Search filters

List of works by Thomas A Einhorn

2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues

scientific article published on August 2013

24R,25-dihydroxyvitamin D3: an essential vitamin D3 metabolite for both normal bone integrity and healing of tibial fracture in chicks

scientific article published in September 1997

A Comparison of Treatment Effects for Nonsurgical Therapies and the Minimum Clinically Important Difference in Knee Osteoarthritis: A Systematic Review

scientific article published on 01 August 2019

A Comprehensive Review of Stem-Cell Therapy

scientific article published on 29 August 2017

A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair

scientific article published in August 2003

Above-knee amputation in patients with prior hip surgery: a caveat

scientific article published on 01 March 1990

Absence of mouse pleiotrophin does not affect bone formation in vivo.

scientific article published in December 2004

Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix

scientific article published in January 2008

Acidosis-induced osteomalacia: metabolic studies and skeletal histomorphometry

scientific article

Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration

scholarly article

American Orthopaedic Association symposium: Evaluating the flood of orthopaedic media and marketing information

scientific article published on 01 June 2005

An AAOS-NIH symposium. Fracture repair: challenges, opportunities, and directions for future research

scientific article published on 01 February 2008

An AOA critical issue. The future of the orthopaedic surgeon-proceduralist or keeper of the musculoskeletal system?

scientific article published on December 2005

An inception cohort analysis to predict nonunion in tibia and 17 other fracture locations.

scientific article published on 27 March 2017

Anabolic agents and bone quality

scientific article

Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression

scientific article published on 06 March 2006

Application of histomorphometric methods to the study of bone repair

scientific article

Are the etiologies of cervical and trochanteric hip fractures different?

scientific article published on March 1996

Attachment to extracellular matrix molecules by cells differing in the expression of osteoblastic traits

scientific article published on March 1993

Atypical Femur Fractures: Review of Epidemiology, Relationship to Bisphosphonates, Prevention, and Clinical Management

scientific article published on 01 April 2019

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research

article

Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research

scientific article

Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research

scientific article published on October 2013

Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells.

scientific article published on 12 January 2007

BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis.

scientific article

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

scientific article published on 12 November 2006

Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and O

article

Beyond a reasonable doubt? Bisphosphonates and atypical femur fractures

scientific article published on 16 February 2012

Bisphosphonate-associated fractures of the femur: pathophysiology and treatment.

scientific article published on July 2014

Bisphosphonates in orthopaedic surgery.

scientific article

Bone and cartilage formation in an experimental model of distraction osteogenesis

scientific article published on February 1998

Bone and mineral metabolism in BB rats with long-term diabetes. Decreased bone turnover and osteoporosis

scientific article published on 01 April 1990

Bone and mineral metabolism in the androgen-resistant (testicular feminized) male rat

scientific article published on 01 July 1993

Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.

scientific article published on May 2008

Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study

scientific article published on 09 November 2016

Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis

scientific article published on March 2007

Bone healing in 2016

scientific article

Bone healing: little secrets ⬇️

scientific article published on January 1, 2011

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

scientific article published on 26 January 2009

Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover and decreased osteocalcin synthesis

scientific article published on 01 February 1989

Bone morphogenetic proteins in orthopaedic surgery

scientific article published on October 2009

Bone strength: the bottom line

scientific article published on 01 November 1992

Bone-turnover markers in fracture healing

scientific article published on March 2010

Breakout session. 1: Definitions of fracture repair

scientific article published on 01 October 1998

Brittle bones in spontaneously diabetic female rats cannot be predicted by bone mineral measurements: studies in diabetic and ovariectomized rats.

scientific article published on October 1994

COX inhibitors and their effects on bone healing

scientific article published on March 2004

Can an anti-fracture agent heal fractures? ⬇️

scientific article published on January 1, 2010

Can we improve fixation and outcomes in the treatment of femoral neck fractures? The use of pharmaceuticals

scientific article published on July 2009

Chemokine expression is upregulated in chondrocytes in diabetic fracture healing

scientific article published on 20 December 2012

Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells.

scientific article published in February 2002

Clinical applications of recombinant human BMPs: early experience and future development

scientific article

Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing.

scientific article

Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.

scientific article

Cox-2: Where are we in 2003? - The role of cyclooxygenase-2 in bone repair

scientific article

Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery.

scientific article published on August 2007

Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects

scientific article published on 26 April 2007

Detection of c-fos expression in benign and malignant musculoskeletal lesions

scientific article published on 01 May 2001

Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment.

scientific article published on 29 October 2008

Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism

scientific article

Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs

scientific article

Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing

scientific article published on 01 March 2002

Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity

scientific article

Direct percutaneous gene delivery to enhance healing of segmental bone defects

article

Do inhibitors of cyclooxygenase-2 impair bone healing?

scientific article published on 01 June 2002

Does knee replacement surgery for osteoarthritis improve survival? The jury is still out.

scientific article published on 17 May 2016

Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty. A meta-analysis

scientific article published in February 2005

Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing

scientific article published in September 2007

Effects of beta-adrenergic blockade in an osteoblast-like cell line

scientific article published on May 1992

Effects of diabetes and steroids on fracture healing.

scientific article

Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing

scientific article published on 06 September 2005

Effects of recombinant human growth hormone and insulin-like growth factor-I, with or without 17 beta-estradiol, on bone and mineral homeostasis of aged ovariectomized rats

scientific article published on 01 November 1996

Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development?

scientific article published on 01 July 2003

Efficacy of Electrical Stimulators for Bone Healing: A Meta-Analysis of Randomized Sham-Controlled Trials

scientific article published on 19 August 2016

Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis

scientific article

Electrical stimulation for long-bone fracture-healing: a meta-analysis of randomized controlled trials

scientific article

Emerging bone healing therapies

scientific article published on March 2010

Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures

scientific article

Enhancement of Experimental Fracture-Healing by Systemic Administration of Recombinant Human Parathyroid Hormone (PTH 1-34)

Epidemiology of Fracture Nonunion in 18 Human Bones

scientific article published on 07 September 2016

Estrogen regulation of growth and alkaline phosphatase expression by cultured human bone marrow stromal cells

scientific article published in March 2002

Expression and role of interleukin-6 in distraction osteogenesis.

scientific article

Expression of angiogenic factors during distraction osteogenesis

scientific article published in December 2003

Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing.

scientific article published in June 2001

Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model.

scientific article

Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model.

scientific article

Factors associated with citation rates in the orthopedic literature.

scientific article published on April 2007

Feasibility of single-use 3D-printed instruments for total knee arthroplasty

scientific article published on 01 July 2019

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

scientific article published on July 2004

Fracture healing and bone repair

scientific article published on 07 April 2011

Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

scientific article

Fracture healing in the elderly patient.

scientific article published on 7 November 2006

Fracture healing: mechanisms and interventions

scientific article

Fracture repair: challenges and opportunities

scientific article

Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation

scientific article published in January 1997

Fragility fractures of the hip and femur: incidence and patient characteristics

scientific article published on 30 May 2009

Functional and molecular changes in colony stimulating factor secretion by osteoblasts

scientific article published on 01 January 1989

Functional role of Runx3 in the regulation of aggrecan expression during cartilage development

scientific article published on November 2013

Funding the mandate for the orthopaedic clinician scientist

scientific article

Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis

scientific article

Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing

scientific article published on August 2008

Giant cell tumor of bone: a unique paradigm of stromal-hematopoietic cellular interactions

scientific article published on 01 July 1994

Grades of recommendation

scientific article published on 01 September 2005

Growth factor regulation of fracture repair.

scientific article

Growth factors: beyond bone morphogenetic proteins

scientific article published on September 2010

Has the Promise Been Kept?

scientific article published on 01 June 2014

Healing Time and Complications in Operatively Treated Atypical Femur Fractures Associated With Bisphosphonate Use: A Multicenter Retrospective Cohort

scientific article published on 19 December 2015

Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose

article

Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

scientific article published on 01 December 2008

High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing

scientific article published on 10 September 2009

Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial

scientific article

Histochemical demonstration of iron but not aluminum in a case of dialysis-associated osteomalacia

scientific article published on April 1988

Hormone replacement therapy

scientific article published on 01 September 2004

How good is the orthopaedic literature?

scientific article published on April 2008

How to design a good case series

scientific article published on 01 May 2009

If it feels good, do it: use of glucosamine sulfate to prevent the progression of osteoarthritis in postmenopausal women

scientific article published in March 2004

Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption.

scientific article published in September 2003

Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling

scientific article

Incorporation of sodium fluoride into cortical bone does not impair the mechanical properties of the appendicular skeleton in rats

scientific article published on 01 August 1992

Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis

scientific article published on 20 September 2004

Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect

scientific article published on 01 May 2002

Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha

scientific article published on 01 September 2001

Inflammatory Profile and Osteogenic Potential of Fracture Haematoma in Humans

scientific article published on 24 December 2019

Interobserver agreement in the application of levels of evidence to scientific papers in the American volume of the Journal of Bone and Joint Surgery.

scientific article

Invited commentary

scientific article published on 01 January 2014

Laying the Foundation for Diagnostic Testing of Impaired Fracture-Healing: Commentary on an article by Vikram Sathyendra, MD, et al.: "Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing. A Preliminary Investigat

scientific article published on 01 August 2014

Letter to the Editor in response to Drs. Safiri and Ayubi.

scientific article

Localization of technetium-99m methylene diphosphonate in bone using microautoradiography

scientific article published on 01 January 1986

Managing EMS pilots: between a rock and a hard place

scientific article published on 01 September 1991

Managing bone defects

scientific article published on 01 August 2011

Matrix vesicle enzymes in human osteoarthritis

scientific article published on 01 January 1985

Mechanical stimulation alters tissue differentiation and molecular expression during bone healing

scientific journal article

Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).

scientific article

Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing

scientific article

Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function.

scientific article

Microscopic bone pathology in two cases of surgically treated secondary hyperparathyroidism. Report of a distinct skeletal lesion

scientific article published on 01 March 1987

Neutral protein-degrading enzymes in experimental fracture callus: a preliminary report

scientific article

New Article Type for JBJS Reviews

scientific article published on 01 March 2016

New technologies for the enhancement of skeletal repair.

scientific article published on March 2007

New technologies for the enhancement of skeletal repair: Challenges and opportunities ⬇️

scientific article published on November 1, 2011

On fluoride and bone strength

scientific article published on 01 May 1995

One of Nature's Best Kept Secrets ⬇️

scientific article published on January 1, 1998

Orthobiologics A Comprehensive Review of the Current Evidence and Use in Orthopedic Subspecialties

scientific article published on 01 December 2018

Orthopaedic war injuries: from combat casualty care to definitive treatment: a current review of clinical advances, basic science, and research opportunities

scientific article published on January 2008

Osteoarthritis and stem cell therapy in humans: a systematic review

scientific article published on 12 March 2018

Osteogenic effects of traumatic brain injury on experimental fracture-healing

scientific article published in April 2006

Osteoid osteoma of the thoracic spine: report of a case

scientific article published on 01 June 1980

Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors

scientific article published on 01 October 1998

Osteoporosis and diabetes: lessons from the diabetic BB rat.

scientific article published in January 1990

Osteotropic agents induce the differential secretion of granulocyte-macrophage colony-stimulating factor by the osteoblast cell line MC3T3-E1.

scientific article published on December 1989

Overview of osteoporosis: pathophysiology and determinants of bone strength

scientific article

Parathyroid hormone enhances fracture healing. A preliminary report

scientific article published on 01 September 1999

Persistence of dialysis osteomalacia despite treatment with 24R,25-dihydroxycholecalciferol

scientific article published on 01 January 1989

Polypeptide factors regulating osteogenesis and bone marrow repair

scientific article published on 01 July 1994

Poor citation of prior evidence in hip fracture trials

scientific article

Principles of a 3D printed mechanical device for total knee balancing

scientific article published on 09 September 2020

Problems with delayed and impaired fracture healing remain a challenge to the orthopedic trauma surgeon

scientific article published on 01 May 1997

Production of a standard closed fracture in laboratory animal bone

scientific article published on 01 January 1984

Programmed removal of chondrocytes during endochondral fracture healing

scientific article published on 01 January 1998

Progranulin promotes diabetic fracture healing in mice with type 1 diabetes

scientific article published on 18 August 2019

Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling

scientific article published on 11 February 2016

Qualitative and quantitative differences between bone graft obtained from the medullary canal (with a Reamer/Irrigator/Aspirator) and the iliac crest of the same patient.

scientific article

Re-engineering the tree of knowledge: orthopaedic research after the fall

scientific article published on 01 July 1996

Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial

scientific article published on 25 October 2016

Recognizing and preventing burnout among orthopaedic leaders

scientific article

Recombinant human bone morphogenetic proteins in the treatment of fractures

scientific article published in December 2005

Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts' consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO

scientific article published on 31 October 2018

Retroviral expression in mononuclear blood cells isolated from a patient with osteopetrosis (Albers-Schönberg disease)

scientific article published on 01 May 1990

Reuse of external fixation components: a randomized trial

scientific article published in February 2008

Revival of bone strength: the bottom line

scientific article published on 21 February 2005

Role of Fas and Treg cells in fracture healing as characterized in the fas-deficient (lpr) mouse model of lupus.

scientific article

Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.

scientific article published on 28 November 2011

Safety of simultaneous bilateral total knee arthroplasty. A meta-analysis

scientific article published in June 2007

Sampling error in diagnosing hyperparathyroid changes in bone in small needle biopsies

scientific article published on 01 February 1986

Selective and Nonselective Cyclooxygenase-2 Inhibitors and Experimental Fracture-Healing

scientific article published on 01 January 2007

Sharing our knowledge: the importance of international exchange of ideas in orthopaedic research.

scientific article

Significant advances have been made in the way surgeons treat fractures.

scientific article published in October 1998

Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells

scientific article

Spatial and temporal distribution of CD44 and osteopontin in fracture callus

scientific article published on 01 May 1999

Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing

scientific article published on 01 September 1997

Spatial and temporal gene expression in chondrogenesis during fracture healing and the effects of basic fibroblast growth factor

scientific article published on 01 September 2001

Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment

scientific article published on February 2008

Stimulation of systemic bone formation induced by experimental blood loss

scientific article

Structure-activity studies of the s-echistatin inhibition of bone resorption

scientific article published on September 1994

Studies on 24R,25-dihydroxyvitamin D3: evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus

scientific article published in August 1998

Systemic administration of PTH 1-84 for fracture repair: an exciting prospect: Commentary on an article by Peter Peichl, MD, et al.: "Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women"

scientific article published on 01 September 2011

TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.

scientific article published on July 2010

TNFα contributes to diabetes impaired angiogenesis in fracture healing.

scientific article published on 8 March 2017

Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures

scientific article published on 01 February 2010

The Role of Patient Education in Arthritis Management: The Utility of Technology

scientific article published on 14 August 2018

The Wnt signaling pathway as a potential target for therapies to enhance bone repair.

scientific article

The biology of fracture healing

scientific article

The cell and molecular biology of fracture healing

scientific article published on 01 October 1998

The clinical importance of meniscal tears demonstrated by magnetic resonance imaging in osteoarthritis of the knee

scientific article published on 01 January 2003

The expression of cytokine activity by fracture callus

scientific article published on August 1995

The mineral and mechanical properties of bone in chronic experimental diabetes

scientific article published on 01 January 1988

The prevalence and severity of burnout among academic orthopaedic departmental leaders

scientific article

The role of angiogenesis in a murine tibial model of distraction osteogenesis.

scientific article

The role of endogenous bone morphogenetic proteins in normal skeletal repair.

scientific article published in December 2009

The role of growth factors in the repair of bone. Biology and clinical applications.

scientific article

The science of fracture healing

scientific article published in November 2005

The structural properties of normal and osteoporotic bone

scientific article

The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation.

scientific article

The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head

scientific article published on 01 January 1998

The use of calcium phosphate bone cement in fracture treatment. A meta-analysis of randomized trials

scientific article published in June 2008

The validity of claims made in orthopaedic print advertisements

scientific article

The validity of measurements made on standard foot orthoroentgenograms

scientific article published in November 1992

Three-dimensional reconstruction of fracture callus morphogenesis.

scientific article published on 24 July 2006

Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture

scientific article published on 26 September 2019

Total hip arthroplasty after renal transplantation. Long-term follow-up study and assessment of metabolic bone status.

scientific article published on January 1988

Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes

scientific article

Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model

scientific article

Treatment of stage I and II osteonecrosis of the femoral head with core decompression and bone marrow aspirate concentrate injection—A 2-year follow-up study

scholarly article published in December 2017

Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study

scientific article

Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing.

scientific article published in February 2005

Tumor necrosis factor alpha activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors

scientific article published on 01 October 2003

Ultrasound assessment of bone

scientific article

Urine matrix metalloproteinases (MMPs) as biomarkers for the progression of fracture healing

scientific article

Use of bone morphogenetic proteins for musculoskeletal applications. An overview.

scientific article

Use of clinical assessment tools in the evaluation of fracture healing

scientific article published on 09 December 2010

Variability in the approach to total hip arthroplasty in patients with displaced femoral neck fractures

scientific article published on 19 August 2011

Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis

scientific article published on 25 February 2012

Vertebroplasty: an opportunity to do something really good for patients

scientific article published on 01 May 2000

Welcome to JBJS Reviews!

scientific article published on November 2013

What's New in Musculoskeletal Basic Science

scientific article published on 10 October 2019

What's New in Musculoskeletal Basic Science

scientific article published on 21 October 2020

Who did what? (Mis)perceptions about authors' contributions to scientific articles based on order of authorship

scientific article published on 01 August 2003

Paulina is supported by:

About Paulina

Help