List of works - Keiran Raine

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

scientific article

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy

scientific article

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

scientific article published on 22 May 2005

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

scientific article published on 23 January 2017

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

scientific article published on 25 November 2021

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scientific article

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups

scientific article published on 6 December 2017

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.

scientific article published on 22 May 2018

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

scientific article published on 25 September 2017

AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes

scientific article published on 7 May 2007

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

scientific article

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Clinical and biological implications of driver mutations in myelodysplastic syndromes

scientific article published on 12 September 2013

Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

scientific article published in October 2017

Corrigendum: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article published in Nature

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

scientific article

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

scientific article published on 03 August 2016

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scholarly article by Colin S Cooper et al published June 2015 in Nature Genetics

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article

Extensive heterogeneity in somatic mutation and selection in the human bladder

scientific article published on 01 October 2020

Framework for quality assessment of whole genome cancer sequences

scientific article published on 07 October 2020

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

scientific article published on 16 June 2013

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

scientific article published in February 2012

Genomic Classification and Prognosis in Acute Myeloid Leukemia

scientific article

Genomic Evolution of Breast Cancer Metastasis and Relapse

scientific article published on August 2017

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

scientific article published on 13 March 2017

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

scientific article (publication date: 8 March 2012)

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Lung cancer: intragenic ERBB2 kinase mutations in tumours

scientific article

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

scientific article

Mutational processes molding the genomes of 21 breast cancers

scientific article

Mutational signatures of ionizing radiation in second malignancies

scientific article

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

scientific article

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

scientific article

Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus

scientific article

Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly

scientific article

Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation

scientific article

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

scientific article published on 05 February 2020

Patterns of somatic mutation in human cancer genomes

scientific article (publication date: 8 March 2007)

Polygenic in vivo validation of cancer mutations using transposons

scientific article

Prediction of acute myeloid leukaemia risk in healthy individuals

scientific article published in Nature

Processed pseudogenes acquired somatically during cancer development

scientific article published on 09 April 2014

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

scientific article

Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

scientific article

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

scientific article published on 16 April 2018

Signatures of mutational processes in human cancer

scientific article (publication date: 22 August 2013)

Single-cell paired-end genome sequencing reveals structural variation per cell cycle

scientific article

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

scientific article

Somatic mutations of the protein kinase gene family in human lung cancer

scientific article published on September 2005

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

scientific article published on 22 June 2015

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

scientific article

The Life History of 21 Breast Cancers

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

scientific article published on January 2013

The landscape of cancer genes and mutational processes in breast cancer

scientific article (publication date: 16 May 2012)

The life history of 21 breast cancers

scientific article (publication date: 25 May 2012)

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

scientific article published on 4 April 2018

Whole exome sequencing of adenoid cystic carcinoma

scientific article published on 17 June 2013

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

scientific article (publication date: 5 June 2011)

List of works by Keiran Raine

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Corrigendum: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Erratum: Corrigendum: Signatures of mutational processes in human cancer

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Extensive heterogeneity in somatic mutation and selection in the human bladder

Framework for quality assessment of whole genome cancer sequences

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

Genomic Classification and Prognosis in Acute Myeloid Leukemia

Genomic Evolution of Breast Cancer Metastasis and Relapse

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Lung cancer: intragenic ERBB2 kinase mutations in tumours

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

Mutational processes molding the genomes of 21 breast cancers

Mutational signatures of ionizing radiation in second malignancies

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus

Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly

Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Patterns of somatic mutation in human cancer genomes

Polygenic in vivo validation of cancer mutations using transposons

Prediction of acute myeloid leukaemia risk in healthy individuals

Processed pseudogenes acquired somatically during cancer development

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Signatures of mutational processes in human cancer

Single-cell paired-end genome sequencing reveals structural variation per cell cycle

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

Somatic mutations of the protein kinase gene family in human lung cancer

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

The Life History of 21 Breast Cancers

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

The landscape of cancer genes and mutational processes in breast cancer

The life history of 21 breast cancers

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

Whole exome sequencing of adenoid cystic carcinoma

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia