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List of works by Ghislain Opdenakker

"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products

scientific article published in July 2009

11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner.

scientific article published on 23 October 2017

4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

scientific article published on 07 March 2008

A Dinucleotide Repeat Polymorphism Located in the IFN-α/β Gene Cluster at Chromosome 9p22 Is Not Associated with Multiple Sclerosis in Sardinia

article

A catalytically inactive gelatinase B/MMP-9 mutant impairs homing of chronic lymphocytic leukemia cells by altering migration regulatory pathways.

scientific article published on 25 October 2017

A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains

scientific article published on 26 October 2006

A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.

scientific article published on August 2003

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

scientific article published on 01 December 2020

Acyclovir-resistant herpes simplex encephalitis in a patient treated with anti-tumor necrosis factor-α monoclonal antibodies

scientific article published on 31 October 2013

Adrenal hormones mediate disease tolerance in malaria

scientific article published in Nature Communications

Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.

scientific article published on 12 August 2009

Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection

scientific article

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

scientific article published on 01 December 2001

Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

scientific article

Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.

scientific article published on October 1997

Analysis of Gelatinases in Complex Biological Fluids and Tissue Extracts

article

Analysis of an IFN- gamma gene (IFNG) Polymorphism in Multiple Sclerosis in Europe: Effect of Population Structure on Association with Disease

article

Analysis of the open reading frames of the main capsid proteins of actinophage VWB.

scientific article published on January 1995

Angiogenesis regulatory factors in the vitreous from patients with proliferative diabetic retinopathy.

scientific article

Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.

scientific article

Angiostatic, tumor inflammatory and anti-tumor effects of CXCL4(47-70) and CXCL4L1(47-70) in an EGF-dependent breast cancer model

scientific article

Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice

scholarly article by Vincent Vanheule et al published October 2018 in Clinical & Experimental Allergy

Anti-interferon-γ antibody treatment, growth of Lewis lung tumours in mice and tumour-associated cachexia

scientific article published on 01 January 1991

Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes

scientific article published on 8 August 2013

Association between recent herpes zoster but not herpes simplex infection and subsequent risk of malignancy in women: a retrospective cohort study ⬇️

scientific article published on August 2, 2013

Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy

scientific article

Author's reply: To PMID 24379662

Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus

scientific article

Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients

scientific article published on 29 June 2011

Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.

scientific article published on February 2008

Biochemical and Biological Characterization of Neutrophil Chemotactic Protein, a Novel Rabbit CXC Chemokine from Alveolar Macrophages†

scientific article published on 01 November 2000

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

scientific article (publication date: December 2002)

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

scientific article

CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8.

scientific article published on 18 May 2009

CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

scientific article published on 7 April 2011

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines

scientific article published in April 2008

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

scientific article published on 6 December 2006

Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase

scientific article published on 01 October 2003

Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator

scientific article published in September 1989

Characterisation of the chromosome breakpoints in a patient with a constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12) and neuroblastoma

scientific article

Characterization of Cowpox Virus (CPV) Mutants Arising under Pressure with Different Acyclic Nucleoside Phosphonates

scientific article published in 2009

Characterization of granulocyte chemotactic activity from human cytokine-stimulated chondrocytes as interleukin 8

scientific article published on 01 March 1990

Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin

scientific article published on May 2005

Chemical Synthesis, Purification and Folding of the Human Monocyte Chemotactic Proteins MCP-2 and MCP-3 into Biologically Active Chemokines

scientific article published on 01 February 1995

Chemically synthesized matrix metalloproteinase and angiogenesis-inhibiting peptides as anticancer agents

scientific article published on 01 March 2014

Chemokine isoforms and processing in inflammation and immunity

scientific article

Chemokine-protease interactions in cancer

scientific article published in June 2004

Chemokines and gelatinases in the aqueous humor of patients with active uveitis

scientific article published on 01 September 2004

Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue

scientific article published on 01 May 2005

Chemotactic factors, passive invasion and metastasis of cancer cells

scientific article published on 01 November 1992

Chlorite oxidized oxyamylose differentially influences the microstructure of fibrin and self assembling peptide hydrogels as well as dental pulp stem cell behavior

scientific article published on 11 March 2021

Chromosome 7q21–22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene

article

Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice

scientific article published on October 2006

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.

scientific article

Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.

scientific article

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

scientific article published on 18 August 2008

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.

scientific article published on 16 July 2009

Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis

scientific article published in March 2002

Cloning and expression in Escherichia coli of a human gelatinase B-inhibitory single-chain immunoglobulin variable fragment (scFv).

scientific article published in September 1997

Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs

scientific article published in February 1997

Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

scientific article published on January 2006

Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy

scientific article published on 30 April 2016

Comparisons of gut microbiota profiles in wild-type and gelatinase B/matrix metalloproteinase-9-deficient mice in acute DSS-induced colitis

Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastoma

scientific article published in September 1990

Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria

scientific article published on 09 October 2019

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium

scientific article

Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

scientific article published on 31 January 2011

Cytokine-regulated proteases in autoimmune diseases.

scientific article published on March 1994

Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.

scientific article published on July 1992

Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease

scientific article published on 03 March 2011

Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-α converting enzyme (TACE/ADAM-17).

scientific article

Differential CXC and CX3C Chemokine Expression Profiles in Aqueous Humor of Patients With Specific Endogenous Uveitic Entities

scientific article published on 01 May 2018

Differential Diagnosis of Autoimmune Pancreatitis From Pancreatic Cancer by Analysis of Serum Gelatinase Levels

scientific article published on 18 December 2015

Differential effects of PKC inhibitors on gelatinase B and interleukin 6 production in the mouse macrophage.

scientific article published on February 1995

Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy

scientific article

Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study

scientific article

Differential regulation of gelatinase b and tissue-type plasminogen activator expression in human bowes melanoma cells

scientific article published on 01 February 1993

Direct visualization of protease action on collagen triple helical structure

scientific article

Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient

scientific article

EDTA/gelatin zymography method to identify C1s versus activated MMP-9 in plasma and immune complexes of patients with systemic lupus erythematosus

article

Effect of catechins and citrus flavonoids on invasion in vitro.

scientific article published on January 1991

Effects of 12-O-Tetradecanoylphorbol 13-Acetate on the Production of mRNAs for Human Tissue-Type Plasminogen Activator

article

Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease

scientific article published in November 2005

Endothelial Response to Glucocorticoids in Inflammatory Diseases

scientific article

Endotoxemia shifts neutrophils with TIMP-free gelatinase B/MMP-9 from bone marrow to the periphery and induces systematic upregulation of TIMP-1.

scientific article published on 3 August 2017

Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin

scientific article published on 09 May 2006

Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives

scientific article published on October 2010

Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan.

scientific article

Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases

scientific article published on 01 September 1994

Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion

scientific article published on 5 March 2018

Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.

scientific article

Expression of a Human Mutant Monocyte Chemotactic Protein 3 in Pichia pastoris and Characterization as an MCP-3 Receptor Antagonist

scientific article published on 01 November 1995

Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders

scientific article published on 01 February 2007

Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer.

scientific article published on 23 March 2010

Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy

scientific article

Expression of chemokines and gelatinase B in sympathetic ophthalmia

scientific article published on 07 April 2006

Expression of gelatinase B in trachomatous conjunctivitis.

scientific article published on January 2000

Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis

scientific article published on 13 February 2019

Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.

scientific article

Expression of thrombospondin-2 as a marker in proliferative diabetic retinopathy

scientific article published on 07 February 2013

Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy.

scientific article published on 18 November 2016

Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres

scientific article published on 01 December 1996

Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration

scientific article published on 19 February 2015

Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.

scientific article

Functional links between gelatinase B/matrix metalloproteinase-9 and prominin-1/CD133 in diabetic retinal vasculopathy and neuropathy

scientific article

Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis

scientific article published on December 2003

GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors

scientific article published on 01 February 2005

Galectin-1 studies in proliferative diabetic retinopathy

scientific article published on 18 July 2019

Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis

scientific article

Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

scientific article

Gelatinase A secretion and its control in peritubular and Sertoli cell cultures: effects of hormones, second messengers and inducers of cytokine production

article

Gelatinase B deficiency impairs reproduction

scientific article published in September 2000

Gelatinase B deficiency protects against endotoxin shock

scientific article (publication date: August 2002)

Gelatinase B in proliferative vitreoretinal disorders

scientific article published in June 1998

Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.

scientific article published on 5 March 2003

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein.

scientific article published in November 1993

Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis

article

Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

scientific article

Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils

scientific article published on 10 September 2007

Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia

scientific article published on 19 November 2018

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity

scientific article published on 09 August 2019

Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy

scientific article published in June 2003

Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis

scientific article published on 3 February 2006

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis

scientific article published in PLoS ONE

Gelatinase B: a tuner and amplifier of immune functions.

scientific article

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

scientific article published in November 1992

Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants.

scientific article

Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta.

scientific article published on October 1993

Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.

scientific article

Genetic Deletion of Tissue Inhibitor of Metalloproteinase-1/TIMP-1 Alters Inflammation and Attenuates Fibrosis in Dextran Sodium Sulphate-induced Murine Models of Colitis

scientific article published on 17 May 2016

Glycoforms modify the dynamic stability and functional activity of an enzyme

scientific article

Glycosaminoglycan mimicry by COAM reduces melanoma growth through chemokine induction and function.

scientific article

Glycosylation of interleukin-6 purified from normal human blood mononuclear cells.

scientific article

Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities

scientific article

Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.

scientific article

Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid

scientific article published in December 2004

Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins

scientific article

Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain

scientific article

Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.

scientific article

Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy

scientific article

Heterogeneity of human tissue-type plasminogen activator

scientific article published on 01 September 1988

Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants.

scientific article published on February 2014

Heterogeneity of α2u -globulin gene products in different translational systems, plasma and urine

article

High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease

article

High-resolution fluorescence mapping of 46 DNA markers to the short arm of human chromosome 1.

scientific article published in October 1993

Holistic approaches to glycobiology

scientific article published on 01 June 2001

Homogeneous interferon- β -inducing 22K factor (IL-1 β ) has connective tissue cell stimulating activities

scientific article published on 01 September 1986

Homotrimeric MMP-9 is an active hitchhiker on alpha-2-macroglobulin partially escaping protease inhibition and internalization through LRP-1

scientific article published on 23 October 2019

Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: Anti-rheumatic activity by protease inhibition

scientific article published on 01 January 1996

Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate.

scientific article published on September 1990

Humoral immunity in phenotypes of chronic lung allograft dysfunction: A broncho-alveolar lavage fluid analysis

scientific article published on 22 August 2016

Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma

scientific article published in Journal of Biological Chemistry

Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier.

scientific article published in November 2016

Immunohistopathology to guide multiple sclerosis treatment

scientific article published in The Lancet

Immunomodulation as Rescue for Chronic Atonic Skin Wounds

scientific article published on 27 February 2018

Immunopathology and Dexamethasone Therapy in a New Model for Malaria-associated Acute Respiratory Distress Syndrome

article

Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.

scientific article published on 14 May 2012

In Vitro -Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs ⬇️

scientific article published on December 21, 2011

In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes

scientific article published in December 2004

In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse

scientific article

Increase in sialylation and branching in the mouse serum N-glycome correlates with inflammation and ovarian tumour progression

scientific article (publication date: 2013)

Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.

scientific article published on 29 October 2008

Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis

article

Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor

scientific article published on 01 October 1985

Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia.

scientific article

Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis

scientific article published in April 2009

Infliximab Restores the Dysfunctional Matrix Remodeling Protein and Growth Factor Gene Expression in Patients with Inflammatory Bowel Disease

article

Inhibition of MMP-9-dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4.

scientific article published on 4 April 2016

Inhibition of enzymatic degradation of adhesive-dentin interfaces

scientific article published on 27 October 2009

Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

scientific article

Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library

scientific article published in September 2006

Inhibition of neutrophil collagenase/MMP-8 and gelatinase B/MMP-9 and protection against endotoxin shock.

scientific article

Inhibition of renal fibrosis with a human CXCL9‐derived glycosaminoglycan‐binding peptide

scientific article published on 01 January 2022

Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody

scientific article published in March 2004

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

scientific article

Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice

scientific article (publication date: 2011)

Interaction of interferon with other cytokines.

scientific article published on June 1989

Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo.

scientific article

Interferon gamma gene in rheumatoid arthritis

scientific article published in The Lancet

Interferon-? gene polymorphism-associated risk for multiple sclerosis in sardinia

article

Interferon-γ Orchestrates the Number and Function of Th17 Cells in Experimental Autoimmune Encephalomyelitis

scientific article published on 25 February 2011

Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes

article

Interleukin 1: amino acid sequencing reveals microheterogeneity and relationship with an interferon-inducing monokine

scientific article published in August 1985

Interleukin-11 Overexpression and M2 Macrophage Density are Associated with Angiogenic Activity in Proliferative Diabetic Retinopathy

scientific article published on 12 August 2019

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

scientific article published on 22 July 2009

Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions

scientific article published on 4 February 2008

Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.

scientific article published on October 2010

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles

scientific article published on 13 December 2013

Introduction of the interferon γ gene into mouse T lymphoma cells with low MHC class I-expression results in selective induction of H-2D k and concomitant enhanced metastasis

article

Is the Large T Antigen a Target for the Inhibition of SV40 Replication?

scientific article published in 2010

Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, Northern Italy, Sardinia and Sweden

article

Langerhans cell histiocytosis: a cytokine/chemokine-mediated disorder?

scientific article published on September 2011

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

scientific article published on 01 May 1993

Limitations of neutrophil depletion by anti-Ly6G antibodies in two heterogenic immunological models

scientific article published on 18 June 2019

Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities

scientific article published on 04 June 2019

Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus

scientific article published in March 1995

MMP-9 affects gene expression in chronic lymphocytic leukemia revealing CD99 as an MMP-9 target and a novel partner in malignant cell migration/arrest

scientific article published on 13 February 2019

MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus

scientific article published on 22 March 2019

MalarImDB: an open-access literature-based malaria immunology database

scientific article

Matrix Metalloproteinase-9-Generated COOH-, but Not NH2-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Chemotactic and Cytokine-Inducing Capacity.

scientific article

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS ⬇️

scientific article published on July 1, 1998

Matrix metalloproteinase in diabetic retinopathy

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.

scientific article published on June 2007

Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer.

scientific article published on 18 August 2016

Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis

scientific article published on 29 March 2006

Matrix metalloproteinase-9 induces a pro-angiogenic profile in chronic lymphocytic leukemia cells

scientific article published on 01 October 2019

Matrix metalloproteinase-9 is essential for physiological Beta cell function and islet vascularization in adult mice

scientific article

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain

scientific article

Matrix metalloproteinases and inhibitors in dentistry

scientific article published on 15 May 2019

Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections.

scientific article

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria

scientific article published on 24 July 2006

Matrix remodelling enzymes, the protease cascade and glycosylation ⬇️

scientific article published on October 3, 2001

Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs

scientific article published on 8 October 2008

Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

scientific article

Messenger RNA for Human Tissue Plasminogen Activator

scientific article published on 01 January 1982

Messenger RNA for a phorbol-ester induced 48,000 dalton protein from human melanoma cells

scientific article published on 01 April 1986

Messenger RNA of human immune interferon: Isolation and partial characterization

scientific article published on 01 January 1982

Messenger RNA of mouse immune interferon (MuIFN-γ)

scientific article published on 01 April 1982

Metalloproteinases and specific inhibitors in multiple sclerosis: from blood to brain or vice versa?

scientific article published in February 1999

Metalloproteinases mediate diabetes-induced retinal neuropathy and vasculopathy

scientific article published on 10 June 2019

Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-γ and provide a mechanism for enhanced synovial chemokine levels in septic arthritis

scientific article published on 01 November 2003

Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases

scientific article

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

scientific article

Microsatellite polymorphisms in the gene promoter of monocyte chemotactic protein-3 and analysis of the association between monocyte chemotactic protein-3 alleles and multiple sclerosis development

scientific article published on 01 March 1999

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

scientific article

Molecular cytogenetic analysis of 1;17 translocations in neuroblastoma.

scientific article published in January 1995

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature.

scientific article

Monoclonal Antibodies Specific for Natural Human Neutrophil Gelatinase B Used for Affinity Purification, Quantitation by Two-Site ELISA and Inhibition of Enzymatic Activity

scientific article published on 01 December 1995

Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation.

scientific article

Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC.

scientific article published on June 1994

Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates

scientific article published on 12 May 2009

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient.

scientific article published on 10 June 2016

Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.

scientific article published on 29 December 2006

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

scientific article published on May 2013

Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection.

scientific article published on 13 August 2010

Myeloid-Related Protein-14/MRP-14/S100A9/Calgranulin B is Associated with Inflammation in Proliferative Diabetic Retinopathy

scientific article published on 16 November 2016

Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT)

scientific article published on 28 January 2015

Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1.

scientific article

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium

scientific article published on 27 June 2011

Natural human monocyte gelatinase and its inhibitor

scientific article published on 01 June 1991

Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy

scientific article

Neutralizing antibodies in gene-defective hosts

scientific article

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

scientific article

Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis

scientific article

Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization

scientific article (publication date: February 2002)

Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.

scientific article

Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase.

scientific article

Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice

scientific article

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

scientific article published on 26 June 2020

New insights in the regulation of leukocytosis and the role played by leukocytes in septic shock.

scientific article

O-Glycan Analysis of Natural Human Neutrophil Gelatinase B Using a Combination of Normal Phase- HPLC and Online Tandem Mass Spectrometry: Implications for the Domain Organization of the Enzyme†

article

Oligosaccharide sequencing technology.

scientific article

Oligosaccharides of recombinant mouse gelatinase B variants

scientific article published on 01 November 1998

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression.

scientific article published on 27 July 2011

On the roles of extracellular matrix remodeling by gelatinase B

scientific article published on January 1, 1997

On the structure and functions of gelatinase B/matrix metalloproteinase-9 in neuroinflammation.

scientific article

Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination

scientific article published on 18 February 2020

Organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses

scientific article published on November 2005

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

scientific article published in June 2017

Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen

scientific article

PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia

scientific article published in November 2003

PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions

scientific article published on 01 February 2006

PECAM1, MPO and PRKAR1A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia

scientific article published on 01 August 2000

Pathogenesis of malaria-associated acute respiratory distress syndrome.

scientific article published on 03 June 2013

Pathogenic CD8+ T Cells Cause Increased Levels of VEGF-A in Experimental Malaria-Associated Acute Respiratory Distress Syndrome, but Therapeutic VEGFR Inhibition Is Not Effective

scientific article published on 20 September 2017

Peptidoglycan from sterile human spleen induces T-cell proliferation and inflammatory mediators in rheumatoid arthritis patients and healthy subjects

scientific article published on 01 April 2001

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation and Anti-HIV-1 Activity

article

Persistent primary cytomegalovirus infection in a kidney transplant recipient: Multi-drug resistant and compartmentalized infection leading to graft loss

scientific article published on 15 June 2019

Phorbol ester stimulates the synthesis and phosphorylation of a 48 kDa-intracellular protein in plasminogen activator secreting melanoma cells

scientific article published in May 1986

Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats

scientific article published on 25 June 2009

Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.

scientific article

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK.

scientific article published on 28 September 2017

Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis

article

Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9).

scientific article published on September 1999

Probing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosis.

scientific article published on October 2011

Production and Characterization of Recombinant Active Mouse Gelatinase B from Eukaryotic Cells and in vivo Effects after Intravenous Administration

article

Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B

scientific article published on 30 November 2018

Protease propeptide structures, mechanisms of activation, and functions

scientific article published on 14 April 2020

Proteases in cancer drug delivery.

scientific article

Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8.

scientific article published on June 1991

Recombinant mouse granulocyte chemotactic protein-2: production in bacteria, characterization, and systemic effects on leukocytes

scientific article published in September 2002

Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

scientific article published on January 2007

Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization

scientific article published on 11 September 2003

Regulation of gelatinase B (MMP-9) in leukocytes by plant lectins

scientific article published in May 1998

Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy

scientific article

Remnant Epitopes Generating Autoimmunity: From Model to Useful Paradigm

scientific article published on 13 April 2020

Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes

scientific article published on January 2003

Remnant epitopes, autoimmunity and glycosylation.

scientific article

Rescue from acute neuroinflammation by pharmacological chemokine-mediated deviation of leukocytes

scientific article

Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.

scientific article published on December 1999

Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis

article

S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis.

scientific article

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 24 April 2020

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 17 November 2020

Selection and Characterization of (S)-1-[3-Hydroxy-2-(Phosphonomethoxypropyl)-2,6-Diaminopurine [HPMPDAP] Resistant Camelpox Viruses

article

Serum Neutrophil Gelatinase B-associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Marker for Mucosal Healing in Patients with Crohn's Disease

scientific article published on 7 September 2015

Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines.

scientific article

Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils

scientific article published on 21 August 2015

Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a

scientific article

Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.

scientific article published in April 2005

Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis

scientific article published on 05 December 2019

Stimulation of fibroblast interferon production by a 22K protein from human leukocytes.

scientific article published in April 1985

Structural Characterization of the Catalytic Active Site in the Latent and Active Natural Gelatinase B from Human Neutrophils

scientific article published in Journal of Biological Chemistry

Structural and functional analysis of the promoter region of the human MCP-3 gene: transactivation of expression by novel recognition sequences adjacent to the transcription initiation site.

scientific article published on February 1997

Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family ⬇️

scientific article published on July 1, 1992

Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

scientific article

Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine.

scientific article published on February 1995

Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo.

scientific article published on 30 November 2017

Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator

article

Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids.

scientific article published on 2 March 2004

Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects

scientific article (publication date: March 2009)

Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer.

scientific article published on 19 December 2016

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow.

scientific article published on 03 August 2016

TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis

scientific article published on 17 July 2006

Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

scientific article published on 01 August 2005

The Biological Potential Hidden in Inclusion Bodies

scientific article published on 15 February 2020

The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis

scientific article published on 21 September 2018

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown

scientific article

The Cytokine Interleukin-6 and the Chemokines CCL20 and CXCL13 Are Novel Biomarkers of Specific Endogenous Uveitic Entities.

scientific article published in September 2016

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

scientific article published on 01 December 1996

The MCP/eotaxin subfamily of CC chemokines

scientific article (publication date: March 1999)

The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy

scientific article published on 04 December 2019

The Tumor Necrosis Factor Superfamily Members TWEAK, TNFSF15 and Fibroblast Growth Factor-Inducible Protein 14 Are Upregulated in Proliferative Diabetic Retinopathy

The Ulcerative Colitis Response Index for Detection of Mucosal Healing in Patients Treated With Anti-tumour Necrosis Factor

scientific article published on 01 February 2020

The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage

scientific article published on 27 April 2006

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

scientific article published on May 2007

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

scientific article

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines.

scientific article published in January 2004

The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers

scientific article

The ectoenzyme-side of matrix metalloproteinases (MMPs) makes inflammation by serum amyloid A (SAA) and chemokines go round

scholarly article by Mieke De Buck et al published June 2018 in immunology Letters

The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.

scientific article published on April 1995

The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.

scientific article

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors

scientific article

The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2

scientific article

The immunological balance between host and parasite in malaria

scientific article

The immunological basis of current and novel therapies of multiple sclerosis.

scientific article

The molecular basis of leukocytosis ⬇️

scientific article published on April 1, 1998

The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases

scientific article published on 30 June 2016

The role of chemokines and their receptors in uveitis

scientific article published on 13 March 2007

The role of metalloproteinases and adhesion molecules in interleukin-8-induced stem-cell mobilization.

scientific article

Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B.

scientific article published on 19 July 2016

Transduction of human MCP-3 by a parvoviral vector induces leukocyte infiltration and reduces growth of human cervical carcinoma cell xenografts

scientific article published in July 2001

Translational glycobiology: from bench to bedside

scientific article published on 17 September 2019

Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction

scientific article

Two distinct interleukin-1? genes in the pig genome

article

Unbalanced Vitreous Levels of Osteoprotegerin, RANKL, RANK, and TRAIL in Proliferative Diabetic Retinopathy

scientific article published on 15 September 2017

Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes

scientific article published in December 2015

Upregulation of Thrombin/Matrix Metalloproteinase-1/Protease-Activated Receptor-1 Chain in Proliferative Diabetic Retinopathy

scientific article published on 3 June 2016

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

scientific article

Wernicke encephalopathy: MR findings in two patients

scientific article published in January 1999

Zymography methods for visualizing hydrolytic enzymes.

scientific article

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