List of works by Stefan Pöhlmann

A Fosmid-Based System for the Generation of Recombinant Cercopithecine Alphaherpesvirus 2 Encoding Reporter Genes

scientific article published on 05 November 2019

A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism

scientific article published on 13 June 2018

A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry.

scientific article published on 22 February 2017

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

scientific article

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

scientific article published in 2021

A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans

scientific article

A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo

scientific article published on 28 November 2006

A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms

scientific article

A system for production of defective interfering particles in the absence of infectious influenza A virus

scientific article published on 01 March 2019

Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors

scientific article published on April 2004

Analysis of Ebola Virus Entry Into Macrophages

scientific article

Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay

scientific article published on 08 August 2019

Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins

scientific article published on 15 October 2019

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism

scientific article published on 9 April 2014

Analysis of the interaction of Ebola virus glycoprotein with DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) and its homologue DC-SIGNR.

scientific article published on November 2007

Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63.

scientific article published on January 2006

Basic amino acid residues in the V3 loop of simian immunodeficiency virus envelope alter viral coreceptor tropism and infectivity but do not allow efficient utilization of CXCR4 as entry cofactor

scientific article published in June 2001

Bitter-sweet symphony: glycan-lectin interactions in virus biology

scientific article published on 06 December 2013

CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity

scientific article

Calcium-modulating cyclophilin ligand does not restrict retrovirus release.

scientific article published in February 2010

Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

scientific article published on 03 April 2019

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

scientific article published on 05 August 2020

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.

scientific article published on 4 January 2012

Cell Entry of Influenza A Viruses: Sweet Talk between HA and Ca V 1.2

scholarly article published by Markus Hoffmann in 2018

Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles

scientific article published on 03 May 2021

Cellular entry of HIV: Evaluation of therapeutic targets.

scientific article

Cellular entry of the SARS coronavirus

scientific article published in October 2004

Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

scientific article published on 19 March 2019

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

scientific article published on 22 July 2020

Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

scientific article published on 12 October 2011

Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo

scientific article published on November 1999

Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions ⬇️

scientific article published on 15 March 2016

Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions.

scientific article published on 16 March 2016

Comparative Analysis of Host Cell Entry of Ebola Virus From Sierra Leone, 2014, and Zaire, 1976.

scientific article

Comparative analysis of Ebola virus glycoprotein interactions with human and bat cells

scientific article

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets

scientific article

DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

scientific article published on January 2003

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus

scientific article published on November 2004

DC-SIGN and DC-SIGNR: helping hands for HIV.

scientific article

DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus

scientific article

DC-SIGN: access portal for sweet viral killers

scientific article published in July 2011

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans

scientific article

DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.

scientific article

Detection systems for antibody responses against herpes B virus

article

Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

scientific article published on 23 March 2011

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.

scientific article

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR

scientific article

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

scientific article

Differential regulation of human immunodeficiency virus type 2 and simian immunodeficiency virus promoter activity

scientific article published in July 2004

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

scientific article

Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection

scientific article published on 26 January 2019

Dissecting Multivalent Lectin-Carbohydrate Recognition Using Polyvalent Multifunctional Glycan-Quantum Dots ⬇️

scientific article published on 8 August 2017

Diversity of receptors binding HIV on dendritic cell subsets

scientific article (publication date: October 2002)

Evaluation of current approaches to inhibit HIV entry.

scientific article

Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide

scientific article

Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

scientific article

Evidence that multiple defects in murine DC-SIGN inhibit a functional interaction with pathogens

scientific article published on 17 November 2005

Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques

scientific article published on 9 September 2015

Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes

scientific article published on July 2000

Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques

scientific article

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

scientific article published in Scientific Reports

Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.

scientific article

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

scientific article published on 07 September 2021

Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN

scientific journal article

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

scientific article published on 01 May 2019

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

scientific article published on 22 April 2020

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

scientific article published on 12 December 2019

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

scientific article

Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR

scientific article

Herpes B virus replication and viral lesions in the liver of a cynomolgus macaque which died from severe disease with rapid onset

scientific article published on 25 April 2017

Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors

scientific article published on September 2006

Host cell factors in filovirus entry: novel players, new insights

scientific article published on December 2012

How Ebola virus counters the interferon system

scientific article

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

scientific article

IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms

scientific article published on 26 September 2014

Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens

scientific article

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

scientific article

Induced and spontaneous heart rate turbulence in mice: influence of coupling interval

scientific article published on 26 March 2014

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells

scientific article

Influenza A virus encoding secreted Gaussia luciferase as useful tool to analyze viral replication and its inhibition by antiviral compounds and cellular proteins

scientific article

Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

scientific article (publication date: 2012)

Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity.

scientific article

Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins

scientific article published on 11 April 2019

Interaction Between the Spike Protein of Human Coronavirus NL63 and its Cellular Receptor ACE2

Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding.

scientific article published on 20 February 2008

Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses

scientific article

Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection

scientific article published on 21 June 2019

Kaposi Sarcoma in Mantled Guereza

scientific article published on 01 August 2019

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus

scientific article

LY6E impairs coronavirus fusion and confers immune control of viral disease

scientific article published on 23 July 2020

Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia

scientific article published on December 2013

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

scientific article published in 2022

Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

scientific article published on 30 July 2007

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance

scientific article published on 01 June 2019

Modulation of virion incorporation of Ebolavirus glycoprotein: effects on attachment, cellular entry and neutralization

scientific article published on 13 June 2006

Mouse LSECtin as a model for a human Ebola virus receptor.

scientific article

Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency

scientific article published on October 2003

Mutations in the spike protein of MERS-CoV transmitted in Korea increase resistance towards antibody-mediated neutralization

scientific article published on 04 January 2019

Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties

scientific article

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin

scientific article

Novel Virus Related to Kaposi's Sarcoma-Associated Herpesvirus from Colobus Monkey

scientific article published on 01 August 2019

Peptide-based inhibitors of the HIV envelope protein and other class I viral fusion proteins

scientific article published in January 2010

Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV

article

Platelet activation suppresses HIV-1 infection of T cells

scientific article

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

scientific article published in December 2020

Prospects of HIV-1 entry inhibitors as novel therapeutics

scientific article published in July 2004

Protease inhibitors targeting coronavirus and filovirus entry

scientific article

Proteolytic activation of the 1918 influenza virus hemagglutinin

scientific article published on 21 January 2009

Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.

scientific article

Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells

scientific article published on September 2002

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

scientific article published on 12 January 2022

Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner

scientific article published on 01 February 2019

Rhesus macaque IFITM3 gene polymorphisms and SIV infection.

scientific article

Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques

scientific article published on 04 November 2019

S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients

scientific article published on June 2004

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants

scientific article published on 06 July 2021

Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

scientific article

Seroprevalence of viral infections in captive rhesus and cynomolgus macaques ⬇️

scientific article published on 26 March 2019

Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines

scientific article

Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry

scientific article

Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.

scientific article

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2

scientific article published on 11 September 2020

Spike residue 403 affects binding of coronavirus spikes to human ACE2

scientific article published on 25 November 2021

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 29 April 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 01 June 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

scientific article (preprint)

Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor

scientific article published on July 2004

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1

scientific article published in Journal of Biological Chemistry

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells

scientific article published on 17 September 2015

TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

scientific article published on 27 March 2013

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

scientific article

TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

scientific article

Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.

scientific article

Tetherin inhibits Nipah virus but not Ebola virus replication in fruit bat cells

scientific article published on 17 January 2019

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

scientific article

The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin

scientific article

The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.

scientific article

The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells

scientific article

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.

scientific article published on 17 February 2016

The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release

scientific article

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors

scientific article

The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies

scientific article published on 05 October 2016

The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection

scientific article published on 01 October 2021

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

scientific article

The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells.

scientific article published on 7 December 2017

The multiple facets of HIV attachment to dendritic cell lectins ⬇️

scientific article published on September 20, 2010

The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

scientific article published on 31 January 2020

The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

scientific article (publication date: August 2002)

The role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection, and transmission.

scientific article

The role of the alternative coreceptor GPR15 in SIV tropism for human cells

scientific article

The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.

scientific article published on July 2006

The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies

scientific article published on 6 March 2013

Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

scientific article

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis

scientific article published on 17 May 2019

Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells

scientific article

Type II transmembrane serine proteases in cancer and viral infections.

scientific article published on 04 July 2009

Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins

scientific article published on 2 November 2016

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

scientific article

Paulina is supported by:

About Paulina

Help