Search filters

List of works by Maria Trojanowska

A role for estrogen receptor-α and estrogen receptor-β in collagen biosynthesis in mouse skin

scientific article published on 16 August 2012

Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis

scientific article published on 26 June 2012

Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts

scientific article

Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts

scientific article published on 25 February 2010

Altered properties of endothelial cells and mesenchymal stem cells underlying the development of scleroderma-like vasculopathy in Klf5+/- ;Fli1+/- mice

scientific article published on 06 July 2020

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma

scientific article published on May 2004

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

scientific article

Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts.

scientific article published on 6 December 2010

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

scientific article

Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway.

scientific article published on 30 August 2011

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis

scientific article published on 29 June 2010

Characterization of a GC-rich Region Containing Sp1 Binding Site(s) as a Constitutive Responsive Element of the α2(I) Collagen Gene in Human Fibroblasts

scientific article published in Journal of Biological Chemistry

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.

scientific article

Collagen binding alpha2beta1 and alpha1beta1 integrins play contrasting roles in regulation of Ets-1 expression in human liver myofibroblasts

scientific article

Comparative studies of oncostatin M expression in the tissues of adult rodents

scientific article

Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells

scientific article

Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells

scientific article published on 22 January 2008

Different Effects of Basic Fibroblast Growth Factor and Transforming Growth Factor-β on the Two Platelet-Derived Growth Factor Receptors' Expression in Scleroderma and Healthy Human Dermal Fibroblasts

scientific article published on 01 January 1995

Differential Responses of Human Papillary and Reticular Fibroblasts to Growth Factors

article

Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts

scientific article

Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts

scientific article published in October 2001

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

scientific article published on 8 November 2005

Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation

scientific article

Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin

scientific article published on 29 June 2007

Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.

scientific article

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

scientific article

Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.

scientific article

Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension

scientific article published on 11 April 2013

Ets factors and regulation of the extracellular matrix

scientific article

Ets proteins in biological control and cancer

scientific article published on April 2004

Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter

scientific article (publication date: 16 December 1999)

Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta

scientific article published on 27 March 2002

Expression of oncostatin M and its receptors in normal and cirrhotic human liver

scientific article published on 26 July 2005

FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in Human Dermal Microvascular Endothelial Cells

scientific article published on 26 September 2020

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor ?

scientific article published on 01 April 2005

Fibrosis in systemic sclerosis

scientific article published on February 2008

Fli-1 Inhibits Collagen Type I Production in Dermal Fibroblasts via an Sp1-dependent Pathway

scientific article published in Journal of Biological Chemistry

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program

scientific article published on 6 July 2006

Fli1 is a negative regulator of estrogen receptor α in dermal fibroblasts

scientific article published on 31 March 2011

GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts

scientific article

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts

scholarly article by Humphrey Gardner et al published June 2006 in Arthritis and Rheumatism

Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes

scientific article published on June 2010

HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells

scientific article published on 24 March 2010

Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding

scientific article published on 17 January 2008

IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts

scientific article

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

article

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension

scientific article

Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma.

scientific article

Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta

scientific article published on June 2000

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2.

scientific article

Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts

scientific article published in October 2004

Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway

scientific article published on 26 March 2004

Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells

scientific article published on 04 November 2005

Mediators of fibrosis

scientific article

Mitogenic effect of transforming growth factor beta 1 on human fibroblasts involves the induction of platelet-derived growth factor alpha receptors

scientific article published in October 1990

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

scientific article published on 6 January 2003

Molecular aspects of scleroderma

scientific article

Molecular pathways as novel therapeutic targets in systemic sclerosis

scientific article published on November 2007

Noncanonical transforming growth factor beta signaling in scleroderma fibrosis

scientific article

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

scientific article published in Journal of Biological Chemistry

Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts

scientific article published on 01 February 2002

Oncostatin M: a cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells

scientific article published on 01 February 2000

Opposing Effects of Protein Kinase Cα and Protein Kinase Cϵ on Collagen Expression by Human Lung Fibroblasts Are Mediated via MEK/ERK and Caveolin-1 Signaling

scientific article published in Journal of Biological Chemistry

Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway

scientific article published on 15 May 2008

Pathogenesis of fibrosis: type 1 collagen and the skin

scientific article published on March 1998

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin

scientific article published on August 2003

Persistent effect of TGF-β1 on extracellular matrix gene expression in human dermal fibroblasts

article

Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta

scientific article published on 21 January 2009

Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors

scientific article published in March 2006

Pulmonary and Activation-Regulated Chemokine Stimulates Collagen Production in Lung Fibroblasts

scientific article published on 12 June 2003

Recent advances in fibroblast signaling and biology in scleroderma

scientific article

Retracted: HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells

retracted article

Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate

article

Role of PDGF in fibrotic diseases and systemic sclerosis

scientific article published on October 2008

Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts

scientific article published on March 2003

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts

scientific article

Self‐Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis

scientific article published on 30 May 2022

Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate

scientific article published in August 2008

Sp3 is a transcriptional activator of the human alpha2(I) collagen gene

scientific article

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

scientific article

Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

scientific article published in August 2001

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

scientific article published on 01 January 1999

Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis

scientific article

TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells

scientific article published in October 2002

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1

scientific journal article

The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway

scientific article published on 15 November 2017

The Role of TGF-β Receptors in Fibrosis

scientific article published on 15 June 2012

The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts

scientific article

The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis

scientific article published on 03 July 2010

The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis

scientific article

The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis

scientific article

The role of the Oncostatin M/ OSM receptor β axis in activating dermal microvascular endothelial cells in Systemic Sclerosis

scientific article published on 17 April 2020

The role of the Oncostatin M/ OSM receptor β axis in activating dermal microvascular endothelial cells in Systemic Sclerosis

scientific article published on 7 July 2020

The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

scientific article published on 31 July 2020

Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin

scientific article

Transcriptional Regulation of the Human α2(I) Collagen Gene

scientific article published in Journal of Biological Chemistry

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways

scientific article published on 15 February 2007

Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation

scientific article

Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways

scientific article published in March 2006

Paulina is supported by:

About Paulina

Help