List of works - Dahai Luo

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

scientific article

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities

scientific article

Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats

scientific article published on 26 October 2020

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

scientific article

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

scientific article

Crystal structure of unlinked NS2B-NS3 protease from Zika virus

scientific article (publication date: 8 December 2016)

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

scientific article published on 01 January 2022

Defining the functional determinants for RNA surveillance by RIG-I

scientific article

Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing

scientific article published on 10 December 2012

Erratum for Vidaillac et al. "Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa"

scientific article published on 03 November 2020

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

scientific article

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

scientific article

Functional interplay among the flavivirus NS3 protease, helicase, and cofactors

scientific article published on 26 March 2014

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.

scientific article published on 24 December 2014

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

scientific article

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

scientific article published on 16 December 2020

LC-MS assay targeting the mycobacterial indirect aminoacylation pathway uncovers glutaminase activities of the non-discriminating aspartyl-synthetase

scientific article published on 12 April 2020

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

scientific article published on 14 April 2018

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

scientific article published on 4 April 2017

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

scientific article

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

scientific article published on 20 November 2017

RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity

scientific article published on 28 June 2019

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections.

scientific article

Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa

scientific article published on 29 September 2020

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors

scientific article published on 23 June 2017

Structural Insights into RNA Recognition by RIG-I

scientific article

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor

scientific article published on 21 February 2018

Structural characterization of the linked NS2B-NS3 protease of Zika virus

scientific article published on 04 July 2017

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

scientific article published on 18 April 2019

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

scientific article (publication date: 15 November 2016)

Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

scientific article (publication date: July 2006)

Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I

scientific article published on 19 August 2019

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

scholarly article by Wint Wint Phoo et al published 10 October 2018 in Antiviral Research

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

scholarly article by Wint Wint Phoo et al published December 2018 in Antiviral Research

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

scientific article

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

scientific article

The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

scientific article

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

scientific article published on 02 April 2015

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes

scientific article

The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus

scientific article

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors

scientific article published on 21 January 2014

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

scientific article published on 30 July 2008

Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.

scientific article published on January 2006

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

scientific article

Zika Virus Protease: An Antiviral Drug Target

scientific article published on 05 August 2017

List of works by Dahai Luo

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities

Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

Crystal structure of unlinked NS2B-NS3 protease from Zika virus

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Defining the functional determinants for RNA surveillance by RIG-I

Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing

Erratum for Vidaillac et al. "Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa"

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

Functional interplay among the flavivirus NS3 protease, helicase, and cofactors

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

LC-MS assay targeting the mycobacterial indirect aminoacylation pathway uncovers glutaminase activities of the non-discriminating aspartyl-synthetase

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections.

Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors

Structural Insights into RNA Recognition by RIG-I

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor

Structural characterization of the linked NS2B-NS3 protease of Zika virus

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes

The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

Zika Virus Protease: An Antiviral Drug Target