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List of works by Kristen J. Brennand

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

scientific article published on 09 March 2020

A guide to generating and using hiPSC derived NPCs for the study of neurological diseases

scientific article

A new recipe for serotonergic neurons

article published in 2015

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition

scientific article published on 27 January 2020

A role for noncoding variation in schizophrenia

scientific article

ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs

scientific article published on 14 February 2020

All beta cells contribute equally to islet growth and maintenance

scientific article

Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients

scientific article published on 30 January 2015

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

scientific article published on 05 July 2016

Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease

scientific article

Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

scientific article published in Nature Communications

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines

scientific article published on July 2011

CRISPR-based functional evaluation of schizophrenia risk variants

scientific article published on 02 July 2019

Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1.

scientific article published on 17 November 2017

Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells.

scientific article published on June 2015

Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

scientific article published on 22 April 2022

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

scientific article published on 16 November 2018

Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection

scientific article published on 21 September 2020

Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia

scientific article

Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance.

scientific article published on 18 September 2007

Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development

scientific article published on 06 January 2020

Cracking the bell jar

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article

Detecting mutant huntingtin protein in HD patients

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

scientific article published on 28 October 2015

Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development

scientific article published on 21 August 2019

Dopaminergic differentiation of schizophrenia hiPSCs

scientific article published on 27 January 2015

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

scientific article published on 21 April 2016

Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

scientific article published in Nature

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

scientific article

Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

scientific article published on 02 August 2019

Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

scientific article published in Nature Communications

Functional annotation of rare structural variation in the human brain

scientific article published on 12 June 2020

Gene expression elucidates functional impact of polygenic risk for schizophrenia

scientific article published on 26 September 2016

High-efficient generation of induced pluripotent stem cells from human astrocytes

scientific article (publication date: 9 December 2010)

Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons

scientific article

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

scientific article

If there is not one cure for schizophrenia, there may be many

scientific article published on 20 April 2020

Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.

scientific article published on 20 October 2015

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

scientific article published on 09 August 2011

Inducing cellular aging: enabling neurodegeneration-in-a-dish

scientific article published on December 2013

Inheritance of fear and trauma

article by Kristen J. Brennand published 26 August 2015 in Science Translational Medicine

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

scientific article

Insights into the pharmacology of depression

scholarly article by Kristen J. Brennand published 7 October 2015 in Science Translational Medicine

Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems

scientific article published on 01 February 2020

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

scientific article

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

scientific article

MODELING PREDISPOSITION TO SZ USING HIPSCS

scientific article

Mapping regulatory variants in hiPSC models.

scientific article published in January 2018

Massively parallel techniques for cataloguing the regulome of the human brain

scientific article published on 16 November 2020

Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells.

scientific article published on 8 July 2014

Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells

scientific article

Modeling hippocampal neurogenesis using human pluripotent stem cells

scientific article published on 27 February 2014

Modeling predisposition to schizophrenia using hiPSCs

Modeling psychiatric disorders at the cellular and network levels

scientific article

Modeling psychiatric disorders through reprogramming

scientific article published on 4 October 2011

Modeling schizophrenia using induced pluripotent stem cell-derived and fibroblast-induced neurons

scientific article published on 19 November 2012

Modeling the complex genetic architectures of brain disease

scientific article published on 23 March 2020

Modelling schizophrenia using human induced pluripotent stem cells

scientific article

Mosaic copy number variation in human neurons

scientific article

Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells

Neural organoids for disease phenotyping, drug screening and developmental biology studies

scientific article published on 12 October 2016

Neural stem and progenitor cells in health and disease

scientific article published on 20 September 2013

Neuronal impact of patient-specific aberrant NRXN1α splicing

scientific article published on 29 November 2019

New considerations for hiPSC-based models of neuropsychiatric disorders

scientific article published on 26 February 2018

Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease

scientific article

Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics

scholarly article

Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity

scientific article published on 2 October 2017

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

scientific article

Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells

scientific article published on 25 November 2015

Rapid cellular turnover in adipose tissue

scientific article

Reprogramming of pancreatic beta cells into induced pluripotent stem cells

scientific article

Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.

scientific article

Slow and steady is the key to beta-cell replication

scientific article

Spatial genome exploration in the context of cognitive and neurological disease

scientific article published on 27 June 2019

Spatial genome organization and cognition

scientific article

Stem cells in gels

Synergistic effects of common schizophrenia risk variants

scientific article published on 23 September 2019

THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders

scientific article published on 25 April 2018

The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample

scientific article

The functional and evolutionary impacts of human-specific deletions in conserved elements ⬇️

Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism

scientific article published on 19 June 2020

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains.

scientific article published on 20 December 2017

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms

scientific article

What if it was easier to prevent schizophrenia than to treat it?

scientific article published on 13 February 2017

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