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List of works by Thomas E Edwards

A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins

scientific article

A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.

scientific article

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO

scientific article published in September 2018

Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice

scientific article published on 15 September 2021

An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum

scientific article

An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

scientific article

Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface.

scientific article

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a `putative β-lactamase-like protein' from Brucella melitensis

scientific article

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

scientific article

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes

scientific article published on 28 August 2020

Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1

scientific article published in October 2023

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase

scientific article

Combining functional and structural genomics to sample the essential Burkholderia structome

scientific article

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

scientific article

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

scientific article

Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar

scientific article published on 01 February 2020

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase

scientific article

Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C

scientific article

Crystal structure of a hypothetical protein from <i>Giardia lamblia</i>

scientific article published in 2022

Crystal structure of a hypothetical protein from <i>Giardia lamblia</i>. Corrigendum

scientific article published in 2022

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia

scientific article

Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis

scientific article published on 16 February 2021

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx

scientific article published in March 2022

Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei

scientific article published on 27 January 2022

Crystal structure of chorismate mutase from Burkholderia phymatum

scientific article published in April 2018

Crystal structure of chorismate mutase from Burkholderia thailandensis.

scientific article

Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis

scientific article published on 01 January 2022

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases

scientific article

Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition

scientific article

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products

scientific article published on 13 March 2019

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei

scientific article

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.

scientific article published on 13 April 2017

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

scientific article published on 20 February 2017

EPR Spectroscopic Analysis of U7 Hammerhead Ribozyme Dynamics during Metal Ion Induced Folding†

article

EPR spectroscopic analysis of TAR RNA–metal ion interactions

article

Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA

scientific article published on 15 September 2022

Electron Paramagnetic Resonance Spectroscopy of Spin-labeled Rna: An Emerging Tool for the Elucidation of Rna Structure and Dynamics ⬇️

doctoral dissertation by Thomas Eugene Edwards, Chemistry, University of Washington, 2003

Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition

scientific article published in December 2002

Evolutionary Diversification of Host-Targeted Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

scientific article published on 31 July 2021

Ferric pyrophosphate citrate: interactions with transferrin

scientific article published on 11 October 2018

Fragment screening of infectious disease targets in a structural genomics environment

scientific article

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus

scientific article

High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease

scientific article

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation

scientific article published in March 2005

Increasing the structural coverage of tuberculosis drug targets

scientific article

Infliximab crystal structures reveal insights into self-association

scientific article

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

scientific article

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis

scientific article

Investigation of RNA-protein and RNA-metal ion interactions by electron paramagnetic resonance spectroscopy. The HIV TAR-Tat motif

scientific article

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.

scientific article published on 7 May 2015

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

scientific article

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms

scientific article

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance

scientific article published on 2 September 2014

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

scientific article published on 9 August 2022

Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR

scientific article

Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.

scientific article

Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins

scientific article

Mycobacterium tuberculosis Rv2179c Protein Establishes a New Exoribonuclease Family with Broad Phylogenetic Distribution

scientific article

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein

scientific article published on 9 November 2017

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

scientific article published on 25 January 2017

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

scientific article published in 2021

Nanometer Distance Measurements on RNA Using PELDOR

scientific article published on 01 March 2003

Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system

scientific article published on 19 August 2010

New therapeutic strategies for pulmonary diseases - untapping the mycolic acid pathway

scientific article published in 2023

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

scientific article

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

Riboswitches: small-molecule recognition by gene regulatory RNAs

scientific article published on 15 June 2007

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

scientific article published on 10 November 2016

SAD phasing using iodide ions in a high-throughput structural genomics environment

scientific article

Site-specific incorporation of nitroxide spin-labels into 2′-positions of nucleic acids

scientific article published on 01 January 2007

Site-specific incorporation of nitroxide spin-labels into internal sites of the TAR RNA; structure-dependent dynamics of RNA by EPR spectroscopy

scientific article published in February 2001

Structural Basis for Specific, High-Affinity Tetracycline Binding by an In Vitro Evolved Aptamer and Artificial Riboswitch

scientific article

Structural Basis for the Strict Substrate Selectivity of the Mycobacterial Hydrolase LipW.

scientific article

Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase

scientific article

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.

scientific article

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1

scientific article

Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody

scientific article

Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface

scientific article published on 14 January 2021

Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1

scientific article published on 4 May 2021

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis

scientific article

Structural diversity in the Mycobacteria DUF3349 superfamily

scientific article published on 21 November 2019

Structural insights into the function of the catalytically active human Taspase1

scientific article published in August 2021

Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D

scientific article

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

scientific article

Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head

scientific article

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.

scientific article published on 18 April 2015

Structure of a Nudix hydrolase (MutT) in the Mg 2+ -bound state from Bartonella henselae , the bacterium responsible for cat scratch fever

scientific article

Structure of acid deoxyribonuclease

scientific article

Structure of aldose reductase from Giardia lamblia

scientific article

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.

scientific article published on 21 April 2015

Structure of fumarate hydratase from Rickettsia prowazekii , the agent of typhus and suspected relative of the mitochondria

scientific article

Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile

scientific article

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans

scientific article

Structure of theReston ebolavirusVP30 C-terminal domain

scientific article

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica

scientific article published on 21 April 2015

Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors

scientific article published on 8 September 2022

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

scientific article published on 21 April 2015

Structures of a putative ζ-class glutathione S -transferase from the pathogenic fungus Coccidioides immitis

scientific article

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia

scientific article published on 21 April 2015

Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis

scientific article published on 28 January 2020

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei

scientific article

Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme ⬇️

scientific article published in April 2022

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP

scientific article published on 21 April 2015

The Protein Maker: an automated system for high-throughput parallel purification

scientific article

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

scientific article published on 15 March 2018

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force

scientific article published on 03 July 2013

Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch

scientific article

Toward a structome of Acinetobacter baumannii drug targets

scientific article published on 20 January 2020

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

scientific article

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase

scientific article

X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source

scientific article

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