

scientific article published on September 2013

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

scientific article published on 30 April 2015

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.

scientific article

Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction

scientific article published on 12 February 2017

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.

scientific article published on 23 October 2012

VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

scientific article

siRNA-mediated depletion of endogenous protein phosphatase 2Acalpha markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells

scientific article published on 28 July 2006

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