List of works - Hemi Malkki

Alzheimer disease: APOE*ε4-associated increase in AD risk linked to phospholipid dysregulation

scientific article

Alzheimer disease: BACE1 inhibition could block CSF tau increase

scientific article published on 3 November 2016

Alzheimer disease: Cancer immunotherapy drug reduces symptoms of Alzheimer disease in mice

scientific article published on 29 January 2016

Alzheimer disease: Effects of the APOE ε4 allele on brain development

scientific article published on 10 December 2013

Alzheimer disease: NGF gene therapy activates neurons in the AD patient brain

scientific article

Alzheimer disease: NSAIDs protect neurons and preserve memory in a mouse model of AD.

scientific article published on 3 June 2016

Alzheimer disease: Sleep alleviates AD-related neuropathological processes

scientific article published on 12 November 2013

Alzheimer disease: The involvement of TREM2 R47H variant in Alzheimer disease confirmed, but mechanisms remain elusive

scientific article

Alzheimer disease: Variations in mitochondrial DNA predict AD-related brain atrophy

scientific article published in October 2013

Alzheimer disease: chaperone protein clusterin is involved in amyloid-β-associated entorhinal atrophy in early AD.

scientific article

Alzheimer disease: increased orexin level correlates with sleep disruption and cognitive decline in Alzheimer disease

scientific article published on 28 October 2014

Alzheimer disease: possible prion-like transmission of AD-like pathology in humans

scientific article

An inexpensive Arduino-based LED stimulator system for vision research

scientific article

Appetitive operant conditioning in mice: heritability and dissociability of training stages

scientific article published on 4 November 2010

Beyond seizure control — vocational outcomes after paediatric epilepsy surgery

article published in 2016

Blood-based biomarkers provide insight into progressive MS

Brain transcriptome profiling reveals involvement of divergent pathways in C9orf72-associated and sporadic ALS

C9orf72 repeat expansion linked to aggressive disease in male patients with spinal-onset ALS

CNS cancer: Astrocytoma cells interconnect to resist radiotherapy

scientific article published on 24 November 2015

CNS infections: Mouse studies confirm the link between Zika virus infection and microcephaly

scientific article

CNS infections: Zika virus infection could trigger Guillain–Barré syndrome

scientific article

Cerebrovascular disease: Subclinical cerebrovascular disease can impede learning

scientific article

Cerebrovascular disorders: Cerebral microbleeds linked to increased risk of cognitive decline.

scientific article

Cerebrovascular disorders: Exercise alleviates vascular cognitive impairment.

scientific article

Chronic migraine linked to reduced antioxidant capacity

article by Hemi Malkki published 21 July 2015 in Nature Reviews Neurology

Coagulation factors could mediate neuroinflammation in multiple sclerosis

Correction: Improved diagnostic sensitivity can aid the correct choice of treatment for patients with myasthenia gravis

Could simvastatin slow down secondary progressive MS?

Could young blood combat age-related cognitive decline?

Declining dementia incidence in the UK

scholarly article by Hemi Malkki published 29 April 2016 in Nature Reviews Neurology

Dehydration might contribute to fatigue in MS

article

Does low vitamin D level during pregnancy increase the risk of MS?

Early treatment could prevent genetic epilepsy in mice

Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep.

scientific article published on 30 March 2016

Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development

scientific journal article

Epilepsy—burning questions and emerging therapies

article published in 2014

Genetics: RNA topoisomerase involved in neurodevelopmental disorders

scientific article published on 10 September 2013

Gut microbiota influence stroke recovery in mice

article published in 2016

High-calorie diet might delay amyotrophic lateral sclerosis

Huntington disease: New study challenges the hypothesis of glutamate transporter dysfunction in Huntington disease

scientific article published on 22 April 2016

Improved diagnostic sensitivity can aid the correct choice of treatment for patients with myasthenia gravis

Insulin resistance could be linked to risk of AD via reduced glucose uptake

scholarly article by Hemi Malkki published 11 August 2015 in Nature Reviews Neurology

Long-term outcomes in childhood low-grade glioma

MET fusion genes implicated as treatment target in paediatric glioblastoma

article

Metabolic syndrome in young adults with epilepsy

Migraine in midlife could be connected to increased risk of late-life parkinsonism

scholarly article by Hemi Malkki published 30 September 2014 in Nature Reviews Neurology

Migraine. Long screen time exposure could increase the risk of migraine

scientific article

Motor Neuron Disease: New insights into genetic risk factors for amyotrophic lateral sclerosis.

scientific article

Motor neuron disease: Multifocal initiation and local propagation model of ALS.

scientific article published on 8 October 2013

Movement disorders: Novel genetic risk variants for essential tremor

scientific article published on 4 November 2016

Multiple sclerosis: Biomarkers predict conversion from clinically isolated syndrome to multiple sclerosis

Multiple sclerosis: Spinal cord grey matter loss correlates with disability in MS.

scientific article

Multiple sclerosis: Worrying data on excess mortality and comorbidity in MS.

scientific article

Multiple sclerosis: neuroimaging provides insights into cognitive dysfunction in MS.

scientific article published on 10 February 2015

Neuro-oncology: Astrocytoma cells interconnect to resist radiotherapy

scientific article published on 20 November 2015

Neuro-oncology: Bevacizumab prolongs progression-free survival but not overall survival in newly diagnosed glioblastoma.

scientific article

Neuro-oncology: Exercise could help to counteract radiation damage in children with brain tumours

scientific article published on 2 September 2016

Neuro-oncology: Mice vaccinated against tumour recurrence.

scientific article

Neuro-oncology: Novel biomarkers for high-grade astrocytoma.

scientific article

Neuro-oncology: Proteomic profiling could facilitate glioblastoma diagnosis

scientific article published on 5 August 2014

Neuro-oncology: TERT promoter mutations could indicate poor prognosis in glioblastoma

scientific article published on 9 September 2014

Neurodegenerative disease: Synaptic scaffolding protein neuroligin 1 links amyloid deposition, neuroinflammation and impaired memory

scientific article published on 4 February 2014

Neurodegenerative disorders: Novel CSF assay for α-synucleinopathies.

scientific article

Neurodevelopmental disorders. Altered epigenetic regulation in early development associated with schizophrenia

scientific article published on 18 December 2015

Neurodevelopmental disorders: Deep brain stimulation alleviates hippocampal memory deficit in a mouse model of Rett syndrome

scientific article published on 3 November 2015

Neurodevelopmental disorders: Elevated fetal sex steroids might confer risk for autism

scientific article published on 17 June 2014

Neurodevelopmental disorders: Fetal exposure to antiepileptic drugs could affect brain activity in newborns

scientific article published on 18 January 2016

Neurodevelopmental disorders: Impaired immune system function linked to social behaviour deficits in mice

scientific article published on 22 July 2016

Neurodevelopmental disorders: Maternal antibodies induce autism-like phenotype in mice

scientific article published on 21 October 2016

Neurodevelopmental disorders: human gut microbiota alleviate behavioural symptoms in a mouse model of autism spectrum disorder

scientific article

Neuroimmunology: Aquaporin-4-antibody-seronegative neuromyelitis optica is less common than previously thought

scientific article published on 17 September 2013

Neuromuscular disease: Mitochondrial dysfunction could precipitate motor neuron loss in spinal muscular atrophy.

scientific article

New study puts its FINGER on prevention of cognitive decline

Novel developments in

scientific article published on 19 November 2018

Novel markers for disease severity in neuromyelitis optica

Parkinson disease: Nonmotor symptoms predict quality of life in patients with early Parkinson disease

scientific article

Parkinson disease: deep brain stimulation might alleviate parkinsonism by reducing excessive synchronization in primary motor cortex

scientific article published on 21 April 2015

Retinal changes could be an early marker of PD

Sleep: Amyloid-β accumulation impairs memory by disrupting deep sleep--but could the vicious cycle be stopped?

scientific article published on 9 June 2015

Stroke: alcohol consumption does not seem to protect against stroke

scientific article published on 13 October 2015

Texture Segregation Causes Early Figure Enhancement and Later Ground Suppression in Areas V1 and V4 of Visual Cortex

scientific article published on 13 August 2016

Towards mouse models of perseveration: a heritable component in extinction of operant behavior in fourteen standard and recombinant inbred mouse lines

scientific article published on 23 May 2011

Traumatic brain injury: Impaired medical decision-making capacity in TBI.

scientific article published on 2 September 2016

Traumatic brain injury: PET imaging detects amyloid deposits after TBI.

scientific article published on 3 December 2013

Traumatic brain injury: TBI could have long-term effects on sleep-wake cycle

scientific article published on 13 May 2016

Trial Watch: Glioblastoma vaccine therapy disappointment in Phase III trial

scientific article

Unmuting Ube3a in mice alleviates Angelman syndrome

Vascular comorbidities linked with early-onset dementia

scholarly article by Hemi Malkki published 2 December 2014 in Nature Reviews Neurology

List of works by Hemi Malkki

Alzheimer disease: APOE*ε4-associated increase in AD risk linked to phospholipid dysregulation

Alzheimer disease: BACE1 inhibition could block CSF tau increase

Alzheimer disease: Cancer immunotherapy drug reduces symptoms of Alzheimer disease in mice

Alzheimer disease: Effects of the APOE ε4 allele on brain development

Alzheimer disease: NGF gene therapy activates neurons in the AD patient brain

Alzheimer disease: NSAIDs protect neurons and preserve memory in a mouse model of AD.

Alzheimer disease: Sleep alleviates AD-related neuropathological processes

Alzheimer disease: The involvement of TREM2 R47H variant in Alzheimer disease confirmed, but mechanisms remain elusive

Alzheimer disease: Variations in mitochondrial DNA predict AD-related brain atrophy

Alzheimer disease: chaperone protein clusterin is involved in amyloid-β-associated entorhinal atrophy in early AD.

Alzheimer disease: increased orexin level correlates with sleep disruption and cognitive decline in Alzheimer disease

Alzheimer disease: possible prion-like transmission of AD-like pathology in humans

An inexpensive Arduino-based LED stimulator system for vision research

Appetitive operant conditioning in mice: heritability and dissociability of training stages

Beyond seizure control — vocational outcomes after paediatric epilepsy surgery

Blood-based biomarkers provide insight into progressive MS

Brain transcriptome profiling reveals involvement of divergent pathways in C9orf72-associated and sporadic ALS

C9orf72 repeat expansion linked to aggressive disease in male patients with spinal-onset ALS

CNS cancer: Astrocytoma cells interconnect to resist radiotherapy

CNS infections: Mouse studies confirm the link between Zika virus infection and microcephaly

CNS infections: Zika virus infection could trigger Guillain–Barré syndrome

Cerebrovascular disease: Subclinical cerebrovascular disease can impede learning

Cerebrovascular disorders: Cerebral microbleeds linked to increased risk of cognitive decline.

Cerebrovascular disorders: Exercise alleviates vascular cognitive impairment.

Chronic migraine linked to reduced antioxidant capacity

Coagulation factors could mediate neuroinflammation in multiple sclerosis

Correction: Improved diagnostic sensitivity can aid the correct choice of treatment for patients with myasthenia gravis

Could simvastatin slow down secondary progressive MS?

Could young blood combat age-related cognitive decline?

Declining dementia incidence in the UK

Dehydration might contribute to fatigue in MS

Does low vitamin D level during pregnancy increase the risk of MS?

Early treatment could prevent genetic epilepsy in mice

Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep.

Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development

Epilepsy—burning questions and emerging therapies

Genetics: RNA topoisomerase involved in neurodevelopmental disorders

Gut microbiota influence stroke recovery in mice

High-calorie diet might delay amyotrophic lateral sclerosis

Huntington disease: New study challenges the hypothesis of glutamate transporter dysfunction in Huntington disease

Improved diagnostic sensitivity can aid the correct choice of treatment for patients with myasthenia gravis

Insulin resistance could be linked to risk of AD via reduced glucose uptake

Long-term outcomes in childhood low-grade glioma

MET fusion genes implicated as treatment target in paediatric glioblastoma

Metabolic syndrome in young adults with epilepsy

Migraine in midlife could be connected to increased risk of late-life parkinsonism

Migraine. Long screen time exposure could increase the risk of migraine

Motor Neuron Disease: New insights into genetic risk factors for amyotrophic lateral sclerosis.

Motor neuron disease: Multifocal initiation and local propagation model of ALS.

Movement disorders: Novel genetic risk variants for essential tremor

Multiple sclerosis: Biomarkers predict conversion from clinically isolated syndrome to multiple sclerosis

Multiple sclerosis: Spinal cord grey matter loss correlates with disability in MS.

Multiple sclerosis: Worrying data on excess mortality and comorbidity in MS.

Multiple sclerosis: neuroimaging provides insights into cognitive dysfunction in MS.

Neuro-oncology: Astrocytoma cells interconnect to resist radiotherapy

Neuro-oncology: Bevacizumab prolongs progression-free survival but not overall survival in newly diagnosed glioblastoma.

Neuro-oncology: Exercise could help to counteract radiation damage in children with brain tumours

Neuro-oncology: Mice vaccinated against tumour recurrence.

Neuro-oncology: Novel biomarkers for high-grade astrocytoma.

Neuro-oncology: Proteomic profiling could facilitate glioblastoma diagnosis

Neuro-oncology: TERT promoter mutations could indicate poor prognosis in glioblastoma

Neurodegenerative disease: Synaptic scaffolding protein neuroligin 1 links amyloid deposition, neuroinflammation and impaired memory

Neurodegenerative disorders: Novel CSF assay for α-synucleinopathies.

Neurodevelopmental disorders. Altered epigenetic regulation in early development associated with schizophrenia

Neurodevelopmental disorders: Deep brain stimulation alleviates hippocampal memory deficit in a mouse model of Rett syndrome

Neurodevelopmental disorders: Elevated fetal sex steroids might confer risk for autism

Neurodevelopmental disorders: Fetal exposure to antiepileptic drugs could affect brain activity in newborns

Neurodevelopmental disorders: Impaired immune system function linked to social behaviour deficits in mice

Neurodevelopmental disorders: Maternal antibodies induce autism-like phenotype in mice

Neurodevelopmental disorders: human gut microbiota alleviate behavioural symptoms in a mouse model of autism spectrum disorder

Neuroimmunology: Aquaporin-4-antibody-seronegative neuromyelitis optica is less common than previously thought

Neuromuscular disease: Mitochondrial dysfunction could precipitate motor neuron loss in spinal muscular atrophy.

New study puts its FINGER on prevention of cognitive decline

Novel developments in

Novel markers for disease severity in neuromyelitis optica

Parkinson disease: Nonmotor symptoms predict quality of life in patients with early Parkinson disease

Parkinson disease: deep brain stimulation might alleviate parkinsonism by reducing excessive synchronization in primary motor cortex

Retinal changes could be an early marker of PD

Sleep: Amyloid-β accumulation impairs memory by disrupting deep sleep--but could the vicious cycle be stopped?