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List of works by Timothy J Mitchell

A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro

scientific article published on 19 June 2015

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

scientific article

A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers

scientific article published on February 1998

A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans

scientific article published on 30 May 2016

A neuraminidase from Streptococcus pneumoniae has the features of a surface protein

scientific article published on September 1994

A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs ⬇️

scientific article published on November 1, 1997

A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae

scientific article published on 01 August 1994

A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae.

scientific article published on March 2004

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.

scientific article published on December 2011

Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization.

scientific article

Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack

scientific article published on 29 July 2016

Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia

scientific article published on 01 March 1998

Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis

scientific article published on February 1994

An operon in Streptococcus pneumoniae containing a putative alkylhydroperoxidase D homologue contributes to virulence and the response to oxidative stress.

scientific article published on 15 March 2006

Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007.

scientific article published on 22 July 2010

Antipneumolysin antibody titers in HIV-seropositive injection drug users before and after pneumococcal bacteremia.

scientific article published on March 2001

Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema

scientific article published on 11 October 2011

Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.

scientific article

Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin

scientific article published on 01 May 1987

Biological properties of pneumolysin

scientific article published on January 1997

Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity

scientific article published on 7 January 2011

Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae

scientific article published on July 1994

Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro

scientific article published on 01 October 2011

Characterization of the solution properties and conformation of pneumolysin, the membrane-damaging toxin of Streptococcus pneumoniae

scientific article published on December 1993

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae.

scientific article published on 11 January 2007

Cloning, overexpression, purification, crystallization and preliminary diffraction analysis of the receiver domain of MicA.

scientific article published on 25 March 2003

Clostridium difficile--a spectrum of virulence and analysis of putative virulence determinants in the hamster model of antibiotic-associated colitis

scientific article published on 01 August 1987

Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages

scientific article published on 05 June 2009

Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2.

scientific article published on July 1990

Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

scientific article published on 10 September 2007

Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein

scientific article published on 01 August 1991

Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae

scientific article

Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae

scientific article published on August 2004

Crystal Structure of the C-terminal Region of Streptococcus mutans Antigen I/II and Characterization of Salivary Agglutinin Adherence Domains ⬇️

scientific article published on April 19, 2011

Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states ⬇️

scientific article

Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae

scientific article

Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae

scientific article published in March 1993

Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types.

scientific article

Delta 32 deletion of CCR5 gene and association with asthma or atopy

scientific article published on 01 October 2000

Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group.

scientific article

Development of a prophage typing system and analysis of prophage carriage in Streptococcus pneumoniae

scientific article published on 23 January 2009

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.

scientific article

Differential alveolar epithelial injury and protein expression in pneumococcal pneumonia

scientific article published in June 2012

Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin

scientific article published on 3 December 2012

Dissecting the components of the humoral immune response elicited by DNA vaccines

scientific article published on 13 September 2005

Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia

scientific article published on 01 April 1996

Distribution of epidemic antibiotic-resistant pneumococcal clones in Scottish pneumococcal isolates analysed by multilocus sequence typing

scientific article published on 01 February 2006

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection

scientific article (publication date: 2013)

Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination

scientific article published in December 2004

Dynamics of pneumococcal colonization in healthy Dutch children

scientific article published in February 2006

Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae

scientific article

Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

scientific article published on November 1992

Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells

scientific article published on 01 March 2000

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

scientific article

Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin

scientific article published on 27 June 2012

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo

scientific article

Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).

scientific article

Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2

scientific article (publication date: 2012)

Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury

scientific article

Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties

scientific article published on 01 January 1989

Expression, purification and X-ray characterization of residues 18-230 from the pneumococcal histidine triad protein A (PhtA) from Streptococcus pneumoniae

scientific article published on 21 April 2004

Expression, purification, crystallization and preliminary X-ray crystallographic data from TktA, a transketolase from the lactic acid bacterium Lactobacillus salivarius

scientific article

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue

scientific article

Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching

scientific article published on December 2004

Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses

scientific article published on 17 February 2015

Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea

scientific article published on 01 April 1995

Growth of Clostridium difficile and production of toxins A and B in complex and defined media

scientific article published on 01 June 1986

Host cellular immune response to pneumococcal lung infection in mice.

scientific article

Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium.

scientific article published on 17 February 2006

IL-17 can be protective or deleterious in murine pneumococcal pneumonia.

scientific article published on 29 May 2018

Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.

scientific article published on 15 April 2005

Identification of a secreted cholesterol-dependent cytolysin (mitilysin) from Streptococcus mitis

scientific article published on 27 October 2006

Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

scientific article published on July 2011

Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.

scientific article

Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae.

scientific article

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.

scientific article published on 6 February 2009

IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media.

scientific article

Immune ageing and susceptibility to Streptococcus pneumoniae

scientific article published on 15 October 2015

Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis

scientific article published on 9 August 2007

Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae

scientific article

Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases

scientific article published on December 2008

Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro

scientific article published on 29 August 2007

Innate immunity and the pneumococcus.

scientific article

Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa.

scientific article

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

scientific article published on 12 December 2011

Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea.

scientific article

Investigating the role of pneumococcal neuraminidase A activity in isolates from pneumococcal haemolytic uraemic syndrome

scientific article

Isolation and characterization of a new plasmid pSpnP1 from a multidrug-resistant clone of Streptococcus pneumoniae

scientific article published on 2 February 2007

Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene

scientific article

Limited protection of TAT-Bcl-X(L) against pneumolysin-induced neuronal cell death

scientific article published on August 2005

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

scientific article published on 6 March 2007

Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation

scientific article published on 9 September 2017

Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence.

scientific article

Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide

scientific article published on September 2000

Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins

scientific article published on January 1993

Molecular analysis of virulence factors of Streptococcus pneumoniae

scientific article published on January 1997

Molecular basis of virulence Commentary ⬇️

scientific article published on March 1, 1998

Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media

scientific article

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.

scientific article published on August 2016

Natural Antibodies against Several Pneumococcal Virulence Proteins in Children during the Pre-Pneumococcal-Vaccine Era: the Generation R Study ⬇️

scientific article published on January 31, 2011

Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase.

scientific article

Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae

scientific article

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

scientific article

Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae.

scientific article published on 24 February 2010

Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae

scientific article published on 10 June 2006

Palladium attenuates the pro-inflammatory interactions of C5a, interleukin-8 and pneumolysin with human neutrophils.

scientific article published in July 2007

PclA, a pneumococcal collagen-like protein with selected strain distribution, contributes to adherence and invasion of host cells.

scientific article published on 28 June 2008

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

scientific article

Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

scientific journal article

Pneumococcal pneumonia: mechanisms of infection and resolution.

scientific article published on August 2012

Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland

scientific article published on 01 August 2006

Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells

scientific article published on 18 November 2005

Pneumolysin Mediates Platelet Activation In Vitro

scientific article published on 18 May 2016

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

scientific article published on 7 October 2014

Pneumolysin activates neutrophil extracellular trap formation

scientific article

Pneumolysin activates phospholipase A in pulmonary artery endothelial cells.

scientific article published on September 1994

Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro.

scientific article published on 24 July 2002

Pneumolysin causes neuronal cell death through mitochondrial damage

scientific article published on 11 June 2007

Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils.

scientific article published in November 2009

Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo

scientific article published on 01 November 1991

Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro

scientific article published on 3 March 2017

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

scientific article published on May 2001

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

scientific article published on April 1994

Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

scientific article published on August 1989

Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4.

scientific article published on 23 October 2010

Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid.

scientific article

Potential impact of conjugate vaccine on the incidence of invasive pneumococcal disease among children in Scotland

scientific article

Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks

scientific article published on 6 August 2007

Production and release of toxins A and B by Clostridium difficile

scientific article published on 01 December 1984

Proinflammatory interactions of pneumolysin with human neutrophils.

scientific article

Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate

scientific article published on 01 August 1994

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

scientific article

Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide

scientific article published on July 1991

Purification, crystallization and preliminary X-ray analysis of the Enterococcus faecalis protein EF0377.

scientific article published on 25 March 2003

Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae

scientific article published on 26 June 2006

Rapid Pneumococcal Evolution in Response to Clinical Interventions ⬇️

scientific article (publication date: 28 January 2011)

Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking.

scientific article

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

scientific article published on 17 January 2008

Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES.

scientific article published on 16 March 2016

Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone

scientific article

Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent

scientific article published on 3 November 2006

Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children.

scientific article published on August 2006

Relationship of structure to function in pneumolysin

scientific article published on January 1997

Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency.

scientific article published on March 2000

Role of HtrA in the virulence and competence of Streptococcus pneumoniae

scientific article

Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81

scientific article

Role of interleukin-18 in experimental infections with Streptococcus pneumoniae.

scientific article published in April 2005

Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.

scientific article

Role of platelet-activating factor in pneumolysin-induced acute lung injury

scientific article published in July 2007

Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia.

scientific article published in July 2006

Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

article

Sensitivities of human monocytes and epithelial cells to pneumolysin are different.

scientific article published on February 2002

Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status

scientific article

Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization

scientific article

Simultaneous nasopharyngeal carriage of two pneumococcal multilocus sequence types with a serotype 3 phenotype

scientific article

Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model.

scientific article published on 13 October 2005

Sporogenesis and toxin A production by Clostridium difficile

scientific article published on 01 August 1986

Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine

scientific article

Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells

scientific article

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

scientific article published on 01 March 1997

Streptococcus pneumoniae produces at least two distinct enzymes with neuraminidase activity: cloning and expression of a second neuraminidase gene in Escherichia coli.

scientific article published on August 1991

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

scientific article published on 10 October 2003

Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium

scientific article published on September 2004

Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody

scientific article published on November 2004

Streptococcus pneumoniae: infection, inflammation and disease

scientific article published on January 2006

Structural and functional characterisation of two proteolytic fragments of the bacterial protein toxin, pneumolysin

scientific article published on 01 August 1997

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

scientific article published on 20 November 2020

Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae ⬇️

scientific article published on November 1, 1991

Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering

scientific article published in November 1999

Subunit organisation and symmetry of pore-forming, oligomeric pneumolysin

scientific article published on 01 August 1995

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease

scientific article published in September 2009

Temporal Analysis of Invasive Pneumococcal Clones from Scotland Illustrates Fluctuations in Diversity of Serotype and Genotype in the Absence of Pneumococcal Conjugate Vaccine. ⬇️

scientific article published in April 2010

Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. ⬇️

scientific article published on 18 November 2009

The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease.

scientific article

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

scientific article published on 06 June 2011

The biology of Gram-positive sortase enzymes

scientific article published on February 2004

The biology of pneumolysin

scientific article published on January 2014

The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro

scientific article published on October 1990

The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia

scientific article published on 01 November 1999

The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers

scientific article published on 01 May 1987

The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and non-immune rabbits

scientific article published on 01 August 1987

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

scientific article published on 01 May 1987

The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype.

scientific article published on 2 November 2009

The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein

scientific article published in January 2004

The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro

scientific article published in May 1992

The mechanism of pneumolysin-induced cochlear hair cell death in the rat.

scientific article published on 28 July 2005

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

scientific article

The pathogenesis of streptococcal infections: from tooth decay to meningitis

scientific article published on December 2003

The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis.

scientific article published on 10 August 2005

The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

scientific article published on May 2004

The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus

scientific article published on 01 July 1995

The role of streptococcal toxins in disease ⬇️

scientific article published on January 1, 1998

The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O.

scientific article

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

scientific article published on 17 August 2009

The use of microarray technology for the analysis of Streptococcus pneumoniae.

scientific article

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

scientific article published on 21 October 2010

Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010.

scientific article published on 24 June 2013

Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.

scientific article

Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo

scientific article published on 01 January 2001

Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae.

scientific article

What is different about serotype 1 pneumococci?

scientific article published on January 2012

ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract

scientific article published on September 2003

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