List of works by Hiromi Rakugi

-374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension

scientific article published on 11 September 2012

2. Treatment of Complicated Hypertension. 6) Treatment of Elderly Hypertension

scientific article published on 01 February 2011

A Case of Nephrocalcinosis Associated with Primary Aldosteronism

scientific article published on 15 March 2012

A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke

scientific article

A candidate gene approach to genetic contributors to the development of IgA nephropathy

scientific article published on 07 July 2011

A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).

scientific article published on 6 May 2009

A case of recessive dystrophic epidermolysis bullosa associated with dwarfism with special reference to pathophysiological role of growth hormone

scientific article published in February 1990

A case of severe systemic edema in an elderly hypertensive patient with systemic lupus erythematodes during long-term treatment with anti-hypertensive drugs

scientific article

A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese

scientific article published in February 2001

A common polymorphism of uncoupling protein 2 gene is associated with hypertension

scientific article published in January 2004

A gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration

article

A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney

scientific article published on 8 June 2012

A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass

scientific article published on 17 December 2008

A phase III, open-label, multicenter study to evaluate the safety and efficacy of long-term triple combination therapy with azilsartan, amlodipine, and hydrochlorothiazide in patients with essential hypertension

scientific article published on 13 December 2017

A pilot study of the effects of eplerenone add-on therapy in patients taking renin–angiotensin system blockers

scholarly article by Noritaka Kawada et al published 24 June 2014 in Journal of the Renin-Angiotensin-Aldosterone System

A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population

scientific article

A potent genetic risk factor for restenosis

article by Mitsuru Ohishi et al published December 1993 in Nature Genetics

A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study).

scientific article published on 11 August 2009

A single daily dose enhances the adherence to immunosuppressive treatment in kidney transplant recipients: a cross-sectional study

scientific article published on 23 October 2012

A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration

scientific article published on 22 December 2011

A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats

scientific article

ACE Insertion/Deletion Polymorphism and Cardiovascular Effect of Hypercholesterolemia

ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy

scientific article published on 22 January 2014

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

scientific article published on 01 November 2020

AL amyloidosis with severe orthostatic hypotension

scientific article published on 01 August 2004

ANG II inhibits insulin-mediated production of PI 3,4,5-trisphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes

scientific article published on 2 July 2010

ANRIL: molecular mechanisms and implications in human health

scientific article

AUGMENTATION OF ANGIOTENSIN II RELEASE FROM ISOLATED MESENTERIC ARTERIES OF WISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS FOLLOWING NEPHRECTOMY

scientific article published on 01 October 1994

Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.

scientific article published on 20 November 2009

Actions of endothelin on adrenergic neuroeffector junction

scientific article published on 01 December 1989

Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5

scientific article published on 18 October 2016

Activated angiotensin II generation and regulation in rat mesenteric arteries following nephrectomy

scientific article published on 01 January 1994

Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats

scientific article

Acute Non-calcific Retropharyngeal Tendinitis

scientific article published on 10 August 2018

Add-on effect of hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension uncontrolled with losartan 50 mg and amlodipine 5 mg.

scientific article published on 26 February 2015

Additive Interaction of Metabolic Syndrome and Chronic Kidney Disease on Cardiac Hypertrophy, and Risk of Cardiovascular Disease in Hypertension

scientific article published on 31 December 2009

Additive effects of nicorandil on coronary blood flow during continuous administration of nitroglycerin

scientific article published in March 2001

Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease

scientific article published in April 2004

Adiponectin and Renal Function, and Implication as a Risk of Cardiovascular Disease

Adiponectin and inflammatory markers in peripheral arterial occlusive disease

scientific article published in October 2006

Adiponectin single nucleotide polymorphism is a genetic risk factor for stroke through high pulse wave pressure: a cohort study

scientific article

Age and prediction of remission and relapse of proteinuria and corticosteroid-related adverse events in adult-onset minimal-change disease: a retrospective cohort study.

scientific article published on 20 March 2013

Akt activation prevents Apop-1-induced death of cells

scientific journal article

Alteration of vascular function is an important factor in the correlation between visit-to-visit blood pressure variability and cardiovascular disease

article

An association between serum γ-glutamyltransferase and proteinuria in drinkers and non-drinkers: a Japanese nationwide cross-sectional survey

scientific article published on 04 February 2014

Analysis and Comparison of New Candiate Loci for Hypertension between Genetic Hypertensive Rat Strains

article

Analysis of Candidate Genes for Insulin Resistance in Essential Hypertension

article

Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet

scientific article published on 6 November 2012

Angiotensin (1-7) and other angiotensin peptides

scientific article published on January 2013

Angiotensin I-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction, but Not With Retinopathy or Nephropathy, in NIDDM

article

Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension

scientific article published in March 1998

Angiotensin II type 1 receptor-mediated peroxide production in human macrophages

scientific article published on January 1999

Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling

scientific article published on 5 October 2009

Angiotensin type 1 receptor blocker reduced proteinuria in patients of focal glomerular sclerosis

scientific article published in July 2004

Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice

article published in 2018

Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients

Angiotensin-converting-enzyme genotype and ischemic heart disease

Anti-Apoptotic Effect of Human Telomerase Reverse Transcriptase on Endothelial Cells under Oxidative Stress, Independent of Telomere Elongation and Telomerase Activity

Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells

scientific article published in 2006

Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes

scientific article published on 13 March 2014

Anti-oxidative effect of Klotho on endothelial cells through cAMP activation

scientific article published on 01 February 2007

Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension

scientific article published on 01 November 1994

Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis

scientific journal article

Approach to healthy longevity as a target of Geriatric Medicine

scientific article published on 01 January 2014

Asp905Tyr Polymorphism of Protein Phosphatase 1 G Subunit Gene in Hypertension

article

Aspirin prevents adhesion of T lymphoblasts to vascular smooth muscle cells

scientific article (publication date: 6 February 2007)

Aspirin: recent developments

scientific article published on February 2008

Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension

scientific article

Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese

article

Association between Density of Coronary Artery Calcification and Serum Magnesium Levels among Patients with Chronic Kidney Disease.

scientific article

Association between a Deletion Polymorphism of the Angiotensin-Converting-Enzyme Gene and Left Ventricular Hypertrophy

article

Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study

scientific article published in August 2004

Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study.

scientific article published on 11 September 2017

Association between heart diseases, social factors and physical frailty in community-dwelling older populations: The septuagenarians, octogenarians, nonagenarians investigation with centenarians study

scientific article published on 03 September 2020

Association between hepatocyte growth factor gene polymorphism and essential hypertension

scientific article published in April 2004

Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population

scientific article published on 28 July 2011

Association between uric acid and atherosclerosis in community-dwelling older people: The SONIC study

scientific article published on 09 November 2020

Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study

article

Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study

article

Association of Polymorphism in the Promoter Region of the Apolipoprotein E Gene with Diastolic Blood Pressure in Normotensive Japanese

article

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population

article

Association of anemia and SRH in older people: the SONIC study

scientific article published on 08 June 2020

Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension

article

Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese

scientific article published on 15 January 2010

Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals

scientific article

Association of hypoadiponectinemia with impaired vasoreactivity

scientific article

Association of hypoadiponectinemia with smoking habit in men.

scientific article published on 16 May 2005

Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population

article

Association of nocturnal hypoxemia with progression of CKD.

scientific article published on 06 June 2013

Association of variants in critical core promoter element of angiotensinogen gene with increased risk of essential hypertension in Japanese

scientific article published in September 1997

Atypical hemolytic uremic syndrome with MCP mutations preceded by respiratory infection

scientific article

Augmentation by Converting Enzyme Inhibition of Accelerated Endothelin Release from Rat Mesenteric Arteries Following Nephrectomy

scientific article published on 01 July 1994

Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis.

scientific article

Autophagy guards against cisplatin-induced acute kidney injury

scientific article published in February 2012

Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress.

scientific article published on 11 July 2013

Autophagy protects the proximal tubule from degeneration and acute ischemic injury.

scientific article

Awareness of the Japanese Society of Hypertension Guidelines for the Management of Hypertension and their use in clinical practices: 2009 survey results

scientific article published on 2 April 2015

Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice

scientific article

Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms.

scientific article published in January 2009

Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years

scientific article published on 13 June 2005

Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals

scientific article published in July 2005

C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women

scientific article published on 21 August 2009

C-reactive protein, left ventricular mass index, and risk of cardiovascular disease in essential hypertension.

scientific article published in December 2007

CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy.

scientific article published on 6 May 2014

CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats

scientific article published on 16 November 2010

CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC.

scientific article

Calcium antagonists and endothelial function

scientific article

Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan

scientific article

Campylobacter fetus peritonitis in a patient with an unused embedded subcutaneous peritoneal catheter

scientific article

Cardiac Angiotensin II Receptors Are Upregulated by Long-Term Inhibition of Nitric Oxide Synthesis in Rats

scientific article published on 01 October 1998

Cardiac and renal protective effects of irbesartan via peroxisome proliferator-activated receptorγ-hepatocyte growth factor pathway independent of angiotensin II Type 1a receptor blockade in mouse model of salt-sensitive hypertension

scientific article published on 22 April 2013

Cardiac troponin T elevation at dialysis initiation is associated with all-cause and cardiovascular mortality on dialysis in patients without diabetic nephropathy.

scientific article

Cardiovascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance

scientific article published on March 2010

Carotid intima-media thickness is correlated with impairment of coronary flow reserve in hypertensive patients without coronary artery disease

scientific article

Carotid plaque score and intima media thickness as predictors of stroke and mortality in hypertensive patients

scientific article published on 4 July 2013

Case report of a long-surviving Werner syndrome patient with severe aortic valve stenosis

Changes in autonomic activity and baroreflex sensitivity with the hypertension process and age in rats

scientific article

Changes in the levels of plasma atrial natriuretic peptide, hemodynamic measurements, and the levels of vasoactive hormones during the clinical course of congestive heart failure

scientific article published on 01 November 1988

Characteristics of mild hypertension in elderly patients

scientific article

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease.

scientific article published on 18 May 2016

Cigarette smoking and chronic kidney diseases

scientific article published on 08 December 2011

Cigarette smoking and progression of IgA nephropathy.

scientific article published on 14 May 2010

Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel

scientific article published in September 2011

Clinical Characteristics and Postoperative Outcomes of Primary Aldosteronism in the Elderly

scholarly article by Masao Takeda et al published 6 August 2018 in The Journal of Clinical Endocrinology and Metabolism

Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients

scientific article published on 26 October 2017

Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients

scientific article

Clinical usefulness and limitations of brachial-ankle pulse wave velocity in the evaluation of cardiovascular complications in hypertensive patients.

scientific article published in December 2006

Combination therapy for hypertension in patients with CKD: a subanalysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events trial

article published in 2013

Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial

article

Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial

scientific article

Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial

scientific article

Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome

article published in 2012

Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

article

Common molecular mechanism of osteoporosis and vascular diseases

scientific article published on 01 January 2011

Comparison between L-type and N/L-type calcium channel blockers in the regulation of home blood-pressure variability in elderly hypertensive patients

scientific article published on 15 February 2018

Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients: the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study.

scientific article published in June 2008

Comparison of olmesartan combined with a calcium channel blocker or a diuretic in elderly hypertensive patients (COLM Study): safety and tolerability.

scientific article

Comparison of strict- and mild-blood pressure control in elderly hypertensive patients: a per-protocol analysis of JATOS.

scientific article published on 5 August 2010

Comparison of the antialbuminuric effects of benidipine and hydrochlorothiazide in Renin-Angiotensin System (RAS) inhibitor-treated hypertensive patients with albuminuria: the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuret

scientific article

Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study

scientific article

Composite malignant pheochromocytoma with malignant peripheral nerve sheath tumour: a case with 28 years of tumour-bearing history

scientific article published on 01 September 2007

Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults

scientific article published on 26 August 2015

Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs.

scientific article published on 14 November 2012

Cross-talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification

scientific article published on 11 April 2013

Crucial role of apoptogenic protein in cellular apoptosis and senescense

scientific article published on 01 January 2011

Cut-Off Value of Brachial-Ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study

scientific article published on 27 December 2012

Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice

scientific article published on 27 March 2013

Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice

scientific article published on 10 November 2011

Deletion Polymorphism in the Gene for Angiotensin-converting Enzyme is not a Risk Factor Predisposing to Abdominal Aortic Aneurysm

article

Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II.

scientific article published on 27 February 2006

Deletion polymorphism of angiotensin-converting enzyme gene is associated with postprandial hyperglycaemia in individuals undergoing general check-up.

scientific article

Development of the Dementia Assessment Sheet for Community-based Integrated Care System 8-items, a short version of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items, for the assessment of cognitive and daily functions

scientific article published on 17 September 2018

Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice

scientific article published on 13 February 2018

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

scientific article

Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis

scientific article published on 11 October 2018

Dialysis vintage and parathyroid hormone level, not fibroblast growth factor-23, determines chronic-phase phosphate wasting after renal transplantation

scientific article published on 14 July 2012

Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats

scientific article published on 20 March 2014

Differences between daytime and nighttime blood pressure variability regarding systemic atherosclerotic change and renal function

article by Tatsuo Kawai et al published 18 October 2012 in Hypertension Research

Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study

scientific article published on 24 March 2016

Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise

scientific article published on 4 August 2011

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs

scientific article

Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy

scientific article

Diffusion Tensor Imaging MRI With Spin-Echo Sequence and Long-Duration Measurement for Evaluation of Renal Fibrosis in a Rat Fibrosis Model

scientific article published in January 2017

Disease-associated polymorphisms in 9p21 are not associated with extreme longevity

scientific article published on 26 September 2014

Does Hypomagnesemia Predict Faster Progression of Nondiabetic Chronic Kidney Disease?

article published in 2014

Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.

scientific article published on 23 March 2018

Dual effects of statins on Aβ metabolism: upregulation of the degradation of APP-CTF and Aβ clearance

scientific article published on February 2012

E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney

scientific journal article

EFFECT OF AN ANTIHYPERTENSIVE DRUG ON BRAIN ANGIOTENSIN II LEVELS IN RENAL AND SPONTANEOUSLY HYPERTENSIVE RATS

scientific article published on 01 September 1995

EFFECTS OF CHRONIC CONVERTING ENZYME INHIBITION ON THE VASCULAR RENIN-ANGIOTENSIN SYSTEM

scientific article published on 01 November 1990

Earlier management of subjects who are prone to hypertension and diabetes mellitus

scientific article published on April 2004

Early Nephrology Referral 6 Months Before Dialysis Initiation Can Reduce Early Death But Does Not Improve Long-Term Cardiovascular Outcome on Dialysis.

scientific article

Effect of atrial natriuretic peptide on catecholamine release from human pheochromocytoma

scientific article

Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension

scientific article

Effect of azilsartan versus candesartan on nocturnal blood pressure variation in Japanese patients with essential hypertension

scientific article published on 25 July 2013

Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice

Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study

Effect of vasodilator prostaglandins on the vascular renin-angiotensin system

scientific article published on 01 January 1988

Effects of Antihypertensive Drugs and Gene Variants in the Renin-Angiotensin System

article

Effects of Calcium-Channel Blocker Benidipine-Based Combination Therapy on Cardiac Events　- Subanalysis of the COPE Trial

scientific article published on 2 September 2017

Effects of a benidipine-based combination therapy on the risk of stroke according to stroke subtype: the COPE trial

scientific article published on 29 August 2013

Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-Acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-Analysis of the COPE Trial

scientific article published on 29 January 2020

Effects of an angiotensin II receptor antagonist, CV-11974, on angiotensin II-induced increases in cytosolic free calcium concentration, hyperplasia, and hypertrophy of cultured vascular smooth muscle cells

scientific article published on 01 February 1994

Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in a Japanese general population: the Tanno-Sobetsu study

article

Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial

scientific article published on December 2016

Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial

scientific article

Effects of chronic kidney disease and post-angiographic acute kidney injury on long-term prognosis after coronary artery angiography

scientific article published on 12 October 2010

Effects of endothelin on neuroeffector junction in mesenteric arteries of hypertensive rats

scientific article published on 01 June 1990

Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure

scientific article published on 28 August 2009

Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease

scientific article published on 23 August 2011

Effects of triple combination therapy with azilsartan/amlodipine/hydrochlorothiazide on office/home blood pressure: a randomized-controlled trial in Japanese essential hypertensive patients.

scientific article published on 12 December 2017

Effects of weight loss on renal function in overweight Japanese men.

scientific article published on 12 May 2011

Efficacy and Safety of Sacubitril/Valsartan (LCZ696) Compared With Olmesartan in Elderly Asian Patients (≥65 Years) With Systolic Hypertension.

scientific article published in November 2017

Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study

scientific article published on 21 May 2019

Efficacy and safety of fixed-dose losartan/hydrochlorothiazide/amlodipine combination versus losartan/hydrochlorothiazide combination in Japanese patients with essential hypertension

Efficacy and safety of losartan 100 mg/hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension: two randomized, controlled trials

Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models

scientific article published on 18 May 2009

Endothelial progenitor cells in clinical settings

scientific article

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries.

scientific article published in August 1990

Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries

scientific article published on 01 March 1989

Endothelin inhibits presynaptic adrenergic neurotransmission in rat mesenteric artery

scientific article

Endothelin inhibits renin release from isolated rat glomeruli

scientific article published on 01 September 1988

Endothelin stimulates the release of prostacyclin from rat mesenteric arteries

scientific article published on 01 April 1989

Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans

scientific article published on 01 November 1997

Enhanced predictability of myocardial infarction in Japanese by combined genotype analysis

scientific article published on May 1995

Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives.

scientific article published in March 1995

Erratum: Efficacy and safety of losartan 100 mg/hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension: two randomized, controlled trials

scholarly article published in Hypertension Research

Erratum: The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)

scholarly article published in Hypertension Research

Estrogen attenuates vascular remodeling in Lp(a) transgenic mice

scientific article published on 25 January 2010

Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification

scientific article published in July 2010

Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice

scientific article published on 7 December 2016

Evaluation of Morning Blood Pressure Elevation and Autonomic Nervous Activity in Hypertensive Patients Using Wavelet Transform of Heart Rate Variability

scientific article published on 01 December 2006

Evaluation of the efficacy and tolerability of combination therapy with candesartan cilexetil and amlodipine besilate compared with candesartan cilexetil monotherapy and amlodipine besilate monotherapy in Japanese patients with mild-to-moderate esse

scientific article published on 21 March 2012

Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension

scientific article published on 16 April 2014

Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia

scientific article published in June 1990

Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

scientific article published on 15 July 2015

Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome.

scientific article published on 7 October 2009

Factors associated with the severity of obstructive sleep apnea in older adults

scientific article

Fas promoter region gene polymorphism is associated with an increased risk for myocardial infarction.

scientific article published on 27 February 2009

Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress

scientific article

Fetuin-mineral complex reflects extraosseous calcification stress in CKD

scientific article

Fibroblast growth factor 23 and 25-hydroxyvitamin D levels are associated with estimated glomerular filtration rate decline.

scientific article

Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action

scientific article

From mercury sphygmomanometer to electric device on blood pressure measurement: correspondence of Minamata Convention on Mercury

scientific article published on 28 January 2016

Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure

scientific article published on 4 February 2009

G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.

scientific article published in November 2004

Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension

scientific article published in December 2007

Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy

article

Gene therapy in peripheral artery disease

article

Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease.

scientific article

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

scientific article published on 01 November 2006

Genetic basis of hypertension for the development of tailored medicine

scientific article published on 19 June 2009

Genetic impact on uric acid concentration and hyperuricemia in the Japanese population

scientific article published on 13 December 2012

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B

article by Ada Congrains et al published February 2012 in Atherosclerosis

Genome-wide association study for white coat effect in Japanese middle-aged to elderly people: The HOMED-BP study

scientific article published on 23 October 2017

Genome-wide association study of coronary artery disease in the Japanese

scientific journal article

Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study

scientific article published in November 2013

Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes

scientific article published on 25 May 2017

Glucose tolerance and insulin resistance in the elderly

scientific article published in May 1997

Graves' Disease with Markedly Elevated Serum Immunoglobulin E

scientific article published on 01 November 1989

Green coffee bean extract improves human vasoreactivity.

scientific article published in October 2004

Guideline-practice gap in the management of predialysis chronic kidney disease mineral bone disorder in Japan

scientific article published in June 2011

Hardness of the habitual diet and its relationship with cognitive function among 70-year-old Japanese elderly: findings from the SONIC study

article

Helicobacter cinaedi-associated Carotid Arteritis

scientific article published on 01 April 2018

Hemodynamic, renal, and hormonal responses to alpha-human atrial natriuretic peptide in patients with congestive heart failure

article

Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice.

scientific article

Hepatocyte growth factor attenuates renal fibrosis through TGF-β1 suppression by apoptosis of myofibroblasts

scientific article published in December 2010

Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway

scientific article published on 13 June 2011

Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation

scientific article

Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition

scientific article

High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study.

scientific article

High plasma norepinephrine levels associated with beta2-adrenoceptor polymorphisms predict future renal damage in nonobese normotensive individuals

scientific article published on June 2007

High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study

scientific article

Histochemical and immunoelectron microscopic analysis of ganglioside GM3 in human kidney

Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element

scientific article published on 27 May 2013

Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus

scientific article published on 01 June 2019

Hypertension attenuates the efficacy of hypoglycemic therapy for preserving coronary flow reserve in patients with type 2 diabetes

scientific article

Hypertension in a patient with Gitelman's syndrome

scientific article published in September 2004

Hypertension in the elderly: a Japanese perspective

scientific article

Hypoadiponectinemia is an independent risk factor for hypertension

scientific article

Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease

scientific article

Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis

scholarly article by Yusuke Sakaguchi et al published January 2014 in Kidney International

IGF Binding Protein-5 Induces Cell Senescence.

scientific article published on 20 February 2018

Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling

scientific article published on 18 May 2016

Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.

scientific article

Impact of Microsomal Triglyceride Transfer Protein (MTP) in Preventing Hepatic Apoptosis

Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort

scientific article

Impact of concomitant diabetes and chronic kidney disease on preload-induced changes in left ventricular diastolic filling in hypertensive patients

Impairment of Instantaneous Autonomic Regulation Relates to Blood Pressure Fall Immediately after Standing in the Elderly and Hypertensives

scientific article published on 01 August 2006

Improvement of metabolic syndrome by irbesartan via the PPARγ/HGF pathway in apolipoprotein E knockout mice

scientific article published on 25 October 2012

Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

scientific article

Increased plasma level of endothelin with vasoconstriction after dextran infusion.

scientific article published in October 1990

Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular Cells

scientific article published on 14 January 2016

Inflammation and Salt Sensitivity in the Early State of Hypertension

scientific article published on 01 February 2007

Influence of Aging on Progression of Cardiovascular Complications Associated with Insulin Resistance in Patients with Essential Hypertension

scientific article published on 01 June 1997

Influence of Renin Angiotensin System Gene Polymorphisms on Visit-to-Visit Blood Pressure Variability in Hypertensive Patients

article

Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study.

scientific article

Influence of lack of posterior occlusal support on cognitive decline among 80-year-old Japanese people in a 3-year prospective study

scientific article published on 16 September 2018

Inhibition of Lp(a)-induced functional impairment of endothelial cells and endothelial progenitor cells by hepatocyte growth factor

scientific article

Insulin resistance and cardiovascular complications in patients with essential hypertension

scientific article published on 01 December 1996

Insulin resistance is related to silent cerebral infarction in patients with essential hypertension

scientific article

Insulin-mediated regulation of the endothelial renin-angiotensin system and vascular cell growth

scientific article published in January 2004

Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis

scientific article published on 06 March 2012

Interaction between the vascular renin-angiotensin system and prostaglandins

scientific article

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

scientific article published in Nature Communications

Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial.

scientific article published on 27 July 2016

Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model

scientific article

JSH2009 for the management of hypertension in the elderly: A perspective of geriatric medicine

scientific article published on 01 January 2010

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

Japan Geriatrics Society "Recommendations for the Promotion of Advance Care Planning": End-of-Life Issues Subcommittee consensus statement

scientific article published on 23 September 2020

Japan as the front-runner of super-aged societies: Perspectives from medicine and medical care in Japan

scientific article published on 5 February 2015

Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney

scientific article

Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression.

scientific article

Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway.

scientific article

Klotho protein promotes adipocyte differentiation

scientific article published on 18 May 2006

Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation

scientific article published on 15 April 2009

Lack of Correlation between Mbo I Restriction Fragment Length Polymorphism of Renin Gene and Essential Hypertension in Japanese

article

Laparoscopy Reveals a Diversity of Peritoneal Change in Patients with Long-Term Vintage of Peritoneal Dialysis.

scientific article published on 31 October 2015

Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population

scientific article

Links Between Hypertension and Osteoporosis: Benidipine Ameliorates Osteoporosis in Ovariectomized Hypertensive Rats Through Promotion of Osteoblast Proliferation and Inhibition of Osteoclast Differentiation

Links between hypertension and myocardial infarction

scientific article published on July 1996

Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence.

scientific article published on 7 December 2017

Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats

scientific article published on 26 May 2015

Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study

scientific article published on 23 February 2017

Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice

scientific article published on 26 February 2010

Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice

scientific article

Low alpha-synuclein levels in the blood are associated with insulin resistance

scientific article published on 10 July 2015

Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation

scientific article

Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity

scientific article published on 6 June 2005

Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species

scientific article published on 26 March 2009

Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease

scientific article published on 10 June 2015

Magnesium modifies the cardiovascular mortality risk associated with hyperphosphatemia in patients undergoing hemodialysis: a cohort study

scientific article

Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

scientific article

Management of elderly hypertension

scientific article published on 01 January 2010

Massive and rapid left ventricular calcification

scientific article published on 12 March 2009

Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.

scientific article published on 27 August 2012

Membranous nephropathy secondary to Graves' disease with deposits of thyroid peroxidase in an adult

scientific article published on 05 September 2013

Methylenetetrahydrofolate reductase gene polymorphism Relation to blood pressure and cerebrovascular disease

article

Microarray analysis of tonsils in immunoglobulin A nephropathy patients.

scientific article

Microarray analysis of tonsils of IgA nephropathy patients.

scientific article

Minimal Change Nephrotic Syndrome Which Was Most Likely Caused by Chronic Sinusitis

scientific article published on 15 September 2015

Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

scientific article

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

scientific article published on 24 March 2011

Multidetector-row computed tomography is useful to evaluate the therapeutic effects of bisphosphonates in glucocorticoid-induced osteoporosis

scientific article

Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients

scientific article

Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blind and parallel-group study

article

Nifedipine inhibits vascular smooth muscle cell dedifferentiation via downregulation of Akt signaling

scientific article published on 7 June 2010

Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors.

scientific article

Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology

scientific article published on 10 September 2019

Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse

scientific article

Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse

scientific article published on 20 April 2011

Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study

scientific article published on 5 January 2018

Oligonucleotidic therapeutics

scientific article published on September 2008

On-Treatment Blood Pressure and Cardiovascular Outcomes in Older Adults With Isolated Systolic Hypertension

scientific article published on 03 January 2017

Oral glucose loading modulates plasma β-amyloid level in alzheimer's disease patients: potential diagnostic method for Alzheimer's disease

scientific article

Orally Active Vitamin D for Potential Chemoprevention of Posttransplant Malignancy

Organs related to glucose metabolism and aging in animal models

scientific article published on 01 January 2011

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

scientific article

Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma

scientific article published on 06 May 2014

Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment.

scientific article published on 28 January 2014

Peripheral artery disease is associated with frailty in chronic hemodialysis patients.

scientific article

Pharmacogenetic analysis of the effect of angiotensin-converting enzyme inhibitor on restenosis after percutaneous transluminal coronary angioplasty

article

Pharmacogenomic approaches to study the effects of antihypertensive drugs

scientific article published on 28 June 2012

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial.

scientific article published on 13 February 2018

Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers

scientific article published on 10 May 2017

Plasma Atrial Natriuretic Peptide Level As an Index for the Severity of Congestive Heart Failure

scientific article published on 01 August 1987

Plasma B-type natriuretic peptide level predicts kidney prognosis in patients with predialysis chronic kidney disease.

scientific article published in October 2012

Plasma B-type natriuretic peptide level predicts the renal outcome in patients with chronic kidney disease

scientific article published on January 2010

Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients

scientific article published in September 2004

Plasma beta-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease

scientific article published on 21 June 2010

Plasmid DNA-based gene transfer with ultrasound and microbubbles

scientific article published on December 2011

Pneumonia in maintenance hemodialysis patients: detection rate of causative organisms in sputum varies with time of sampling and quality

scientific article published in January 2014

Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease

scientific article published in December 1997

Polymorphism of the apolipoprotein E and angiotensin-converting enzyme genes in Japanese subjects with silent myocardial ischemia

scientific article published in June 1996

Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors

scientific article

Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation

scientific article published on July 1994

Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells

scientific article

Practitioner's trial on the efficacy of antihypertensive treatment in elderly patients with hypertension II (PATE-hypertension II study) in Japan

scientific article

Prediction of Postoperative Complications Following Elective Surgery in Elderly Patients with Colorectal Cancer Using the Comprehensive Geriatric Assessment.

scientific article published on 2 June 2016

Preferable effects of olmesartan/calcium channel blocker to olmesartan/diuretic on blood pressure variability in very elderly hypertension: COLM study subanalysis.

scientific article

Prevalence of frailty in Japan: A systematic review and meta-analysis

scientific article

Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis

scientific article published on 28 October 2019

Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension

scholarly article by Masunori Matsuzaki et al published August 2011 in Journal of Hypertension

Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats

scientific article

Prognostic impact of regional arterial stiffness in hypertensive patients

scientific article

Prognostic significance of left ventricular hypertrophy observed at dialysis initiation depends on the pre-dialysis use of erythropoiesis-stimulating agents

scientific article

Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study

scientific article

Pulmonary venous flow and risk of cardiovascular disease in essential hypertension.

scientific article published in April 2008

Quantitative Ultrasonic Tissue Characterization Can Identify High-Risk Atherosclerotic Alteration in Human Carotid Arteries

scientific article published on 01 August 2000

Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy

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Quiz Page June 2009

scientific article published on 01 June 2009

RENAL INTERACTION OF ATRIAL NATRIURETIC PEPTIDE WITH ANGIOTENSIN II: GLOMERULAR AND TUBULAR EFFECTS

scientific article published on 01 February 1989

Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients.

scientific article published on 23 January 2009

Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor

scientific article published in November 2005

Recent multi-center clinical studies about calcium blockade and cardiovascular diseases

scientific article published in January 2006

Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors

scientific article published on March 1997

Redefining the elderly as aged 75 years and older: Proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society

Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance

scientific article

Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study.

scientific article published on 17 August 2017

Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography

Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications: a sub-analysis of the CASE-J trial

scientific article

Relationship of Bradykinin B2 Receptor Gene Polymorphism with Essential Hypertension and Left Ventricular Hypertrophy

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Relative localization of angiotensin-converting enzyme, chymase and angiotensin II in human coronary atherosclerotic lesions

scientific article published on 01 April 1999

Renal protective effect in hypertensive patients: the high doses of angiotensin II receptor blocker (HARB) study

scientific article

Renal transplantations from parents to siblings with autosomal recessive Alport syndrome caused by a rearrangement in an intronic antisense Alu element in the COL4A3 gene led to different outcomes

scientific article published on 09 December 2012

Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study

scientific article published in September 2007

Renin inhibitor and converting enzyme inhibitors suppress vascular angiotensin II

scientific article published on 01 June 1989

Renin-Angiotensin Inhibition Reverses Advanced Cardiac Remodeling in Aging Spontaneously Hypertensive Rats

scientific article published on 01 July 2007

Reply to ‘Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years’

Reply to “FGF23 adds value to risk prediction in patients with chronic kidney disease”

Response to Hepatocyte Growth Factor and Cardiomyopathy in Dialysis Patients

Response to comment on: Takeda et al. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes 2013;62:223-233.

scientific article published in July 2013

Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats

Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure

scientific article published in October 2001

Rhabdomyolysis caused by peripheral T-cell lymphoma in skeletal muscle

scientific article published on 27 June 2013

Risk Evaluation of Postoperative Delirium Using Comprehensive Geriatric Assessment in Elderly Patients with Esophageal Cancer

scientific article published on 6 June 2016

Risk factors for adverse drug reactions in older inpatients of geriatric wards at admission: Multicenter study

scientific article published on 12 December 2019

Role of angiotensin II in the renal response to atrial natriuretic peptide in normal subjects

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Role of endothelin-1 induced by insulin in the regulation of vascular cell growth

scientific article published on 01 March 2003

Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential

scientific article published on July 2011

Role of serotonin in angiogenesis: induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice

scientific article published on 9 November 2011

Roles of TGF-beta1 and apoptosis in the progression of glomerulosclerosis in human IgA nephropathy

scientific article published on 01 June 2006

Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients

scientific article published on 5 August 2011

Salt sensitivity of Japanese from the viewpoint of gene polymorphism

scientific article

Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure

scientific article

Screening Tool for Older Persons' Appropriate Prescriptions for Japanese: Report of the Japan Geriatrics Society Working Group on "Guidelines for medical treatment and its safety in the elderly".

scientific article published on September 2016

Selective Blockade of Periostin Exon 17 Preserves Cardiac Performance in Acute Myocardial Infarction

scientific article

Self-reported sleep duration and prediction of proteinuria: a retrospective cohort study

scientific article published on 22 October 2011

Senescence gene and anti-aging medicine

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Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients

scientific article

Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients

scientific article

Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease patients: a cross-sectional study

scientific article published on 28 July 2011

Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease

scientific article published on 24 July 2012

Serum interleukin-15 concentration in patients with essential hypertension.

scientific article published in August 2005

Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug.

scientific article published on 18 December 2008

Source of Chronic Inflammation in Aging.

scientific article published on 22 February 2018

Specialist care and improved long-term survival of dialysis patients

scientific article published on 8 January 2010

Standard control for diabetes in older adults based on practice guidelines--the target values of blood glucose, blood pressure and lipids

scientific article published in November 2013

Strong suppression of the renin-angiotensin system has a renal-protective effect in hypertensive patients: high-dose ARB with ACE inhibitor (Hawaii) study

scientific article published on 12 August 2010

Swollen Extraocular Muscle and Tingling Extremities

scientific article published on 21 August 2018

Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study

scientific article published on 7 June 2010

Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-γ/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade

scientific article published on 17 January 2012

Telmisartan modulates mitochondrial function in vascular smooth muscle cells

scientific article published on 20 December 2012

Telmisartan-induced inhibition of vascular cell proliferation beyond angiotensin receptor blockade and peroxisome proliferator-activated receptor-gamma activation

scientific article published on 12 October 2009

The Authors Reply:

The Authors Reply:

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

scientific article published on 18 May 2020

The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature

scientific article published on 14 May 2009

The Japan Geriatrics Society consensus statement "recommendations for older persons to receive the best medical and long-term care during the COVID-19 outbreak-considering the timing of advance care planning implementation"

scientific article published on 02 November 2020

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)

scientific article published on 01 April 2014

The Japanese Society of Hypertension-Digest of plan for the future

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The Prevalence of Frailty and its Associated Factors in Japanese Hemodialysis Patients.

scientific article published in April 2018

The Usefulness of an Alternative Diagnostic Method for Sarcopenia Using Thickness and Echo Intensity of Lower Leg Muscles in Older Males

scientific article published on 20 March 2019

The combination of chronic kidney disease and increased arterial stiffness is a predictor for stroke and cardiovascular disease in hypertensive patients

scientific article published on 4 August 2011

The combination therapy of hypertension to prevent cardiovascular events (COPE) trial: rationale and design

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The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells

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The impact of diabetes mellitus on vitamin D metabolism in predialysis patients

scientific article published on 23 July 2009

The impact of visit-to-visit variability in blood pressure on renal function

The influence of aging on the diagnosis of primary aldosteronism

The metabolic syndrome in the asian population

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The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats

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The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats

The role of gerontology in the era of a super-aged society

scientific article published on 01 January 2014

The role of sympathetic nervous activity in renal injury and end-stage renal disease.

scientific article published on 26 March 2010

The standard value of hypertension from the view of independence

scientific article published in January 2013

Therapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent

scientific article published on April 2014

Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease

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Therapeutic option of plasmid-DNA based gene transfer

scientific article published on January 2012

Therapeutic vaccine against DPP4 improves glucose metabolism in mice

scientific article published on 17 March 2014

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule.

scientific article published on 17 March 2016

Timp-3 deficiency impairs cognitive function in mice

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Tissue Inhibitor of Metalloproteinase-3 Deficiency Inhibits Blood Pressure Elevation and Myocardial Microvascular Remodeling Induced by Chronic Administration of N.OMEGA.-Nitro-L-Arginine Methyl Ester in Mice

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Tissue Inhibitor of Metalloproteinase-3 Plays Important Roles in the Kidney Following Unilateral Ureteral Obstruction

scientific article published on 01 April 2006

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis

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Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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Trp64Arg Mutation of ?-Adrenergic Receptor in Essential Hypertension Insulin Resistance and the Adrenergic System

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Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient

Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.

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Ultrasonographic measurement of intima-media thickness in the diagnosis of arteriosclerosis

scientific article published in March 2004

Upregulation of Angiotensin-Converting Enzyme During the Healing Process After Injury at the Site of Percutaneous Transluminal Coronary Angioplasty in Humans

scientific article published on 01 November 1997

Upregulation of cAMP is a new functional signal pathway of Klotho in endothelial cells

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Upregulation of renin-angiotensin system during differentiation of monocytes to macrophages

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Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension.

scientific article published on 27 December 2005

Urinary Type IV Collagen in Nondiabetic Kidney Disease

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Urine Osmolarity Predicts the Body Weight-Reduction Response to Tolvaptan in Chronic Kidney Disease Patients: A Retrospective, Observational Study

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Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy

Usefulness of bone resorption markers in hemodialysis patients.

scientific article published on 28 March 2009

Usefulness of the resistive index in renal Doppler ultrasonography as an indicator of vascular damage in patients with risks of atherosclerosis

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Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease

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Variation in OSBPL10 is associated with dyslipidemia

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Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity

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Vascular injury induces angiotensinogen gene expression in the media and neointima

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Vascular signaling pathways in the metabolic syndrome

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Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence

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Vitamin D deficiency predicts decline in kidney allograft function: a prospective cohort study

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