List of works by Helen M. Lazear

A Mouse Model of Zika Virus Pathogenesis

scientific article

A Reverse Genetics Platform That Spans the Zika Virus Family Tree

scientific article (publication date: 7 March 2017)

Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

scientific article published on 03 December 2019

Antiviral Effector RTP4 Bats against Flaviviruses

scientific article published on 01 December 2020

Antiviral immunity backfires: Pathogenic effects of type I interferon signaling in fetal development

scientific article published in January 2018

Beta interferon controls West Nile virus infection and pathogenesis in mice

scientific article published on 4 May 2011

COVID-19 and emerging viral infections: The case for interferon lambda

scientific article published on 01 May 2020

Completely assembled virus particles detected by transmission electron microscopy in proximal and mid-axons of neurons infected with herpes simplex virus type 1, herpes simplex virus type 2 and pseudorabies virus

scientific article published on 30 October 2010

Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication

scientific article

Development of envelope protein antigens to serologically differentiate Zika from dengue virus infection

scientific article published on 20 December 2017

Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy

scientific article published on 26 August 2019

Envelope protein glycosylation mediates Zika virus pathogenesis

scientific article published on 29 May 2019

Flavivirus envelope protein glycosylation: impacts on viral infection and pathogenesis

scientific article published on 11 March 2020

Human antibody response to Zika targets type-specific quaternary structure epitopes

scholarly article by Matthew H Collins et al published 18 April 2019 in JCI insight

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection

scientific article published on 01 April 2020

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

scientific article

Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection

scientific article

Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection

scientific journal article

Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System

scientific article

Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity

scientific article

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

scientific article published on April 2015

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

scientific article (publication date: 21 July 2015)

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

scientific article published on 26 January 2014

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

scientific article (publication date: May 2017)

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

scientific article (publication date: 11 January 2017)

Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid

scientific article published on 28 November 2012

New insights into innate immune restriction of West Nile virus infection

scientific article

Oligomeric state of the ZIKV E protein defines protective immune responses

scientific article published on 10 October 2019

Oropouche virus infection and pathogenesis are restricted by MAVS, IRF-3, IRF-7, and type I interferon signaling pathways in nonmyeloid cells

scientific article

Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system

scientific article published on 21 August 2013

Propagation, quantification, detection, and storage of West Nile virus

scientific article published on 5 November 2013

Protective and Pathogenic Effects of Interferon Signaling During Pregnancy

scientific article published on 23 September 2019

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection

scientific article published on 30 January 2017

Selective Blockade of Interferon-α and -β Reveals Their Non-Redundant Functions in a Mouse Model of West Nile Virus Infection

scientific article published on 26 May 2015

Shared and Distinct Functions of Type I and Type III Interferons

scientific article published on 01 April 2019

The Emerging Zika Virus Epidemic in the Americas: Research Priorities

scientific article

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

scientific article

The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo

scientific article

The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response

scientific article published on 16 March 2011

Two genetic differences between closely-related Zika virus strains determine pathogenic outcome in mice

scientific article published on 12 August 2020

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

What to Expect When You’re Expecting Zika

scientific article (publication date: March 2017)

Why Is IFN-λ Less Inflammatory? One IRF Decides

scientific article published on 01 September 2019

Zika Virus Replicates in the Vagina of Mice with Intact Interferon Signaling

scientific article published in 2022

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

scientific article

Zika virus infection in Collaborative Cross mice

scientific article published on 08 July 2019

Zika virus — reigniting the TORCH

scientific article

Paulina is supported by:

About Paulina

Help