List of works - Valter Longo

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

scientific article published on 25 May 2016

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

scientific article published on 18 June 2015

A Radical Signal Activates the Epigenetic Regulation of Longevity ⬇️

scientific article published on June 4, 2013

A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer

scientific article published on 29 July 2020

A protein restriction-dependent sulfur code for longevity

scientific article published on January 2015

A review of the biomedical innovations for healthy longevity

scientific article

Abstract 3374: Fasting chemosensitizes tumor cells by affecting their metabolism

Acetic acid and acidification accelerate chronological and replicative aging in yeast

scientific article published on 5 September 2012

Acetyl-CoA synthetase is a conserved regulator of autophagy and life span

scientific article

Analysis of gene expression profile in yeast aging chronologically

scientific article published in January 2005

Assessing chronological aging in Saccharomyces cerevisiae.

scientific article published on January 2013

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

scientific article published on 04 December 2020

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.

scientific article published on 10 January 2017

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

scientific article

Cell resilience in species life spans: a link to inflammation?

scientific article

Chronological Aging in Saccharomyces cerevisiae ⬇️

scientific article published on January 1, 2012

Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant

scientific article

Conserved role of Ras-GEFs in promoting aging: from yeast to mice ⬇️

scientific article published on April 1, 2011

Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

scientific article published on May 2017

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies

scientific article published on May 2016

Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease

scientific article published on 01 March 2019

Dietary protein restriction inhibits tumor growth in human xenograft models

scientific article published on December 2013

Dietary restriction with and without caloric restriction for healthy aging

scientific article

Dysregulated metabolism contributes to oncogenesis

scientific article

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice ⬇️

scientific article published on February 2017

Evolutionary medicine: from dwarf model systems to healthy centenarians?

scientific article

Extending healthy life span--from yeast to humans

scientific article

Fasting and Caloric Restriction in Cancer Prevention and Treatment

scientific article

Fasting and cancer treatment in humans: A case series report.

scientific article

Fasting and differential chemotherapy protection in patients

scientific article

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

scientific article

Fasting enhances the response of glioma to chemo- and radiotherapy

scientific article (publication date: 2012)

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.

scientific article published in May 2015

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

scientific article published on 23 June 2020

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

scientific article

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

scientific article

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

article by Priya Rangan et al published 5 March 2019 in Cell Reports

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

scientific article published in February 2017

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

scientific article

Fasting-mimicking diet and hormone therapy induce breast cancer regression

scientific article published on 15 July 2020

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

scientific article published in February 2017

Fasting: molecular mechanisms and clinical applications

scientific article

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity

scientific article published on 18 May 2015

Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity

scientific article published on 19 February 2020

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

scientific article

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

scientific article published in Scientific Reports

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

scientific article

IGF-I regulates the age-dependent signaling peptide humanin.

scientific article

Impact papers on aging in 2009.

scientific article

Inference of transcription modification in long-live yeast strains from their expression profiles

scientific article

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain

scientific article

Intermittent supplementation with rapamycin as a dietary restriction mimetic.

scientific article published in November 2011

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

scientific article

Linking Klotho, Nrf2, MAP kinases and aging

scientific article published on October 2010

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.

scientific article

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

scientific article

Meal frequency and timing in health and disease

scientific article

Medical research: treat ageing.

scientific article

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

scientific article published on 27 January 2017

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism

scientific article published on 17 August 2009

Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.

scientific article published in May 2002

Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

scientific article

Protective effects of short-term dietary restriction in surgical stress and chemotherapy

scientific article published on 16 February 2017

Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity

scientific article published on 01 November 2019

Protein and amino acid restriction, aging and disease: from yeast to humans

scientific article

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.

scientific article

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index

scientific article

Replicative and chronological aging in Saccharomyces cerevisiae.

scientific article

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

scientific article

SIRT1 is essential for normal cognitive function and synaptic plasticity

scientific article

Safety and feasibility of fasting in combination with platinum-based chemotherapy

scientific article

Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging

scientific article

Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression.

scientific article published on 21 February 2013

Significant and systematic expression differentiation in long-lived yeast strains

scientific article

Sir2 blocks extreme life-span extension.

scientific article

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

scientific article published on July 2008

Sirtuins in aging and age-related disease.

scientific article published on July 2006

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity ⬇️

scientific article published on April 1, 2013

Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.

scientific article

Starvation, Stress Resistance, and Cancer

scientific article published on 17 February 2018

Starvation, detoxification, and multidrug resistance in cancer therapy ⬇️

scientific article published on February 1, 2012

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

scholarly article

Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model.

scientific article published on 29 September 2011

Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase

scientific article

Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae

scientific article published in September 2004

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

scientific article published on 11 May 2020

The Longevity Diet

book by Valter Longo

The chronological life span of Saccharomyces cerevisiae

scientific article

The chronological life span of Saccharomyces cerevisiae

scientific article published on 01 January 2007

The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease.

scientific article

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

scientific article published on 23 June 2020

Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity

scientific article

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

scientific article published on 8 May 2009

When Fasting Gets Tough, the Tough Immune Cells Get Going—or Die

scientific article published on 22 August 2019

List of works by Valter Longo

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

A Radical Signal Activates the Epigenetic Regulation of Longevity ⬇️

A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer

A protein restriction-dependent sulfur code for longevity

A review of the biomedical innovations for healthy longevity

Abstract 3374: Fasting chemosensitizes tumor cells by affecting their metabolism

Acetic acid and acidification accelerate chronological and replicative aging in yeast

Acetyl-CoA synthetase is a conserved regulator of autophagy and life span

Analysis of gene expression profile in yeast aging chronologically

Assessing chronological aging in Saccharomyces cerevisiae.

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

Cell resilience in species life spans: a link to inflammation?

Chronological Aging in Saccharomyces cerevisiae ⬇️

Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant

Conserved role of Ras-GEFs in promoting aging: from yeast to mice ⬇️

Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies

Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease

Dietary protein restriction inhibits tumor growth in human xenograft models

Dietary restriction with and without caloric restriction for healthy aging

Dysregulated metabolism contributes to oncogenesis

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice ⬇️

Evolutionary medicine: from dwarf model systems to healthy centenarians?

Extending healthy life span--from yeast to humans

Fasting and Caloric Restriction in Cancer Prevention and Treatment

Fasting and cancer treatment in humans: A case series report.

Fasting and differential chemotherapy protection in patients

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

Fasting enhances the response of glioma to chemo- and radiotherapy

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

Fasting: molecular mechanisms and clinical applications

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity

Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

IGF-I regulates the age-dependent signaling peptide humanin.

Impact papers on aging in 2009.

Inference of transcription modification in long-live yeast strains from their expression profiles

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain

Intermittent supplementation with rapamycin as a dietary restriction mimetic.

Interventions to Slow Aging in Humans: Are We Ready?

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

Linking Klotho, Nrf2, MAP kinases and aging

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Meal frequency and timing in health and disease

Medical research: treat ageing.

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism

Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.

Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity

Protein and amino acid restriction, aging and disease: from yeast to humans

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index

Replicative and chronological aging in Saccharomyces cerevisiae.

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

SIRT1 is essential for normal cognitive function and synaptic plasticity

Safety and feasibility of fasting in combination with platinum-based chemotherapy

Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging

Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression.

Significant and systematic expression differentiation in long-lived yeast strains

Sir2 blocks extreme life-span extension.

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Sirtuins in aging and age-related disease.