Search filters

List of works by Jair Siqueira-Neto

4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

scientific article

A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani

scientific article published on 26 November 2022

An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi

scientific article (publication date: 2014)

An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages

scientific article (publication date: 2012)

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds

scientific article

Antimalarial drug discovery: progress and approaches

scientific article published on 31 August 2023

Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle

scientific article (publication date: 2008)

Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.

scientific article

Current and Future Chemotherapy for Chagas Disease

scientific article published on 19 October 2015

Cysteine proteases in protozoan parasites

scholarly article by Jair Siqueira-Neto et al published 1 August 2018 in PLoS Neglected Tropical Diseases

Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi.

scientific article published on 20 July 2016

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

scientific article published on 13 June 2022

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease

scientific article

Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei

scientific article

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

scientific article published on 13 August 2015

Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi

scientific article published on 06 October 2020

Identification of Leucinostatins from <i>Ophiocordyceps</i> sp. as Antiparasitic Agents against <i>Trypanosoma cruzi</i>

scientific article published on 28 January 2022

LaRbp38: a Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs.

scientific article

Lead identification to clinical candidate selection: drugs for Chagas disease

scientific article

Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis

scientific article

Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

scientific article published on 24 September 2020

Molecular dissection of chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

scientific article published on 20 May 2020

Open drug discovery for the Zika virus

scientific article

Pirfenidone Prevents Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

scientific article published on 3 July 2024

Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window

scientific article

RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain.

scientific article

Shedding Light on Synergistic Chemical Genetic Connections with Machine Learning.

scientific article published on 23 December 2015

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease

scientific article published on 04 October 2021

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

scientific article

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase

scientific article

The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres

scientific article

Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

scientific article published on 28 January 2012

Paulina is supported by:

About Paulina

Help