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List of works by James E. Crowe, Jr.

2593. Human Monoclonal Antibodies Potently Neutralize Enterovirus D68 in both a Clade-Specific and -Independent Manner

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses

scientific article

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV

scientific article

A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3.

scientific article published in January 2000

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

scientific article published on 01 August 2018

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

scientific article published on 01 May 2019

A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin

scientific article

A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase

scientific article

A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction

scientific article published on 11 February 2009

A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes

scientific article

A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV.

scientific article published in November 1993

A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles

scientific article published on 7 February 2012

A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice

scientific article published on 06 August 2020

A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees

scientific article published on July 1994

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

scientific article

A human antibody against Zika virus crosslinks the E protein to prevent infection

scientific article (publication date: 16 March 2017)

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

scientific article published on 01 May 2019

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.

scientific article published on 10 July 2018

A new quaternary structure epitope on dengue virus serotype 2 is the target of durable type-specific neutralizing antibodies

scientific article

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein

scientific article

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

scientific article

A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections

scientific article

A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions

scientific article published on 19 November 2018

A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo

scientific article

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

scientific article

A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis

scientific article

Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene

scientific article published in January 1996

Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication

scientific article published on 5 March 2011

Adverse events after smallpox immunizations are associated with alterations in systemic cytokine levels

scientific article published on 5 April 2004

Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia

scientific article

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

scientific article

An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats

scientific article published on 10 September 2008

An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies

scientific article

An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines

scientific article published on April 1994

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

scientific article published on 04 February 2020

Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface

scientific article published on 04 August 2020

Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

scientific article published on 19 October 2020

Antibody Determinants of Influenza Immunity

scientific article published on 01 April 2019

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site

scientific article

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors

scientific article published on 01 August 2018

Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA

scientific article published on 3 March 2014

Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors

scientific article published on 01 August 2018

Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine

scientific article published on 05 February 2019

Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells

scientific article

Application of semiconductor fluorescent nanocrystals as optical probes for rapid early viral detection

Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein

scientific article published on 30 July 2015

Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

scientific article published on 23 August 2018

B-Cell Development

article

Broad dengue neutralization in mosquitoes expressing an engineered antibody

scientific article published on 16 January 2020

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress

scientific article

Broadly Neutralizing Antibodies Targeting New Sites of Vulnerability in Hepatitis C Virus E1E2

scientific article published on 28 June 2019

Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection

scholarly article published by Pamela J. Bjorkman in 2018

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.

scientific article

Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

scientific article

CD154 regulates primate humoral immunity to influenza

scientific article published in June 2003

CD40-ligand in primate cardiac allograft and viral immunity

scientific article published in January 2001

Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis

scientific article

Cellular immune responses to diluted and undiluted aventis pasteur smallpox vaccine

scientific article published on 7 July 2006

Challenges and opportunities in developing respiratory syncytial virus therapeutics

scientific article

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells

scientific article

Characterization of recombinant yellow fever-dengue vaccine viruses with human monoclonal antibodies targeting key conformational epitopes

scientific article published on 26 April 2018

Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies

scientific article published on 27 January 2016

Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization

scientific article published on June 1995

Combining single RNA sensitive probes with subdiffraction-limited and live-cell imaging enables the characterization of virus dynamics in cells ⬇️

scientific article

Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head

scientific article published on October 2014

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

scientific article published on 10 September 2020

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

scientific article published on 08 June 2022

Computationally Designed Cyclic Peptides Derived from an Antibody Loop Increase Breadth of Binding for Influenza Variants

scientific article published on 11 May 2020

Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus

scientific article

Coronavirus infection and hospitalizations for acute respiratory illness in young children

scientific article published on May 2009

Correction: Broad dengue neutralization in mosquitoes expressing an engineered antibody

scientific article published on 29 April 2020

Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires

scientific article published on 24 January 2020

Corrigendum: Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

scientific article published in Nature

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections

scientific article

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

scientific article published on 20 January 2016

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

scientific article published on 20 December 2020

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

scientific article published on 17 April 2019

Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity

scientific article

Current Understanding of Humoral Immunity to Enterovirus D68

scientific article published on 01 December 2018

Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV). A meeting report of the WHO Programme for Vaccine Development

scientific article

Cytokine expression patterns associated with systemic adverse events following smallpox immunization

scientific article

DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

scientific article

Deciphering the human immunome

Deep sequencing and human antibody repertoire analysis

scientific article published on 08 April 2016

Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site

scientific article

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice

scientific article published on 5 February 2019

Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

scientific article published on 02 January 2014

Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera

scientific article

Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences

scientific article published on 6 July 2015

Detection of viral infections using colloidal quantum dots

Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6.

scientific article published on 11 July 2016

Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique

scientific article published on January 2016

Diagnostic errors in interpretation of pediatric musculoskeletal radiographs at common injury sites.

scientific article

Differential accessibility of a rotavirus VP6 epitope in trimers comprising type I, II, or III channels as revealed by binding of a human rotavirus VP6-specific antibody

scientific article published on 23 October 2013

Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization

scientific article published in March 2005

Discovering naturally processed antigenic determinants that confer protective T cell immunity

scientific article published on April 2013

Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions

scientific article published on 23 November 2020

Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis

scientific article published on 07 July 2020

E. coli production process yields stable dengue 1 virus-sized particles (VSPs)

scientific article published on 17 March 2020

Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection

scholarly article by Lauren E Williamson et al published 15 April 2019 in Journal of Virology

Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation

scientific article published on 27 January 2016

Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects

scientific article published in 2021

Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies

scholarly article by Philipp A Ilinykh et al published 22 November 2018 in Journal of Infectious Diseases

Effect of zinc salts on respiratory syncytial virus replication

scientific article published on March 2004

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

scholarly article by Pavlo Gilchuk et al published 22 November 2018 in Journal of Infectious Diseases

Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization

scientific article published on 18 November 2019

Emerging studies of human HIV-specific antibody repertoires

scientific article

Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1

scientific article published on 18 May 2016

Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope

scientific article published on 26 July 2008

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface.

scientific article published on 2 August 2017

Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence

scientific article

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

scientific article published on 03 March 2014

Evaluation of Two Live, Cold‐Passaged, Temperature‐Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children ⬇️

scientific article published on December 1, 1997

Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy

scientific article published on 22 September 2000

Evaporative cooling feature selection for genotypic data involving interactions

scientific article

Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells

scientific article published on 29 December 2006

Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region

scientific article published on 11 October 2006

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

scientific article published on 07 October 2020

Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein

scientific article published on 17 October 2003

Feature Selection using a Random Forests Classifier for the Integrated Analysis of Multiple Data Types

Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire

scientific article published in September 2012

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding

scientific article

Functional Maturation of the Human Antibody Response to Rotavirus

article

Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1.

scientific article published on 9 March 2016

Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles

scientific article

Genetic Predisposition for Adverse Events after Vaccination

article by James E. Crowe, Jr. published 15 July 2007 in Journal of Infectious Diseases

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

scientific article published on 21 September 2021

Genetic and structural determinants of virus neutralizing antibodies.

scientific article

Genetic basis for adverse events after smallpox vaccination

scientific article published on July 2008

Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years

scientific article published on 9 September 2009

Gold nanorod vaccine for respiratory syncytial virus

scientific article published on 25 June 2013

H7N9 influenza virus neutralizing antibodies that possess few somatic mutations

scientific article

HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design

scientific article published on 01 November 2018

High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

scientific article published on 01 July 2020

High frequency of shared clonotypes in human B cell receptor repertoires

scientific article published on 13 February 2019

High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals

scientific article published on 24 May 2012

Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells

scientific article published on January 2010

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

scientific article

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein

scientific article

Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses

scientific article published on 28 August 2018

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

scientific article published on 12 October 2021

Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

scientific article

Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

scientific article published on 22 October 2019

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

scientific article published on 01 July 2020

Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses

scientific article

Human antibodies that neutralize respiratory droplet transmissible H5N1influenza viruses.

scientific article published in November 2013

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.

scientific article published on 22 February 2018

Human germline antibody gene segments encode polyspecific antibodies

scientific article

Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site

scientific article published on 07 August 2020

Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms

scientific article published on 01 April 2019

Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children

scientific article published on January 2004

Human metapneumovirus as a major cause of human respiratory tract disease

scientific article

Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats

scientific article published on 18 October 2006

Human metapneumovirus infection in children hospitalized for wheezing

scientific article published on June 2005

Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

scientific article

Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation

scientific article published on November 2008

Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity ⬇️

scientific article published on November 1, 1992

Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease

scientific article published on 04 May 2020

Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics

scientific article published on 22 March 2013

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses

scientific article

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection

scientific article published on 28 December 2020

Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes

scientific article

Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS

scientific article

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires

scientific article published on 01 January 2020

Humoral Immunity to Hantavirus Infection ⬇️

scientific article published on 15 July 2020

Hybrid grammar-based approach to nonlinear dynamical system identification from biological time series

scientific article

Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring

scientific article published on 06 August 2020

Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein

scientific article published in April 2003

Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus

scientific article

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

scientific article

Identification of potential human respiratory syncytial virus and metapneumovirus T cell epitopes using computational prediction and MHC binding assays

scientific article

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis

scientific article

Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures

scientific article published on 04 December 2019

Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines ⬇️

scientific article published on August 1, 1998

Immunodominance of the VH1-46 Antibody Gene Segment in the Primary Repertoire of Human Rotavirus-Specific B Cells Is Reduced in the Memory Compartment through Somatic Mutation of Nondominant Clones

article

Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates

scientific article published on 6 January 2016

Immunology of viral respiratory tract infection in infancy

scientific article

Immunology. Crowdsourcing immunity

scientific article

Impact of new sequencing technologies on studies of the human B cell repertoire

scientific article published on 22 October 2013

Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints

scientific article

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

scientific article published on 01 November 2018

Inappropriate Citation of Vaccine Article

scientific article published on 03 June 2019

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth

scientific article published in PLoS ONE

Independent structural domains in paramyxovirus polymerase protein

scientific article published on 3 January 2012

Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires

scientific article published in November 2003

Influence of maternal antibodies on neonatal immunization against respiratory viruses.

scientific article

Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice

scientific article published on 19 November 2019

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

scientific article

Influenza Virus Resistance to Human Neutralizing Antibodies ⬇️

scientific article published on July 31, 2012

Influenza Virus-Specific Human Antibody Repertoire Studies

Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice.

scientific article

Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics

scientific article published on 03 August 2020

Integrated technology platform for accelerated discovery of antiviral antibody therapeutics

scientific article published on 15 May 2020

Integrating linear optimization with structural modeling to increase HIV neutralization breadth.

scientific article published on 16 February 2018

Intracellular neutralization of a virus using a cell-penetrating molecular transporter

scientific article published on 6 November 2013

Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection

scientific article published on 18 June 2020

Introduction

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Potential for a Universal Influenza Vaccine

scientific article published on 29 June 2017

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

scientific article published in July 2015

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

scientific article published in 2015

Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus

scientific article

Isolation of a Second Recombinant Human Respiratory Syncytial Virus Monoclonal Antibody Fragment (Fab RSVF2–5) that Exhibits Therapeutic Efficacy In Vivo ⬇️

scientific article published on April 1, 1998

Isolation of dengue virus-specific memory B cells with live virus antigen from human subjects following natural infection reveals the presence of diverse novel functional groups of antibody clones

scientific article

Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates

scientific article published in April 1996

Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity

scientific article published on 21 June 2012

Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization

scientific article published on 4 April 2016

Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells

scientific article

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations

scientific article published on 31 December 2015

Machine learning competition in immunology - Prediction of HLA class I binding peptides.

scientific article published on 29 September 2011

Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to DENV4 Infection and Vaccination

scientific article (publication date: 28 December 2016)

Maturation-induced cloaking of neutralization epitopes on HIV-1 particles

scientific article

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody

scientific article published on 21 November 2018

Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge

scientific article published on 01 February 2020

Mechanism of human antibody-mediated neutralization of Marburg virus

scientific article

Molecular mechanisms driving respiratory syncytial virus assembly

scientific article published on January 2013

Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action

scientific article

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein

scientific article published on December 1998

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.

scientific article

Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells

scientific article published on 04 October 2019

Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

scientific article published on 31 May 2018

Multi-state design of flexible proteins predicts sequences optimal for conformational change

scientific article published on 07 February 2020

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

scientific article published on 21 August 2018

Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mxra8 is a receptor for multiple arthritogenic alphaviruses

scientific article published in Nature

Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes

scientific article published in June 2005

Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses.

scientific article

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.

scientific article

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

scientific article published on 7 November 2016

New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications

scientific article published on 07 February 2019

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

scientific article published on 08 April 2020

Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate

scientific article published in November 1996

Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors

scientific article published on 13 August 2018

Paramyxoviruses: Respiratory Syncytial Virus and Human Metapneumovirus

Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus

scientific article published in October 1999

Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines

scientific article

Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence

scientific article published on 20 July 2016

Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection

scientific article published on 14 December 2011

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases

scientific article

Plasma deconvolution identifies broadly neutralizing antibodies associated with hepatitis C virus clearance

scientific article published on 13 August 2019

Pneumocystis carinii pneumonia in a girl with a midbrain glioma

scientific article

Population-based incidence of human metapneumovirus infection among hospitalized children

scientific article

Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine

scholarly article by Wen-Yang Tsai et al published 1 December 2018 in Journal of Virology

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

scientific article published on 04 February 2019

Potently neutralizing and protective human antibodies against SARS-CoV-2

scientific article published on 15 July 2020

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

scientific article published on 22 May 2020

Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity

scientific article published on 19 January 2012

Prevalence of Reovirus‐Specific Antibodies in Young Children in Nashville, Tennessee

article

Prevention of Fetal and Early Life Infections Through Maternal–Neonatal Immunization

Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design

scientific article published on August 2017

Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans

scientific article published on 4 October 2017

Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes

scientific article

Proof of principle for epitope-focused vaccine design

scientific article

Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model

scientific article published on 08 February 2013

Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies

scientific article

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

scientific article published on 19 November 2018

Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses

scientific article

Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV.

scientific article published on July 2010

PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST

scientific article published on 16 July 2020

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

scientific article published on 14 May 2020

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

scientific article published on 10 July 2020

Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches

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Viral Pneumonia

Viral Pneumonia

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