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List of works by Sofie Struyf

Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor

scientific article

Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection

scientific article

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

scientific article published on 01 December 2001

Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

scientific article

Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.

scientific article

Angiostatic, tumor inflammatory and anti-tumor effects of CXCL4(47-70) and CXCL4L1(47-70) in an EGF-dependent breast cancer model

scientific article

Antitumoral activity of parvovirus-mediated IL-2 and MCP-3/CCL7 delivery into human pancreatic cancer: implication of leucocyte recruitment

scientific article published on 11 May 2012

Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy

scientific article published in April 2013

Biochemical and Biological Characterization of Neutrophil Chemotactic Protein, a Novel Rabbit CXC Chemokine from Alveolar Macrophages†

scientific article published on 01 November 2000

CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8.

scientific article published on 18 May 2009

CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I.

scientific article published in February 2003

CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.

scientific article

CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.

scientific article published in April 1999

CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology

scientific article

COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.

scientific article

CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

scientific article published on 7 April 2011

CXCL4 and CXCL4L1 Differentially Affect Monocyte Survival and Dendritic Cell Differentiation and Phagocytosis.

scientific article

CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase.

scientific article published on 28 January 2014

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model

scientific article published on 23 August 2013

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions

scientific article

CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue

scientific article published in July 2004

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines

scientific article published in April 2008

CXCR3 ligands in disease and therapy.

scientific article

CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection

scientific article published on 7 March 2011

Capacity of wild-type and chemokine-armed parvovirus H-1PV for inhibiting neo-angiogenesis

scientific article published on 4 October 2013

Carcinoma cell-derived chemokines and their presence in oral fluid.

scientific article published in August 2009

Cardiovascular determinants and prognostic significance of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary artery disease.

scientific article

Chemokine isoforms and processing in inflammation and immunity

scientific article

Chemokine-protease interactions in cancer

scientific article published in June 2004

Chemokines and gelatinases in the aqueous humor of patients with active uveitis

scientific article published on 01 September 2004

Chemokines and other GPCR ligands synergize in receptor-mediated migration of monocyte-derived immature and mature dendritic cells.

scientific article

Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

scientific article published in September 2006

Chemokines in the limbal form of vernal keratoconjunctivitis

scientific article

Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue

scientific article published on 01 May 2005

Circulating bone-marrow-derived endothelial precursor cells contribute to neovascularization in diabetic epiretinal membranes

scientific article published on 01 May 2011

Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes

scientific article published on 25 April 2008

Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.

scientific article

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

scientific article published on 18 August 2008

Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist

scientific article (publication date: September 2000)

Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

scientific article published on January 2006

Contribution of intracellular Ca2+ stores to Ca2+ signaling during chemokinesis of human neutrophil granulocytes.

scientific article

Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis

scientific article

Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

scientific article published on 31 January 2011

Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo

scientific article (publication date: March 2001)

Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and interferon-gamma reveals MCP-3 heterogeneity

scientific article published in February 1999

Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor

scientific article

Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis

scientific article published on October 2002

Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer.

scientific article published on 23 March 2010

Expression of chemokine receptors in vernal keratoconjunctivitis

scientific article

Expression of chemokines and gelatinase B in sympathetic ophthalmia

scientific article published on 07 April 2006

Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes.

scientific article

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

scientific article (publication date: 11 July 2003)

Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.

scientific article

GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors

scientific article published on 01 February 2005

Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants.

scientific article

Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage

scientific article published on November 1997

Identification and characterization of MIP-1α/CCL3 isoform 2 from bovine serum as a potent monocyte/dendritic cell chemoattractant.

scientific article published on 7 December 2012

Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma

scientific article published in Journal of Biological Chemistry

Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1

scientific article published on 15 April 2001

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

scientific article

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

scientific article published on 22 July 2009

Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity

scientific article published in September 1998

Isolation of a lymphocyte chemotactic factor produced by the murine thymic epithelial cell line MTEC1: identification as a 30 kDa glycosylated form of MCP-1.

scientific article published on September 1996

Isolation of human monocyte chemotactic proteins and study of their producer and responder cells by immunotests and bioassays

scientific article published on 01 January 1997

Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms

scientific article

Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis

scientific article published on 13 January 2011

Langerhans cell histiocytosis: a cytokine/chemokine-mediated disorder?

scientific article published on September 2011

Leukocyte migration and activation by murine chemokines.

scientific article published on October 1996

Longitudinal changes in gingival crevicular fluid after placement of fixed orthodontic appliances

scientific article published in June 2011

MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells

scientific article published in 2007

Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-γ and provide a mechanism for enhanced synovial chemokine levels in septic arthritis

scientific article published on 01 November 2003

Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT)

scientific article published on 28 January 2015

Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.

scientific article published on 23 August 2016

Natural post-translational modifications of chemokines

scientific article published on December 2006

Natural substrates of dipeptidyl peptidase IV.

scientific article

Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor.

scientific article

Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy

scientific article

Neutrophils from Patients with Primary Ciliary Dyskinesia Display Reduced Chemotaxis to CXCR2 Ligands.

scientific article published on 22 September 2017

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

scientific article published in June 2017

PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia

scientific article published in November 2003

PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function

scientific article

Pathogenesis of malaria-associated acute respiratory distress syndrome.

scientific article published on 03 June 2013

Platelet factor-4 variant chemokine CXCL4L1 inhibits melanoma and lung carcinoma growth and metastasis by preventing angiogenesis.

scientific article

Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.

scientific article published on 30 September 2004

Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response

scientific article published on July 2012

Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.

scientific article published in April 1998

Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1alpha

scientific article

Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production.

scientific article published on 2 January 2007

Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration

scientific article

Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6.

scientific article published in November 2004

Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence

scientific article published on 24 July 2009

Recombinant Parvoviruses Armed to Deliver CXCL4L1 and CXCL10 Are Impaired in Their Antiangiogenic and Antitumoral Effects in a Kaposi Sarcoma Tumor Model Due To the Chemokines' Interference with the Virus Cycle

scientific article published on 2 January 2017

Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells

scientific article (publication date: 15 October 2000)

Regulation of the immune response by the interaction of chemokines and proteases

scientific article (publication date: 2003)

Relative distribution and biological characterization of CXCL4L1 isoforms in platelets from healthy donors.

scientific article published on 28 August 2017

Role of chemokines in vernal keratoconjunctivitis

scientific article

Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma.

scientific article published on October 2002

Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis

scientific article published in December 2001

Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines.

scientific article

Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils

scientific article published on 21 August 2015

Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells

scientific article published on 7 September 2007

Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

scientific article

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

scientific article published on 5 October 2006

Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids.

scientific article published on 2 March 2004

Synergistic induction of MCP-1 and -2 by IL-1beta and interferons in fibroblasts and epithelial cells

scientific article

Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects

scientific article (publication date: March 2009)

Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

scientific article

Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration

scientific article published on 9 April 2004

Synergy in cytokine and chemokine networks amplifies the inflammatory response.

scientific article

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4

scientific article

TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis

scientific article published on 17 July 2006

TNF-α and the IFN-γ-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma

scientific article published in August 2008

The CC chemokine CCL20 and its receptor CCR6.

scientific article

The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo.

scientific article published on 9 March 2010

The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8.

scientific article

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown

scientific article

The Cytokine Interleukin-6 and the Chemokines CCL20 and CXCL13 Are Novel Biomarkers of Specific Endogenous Uveitic Entities.

scientific article published in September 2016

The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages

scientific article published on May 2001

The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine

scientific article published on August 1999

The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis

scientific article published on November 2003

The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage

scientific article published on 27 April 2006

The cytokine-serum amyloid A-chemokine network

scientific article

The expression and role of CXC chemokines in colorectal cancer.

scientific article published on 14 October 2011

The role of CD26/DPP IV in chemokine processing

scientific article

The role of CXC chemokines and their receptors in cancer.

scientific article published on 24 June 2008

The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer.

scientific article

The role of chemokines and their receptors in uveitis

scientific article published on 13 March 2007

The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer

scientific article

The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure.

scientific article

The unique structural and functional features of CXCL12

scientific article published in April 2018

Transforming Growth Factor Beta Switch in Aqueous Humor of Patients With Fuchs' Endothelial Corneal Dystrophy

scientific article published on 26 February 2016

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

scientific article published on 16 March 2017

Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction

scientific article

Tumor angiogenesis revisited: Regulators and clinical implications.

scientific article

Unique regulation of CCL18 production by maturing dendritic cells

scientific article (publication date: April 2003)

[The role of plasma chemokines in cancer]

scientific article published in 2007

cis requirements for the efficient production of recombinant DNA vectors based on autonomous parvoviruses.

scientific article published on July 1999

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