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List of works by Manfred Uhr

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

scientific article published on September 2009

A mega-analysis of genome-wide association studies for major depressive disorder

scientific article

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice

scientific article published on 28 April 2014

ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response

scientific article published on August 2006

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

scientific article published on November 2003

ABCB1 genotyping in the treatment of depression

scientific article published on 5 December 2016

Acute antidepressive efficacy of lithium monotherapy, not citalopram, depends on recurrent course of depression

scientific article

Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression

scientific article published on 28 January 2008

Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression

scientific article

Affective set-shifting deficits in patients with major depression in remission

scientific article published on 2 October 2012

Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress

scientific article published in March 2007

Alcohol administration attenuates hypothalamic-pituitary-adrenal (HPA) activity in healthy men at low genetic risk for alcoholism, but not in high-risk subjects ⬇️

scientific article published on January 19, 2012

Analyzing pathways from childhood maltreatment to internalizing symptoms and disorders in children and adolescents (AMIS): a study protocol

scientific article published on 10 June 2015

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

scientific article

Association between response to lithium augmentation and the combined DEX/CRH test in major depressive disorder

scientific article published on March 2003

Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study

scientific article published on 24 November 2015

Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans

scientific article (publication date: November 2014)

Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients

scientific article published on February 2010

Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders

scientific article

Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls

scientific article published on 4 January 2006

Cerebrospinal Fluid Biomarkers for Major Depression Confirm Relevance of Associated Pathophysiology ⬇️

scientific article published on December 14, 2011

Cerebrospinal fluid analyses for the diagnosis of subarachnoid haemorrhage and experience from a Swedish study. What method is preferable when diagnosing a subarachnoid haemorrhage?

scientific article

Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment

scientific article

Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine

scientific article published in April 2006

Childhood abuse and depression in adulthood: The mediating role of allostatic load

Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project

scientific article published on 30 June 2008

Combined Dexamethasone/Corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression–A Potential Biomarker?

scientific article published on 21 November 2006

Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017).

scientific article

Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity

scientific article published on 28 December 2017

Dexamethasone stimulated gene expression in peripheral blood indicates glucocorticoid-receptor hypersensitivity in job-related exhaustion

scientific article published on 3 March 2014

Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients

scientific article

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption ⬇️

scientific article published on October 15, 2003

Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers

scientific article published in June 2004

Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men

scholarly article by Johannes M Hennings et al published 10 January 2019 in JCI insight

Effect of psychosocial stress on FKBP5 and NR3C1 gene expression in healthy young men

article

Effects of Hypericum extract (LI160) on the change of auditory evoked potentials by cortisol administration

scientific article

Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression

scientific article published in March 2011

Endocrine rhythms in patients with restless legs syndrome

scientific article published in February 2002

Erratum: Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

article

Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers

scientific article published on 25 February 2009

Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression

scientific article published on 5 March 2004

Evaluation of the comparability of commercial ghrelin assays

scientific article published on 01 February 2004

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

scientific journal article

Evidence for a normal HPA axis response to psychosocial stress in patients remitted from depression

scientific article published on 8 August 2013

FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression

article

FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls

scientific article

FKBP5 polymorphisms moderate the influence of adverse life events on the risk of anxiety and depressive disorders in preschool children

scientific article published on 23 October 2015

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis

scientific article published in February 2005

Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response

scientific article

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

scientific article published in June 2015

Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks

scientific article published on January 2011

Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation

scientific article published in July 2008

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

Ghrelin Suppresses Secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) in Women ⬇️

scientific article published on January 18, 2012

Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma

scientific article published on 27 April 2010

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

scientific article

Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep

scientific article published in September 2007

Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women

scientific article published on 3 August 2009

Ghrelin levels increase after pictures showing food

scientific article published on 12 January 2012

Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls

scientific article

Ghrelin suppresses nocturnal secretion of luteinizing hormone (LH) and thyroid stimulating hormone (TSH) in patients with major depression

scientific article published on 29 May 2013

Glyoxalase-I mRNA expression and CCK-4 induced panic attacks

scientific article

Hair cortisol in maltreated children and adolescents: Importance of developmental period and maltreatment characteristics

scholarly article by Tobias Stalder et al published September 2016 in Psychoneuroendocrinology

Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers

scientific article

High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response

scientific article

Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice

scientific article published on January 2004

IGF-I in major depression and antidepressant treatment response

scientific article published on 5 January 2015

Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

scientific article

Impact of citalopram on the HPA system. A study of the combined DEX/CRH test in 30 unipolar depressed patients ⬇️

scientific article published on October 26, 2011

Impact on cortisol and antidepressant efficacy of quetiapine and escitalopram in depression

scientific article published on 23 October 2013

Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style

scientific article published on 27 September 2014

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study

scientific article published on 24 August 2011

Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

scientific article published on 10 December 2012

Lithium Monotherapy Increases ACTH and Cortisol Response in the Dex/CRH Test in Unipolar Depressed Subjects. A Study with 30 Treatment-Naive Patients ⬇️

scientific article published on November 23, 2011

Lithium augmentation increases post-dexamethasone cortisol in the dexamethasone suppression test in unipolar major depression

scientific article

Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression

scientific article published in September 2002

Long-term outcome after lithium augmentation in unipolar depression: focus on HPA system activity

scientific article published on 14 August 2009

Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity

scientific article published on March 2002

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: A translational approach

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach

scientific article published on 23 July 2014

Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations

scientific article

Nocturnal ghrelin levels--relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol--and gender differences

scientific article published in December 2005

Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial

scientific article published on 26 November 2008

P-glycoprotein has negligible effects on estradiol and testosterone in mice

scientific article published on 17 October 2007

P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.

scientific article published in December 2004

P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline

scientific article published in March 2004

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

scientific article published on 5 July 2006

PTSD psychotherapy improves blood pressure but leaves HPA axis feedback sensitivity stable and unaffected: First evidence from a pre-post treatment study

scientific article published on 22 October 2018

Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice

scientific article published on 3 July 2010

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

scientific article

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

scientific article published in July 2008

Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients

scientific article published on January 2009

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

scientific article

Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder

scientific article

Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder

scientific article

Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach

scientific article

Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters

scientific article published on 01 December 2005

Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters

scientific article published on 17 August 2013

Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans

scientific article published on 12 October 2016

Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence

scientific article published on 28 February 2017

Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.

scientific article published on 25 July 2002

Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder

scientific article published on 12 July 2006

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

scientific article published on 13 January 2016

Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels

scientific article

Selective inhibitors of the FK506-binding protein 51 by induced fit

scientific article

Sex-related differential response to dexamethasone in endocrine and immune measures in depressed in-patients and healthy controls

scientific article published on 3 January 2018

Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol

scientific article published on 29 January 2010

Sleep enhances nocturnal plasma ghrelin levels in healthy subjects.

scientific article published on 10 February 2004

Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans

scientific article published on 12 August 2002

Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis

scientific article published on 20 September 2006

Successful treatment of chronic fatigue syndrome with duloxetine and trijodthyronine--a case study

scientific article

Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action

scientific article

TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>.

scientific article published in March 2018

The Clinical Impact of ABCB1 Polymorphisms on the Treatment of Psychiatric Diseases ⬇️

scientific article published on January 1, 2011

The Role of mA/m-RNA Methylation in Stress Response Regulation

article published in 2018

The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior

scientific article published on 13 July 2015

The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice

scientific article published on 26 April 2005

The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior

scientific article published in January 2014

The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study

scientific article published on 23 July 2013

The effect of treatment with ketoconazole on central CRH systems of depressed patients ⬇️

scientific article published on January 1, 2011

The influence of Hatha yoga as an add-on treatment in major depression on hypothalamic-pituitary-adrenal-axis activity: a randomized trial

scientific article published on 11 March 2014

The neuronal transporter gene SLC6A15 confers risk to major depression

scientific article

Time-dependent effects of dexamethasone plasma concentrations on glucocorticoid receptor challenge tests

scientific article published on 14 April 2016

Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects ⬇️

scientific article published on November 1, 2003

Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression

scientific article published in March 2005

Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes

scientific article published on 18 November 2009

Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome

scientific article

Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results

scientific article

[Erratum to: Therapeutic drug monitoring in neuropsychopharmacology : Summary of the consensus guidelines 2017 of the TDM task force of the AGNP]

scientific article published on 01 September 2019

[Therapeutic drug monitoring in neuropsychopharmacology : Summary of the consensus guidelines 2017 of the TDM task force of the AGNP]

scientific article published on 01 May 2019

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

scientific article published in May 2003

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