List of works by Harald Wajant

A CD40–CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95

scientific article published on 04 August 2006

A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death

scientific article

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo

scientific article published on January 2014

ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade

scientific article published on 06 December 2013

Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

scientific article

Activation of CD95L fusion protein prodrugs by tumor-associated proteases

scientific article published on 20 October 2006

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

scientific article published on 22 September 2016

Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis

scientific article published on 6 September 2012

Analyzing the signaling capabilities of soluble and membrane TWEAK

scientific article published on 01 January 2014

Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis

scientific article

Apoptosis is not required for acantholysis in pemphigus vulgaris

scientific article

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

scientific article published on 01 July 2002

Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model

scientific article published on 02 December 2019

Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

scientific article published on 6 December 2013

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

scientific article published on 19 July 2018

Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact Cells

scientific article published on 31 December 2015

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD.

scientific article

CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism

scientific article published on 01 January 2020

CD40-directed scFv-TRAIL fusion proteins induce CD40-restricted tumor cell death and activate dendritic cells

scientific article published on 14 November 2013

CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants

scientific article published on 30 January 2014

CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.

scientific article published on 24 January 2005

CD95L/FasL and TRAIL in tumour surveillance and cancer therapy.

scientific article

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

scientific article published on 01 September 2000

Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation

scientific article published on 22 April 2003

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2.

scientific article published on 19 November 2016

Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex

scientific article published on 22 March 2011

Characterization and synthetic applications of recombinant AtNIT1 from Arabidopsis thaliana

scientific article published in January 2002

Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.

scientific article published in June 1996

Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold).

scientific article published on May 1996

Conference

scientific article published on 01 September 1998

Continuous autotropic signaling by membrane-expressed tumor necrosis factor

scientific article published on 01 June 1999

Crystallization and preliminary x-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta).

scientific article published in April 1999

Crystallographic studies and preliminary X-ray investigation of (S)-p-hydroxy-mandelonitrile lyase from Sorghum bicolor (L.).

scientific article published on 01 July 1996

Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands

scientific article published on January 2009

Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing

scientific article published on August 2005

Death receptors.

scientific article

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

scientific article published on 01 July 2001

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

scientific article published in January 1998

Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development.

scientific article published in January 2001

E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin

scientific article

Enantioselective synthesis of aliphatic (S)-cyanohydrins in organic solvents using hydroxynitrile lyase from Manihot esculenta

scientific article published on 01 October 1996

Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis

scientific article published on 8 July 2002

Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L

scientific article published on 17 August 2007

Engineering death receptor ligands for cancer therapy

scientific article published on 14 January 2011

Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1.

scientific article

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site

scientific article published on 01 March 1997

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

scientific article published on 15 August 2016

Exogenous administration of a recombinant variant of TWEAK impairs healing after myocardial infarction by aggravation of inflammation

scientific article

Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway

scientific article published on 30 May 2001

Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity

scientific article published on 26 March 2013

Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation

scientific article published on 28 May 2003

Genetic engineering of death ligands for improvement of therapeutic activity

scientific article published on 01 January 2011

Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values

scientific article

Hydroxynitrile lyases of higher plants

scientific article

Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans

scientific article published on 01 December 1998

Identification of potential active-site residues in the hydroxynitrile lyase from Manihot esculenta by site-directed mutagenesis

scientific article published on 01 October 1996

Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions

scientific article published on 01 June 2006

Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects

scientific article published on July 2009

Increasing complexity in TNFR1 signaling

scientific article published on 08 February 2011

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

scientific article

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells

scientific article published on 23 November 2016

Integrin-linked kinase is dispensable for multiple myeloma cell survival

scientific article published on 01 June 2012

Interferons induce proteolytic degradation of TRAILR4.

scientific article published on November 2005

Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)

scientific article (publication date: October 2002)

MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis

scientific article published on 13 January 2015

Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2).

scientific article

Molecular Mode of Action of TRAIL Receptor Agonists-Common Principles and Their Translational Exploitation

scientific article published on 07 July 2019

Molecular cloning of acetone cyanohydrin lyase from flax (Linum usitatissimum). Definition of a novel class of hydroxynitrile lyases.

scientific article

Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases

scientific article published in October 1994

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

scientific article published on 9 April 2010

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

scientific article published on June 2001

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

scientific article published on August 2004

New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated sp. UR67 ⬇️

No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system.

scientific article published on September 2000

Non-apoptotic Fas signaling.

scientific article

Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells

scientific article

Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways

scientific article

Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33–34 ⬇️

scientific article published on August 11, 1997

Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins.

scientific article

Principles and mechanisms of CD95 activation

scientific article

Principles of antibody-mediated TNF receptor activation

scientific article (publication date: November 2015)

Production, purification, and characterization of scFv TNF ligand fusion proteins

scientific article published on 01 January 2012

Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes

scientific article published on October 1998

Purification and Characterization of a Novel (R)-Mandelonitrile Lyase from the Fern Phlebodium aureum

scientific article published on 01 December 1995

Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling

scientific article published on 13 May 2020

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

scientific article published on 11 February 2019

Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug

scientific article

Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells

scientific article published on 16 September 2002

Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells

scientific article published on 3 January 2007

Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling

scientific article published on 15 April 2011

Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis

scientific article published on November 2002

Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts

scientific article published on 29 May 2012

Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.

scientific article

Soluble TL1A is sufficient for activation of death receptor 3.

scientific article published on 28 October 2015

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis

scientific article published on 22 October 2018

Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway

scientific article published on 7 July 2010

Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta

scientific article

Studies of binding of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to fibroblast growth factor inducible 14 (Fn14).

scientific article

Substrate specificity of mutants of the hydroxynitrile lyase from Manihot esculenta.

scientific article

Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists

scientific article

Superior serum half life of albumin tagged TNF ligands

scientific article

Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner

scientific article published on 22 November 2006

TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK.

scientific article published on 18 February 2014

TNF receptor associated factors in cytokine signaling.

scientific article

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

scientific article

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms

scientific article published on 18 August 2011

TNFR1-induced activation of the classical NF-κB pathway

scientific article published on 08 February 2011

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling

scientific article published on 11 September 2018

TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60

scientific article published on 01 September 1998

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

scientific article published on 04 March 2019

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis

scientific article published on 9 October 2014

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.

scientific article published on 4 December 2014

TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma

scientific article published on 05 June 2006

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.

scientific article published on 31 March 2010

TRAIL- and TNF-induced signaling complexes-so similar yet so different

scientific article

TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways

scientific article published on December 1998

TWEAK can induce cell death via endogenous TNF and TNF receptor 1.

scientific article

TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes

scientific article published on 5 August 2013

Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface

scientific article published on 25 April 2006

Targeted cancer immunotherapy using ligands of the tumor necrosis factor super-family

scientific article published on February 2009

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

scientific article published on 17 April 2014

Targeting of the WT191-138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination.

scientific article published on 28 November 2016

Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy.

scientific article published on May 2003

The CD95 Receptor: Apoptosis Revisited

scientific article published on 01 May 2007

The Fas signaling pathway: more than a paradigm

scientific article

The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors

scientific article

The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death

scientific article published on 13 August 2019

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators

scientific article (publication date: June 2001)

The TWEAK-Fn14 system as a potential drug target

scientific article published on October 2013

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability

scientific article published on March 2005

The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase

scientific article published on 01 July 1999

The role of FasL and Fas in health and disease.

scientific article published on January 2009

The role of TNF in cancer

scientific article published on January 2009

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

scientific journal article

The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation

scientific article published on 01 October 2000

Therapeutic targeting of CD70 and CD27.

scientific article published on 25 February 2016

Therapeutic targeting of CD95 and the TRAIL death receptors

scientific article published on September 2011

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

scientific article published in 2021

Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand

scientific article

Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma

scientific article

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

scientific article published on 01 January 1998

Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.

scientific article

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

scientific article published on 5 February 2013

Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation

scientific article published on 13 October 2003

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.

scientific article

Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation

scientific article published on 16 March 2009

Tumor necrosis factor signaling.

scientific article

Tumor necrosis factors in 1996.

scientific article

XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

scientific article

[From tumor necrosis factor to TRAIL-AMAIZe: second generation antitumorally effective cytokines]

scientific article published on 01 February 2001

p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

scientific article published on February 2001

Paulina is supported by:

About Paulina

Help