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List of works by Valeria Poli

"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells

scientific article published on 6 December 2013

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.

scientific article

A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.

scientific article published in February 2007

A role of STAT3 in Rho GTPase-regulated cell migration and proliferation

scientific article published on 10 February 2005

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

scientific article published on 19 June 2019

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

scientific article

Analysis of SOCS-3 promoter responses to interferon gamma

scientific article published on 23 January 2004

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

scientific article published on 9 June 2015

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 01 September 2018

C/EBP beta blocks p65 phosphorylation and thereby NF-kappa B-mediated transcription in TNF-tolerant cells

scientific article published on July 2006

C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages.

scientific article published on April 2002

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways

scientific article

C/EBPbeta is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not Interleukin-6, regulation

article

C/EBPβ Phosphorylation by RSK Creates a Functional XEXD Caspase Inhibitory Box Critical for Cell Survival ⬇️

scientific article published on October 1, 2001

CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy

scientific journal article

Characterization of an IL-6-responsive element (IL6RE) present on liver-specific genes and identification of the cognate IL-6-dependent DNA-binding protein (IL6DBP)

article

Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints

scientific article published on 8 December 2014

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

scientific article published on 9 March 2010

Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 01 April 2020

Correction: Prevention of Hypovolemic Circulatory Collapse by IL-6 Activated Stat3.

scientific article

Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

scientific article published on 13 October 2005

Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3.

scientific article

Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice.

scientific article published on September 1997

Defective inflammatory response in interleukin 6-deficient mice

scientific article

Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta

scientific article published on July 2005

Diazoxide postconditioning induces mitochondrial protein S-nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE.

scientific article published on 20 July 2013

Differential effects of IL-6 on systemic and central production of TNF: a study with IL-6-deficient mice

scientific article published on May 1997

Differential transcriptional pattern of the hemopexin gene

scientific article

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

scientific article

Effect of TGF beta on liver genes expression. Antagonistic effect of TGF beta on IL-6-stimulated genes in Hep 3B cells

scientific article published on April 1992

Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies

scientific article published in June 1998

Endogenous leukemia inhibitory factor attenuates endotoxin response

scientific article

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Inactivation in the Liver

scientific article published in April 2001

From the nucleus to the mitochondria and back: The odyssey of a multitask STAT3

scientific article published on 01 October 2011

From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities.

scientific article published in June 2012

Functional analysis of IL-6 and IL-6DBP/C/EBP beta by gene targeting

article

Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3.

scholarly article

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

scientific article

IL-6 knock-out mice show modified basal immune functions, but normal immune responses to stress

scientific article published on September 1998

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

scientific article published on June 2012

IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing.

scientific article

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP

scientific journal article

IMPAIRED STAT3 ACTIVATION FOLLOWING LOCALIZED INFLAMMATORY STIMULUS IN IL-6-DEFICIENT MICE

scientific article published on 01 January 1998

Identification of functional cis-regulatory polymorphisms in the human genome.

scientific article published on 5 April 2013

Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBPbeta

scientific article published on 01 July 1997

Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans

scientific article

In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway

scientific article published in August 1998

Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice

scientific article

Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis

scientific article published in April 2004

Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice

scientific article

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation

scientific article published on February 1997

Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus

scientific article

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

scientific article

Interleukin 6 is required for the development of collagen-induced arthritis

scientific article

Interleukin-6 and CAAT/Enhancer Binding Protein β-Deficient Mice Act as Tools to Dissect the IL-6 Signalling Pathway and IL-6 Regulation ⬇️

scientific article published on December 1, 1997

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

scientific article published on March 1994

Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo

scientific article published on August 1997

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice

scientific article published in November 1996

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

scientific article published on 02 September 2014

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

scientific article published in Nature Communications

Magnetically enriched bone marrow-derived macrophages loadedin vitro with iron oxide can migrate to inflammation sites in mice

scientific article published on 01 February 2008

Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.

scientific article

MicroRNAs-143 and -145 induce epithelial to mesenchymal transition and modulate the expression of junction proteins

scientific article

Mutational switch of an IL-6 response to an interferon-gamma-like response

scientific article

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

scientific article published on 22 January 2015

Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section

scientific article published in December 1997

Nucleocytoplasmic shuttling of persistently activated STAT3.

scientific article published on 28 August 2007

Of alphas and betas: distinct and overlapping functions of STAT3 isoforms

scientific article published on May 2008

Overexpression of interleukin-6 in the central nervous system of transgenic mice increases central but not systemic proinflammatory cytokine production

scientific article published in November 1996

PKM2, STAT3 and HIF-1α: The Warburg's vicious circle

scientific article published on July 2012

PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

scientific journal article

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

scientific article published on 30 September 2014

Presence of a reduced opioid response in interleukin-6 knock out mice

scientific article published in May 1999

Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha.

scientific article published on 15 June 2008

Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3.

scientific article published on February 2009

Pro-malignant properties of STAT3 during chronic inflammation ⬇️

scientific article published on April 1, 2012

Psoriasis: A STAT3-Centric View

scientific article published on 6 January 2018

Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

scientific article

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

scientific article

Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice

scientific article published in August 2000

Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons

scientific article

Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth

scientific article published in October 1997

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.

scientific article

STAT1 and STAT3 in tumorigenesis: A matter of balance.

scientific article

STAT3 Activities and Energy Metabolism: Dangerous Liaisons.

scientific article published on 31 July 2014

STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration.

scientific article

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy.

scientific article published on 5 March 2013

STAT3 and metabolism: how many ways to use a single molecule?

scientific article published on 19 February 2014

STAT3 can serve as a hit in the process of malignant transformation of primary cells

scientific article

STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration

scientific article

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 11 June 2018

STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses

scientific article published on 24 July 2018

STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published on 22 July 2015

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

scientific article published on 08 June 2015

STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.

scientific article published on 25 April 2006

STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.

scientific article

Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis

scientific article published on February 1997

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

article

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

scientific article published on 10 June 2004

Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.

scientific article

Stat3 and the inflammation/acute phase response in involution and breast cancer

scientific article published on 08 May 2009

Stat3 controls lysosomal-mediated cell death in vivo

scientific article published on 20 February 2011

Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

scientific article

Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene

scientific article

Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors

scientific article

Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.

scientific article

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin

scientific article

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

scientific article published on March 2010

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.

scientific article

The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4

scientific article

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

scientific article published on 26 June 2009

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

scientific article published in Journal of Biological Chemistry

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 08 July 2019

The STAT3 isoforms alpha and beta have unique and specific functions

scientific article published on 14 March 2004

The Transcription Factor CCAAT/Enhancer-binding Protein β Regulates Gluconeogenesis and Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription during Diabetes

scientific article published in Journal of Biological Chemistry

The analysis of the human hemopexin promoter defines a new class of liver-specific genes

scientific article published on November 1989

The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3

article

The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors

scientific article

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

scientific article published on 01 April 2000

The role of IL-6 in the inflammatory and humoral response to adenoviral vectors

scientific article published in May 2000

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3.

scientific article published on 15 February 2011

The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts

scientific article published on 24 August 2001

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

scientific article published on 19 June 2009

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

scientific article

Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants

scientific article

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

scientific article published on 22 June 2008

Where Sin3a Meets STAT3: Balancing STAT3-Mediated Transcriptional Activation and Repression

scientific article published on 01 June 2019

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