Search filters

List of works by Asfar S Azmi

A multi-targeted approach to suppress tumor-promoting inflammation

scientific article

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

scientific article

A(3) adenosine receptor: a plausible therapeutic target for cardio-protection in diabetes

scientific article published on 01 April 2012

Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective

scientific article published on December 2011

Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype

scientific article published on March 2013

Adopting network pharmacology for cancer drug discovery

scientific article published on June 2013

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction

scientific article published on 18 May 2017

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

scientific article published on 03 December 2009

An efficient method for significant motifs discovery from multiple DNA sequences.

scientific article published on 11 May 2017

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

scientific article published on 28 September 2016

Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties.

scientific article

Author Correction: The nuclear export protein XPO1 - from biology to targeted therapy

scientific article published on 24 November 2020

Broad targeting of resistance to apoptosis in cancer.

scientific article

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

scientific article published on 22 March 2020

Can network pharmacology rescue neutraceutical cancer research?

scientific article published on 16 June 2012

Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species

scientific article published on 11 August 2010

Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A.

scientific article published in November 2009

Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer

scientific article

Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression ⬇️

scientific article published on November 22, 2011

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

scientific article published on 29 November 2016

Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer

scientific article published on 6 June 2014

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

scientific article published on January 2011

Emerging Bcl-2 inhibitors for the treatment of cancer ⬇️

scientific article published on September 3, 2010

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

scientific article published on December 2013

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.

scientific article published on 17 July 2017

Gastric cancer: a comprehensive review of current and future treatment strategies

scientific article published on 07 September 2020

Hypoxia Induced Aggressiveness of Prostate Cancer Cells Is Linked with Deregulated Expression of VEGF, IL-6 and miRNAs That Are Attenuated by CDF ⬇️

scientific article published on August 27, 2012

Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment

scientific article

MDM2 inhibitors for pancreatic cancer therapy

scientific article published on June 2010

MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy ⬇️

scientific article published on September 6, 2010

Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

scientific article

Nab-paclitaxel: potential for the treatment of advanced pancreatic cancer

scientific article published on 04 February 2014

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors ⬇️

scientific article published on May 1, 2011

Network Pharmacology for Cancer Drug Discovery: Are We There Yet? ⬇️

scientific article published on May 1, 2012

Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism ⬇️

scientific article published on July 26, 2011

Network perspectives on HDM2 inhibitor chemotherapy combinations

scientific article published on January 2011

Network pharmacology: an emerging field in cancer drug discovery)

scientific article published on 01 June 2013

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

scientific article published on January 2009

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

scientific article

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

scientific article published on 15 November 2016

Nuclear Export Inhibition for Pancreatic Cancer Therapy.

scientific article

Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol

scientific article published on January 2012

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

scientific article

Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.

scientific article published on June 2013

Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties.

scientific article published on 10 May 2007

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

scientific article published on 12 July 2021

PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors

scientific article published on 29 November 2019

PAR-4 as a possible new target for pancreatic cancer therapy

scientific article published on June 2010

Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers.

scientific article published on 28 March 2018

Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells

scientific article

Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1.

scientific article published on 9 April 2014

Pancreatic cancer: understanding and overcoming chemoresistance

scientific article

Pharmaceutical reactivation of p53 pathways in cancer

scientific article published on 01 January 2011

Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties

scientific article published on 28 December 2005

Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism

scientific article published in August 2008

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

scientific article

Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 12 December 2019

Prior exposure to restraint stress enhances 7,12-dimethylbenz(a)anthracene (DMBA) induced DNA damage in rats

scientific article published on 21 June 2006

Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property

scientific article published on 4 June 2013

Progress in nanotechnology based approaches to enhance the potential of chemopreventive agents

scientific article published on 21 January 2011

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations ⬇️

scientific article published on November 1, 2010

Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties.

scientific article published on 29 November 2006

Prostate cancer stem cells: molecular characterization for targeted therapy

scientific article published on 25 June 2012

Prostate cancer: evidence-based indications for postoperative radiotherapy

scientific article published on 06 September 2010

Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: "Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase".

scientific article published on September 2013

Rectifying cancer drug discovery through network pharmacology

scientific article published on April 2014

Regulation of KRAS-PAK4 axis by microRNAs in cancer

scientific article published on January 2014

Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo

scientific article

Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer

scientific article published on 30 January 2010

Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: implications for anticancer properties

scientific article published in June 2005

Resveratrol‐induced apoptosis is enhanced in low pH environments associated with cancer ⬇️

scientific article published on April 1, 2012

Retracted: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

retracted article

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

scientific article

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.

scientific article published on 16 February 2009

Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas

scientific article published on 12 February 2013

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

scientific article published on 04 October 2016

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy ⬇️

scientific article published on June 1, 2011

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer

scientific article

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25.

scientific article published on 03 September 2013

Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy

scientific article published on December 2012

Systems and network biology in pharmaceutical drug discovery

scientific article published on 01 January 2014

Systems biology approaches to pancreatic cancer detection, prevention and treatment

scientific article published on January 2014

Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells

scientific article published on 09 August 2012

Targeting Cancer at the Nuclear Pore

scientific article published on 23 October 2016

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer

scientific article published on 15 May 2017

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

scientific article

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer

scientific article published on 28 September 2019

Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.

scientific article published on 22 June 2017

Targeting XPO1 and PAK4 in 8505C Anaplastic Thyroid Cancer Cells: Putative Implications for Overcoming Lenvatinib Therapy Resistance

scientific article published on 29 December 2019

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance.

scientific article

Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

scientific article published on April 2011

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma

scientific article

The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA.

scientific article published on 9 April 2008

The biflavonoid, amentoflavone degrades DNA in the presence of copper ions

scientific article

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.

scientific article published on 10 May 2012

The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.

scientific article

The evolving role of nuclear transporters in cancer

scientific article published on 02 May 2014

The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent.

scientific article published on 29 November 2011

The nuclear export protein XPO1 - from biology to targeted therapy

scientific article published on 10 November 2020

Understanding XPO1 target networks using systems biology and mathematical modeling

scientific article published on January 2014

Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition

scientific article

Paulina is supported by:

About Paulina

Help