List of works - Stephen Hanessian

3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin

scientific article published in September 2005

6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase.

scientific article published on 12 March 2007

A Constrained Tricyclic Nucleic Acid Analogue of α-l-LNA: Investigating the Effects of Dual Conformational Restriction on Duplex Thermal Stability ⬇️

scientific article published on 04 September 2013

A New Approach to the Synthesis of Peptidomimetic Renin Inhibitors: Palladium-Catalyzed Asymmetric Allylation of Acyclic Alkyl Aryl Ketones ⬇️

scientific article published on 05 June 2012

A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors.

scientific article published in October 2006

Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes

scientific article published on 22 December 2015

Alternative and expedient asymmetric syntheses of L-(+)-noviose

scientific article published on 15 December 2007

Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences

scientific article published on 17 November 2014

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site

scientific article published in December 2004

Application of Conformation Design in Acyclic Stereoselection: Total Synthesis of Borrelidin as the Crystalline Benzene Solvate ⬇️

scientific article published on November 12, 2003

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

scientific article

Applications of Organocatalytic Asymmetric Synthesis to Drug Prototypes—Dual Action and Selective Inhibitors of n-Nitric Oxide Synthase with Activity Against the 5-HT1D/1B Subreceptors ⬇️

scientific article published on January 27, 2011

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

scientific article published on 14 December 2015

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin

scientific article published on 15 February 2010

Chemistry and biology of the aeruginosin family of serine protease inhibitors

scientific article published on January 2008

Chemistry of the glycosidic linkage. An efficient synthesis of 1,2- trans -di-saccharides

Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs

scientific article published on 27 August 2018

Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren

scientific article published on 06 October 2014

Concise and Stereocontrolled Synthesis of the Tetracyclic Core of Daphniglaucin C ⬇️

scientific article published on July 26, 2013

Conformationally stable and constrained macrocarbocyclic pseudopeptide mimics of beta-hairpin structures

scientific article

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors

scientific article published on 10 October 2006

Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit

scientific article

Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity

scientific article

Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites

scientific article

Cyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines

scientific article published on 22 October 2020

Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods

scientific article published on 01 November 2015

Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis

scientific article

Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs

scientific article published on 05 August 2019

Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras

scientific article published on 05 March 2020

Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics

scientific article

Design and synthesis of bridged piperidine and piperazine isosteres

scientific article published on 19 June 2018

Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme

scientific article published on 01 March 2006

Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa.

scientific article published on 8 October 2010

Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors

scientific article published on 12 October 2016

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists

scientific article published on 15 December 2013

Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).

scientific article published on October 2013

Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists

scientific article published on 13 February 2014

Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

scientific article published on 19 July 2019

Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

scientific article published on 01 February 2016

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm

scientific article published in December 2002

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

scientific article

Docking of aminoglycosides to hydrated and flexible RNA.

scientific article published in February 2006

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

scientific article published on 27 November 2018

Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death

scientific article

Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst

scientific article published on 01 November 2006

Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA

scientific article published on 25 July 2006

From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs

scientific article published on 26 July 2009

Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells

scientific article published in August 2003

Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics

scientific article published in October 2001

Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics We thank the NSERC of Canada for financial support through the Medicinal Chemistry Chair program. We thank Dr

scientific article published on 01 October 2001

Hybrid Aminoglycoside Antibiotics via Tsuji Palladium-Catalyzed Allylic Deoxygenation ⬇️

scientific article published on November 15, 2011

Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products.

scientific article published on 16 December 2013

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

scientific article published on 21 September 2018

Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues ⬇️

scientific article published on September 8, 2011

Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design

scientific article published on 01 September 2006

Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes

scientific article published on 07 May 2014

Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates

scientific article

Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins

scientific article published in September 2006

Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues

scientific article published in November 2005

Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.

scientific article published in September 2003

Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2-Functionalized Isoquinolones: Creating Diversity at C-6 and C-7 to Address Bioactive Analogues

scientific article published on 16 October 2020

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

scientific article published on 12 November 2010

Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

scientific article

Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline

scientific article published on 01 October 2006

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure

scientific article

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity ⬇️

scientific article published on January 31, 2013

Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones

scientific article published in November 2005

Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles

scientific article published on 04 March 2008

Recent Progress in the Chemistry of Daphniphyllum Alkaloids †.

scientific article published on 16 February 2017

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines

scientific article published on 26 June 2019

Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants

scientific article published on 21 July 2007

Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure

scientific article published on 7 December 2007

Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex

scientific article published on 15 June 2016

Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids

scientific article published in August 2005

Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids

scientific article published in August 2005

Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis

scientific article published on 02 June 2016

Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer

scientific article published on 08 September 2015

Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside

scientific article published on 04 July 2018

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE)

scientific article published on 01 July 2006

Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors

scientific article

Structure-based design of a highly constrained nucleic acid analogue: improved duplex stabilization by restricting sugar pucker and torsion angle γ

scientific article published on 22 August 2012

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria ⬇️

scientific article published on September 19, 2010

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

scientific article published on 26 April 2007

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

scientific article published on August 2005

Structure-based organic synthesis of a tricyclic N-malayamycin analogue

scientific article published on 01 December 2006

Structure-based organic synthesis of drug prototypes: a personal odyssey

scientific article published on December 2006

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin

scientific article published in June 2007

Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma

scientific article published on 01 June 2018

Studies toward the generation of functionalized quaternary carbon centers relying on Wittig and Wittig-Still allylic ether anionic transpositions

scientific article

Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics

scientific article published on 01 May 2010

Sulfonamide-based acyclic and conformationally constrained MMP inhibitors: from computer-assisted design to nanomolar compounds

scientific article published in January 2004

Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin

scientific article published on June 2009

Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs

scientific article

Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans

scientific article published on 01 January 2009

Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A

scientific article published on 01 August 2006

Synthesis of 1',2'-methano-2',3'-dideoxynucleosides as potential antivirals

scientific article published on 24 December 2018

Synthesis of 3 10-helix-inducing constrained analogues of L-proline.

scientific article published in July 2004

Synthesis of a Model Tetracyclic Core Structure of Calyciphylline B-Type Alkaloids

scientific article published on 15 February 2016

Synthesis of a potent antagonist of E-selectin

scientific article

Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs

scientific article published on 31 December 2007

Synthesis of cis- and trans-α-l-[4.3.0]Bicyclo-DNA Monomers for Antisense Technology: Methods for the Diastereoselective Formation of Bicyclic Nucleosides ⬇️

scientific article published on September 4, 2013

Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation

scientific article published in September 2003

Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol

scientific article published in September 2003

Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines

scientific article published on 12 February 2020

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms

scientific article published on 2 February 2016

Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers

scientific article published in June 2005

Tandem functionalization of nonactivated alkenes and alkynes in intramolecular N-acyloxyiminium ion carbocyclization. Synthesis of 6-substituted hydroindole 2-carboxylic acids

scientific article published on 01 December 2004

Targeting ACE and ECE with dual acting inhibitors

scientific article published on 10 December 2007

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

scientific article published on 26 September 2016

Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones

scientific article published in October 2002

The Enterprise of Synthesis: From Concept to Practice ⬇️

scientific article published on July 11, 2012

The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin

scientific article

The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity

scientific article published on January 2003

The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor

scientific article

The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids

scientific article published on 23 July 2008

Total Synthesis and Absolute Configuration of (−)-Anthoplalone ⬇️

scientific article published on June 25, 1999

Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2

scientific article published on 05 July 2018

Total Synthesis and Stereochemical Confirmation of (-)-Olivil, (+)-Cycloolivil, (-)-Alashinols F and G, (+)-Cephafortin A, and Their Congeners: Filling in Biosynthetic Gaps

scientific article published on 15 April 2020

Total Synthesis and Structural Confirmation of Malayamycin A: A Novel Bicyclic C-Nucleoside from Streptomyces malaysiensis ⬇️

scientific article published on November 13, 2003

Total Synthesis of (-)-Reserpine Using the Chiron Approach

scientific article published on 01 February 1997

Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum.

scientific article published on 14 January 2016

Total Synthesis of Pactamycin ⬇️

scientific article published on 02 March 2011

Total Synthesis of Pactamycin and Pactamycate: A Detailed Account ⬇️

scientific article published on October 19, 2012

Total synthesis and stereochemical confirmation of manassantin A, B, and B1

scientific article published on 01 November 2006

Total synthesis and structural confirmation of (+)-longicin

scientific article published on 01 September 2005

Total synthesis and structural confirmation of chlorodysinosin A.

scientific article

Total synthesis and structural confirmation of the marine natural product Dysinosin A: a novel inhibitor of thrombin and Factor VIIa

scientific article published in November 2002

Total synthesis and structural revision of the presumed aeruginosins 205A and B

scientific article published on 01 September 2009

Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension

scientific article published in April 2010

Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit

scientific article published on August 2010

Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791

scientific article published on 27 January 2011

Total synthesis of (-)-tetrahydrolipstatin

Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase

scientific article published in May 2002

Total synthesis of N-malayamycin A and related bicyclic purine and pyrimidine nucleosides

scientific article published in August 2005

Total synthesis of jerangolid A.

scientific article published in July 2010

Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F

scientific article published on 01 October 2009

Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates

scholarly article

Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue

scientific article published on 29 September 2011

Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs

scientific article

Vorinostat-like molecules as structural, stereochemical, and pharmacological tools

scientific article

trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition

scientific article published in December 1997

List of works by Stephen Hanessian

3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin

6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase.

A Constrained Tricyclic Nucleic Acid Analogue of α-l-LNA: Investigating the Effects of Dual Conformational Restriction on Duplex Thermal Stability ⬇️

A New Approach to the Synthesis of Peptidomimetic Renin Inhibitors: Palladium-Catalyzed Asymmetric Allylation of Acyclic Alkyl Aryl Ketones ⬇️

A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors.

Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes

Alternative and expedient asymmetric syntheses of L-(+)-noviose

Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site

Application of Conformation Design in Acyclic Stereoselection: Total Synthesis of Borrelidin as the Crystalline Benzene Solvate ⬇️

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

Applications of Organocatalytic Asymmetric Synthesis to Drug Prototypes—Dual Action and Selective Inhibitors of n-Nitric Oxide Synthase with Activity Against the 5-HT1D/1B Subreceptors ⬇️

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin

Chemistry and biology of the aeruginosin family of serine protease inhibitors

Chemistry of the glycosidic linkage. An efficient synthesis of 1,2- trans -di-saccharides

Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs

Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren

Concise and Stereocontrolled Synthesis of the Tetracyclic Core of Daphniglaucin C ⬇️

Conformationally stable and constrained macrocarbocyclic pseudopeptide mimics of beta-hairpin structures

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors

Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit

Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity

Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites

Cyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines

Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods

Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis

Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs

Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras

Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics

Design and synthesis of bridged piperidine and piperazine isosteres

Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme

Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa.

Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists

Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).

Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists

Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

Docking of aminoglycosides to hydrated and flexible RNA.

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death

Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst

Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA

From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs

Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells

Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics

Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics We thank the NSERC of Canada for financial support through the Medicinal Chemistry Chair program. We thank Dr

Hybrid Aminoglycoside Antibiotics via Tsuji Palladium-Catalyzed Allylic Deoxygenation ⬇️

Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products.

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues ⬇️

Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design

Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes

Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates

Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins

Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues

Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.

Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2-Functionalized Isoquinolones: Creating Diversity at C-6 and C-7 to Address Bioactive Analogues

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity ⬇️

Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones

Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles

Recent Progress in the Chemistry of Daphniphyllum Alkaloids †.

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines

Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants

Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure

Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex

Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids

Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids

Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis

Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer

Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE)