List of works - Jennifer E. Golden

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

scientific article

A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV

scientific article published on 10 May 2013

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

scientific article published on 01 November 2002

A Novel Compound, ML336, Inhibits VEEV Replication by Interfering with Viral RNA Synthesis

A Pan-GTPase Inhibitor as a Molecular Probe

scientific article

A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

scientific article

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

scientific article

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

scientific article

A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

A targeted delivery strategy for the development of potent trypanocides.

scientific article

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)

Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids

scientific article

Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production

scientific article published on 06 December 2019

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

scientific article published on 4 February 2013

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

scientific article published in March 2014

Combinatorial Chemistry and Multiple Parallel Synthesis

Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.

scientific article published on 18 March 2016

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

scientific article

Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9

scientific article published on 10 May 2013

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.

scientific article

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

scientific article published on 30 December 2019

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

scientific article

Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State

scientific article

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

scientific article

Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2

scientific article (publication date: June 2014)

Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process

scientific article published on 06 February 2020

Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses

scientific article published on 07 April 2019

Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depends on the Microenvironment

scientific article published on 02 September 2020

Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase

scientific article published on 25 April 2019

Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

scientific article (publication date: December 2016)

Evaluation of substituted ebselen derivatives as potential trypanocidal agents

scientific article

Facile C−N Cleavage in a Series of Bridged Lactams

scientific article published in 2005

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us

article by Paul A Wender et al published 29 December 2014 in Organic chemistry frontiers : an international journal of organic chemistry

High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity

scientific article

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening

scientific article

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity

scientific article

Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization

scientific article published on 10 May 2013

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

scientific article published in February 2012

Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase

scientific article

ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)

scientific article

ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel

scientific article published on 31 January 2014

Modulating N- versus O-arylation in pyrazolone-aryl halide couplings

Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity

scientific article

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

scientific article

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement

scientific article published on 6 April 2016

Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.

scientific article published on 4 November 2017

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

scientific article

Palladium-Catalyzed Cyclocarbonylation of Pyridinylated Vinylogous Amides and Ureas to Generate Ring-Fused Pyridopyrimidinones

scientific article published in 2018

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.

scientific article

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

article

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

scientific article published on 10 May 2013

Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2

scientific article published on 10 May 2013

Selective small molecule activator of the apoptotic arm of the UPR

scientific article published on 10 May 2013

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

article

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction

scientific article published on 09 April 2008

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

scientific article published on 13 December 2019

Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements

scientific article published on 01 March 2019

List of works by Jennifer E. Golden

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

A Novel Compound, ML336, Inhibits VEEV Replication by Interfering with Viral RNA Synthesis

A Pan-GTPase Inhibitor as a Molecular Probe

A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

A targeted delivery strategy for the development of potent trypanocides.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)

Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids

Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

Combinatorial Chemistry and Multiple Parallel Synthesis

Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2

Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process

Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses

Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depends on the Microenvironment

Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase

Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

Evaluation of substituted ebselen derivatives as potential trypanocidal agents

Facile C−N Cleavage in a Series of Bridged Lactams

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us

High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity

Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase

ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)

ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel

Modulating N- versus O-arylation in pyrazolone-aryl halide couplings

Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement

Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

Palladium-Catalyzed Cyclocarbonylation of Pyridinylated Vinylogous Amides and Ureas to Generate Ring-Fused Pyridopyrimidinones

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2

Selective small molecule activator of the apoptotic arm of the UPR

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements