List of works - Adrien Six

A TCRβ Repertoire Signature Can Predict Experimental Cerebral Malaria

scientific article published on 4 February 2016

A conserved sequence in the mouse variable T cell receptor alpha recombination signal sequence 23-bp spacer can affect recombination.

scientific article published on August 2004

A novel strategy for molecular signature discovery based on independent component analysis.

scientific article

A profound alteration of blood TCRB repertoire allows prediction of cerebral malaria

scientific article published in October 2004

A unique CD8(+) T lymphocyte signature in pediatric type 1 diabetes.

scientific article published on 15 June 2016

Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients.

scientific article published on 23 November 2011

Behçet's disease physiopathology: a contemporary review

scientific article published on 12 February 2016

Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells

scientific article

Characterization of avian T-cell receptor gamma genes

scientific article published on December 1996

Clinical grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene: authors' reponse.

scientific article

Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene

scientific article published in August 2008

Contrasted TCRβ diversity of CD8+ and CD8- T cells in rainbow trout

scientific article

Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells.

scientific article published in October 2009

Diversity, molecular characterization and expression of T cell receptor γ in a teleost fish, the sea bass (Dicentrarchus labrax, L).

scientific article

Dynamical and Mechanistic Reconstructive Approaches of T Lymphocyte Dynamics: Using Visual Modeling Languages to Bridge the Gap between Immunologists, Theoreticians, and Programmers

scientific article published on October 2013

Early Transcriptome Signatures from Immunized Mouse Dendritic Cells Predict Late Vaccine-Induced T-Cell Responses

scientific article

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection

scientific article

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.

scientific article published on August 2014

GeVaDSs - decision support system for novel Genetic Vaccine development process

scientific article

Genetic structure of a wide-spectrum chicken gene pool

scientific article published on 3 June 2009

Germline genomic structure of the B10.A mouse Tcra-V2 gene subfamily

scientific article published in January 1996

HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

scientific article published on 26 October 2015

Half of the T-cell repertoire combinatorial diversity is genetically determined in humans and humanized mice.

scientific article published on 20 December 2011

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

ISEApeaks: an Excel platform for GeneScan and Immunoscope data retrieval, management and analysis.

scientific article

Identification of an endogenous mammary tumor virus involved in the clonal deletion of V beta 2 T cells.

scientific article published on November 1993

Immune Repertoire Diversity

Immunomonitoring

Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis

article

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

scientific article published on 26 January 2015

Lymphocyte Labeling, Cell Division Investigation

Lymphocyte Population Kinetics

Marginal zone B cell enrichment and strong follicular B cell reduction correlate with a delayed IgG response in a light chain diversity restricted mouse model.

scientific article published in October 2004

Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.

scientific article published in September 2009

Mechanisms of the natural reactivity of lymphocytes from noninfected individuals to membrane-associated Leishmania infantum antigens.

scientific article

Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice.

scientific article published on 28 July 2015

Modeling Formalisms, Lymphocyte Dynamics and Repertoires

New methods and software tools for high throughput CDR3 spectratyping. Application to T lymphocyte repertoire modifications during experimental malaria.

scientific article published in July 2003

New perspectives for large-scale repertoire analysis of immune receptors

scientific article published on 14 February 2008

Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves

scientific article

Organism State, Lymphocyte

Phenotypic and functional similarity of gut intraepithelial and systemic T cells in a teleost fish

scientific article published on 01 April 2006

Preserving the B-cell compartment favors operational tolerance in human renal transplantation ⬇️

scientific article

Refitting Harel Statecharts for Systemic Mathematical Models in Computational Immunology

Regulatory CD4+ CD25+ Foxp3+ T cells expand during experimental Plasmodium infection but do not prevent cerebral malaria.

scientific article published on 19 January 2007

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

scientific article published in December 2011

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation

scientific article published on 17 October 2012

Reverse Vaccinology

Serum biomarker signature identifies patients with B-cell non-Hodgkin lymphoma associated with cryoglobulinemia vasculitis in chronic HCV infection

scientific article

State-transition diagrams for biologists

scientific article

Su.43. Compartmentalized Modifications of the Peripheral T-Cell Repertoire Are Associated to Experimental Cerebral Malaria

scholarly article by Encarnita Mariotti-Ferrandiz et al published January 2006 in Clinical Immunology

Systems Immunology, Novel Evaluation of Vaccine

scholarly article published 2013

Systems biology in vaccine design ⬇️

scientific article published on December 21, 2011

T cell diversity and TcR repertoires in teleost fish ⬇️

scientific article published on 06 September 2010

T follicular helper and T follicular regulatory cells have different TCR specificity.

scientific article published on 21 April 2017

TCR repertoire dynamics in the pancreatic lymph nodes of non-obese diabetic (NOD) mice at the time of disease initiation

scientific article published on 08 May 2008

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

scientific article

Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection

scientific article (publication date: 2013)

Th1 response and systemic treg deficiency in inclusion body myositis.

scientific article

The Ig light chain restricted B6.kappa(-)lambda(SEG) mouse strain suggests that the IGL locus genomic organization is subject to constant evolution

scientific article

The astonishing diversity of Ig classes and B cell repertoires in teleost fish

scientific article (publication date: 2013)

The expansion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones

scientific article published on 01 April 1996

The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis

scientific article

List of works by Adrien Six

A TCRβ Repertoire Signature Can Predict Experimental Cerebral Malaria

A conserved sequence in the mouse variable T cell receptor alpha recombination signal sequence 23-bp spacer can affect recombination.

A novel strategy for molecular signature discovery based on independent component analysis.

A profound alteration of blood TCRB repertoire allows prediction of cerebral malaria

A unique CD8(+) T lymphocyte signature in pediatric type 1 diabetes.

Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients.

Behçet's disease physiopathology: a contemporary review

Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells

Characterization of avian T-cell receptor gamma genes

Clinical grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene: authors' reponse.

Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene

Contrasted TCRβ diversity of CD8+ and CD8- T cells in rainbow trout

Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells.

Diversity, molecular characterization and expression of T cell receptor γ in a teleost fish, the sea bass (Dicentrarchus labrax, L).

Dynamical and Mechanistic Reconstructive Approaches of T Lymphocyte Dynamics: Using Visual Modeling Languages to Bridge the Gap between Immunologists, Theoreticians, and Programmers

Early Transcriptome Signatures from Immunized Mouse Dendritic Cells Predict Late Vaccine-Induced T-Cell Responses

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.

GeVaDSs - decision support system for novel Genetic Vaccine development process

Genetic structure of a wide-spectrum chicken gene pool

Germline genomic structure of the B10.A mouse Tcra-V2 gene subfamily

HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

Half of the T-cell repertoire combinatorial diversity is genetically determined in humans and humanized mice.

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells

ISEApeaks: an Excel platform for GeneScan and Immunoscope data retrieval, management and analysis.

Identification of an endogenous mammary tumor virus involved in the clonal deletion of V beta 2 T cells.

Immune Repertoire Diversity

Immunomonitoring

Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

Lymphocyte Labeling, Cell Division Investigation

Lymphocyte Population Kinetics

Marginal zone B cell enrichment and strong follicular B cell reduction correlate with a delayed IgG response in a light chain diversity restricted mouse model.

Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.

Mechanisms of the natural reactivity of lymphocytes from noninfected individuals to membrane-associated Leishmania infantum antigens.

Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice.

Modeling Formalisms, Lymphocyte Dynamics and Repertoires

New methods and software tools for high throughput CDR3 spectratyping. Application to T lymphocyte repertoire modifications during experimental malaria.

New perspectives for large-scale repertoire analysis of immune receptors

Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves

Organism State, Lymphocyte

Phenotypic and functional similarity of gut intraepithelial and systemic T cells in a teleost fish

Preserving the B-cell compartment favors operational tolerance in human renal transplantation ⬇️

Refitting Harel Statecharts for Systemic Mathematical Models in Computational Immunology

Regulatory CD4+ CD25+ Foxp3+ T cells expand during experimental Plasmodium infection but do not prevent cerebral malaria.

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation

Reverse Vaccinology

Serum biomarker signature identifies patients with B-cell non-Hodgkin lymphoma associated with cryoglobulinemia vasculitis in chronic HCV infection

State-transition diagrams for biologists

Su.43. Compartmentalized Modifications of the Peripheral T-Cell Repertoire Are Associated to Experimental Cerebral Malaria

Systems Immunology, Novel Evaluation of Vaccine

Systems biology in vaccine design ⬇️

T cell diversity and TcR repertoires in teleost fish ⬇️

T follicular helper and T follicular regulatory cells have different TCR specificity.

TCR repertoire dynamics in the pancreatic lymph nodes of non-obese diabetic (NOD) mice at the time of disease initiation

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection

Th1 response and systemic treg deficiency in inclusion body myositis.

The Ig light chain restricted B6.kappa(-)lambda(SEG) mouse strain suggests that the IGL locus genomic organization is subject to constant evolution

The astonishing diversity of Ig classes and B cell repertoires in teleost fish

The expansion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones

The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis

Vaccinomics