List of works by Nils G Walter

A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking

scientific article published in February 2001

A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.

scientific article

A bird's eye view tracking slow nanometer-scale movements of single molecular nano-assemblies

scientific article

A novel method to accurately locate and count large numbers of steps by photobleaching

scientific article published on 21 September 2016

A rugged free energy landscape separates multiple functional RNA folds throughout denaturation

scientific article

Analysis of complex single-molecule FRET time trajectories

scientific article published on January 2010

Assay for glucosamine 6-phosphate using a ligand-activated ribozyme with fluorescence resonance energy transfer or CE-laser-induced fluorescence detection.

scientific article

Automatic classification and segmentation of single-molecule fluorescence time traces with deep learning

scientific article published on 17 November 2020

Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing

scientific article

Biological Pathway Specificity in the Cell-Does Molecular Diversity Matter?

scientific article published on 27 June 2019

Biopolymers celebrates 50 years of nucleic acids research

scientific article published in December 2013

Catalytic core structure of the trans-acting HDV ribozyme is subtly influenced by sequence variation outside the core

scientific article published on 01 June 2006

Cations and hydration in catalytic RNA: molecular dynamics of the hepatitis delta virus ribozyme

scientific article

Chemical feasibility of the general acid/base mechanism of glmS ribozyme self-cleavage

scientific article published on October 2015

Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum

scientific article published on 5 September 2007

Conformational dynamics of single pre-mRNA molecules during in vitro splicing

scientific article published on 21 March 2010

Cooperative and directional folding of the preQ1 riboswitch aptamer domain

scientific article

Correlating structural dynamics and function in single ribozyme molecules

scientific article

DNA-cholesterol barges as programmable membrane-exploring agents

scientific article published on 19 May 2014

Diffusely bound Mg2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core

scientific article

Direct Kinetic Fingerprinting for High-Accuracy Single-Molecule Counting of Diverse Disease Biomarkers

scientific article published on 31 December 2020

Direct kinetic fingerprinting and digital counting of single protein molecules

scientific article published on 31 August 2020

Discovering anomalous hybridization kinetics on DNA nanostructures using single-molecule fluorescence microscopy.

scientific article published on 3 March 2014

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver

scientific article

Dissecting non-coding RNA mechanisms in cellulo by Single-molecule High-Resolution Localization and Counting

scientific article published on 29 June 2013

Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic "fingerprinting".

scholarly article

Do-it-yourself guide: how to use the modern single-molecule toolkit

scientific article

Dynamics inherent in helix 27 from Escherichia coli 16S ribosomal RNA.

scientific article published in November 2004

Editorial for "non-coding RNA methods".

scientific article published in September 2013

Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.

scientific article published on 13 July 2015

Exploring the speed limit of toehold exchange with a cartwheeling DNA acrobat

scientific article published on 07 May 2018

Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme

scientific article published on May 2010

Flexible casting of modular self-aligning microfluidic assembly blocks.

scientific article published on 16 March 2011

Focus on function: single molecule RNA enzymology.

scientific article published on December 2007

Following the messenger: Recent innovations in live cell single molecule fluorescence imaging

scientific article published on 28 January 2020

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

scientific article published on 30 March 2018

Future of biomedical sciences: single molecule microscopy.

scientific article published on February 2007

General base catalysis for cleavage by the active-site cytosine of the hepatitis delta virus ribozyme: QM/MM calculations establish chemical feasibility

scientific article published on 8 August 2008

Global structure and flexibility of hairpin ribozymes with extended terminal helices

scientific article published on 01 June 1999

Going viral: riding the RNA wave to discovery

scientific article

Hierarchical mechanism of amino acid sensing by the T-box riboswitch.

scientific article

High-resolution three-dimensional mapping of mRNA export through the nuclear pore

scientific article

Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles

scientific article published on 09 November 2020

Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme.

scientific article published in April 2007

Introduction to Single Molecule Imaging and Mechanics: Seeing and Touching Molecules One at a Time

scientific article published on 01 March 2014

Introductory editorial: Special section on single-molecule and super-resolution microscopy of biopolymers

scientific article published on 01 October 2016

KRAS Engages AGO2 to Enhance Cellular Transformation

scientific article published on 03 February 2016

Kinetic fingerprinting to identify and count single nucleic acids

scientific article

Kinetics coming into focus: Single-molecule microscopy of riboswitch dynamics

scientific article published on 29 October 2018

Leakage and slow allostery limit performance of single drug-sensing aptazyme molecules based on the hammerhead ribozyme.

scientific article

Life under the Microscope: Single-Molecule Fluorescence Highlights the RNA World

scientific article

Local conformational changes in the catalytic core of the trans-acting hepatitis delta virus ribozyme accompany catalysis

scientific article published in October 2002

Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

scientific article published on 20 September 2019

Long-range impact of peripheral joining elements on structure and function of the hepatitis delta virus ribozyme

scientific article

Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations

scientific article

Magnesium dependence of the amplified conformational switch in the trans-acting hepatitis delta virus ribozyme

scientific article published in July 2004

Meeting report: SMART timing--principles of single molecule techniques course at the University of Michigan 2014.

scientific article

Mg2+-induced compaction of single RNA molecules monitored by tethered particle microscopy

scientific article

Michaelis-Menten is dead, long live Michaelis-Menten!

scientific article published on 01 February 2006

Modelling viral evolution in vitro using exo- Klenow polymerase: continuous selection of strand displacement amplified DNA that binds an oligodeoxynucleotide to form a triple-helix

scientific article published on 01 December 1995

Molecular dynamics and quantum mechanics of RNA: conformational and chemical change we can believe in

scientific article published on January 2010

Molecular dynamics simulations of RNA: an in silico single molecule approach.

scientific article

Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.

scientific article published on 17 February 2009

Molecular robots guided by prescriptive landscapes

scientific article

Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm

scientific article published on 25 May 2014

Multifactorial modulation of binding and dissociation kinetics on two-dimensional DNA nanostructures

scientific article published on 28 May 2013

Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion

scientific article published on 10 February 2016

Native purification and labeling of RNA for single molecule fluorescence studies

scientific article published on January 2015

Nondenaturing purification of co-transcriptionally folded RNA avoids common folding heterogeneity

scientific article

On-line polymerase chain reaction (PCR) monitoring

scientific article published on 01 November 1998

Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action

scientific article published on 21 February 2013

Probing RNA-protein interactions using pyrene-labeled oligodeoxynucleotides: Qbeta replicase efficiently binds small RNAs by recognizing pyrimidine residues

scientific article

Probing non-selective cation binding in the hairpin ribozyme with Tb(III).

scientific article

Program review. The Interdisciplinary Biophysics Graduate Program at the University of Michigan.

scientific article published on April 2008

Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure

scientific article published on 01 February 2020

Protonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics

scientific article published on July 2010

Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

scientific article published on 19 June 2009

Putting Humpty-Dumpty Together: Clustering the Functional Dynamics of Single Biomolecular Machines Such as the Spliceosome.

scientific article published on 13 October 2016

Pyrrolo-C as a fluorescent probe for monitoring RNA secondary structure formation

scientific article published on 23 January 2006

QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms

scientific article published on 8 November 2011

RNA chaperones stimulate formation and yield of the U3 snoRNA-Pre-rRNA duplexes needed for eukaryotic ribosome biogenesis.

scientific article

RNA degradation in cell extracts: real-time monitoring by fluorescence resonance energy transfer

scientific article published in November 2003

RNA dynamics: it is about time.

scientific article published on 09 June 2008

Rational design of DNA-actuated enzyme nanoreactors guided by single molecule analysis.

scientific article published on 20 January 2016

Reaction pathway of the trans-acting hepatitis delta virus ribozyme: a conformational change accompanies catalysis

scientific article

Secondary structure of bacteriophage T4 gene 60 mRNA: implications for translational bypassing

scientific article published on 14 March 2013

Significant kinetic solvent isotope effects in folding of the catalytic RNA from the hepatitis delta virus

scientific article published in November 2003

Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics

scientific article published on 28 September 2015

Single VS ribozyme molecules reveal dynamic and hierarchical folding toward catalysis.

scientific article

Single molecule fluorescence approaches shed light on intracellular RNAs

scientific article

Single molecule fluorescence control for nanotechnology.

scientific article

Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure

scientific article

Single-Molecule Kinetic Fingerprinting for the Ultrasensitive Detection of Small Molecules with Aptasensors

scientific article published on 02 January 2019

Single-Molecule Pull-Down FRET to Dissect the Mechanisms of Biomolecular Machines

scientific article

Single-molecule enzymology à la Michaelis-Menten

scientific article

Single-molecule tools for enzymology, structural biology, systems biology and nanotechnology: an update

scientific article

Solution probing of metal ion binding by helix 27 from Escherichia coli 16S rRNA.

scientific article published in November 2005

Solution structure of an alternate conformation of helix27 from Escherichia coli16S rRNA

scientific article

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites

scientific article published on February 2016

Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics

scientific article

Structural basis for the guanosine requirement of the hairpin ribozyme

scientific article published on 01 December 1999

Structural dynamics of catalytic RNA highlighted by fluorescence resonance energy transfer.

scientific article

Structural dynamics of precursor and product of the RNA enzyme from the hepatitis delta virus as revealed by molecular dynamics simulations

scientific article

Structural modeling of sequence specificity by an autoantibody against single-stranded DNA.

scientific article published on 16 May 2007

Super-resolution fingerprinting detects chemical reactions and idiosyncrasies of single DNA pegboards.

scientific article

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors

scientific article published on 13 February 2018

Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme

scientific article published in August 2004

The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation.

scientific article

The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts

scientific article

The Small Ribozymes: Common and Diverse Features Observed through the FRET Lens

scientific article published on January 2009

The blessing and curse of RNA dynamics: past, present, and future

scientific article published on 01 October 2009

The hairpin ribozyme: structure, assembly and catalysis

scientific article published on 01 February 1998

The hairpin ribozyme: structure, assembly and catalysis

The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

scientific article

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling.

scientific article published on 6 January 2015

The role of an active site Mg(2+) in HDV ribozyme self-cleavage: insights from QM/MM calculations.

scientific article

The solvent-protected core of the hairpin ribozyme-substrate complex

scientific article published on 01 October 1998

Theoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM.

scientific article published on 04 May 2009

Trans-acting glmS catalytic riboswitch: locked and loaded

scientific article published on 5 February 2007

Trans-acting hepatitis delta virus ribozyme: catalytic core and global structure are dependent on the 5' substrate sequence

scientific article

Tuning RNA folding and function through rational design of junction topology

scientific article published in September 2017

Ultraspecific and Amplification-Free Quantification of Mutant DNA by Single-Molecule Kinetic Fingerprinting

scientific article published on 05 September 2018

Under the microscope: single molecule symposium at the University of Michigan, 2006

scientific article published on 01 February 2007

Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch.

scientific article published on 18 October 2011

Versatile transcription control based on reversible dCas9 binding

scientific article published on 18 July 2019

Wobble pairs of the HDV ribozyme play specific roles in stabilization of active site dynamics

scientific article published on February 2015

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